JP2013231021A - Plaster - Google Patents
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- Publication number
- JP2013231021A JP2013231021A JP2012115997A JP2012115997A JP2013231021A JP 2013231021 A JP2013231021 A JP 2013231021A JP 2012115997 A JP2012115997 A JP 2012115997A JP 2012115997 A JP2012115997 A JP 2012115997A JP 2013231021 A JP2013231021 A JP 2013231021A
- Authority
- JP
- Japan
- Prior art keywords
- patch
- water
- containing layer
- plaster
- hydrous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011505 plaster Substances 0.000 title abstract 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 43
- 239000000853 adhesive Substances 0.000 claims abstract description 7
- 230000001070 adhesive effect Effects 0.000 claims abstract description 7
- 238000000465 moulding Methods 0.000 claims abstract description 7
- 238000004040 coloring Methods 0.000 claims abstract 2
- 238000005192 partition Methods 0.000 claims description 18
- 239000003814 drug Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 12
- 239000003795 chemical substances by application Substances 0.000 abstract description 3
- 238000000638 solvent extraction Methods 0.000 abstract 3
- 239000004480 active ingredient Substances 0.000 description 4
- 239000004745 nonwoven fabric Substances 0.000 description 3
- 230000007423 decrease Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 229940124532 absorption promoter Drugs 0.000 description 1
- 238000004873 anchoring Methods 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000020411 cell activation Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Images
Landscapes
- Medicinal Preparation (AREA)
Abstract
Description
本発明は、含水層が積層されてなる貼付剤に関し、貼付部位によって使用する原料を変えることで1枚の貼付剤で複数の異なる効果を持たせられる事が可能な貼付剤に関する。 The present invention relates to a patch in which a water-containing layer is laminated, and relates to a patch capable of having a plurality of different effects with one patch by changing the raw material to be used depending on the patch site.
美容や治療等の目的で皮膚に貼り付けて用いられる貼付剤は、化粧料や薬剤を含有する含水層と、この含水層を支持する支持体とから構成され、含水層の表面には剥離可能な外装部が貼着されている。 A patch used by applying to the skin for the purpose of beauty or treatment is composed of a water-containing layer containing cosmetics and drugs, and a support that supports this water-containing layer, and can be peeled off on the surface of the water-containing layer The exterior part is stuck.
特許文献1には、支持体としてポリウレタン、ポリエステル等を用い、含水層と支持体との投錨性を向上させるために、プライマー層が設けられた貼付剤が開示されている。また、支持体は、一般的な不織布でもよい。支持体については、投錨していても投錨していなくてもどちらでもよい。
しかしながら、特許文献1又は従来の貼付剤では、1シート状に同一の成分しか配合できず、貼付部位によって効果を変えることが不可能であった。 However, in
また、特許文献1に限らず既存の貼付剤は部位により任意に厚みを変更させることが不可能であった。Moreover, it is impossible to change the thickness of an existing patch as well as
更に、配合させる成分により含水層の粘着力が低下してしまい、貼りつきにくいという傾向にあった。Furthermore, the adhesive force of the water-containing layer was lowered by the component to be blended, and there was a tendency that it was difficult to stick.
解決しようとする問題点は、従来の貼付剤では1シート上に同一の成分しか配合できず、貼付部位によって効果を変えることができないという点である。そこで本発明は、1つのシート上に複数の異なる効果を持たせ、かつ、貼付剤上で薬剤等が混ざることなく安定性に優れた貼付剤の提供を目的とする。 The problem to be solved is that in the conventional patch, only the same component can be blended on one sheet, and the effect cannot be changed depending on the application site. Therefore, the present invention has an object to provide a patch having excellent stability without giving a plurality of different effects on one sheet and mixing a medicine or the like on the patch.
請求項1に係る発明は、複数の含水層と該含水層を区分けする仕切り部材と含水層の少なくとも片面に積層された支持体とからなる含水層が貼付する貼付剤で、各々の含水層が部位により複数の効果を持たせたことを特徴とする貼付剤に関する。 The invention according to
請求項2に係る発明は、前記複数の効果が有効成分により、含水率が部位により任意に変えることができることを特徴とする貼付剤に関する。複数の手段としては、異なる着色の構成、また、異なる匂いの構成、また、異なる粘着力の構成を持たせることに関する。 The invention according to claim 2 relates to a patch characterized in that the plurality of effects can be arbitrarily changed by active ingredients and the water content can be changed depending on the site. The plurality of means relate to providing different colored configurations, different odor configurations, and different adhesive strength configurations.
請求項3に係る発明は、前記複数の異なる含水層が外装部に仕切りを作ることで、混ざることなく安定性に優れることを特徴とする貼付剤に関する。仕切り部材の作製方法は、外装部成型時に凸部を設けても、別で成型された仕切り部材を設けて凸部を作製してもよい。 The invention according to claim 3 relates to a patch characterized in that the plurality of different water-containing layers form a partition in the exterior part and are excellent in stability without being mixed. As a method for manufacturing the partition member, a convex portion may be provided at the time of molding the exterior portion, or a convex member may be manufactured by providing a partition member formed separately.
請求項4に係る発明は、前記含水層の厚みを任意に調整できることを特徴とする貼付剤に関する。 The invention according to
請求項1に係る発明によれば、含水層と該含水層の少なくとも片面に積層させた支持体で構成された貼付剤で、使用したい部位に応じて薬効成分を変えた箇所を設けることで、より適した使用方法が可能となる。 According to the invention according to
請求項2に係る発明によれば、前記貼付剤に異なる着色構成を持たせることで、視認性の向上が可能となる。または、異なる匂いの構成を持たせることで、香料の使用量を減らせることが可能となる。または、外周部に高い粘着力を持たせた含水層を用いる事で、有効成分の影響で粘着力が落ちた際にでも、貼付剤の外装部に粘着力の高い含水層を設けることで、長時間の貼付が可能となる。または、異なる含水率の含水層を持たせることで、柔らかい触感の固形保持性に優れた貼付剤を提供することが可能となる。According to the invention which concerns on Claim 2, visibility improvement is attained by giving a different colored structure to the said patch. Or it becomes possible to reduce the usage-amount of a fragrance | flavor by giving the structure of a different odor. Or, by using a water-containing layer with high adhesive strength on the outer periphery, even when the adhesive strength drops due to the effect of the active ingredient, by providing a water-containing layer with high adhesive strength on the exterior of the patch, Long time sticking is possible. Or it becomes possible to provide the patch which was excellent in the solid retainability of a soft tactile sensation by giving the water-containing layer of a different moisture content.
請求項3に係る発明によれば、前記貼付剤に異なる部位を持たせた際に、薬剤が混ざることなく部位への貼付が可能となる。 According to the invention which concerns on Claim 3, when a different site | part is given to the said patch, it can stick to a site | part, without a chemical | medical agent mixing.
請求項4に係る発明によれば、前記貼付剤の厚みを任意で変更させることで、高価な薬効成分の使用量を抑えることが可能となる。 According to the invention which concerns on
以下、本発明に係る貼付剤について詳述する。
図1、図2は本発明に係る貼付剤の一例を示す図である。
本発明に係る貼付剤(1)は、含水層(2)と、含水層(2)を支持する支持体(3)とが積層して構成されており、外装部(4)上に構成される。Hereinafter, the patch according to the present invention will be described in detail.
1 and 2 are diagrams showing an example of a patch according to the present invention.
The patch (1) according to the present invention is formed by laminating a water-containing layer (2) and a support (3) that supports the water-containing layer (2), and is formed on the exterior part (4). The
含水層(2)は貼付時に被貼付面(皮膚)に対して、保湿、細胞賦活、美肌、美白等の効果をもたらす層である。これらの効果を得るために、公知の有効成分が含水層(2)に配合され、その配合量も適宜調整される。また、含水層(2)には保存剤、乳化剤、pH調整剤、吸収促進剤等を添加しても良く、その添加量は適宜調整される。The water-containing layer (2) is a layer that provides effects such as moisturizing, cell activation, skin beautification and whitening on the surface to be applied (skin) at the time of application. In order to acquire these effects, a known active ingredient is mix | blended with a water-containing layer (2), and the compounding quantity is also adjusted suitably. Moreover, you may add a preservative, an emulsifier, a pH adjuster, an absorption promoter, etc. to a water-containing layer (2), and the addition amount is adjusted suitably.
含水層(2)はゲル状であり、40〜90重量%の水分を保持する含水ゲル(ハイドロゲル)であることが望ましい。 The water-containing layer (2) is gel-like, and is preferably a water-containing gel (hydrogel) that retains 40 to 90% by weight of water.
含水層(2)の厚みは0.3〜5mmであることが望ましい。0.3mm未満であると単位面積当たりの含水量が低下するため、有効成分量が少なくなり上記した効果を得ることが期待できず、3mmを超えると、含水量が増加するため皮膚に貼り付けて使用した際に貼付剤の自重によって貼着状態を維持することが困難となり、ずれや脱離が生じることとなり、いずれの場合も好ましくない。 The thickness of the water-containing layer (2) is desirably 0.3 to 5 mm. If it is less than 0.3 mm, the water content per unit area decreases, so the amount of active ingredients decreases and the above-mentioned effects cannot be expected. When it is used, it becomes difficult to maintain the sticking state due to the weight of the patch, resulting in deviation or detachment, which is not preferable in either case.
含水層(2)を支持する支持体(3)はシート状とされ、含水層(2)の少なくとも片面に積層される(図1参照)。
支持体(3)の厚みは10〜100μmであることが望ましく、より好ましくは20〜50μmである。20μm未満であると含水層(2)の支持が不十分となり、貼付作業が困難となる。一方、50μmを超えると支持体(3)の厚みで柔軟性が乏しくなり貼付部位の凹凸に追従せず、貼付困難となる。従って、いずれの場合も好ましくない。The support (3) that supports the water-containing layer (2) is in the form of a sheet and is laminated on at least one side of the water-containing layer (2) (see FIG. 1).
As for the thickness of a support body (3), it is desirable that it is 10-100 micrometers, More preferably, it is 20-50 micrometers. When it is less than 20 μm, the support of the water-containing layer (2) becomes insufficient, and the pasting work becomes difficult. On the other hand, when the thickness exceeds 50 μm, the thickness of the support (3) becomes poor, and the unevenness of the application site does not follow, making application difficult. Therefore, it is not preferable in either case.
本発明に用いられる支持体(3)としては、ポリウレタン、ポリエステル、ポリアミド、ポリオレフィン、ポリスチレン、ポリ塩化ビニル等の透明フィルム、或いは不織布が用いられるが、含水層(2)中の水分を適度に揮発させることができるため不織布が好適に用いられる。 As the support (3) used in the present invention, a transparent film such as polyurethane, polyester, polyamide, polyolefin, polystyrene, polyvinyl chloride, or nonwoven fabric is used, but the water in the water-containing layer (2) is appropriately volatilized. Therefore, a nonwoven fabric is preferably used.
図3は、本発明に係る貼付剤の別の例を示す図である。
本発明に係る貼付剤において、外装部(4)に凸状仕切り部材(31)を設けることが望ましい。
外装部(4)に設けられる仕切り部材(31)は、含水層(2)中の異なる薬効成分が混ざらないようにするためのしきりである。図3−1は浮いた状態であり、図3−2は外装部に設置している図である。粘度等により、仕切り部材は外装部から浮いていても設置していてもよい。
凸状の仕切り部材(31)は、真空成型やインフレーション成型の加工時に設けられる。また、外装部を重ねたり、凸状の器具を後で取りつけてもよい。FIG. 3 is a view showing another example of the patch according to the present invention.
In the patch according to the present invention, it is desirable to provide a convex partition member (31) in the exterior part (4).
The partition member (31) provided in the exterior part (4) is a threshold for preventing different medicinal components in the water-containing layer (2) from being mixed. FIG. 3-1 is a floating state, and FIG. 3-2 is a view of being installed in the exterior part. Depending on the viscosity or the like, the partition member may float or be installed from the exterior portion.
The convex partition member (31) is provided during vacuum molding or inflation molding. Moreover, an exterior part may be piled up and a convex instrument may be attached later.
外装部(4)には、図3に示すように部分的に亘って仕切り部材(31)を設けてもよい。仕切り部材(31)を網目状とする場合、網目の大きさは特に限定されず、貼付剤(1)の大きさによって適宜調整される。
仕切り部材(31)は、図3に示すように網目状に限定されず、図柄として設けることもできる。また仕切り部材(31)は、貼付剤(1)の形状全体に亘って設けられてもよいが、一部分のみに設けられてもよく、いずれの場合においても複数の貼付剤を安定して作製することが可能となる。As shown in FIG. 3, a partition member (31) may be partially provided in the exterior part (4). When the partition member (31) has a mesh shape, the size of the mesh is not particularly limited, and is appropriately adjusted depending on the size of the patch (1).
The partition member (31) is not limited to a mesh shape as shown in FIG. 3, and may be provided as a design. Further, the partition member (31) may be provided over the entire shape of the patch (1), but may be provided only in a part, and in any case, a plurality of patches can be stably produced. It becomes possible.
図3、図4は、本発明に係る貼付剤の別の例を示す図である。
本発明に係る貼付剤において、外装部(4)に凸状仕切り部材(31)を設けることが望ましい。
外装部(4)に設けられる仕切り部材(31)は、含水層(2)中の異なる薬効成分が混ざらないようにするためのしきりである。図3は浮いた状態であり、図4は外装部に設置している図である。粘度等により、仕切り部材は外装部から浮いていても設置していてもよい。
凸状の仕切り部材(31)は、真空成型やインフレーション成型の加工時に設けられる。また、外装部を重ねたり、凸状の器具を後で取りつけてもよい。3 and 4 are diagrams showing another example of the patch according to the present invention.
In the patch according to the present invention, it is desirable to provide a convex partition member (31) in the exterior part (4).
The partition member (31) provided in the exterior part (4) is a threshold for preventing different medicinal components in the water-containing layer (2) from being mixed. FIG. 3 is a floating state, and FIG. 4 is a view of being installed in the exterior part. Depending on the viscosity or the like, the partition member may float or be installed from the exterior portion.
The convex partition member (31) is provided during vacuum molding or inflation molding. Moreover, an exterior part may be piled up and a convex instrument may be attached later.
Claims (4)
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JPH10508849A (en) * | 1994-11-14 | 1998-09-02 | アルザ・コーポレーション | Compositions, devices and methods for electrotransport agent administration |
JPH11504229A (en) * | 1995-04-28 | 1999-04-20 | アルザ コーポレイション | Compositions and methods for enhancing electrotransport drug distribution |
JPH11158081A (en) * | 1996-03-11 | 1999-06-15 | Fuisz Technol Ltd | Drug delivery system |
JPH11269031A (en) * | 1998-03-20 | 1999-10-05 | Kanebo Ltd | Transparent sheet-form cosmetic material, production thereof and makeup method |
JP2000143484A (en) * | 1998-11-06 | 2000-05-23 | Nitto Denko Corp | Cosmetic gel sheet |
JP2002532569A (en) * | 1998-12-22 | 2002-10-02 | アルザ・コーポレーション | Polymer membrane drug storage |
JP2000212074A (en) * | 1999-01-27 | 2000-08-02 | Sekisui Plastics Co Ltd | Multilayer gel structural self-adhesive sheet for living body and cosmetic and quasi-drug using the same |
JP2001213768A (en) * | 2000-02-01 | 2001-08-07 | Okayama Taiho Pharmaceutical Co Ltd | Poultice |
JP2007523695A (en) * | 2004-01-08 | 2007-08-23 | ロバート タッパー | Ion, molecular or electronic control methods, apparatus, and charged chemicals |
JP2005245874A (en) * | 2004-03-05 | 2005-09-15 | Terumo Corp | Pressure sensitive adhesive sheet for hair removal |
JP2008543872A (en) * | 2005-06-17 | 2008-12-04 | アルテア セラピューティクス コーポレイション | Permeate delivery system and method of use |
JP2007297353A (en) * | 2006-05-02 | 2007-11-15 | Advance Co Ltd | Adhesion type aromatic sheet |
WO2011068522A1 (en) * | 2009-12-02 | 2011-06-09 | Nimble Epitech | Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor |
WO2011103041A1 (en) * | 2010-02-18 | 2011-08-25 | Yu Chris C | Method of fabricating micro-devices |
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