JP2013241476A5 - - Google Patents
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- Publication number
- JP2013241476A5 JP2013241476A5 JP2013188248A JP2013188248A JP2013241476A5 JP 2013241476 A5 JP2013241476 A5 JP 2013241476A5 JP 2013188248 A JP2013188248 A JP 2013188248A JP 2013188248 A JP2013188248 A JP 2013188248A JP 2013241476 A5 JP2013241476 A5 JP 2013241476A5
- Authority
- JP
- Japan
- Prior art keywords
- topiramate
- sodium
- solid preparation
- crystals
- carmellose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical compound C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 claims 17
- 229960004394 topiramate Drugs 0.000 claims 17
- 239000013078 crystal Substances 0.000 claims 12
- 238000002360 preparation method Methods 0.000 claims 12
- 239000007787 solid Substances 0.000 claims 11
- 238000000034 method Methods 0.000 claims 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims 4
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 claims 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 4
- 239000000654 additive Substances 0.000 claims 4
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 4
- 229950008138 carmellose Drugs 0.000 claims 4
- 235000012239 silicon dioxide Nutrition 0.000 claims 4
- 230000000996 additive effect Effects 0.000 claims 3
- 230000006641 stabilisation Effects 0.000 claims 3
- 238000011105 stabilization Methods 0.000 claims 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 2
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 2
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 claims 2
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 claims 2
- 239000011575 calcium Substances 0.000 claims 2
- 229910052791 calcium Inorganic materials 0.000 claims 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 2
- 239000000378 calcium silicate Substances 0.000 claims 2
- 229910052918 calcium silicate Inorganic materials 0.000 claims 2
- OYACROKNLOSFPA-UHFFFAOYSA-N calcium;dioxido(oxo)silane Chemical compound [Ca+2].[O-][Si]([O-])=O OYACROKNLOSFPA-UHFFFAOYSA-N 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 150000007942 carboxylates Chemical class 0.000 claims 2
- 150000001734 carboxylic acid salts Chemical class 0.000 claims 2
- 229960001681 croscarmellose sodium Drugs 0.000 claims 2
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 2
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims 2
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 claims 2
- 239000004503 fine granule Substances 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000008187 granular material Substances 0.000 claims 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims 2
- 239000001095 magnesium carbonate Substances 0.000 claims 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 235000013923 monosodium glutamate Nutrition 0.000 claims 2
- 239000011591 potassium Substances 0.000 claims 2
- 229910052700 potassium Inorganic materials 0.000 claims 2
- 238000010298 pulverizing process Methods 0.000 claims 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims 2
- 239000000377 silicon dioxide Substances 0.000 claims 2
- 239000011734 sodium Substances 0.000 claims 2
- 229910052708 sodium Inorganic materials 0.000 claims 2
- 239000000661 sodium alginate Substances 0.000 claims 2
- 235000010413 sodium alginate Nutrition 0.000 claims 2
- 229940005550 sodium alginate Drugs 0.000 claims 2
- 229910000029 sodium carbonate Inorganic materials 0.000 claims 2
- 229940073490 sodium glutamate Drugs 0.000 claims 2
- WTWSHHITWMVLBX-DKWTVANSSA-M sodium;(2s)-2-aminobutanedioate;hydron Chemical compound [Na+].[O-]C(=O)[C@@H](N)CC(O)=O WTWSHHITWMVLBX-DKWTVANSSA-M 0.000 claims 2
- 230000000087 stabilizing effect Effects 0.000 claims 2
- 239000008107 starch Substances 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- 239000006188 syrup Substances 0.000 claims 2
- 235000020357 syrup Nutrition 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims 1
- -1 is La Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013188248A JP6125957B2 (ja) | 2007-04-12 | 2013-09-11 | トピラマート含有固形製剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007104853 | 2007-04-12 | ||
| JP2007104853 | 2007-04-12 | ||
| JP2013188248A JP6125957B2 (ja) | 2007-04-12 | 2013-09-11 | トピラマート含有固形製剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008103209A Division JP5424571B2 (ja) | 2007-04-12 | 2008-04-11 | トピラマート含有固形製剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016207609A Division JP2017014289A (ja) | 2007-04-12 | 2016-10-24 | トピラマート含有固形製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013241476A JP2013241476A (ja) | 2013-12-05 |
| JP2013241476A5 true JP2013241476A5 (enExample) | 2014-02-13 |
| JP6125957B2 JP6125957B2 (ja) | 2017-05-10 |
Family
ID=40141447
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008103209A Active JP5424571B2 (ja) | 2007-04-12 | 2008-04-11 | トピラマート含有固形製剤 |
| JP2013188248A Active JP6125957B2 (ja) | 2007-04-12 | 2013-09-11 | トピラマート含有固形製剤 |
| JP2016207609A Pending JP2017014289A (ja) | 2007-04-12 | 2016-10-24 | トピラマート含有固形製剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008103209A Active JP5424571B2 (ja) | 2007-04-12 | 2008-04-11 | トピラマート含有固形製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016207609A Pending JP2017014289A (ja) | 2007-04-12 | 2016-10-24 | トピラマート含有固形製剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (3) | JP5424571B2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110009347A1 (en) | 2009-07-08 | 2011-01-13 | Yin Liang | Combination therapy for the treatment of diabetes |
| TWI599360B (zh) * | 2010-05-11 | 2017-09-21 | 健生藥品公司 | 醫藥調配物 |
| RS55056B1 (sr) | 2011-04-13 | 2016-12-30 | Janssen Pharmaceutica Nv | Proces za pripremu jedinjenja koja su korisna kao inhibitori sglt2 |
| IN2013MU02470A (enExample) * | 2013-07-25 | 2015-06-26 | Cadila Healthcare Ltd | |
| CN108379588B (zh) * | 2018-03-05 | 2024-07-02 | 合肥合源药业有限公司 | 托吡酯组合物 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU651244B2 (en) * | 1991-09-19 | 1994-07-14 | Mcneilab, Inc. | Process for the preparation of chlorosulfate and sulfamate derivatives of 2,3:4,5-bis-0-(1-methylethylidene)-beta-D- fructopyranose and (1-methylcyclohexyl)methanol |
| UA65607C2 (uk) * | 1998-03-04 | 2004-04-15 | Орто-Макнейл Фармацевтикал, Інк. | Фармацевтична композиція (варіанти) та спосіб її приготування |
| EP1157682A1 (en) * | 2000-05-25 | 2001-11-28 | Cilag AG | Blister package for topiramate tablets |
| DE10153078A1 (de) * | 2001-10-30 | 2003-05-22 | Degussa | Verwendung von Granulaten auf Basis von pyrogen hergestelltem Siliciumdioxid in pharmazeutischen Zusammensetzungen |
| EP1587499A1 (en) * | 2003-01-31 | 2005-10-26 | Elan Pharma International Limited | Nanoparticulate topiramate formulations |
| WO2005065648A2 (en) * | 2003-12-29 | 2005-07-21 | Alza Corporation, Inc., | Novel drug compositions and dosage forms of topiramate |
| EP1973528B1 (en) * | 2006-11-17 | 2012-11-07 | Supernus Pharmaceuticals, Inc. | Sustained-release formulations of topiramate |
| WO2008070670A2 (en) * | 2006-12-04 | 2008-06-12 | Supernus Pharmaceuticals, Inc. | Enhanced immediate release formulations of topiramate |
-
2008
- 2008-04-11 JP JP2008103209A patent/JP5424571B2/ja active Active
-
2013
- 2013-09-11 JP JP2013188248A patent/JP6125957B2/ja active Active
-
2016
- 2016-10-24 JP JP2016207609A patent/JP2017014289A/ja active Pending
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