JP2013124226A - Emulsified composition containing ceramide - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a new emulsified composition having ceramide combined stably, and excellent in moisturizing effect, moisture evaporation inhibitory effect, feeling of use, and preparation stability.SOLUTION: The aimed emulsified composition includes ceramide, phospholipid, isostearic acid, and a hydroxyalkyl (C12-18) hydroxy-dimer dilinoleyl ether. Preferably, ceramide is of the type 2, or the content of ceramide is 0.01-5 mass%, or the content of phospholipid is 0.01-5 mass%.

Description

The present invention relates to a new emulsified composition containing ceramide, phospholipid, isostearic acid, and an oil agent and having good moisturizing effect, moisture transpiration inhibiting effect, feeling of use, and formulation stability.

The stratum corneum exists in the outermost layer of the skin, and can be said to be an important biological defense organ having a function of preventing physical and chemical stimulation from the outside. Such protection is derived from the dense layered structure of the stratum corneum cells constituting the stratum corneum, that is, the skin barrier structure. Such a skin barrier function is largely derived from the structure of stratum corneum cells, and if an abnormality occurs in the stratum corneum cells or the stratum corneum that is a layered structure thereof, it is impossible to prevent the invasion of foreign substances. , Undesirable bacteria, viruses, substances that adversely affect the living body enter the living body, cause diseases such as inflammation, the retention of the in vivo substance in the body is incomplete, and suppress the dissipation of water from the skin It becomes impossible to reduce the amount of moisture in the skin and impairs the appearance of the skin, such as the dryness and freshness of the skin.

In order to improve the skin barrier function, various cosmetics have been developed for the purpose of maintaining and reinforcing the cosmetics containing ceramide, which occupies most of the stratum corneum intercellular lipids, and the moisture retention function of the stratum corneum. Emulsified cosmetics such as emulsions and creams containing oils have been developed.

Ceramide is an important component constituting the skin, and is said to have a skin barrier function as its function. For this reason, many attempts have been made to blend into cosmetics, etc., but since there is not much compatibility with water and oily components, the blending is a lot difficult from a pharmaceutical standpoint. Accompanied by. For example, the case where insoluble matters are formed by long-term storage can be exemplified.

Based on these issues, a technology has been devised in which a liquid crystal structure is prepared using polyhydric alcohol, higher alcohol, acylated polyglycerin, etc., and ceramide is stably contained in the form of liquid crystal (for example, patents) Literature 1, Patent Literature 2). There is also a technique for forming vesicles with ceramide, phospholipid, and cationic surfactant (for example, Patent Document 3). Furthermore, by adding ceramide to a product obtained by neutralizing isostearic acid with a basic substance and adding a higher alcohol, a closed vesicle composed of a bilayer membrane can be formed, whereby a large amount of ceramide is contained in an aqueous medium. There are also techniques for blending (for example, Patent Document 4). However, the dispersion stability of liquid crystals and vesicles in such a system is not good in long-term storage.

On the other hand, the emulsion composition can be blended with a wide variety of oils and is in a useful dosage form. Among such emulsified compositions, since many ceramides are blended, an ester oil and an emulsified composition having improved solubility of hardly soluble substances such as ceramide have been proposed (for example, Patent Document 5). However, since these ester oils have high polarity, there are problems in stability over time and at high temperatures when an emulsion composition is used. Therefore, it has been desired to develop a new emulsion composition that can dissolve a large amount of ceramide and has excellent emulsion stability.

JP 2004-331595 A JP 2004-331594 A JP 2006-193464 A JP 2008-94810 A JP 2003-104911 A

An object of the present invention is to provide a new emulsified composition containing ceramide stably, having a moisturizing effect, a moisture transpiration suppressing effect, a feeling of use, and a good formulation stability.

In view of such a situation, the present inventors used oil agents and emulsifiers that can be used in the cosmetics field in combination, and as a result of earnest research aimed at new emulsified compositions, the following emulsified compositions as shown below However, the inventors have found that it is possible to stably blend ceramide and to secure an emulsified composition having a moisturizing effect, a moisture transpiration suppressing effect, a feeling of use, and a good formulation stability, and the present invention has been completed. That is, the present invention is as follows.

(1) An emulsified composition comprising (A) ceramide, (B) phospholipid, (C) isostearic acid, and (D) hydroxyalkyl (C12-18) hydroxydimerlinoleyl ether. object.
(2) The emulsified composition according to (1), wherein the ceramide is ceramide type 2.
(3) Content of said ceramide is 0.01-5 mass%, The emulsion composition as described in (1) or (2) characterized by the above-mentioned.
(4) The emulsified composition according to any one of (1) to (3), wherein the phospholipid content is 0.01 to 5% by mass.

  According to the present invention, it is possible to provide a new emulsified composition having a moisturizing effect, a moisture transpiration suppressing effect, a feeling of use, and a formulation stability.

<Ceramide essential for the present invention>
The emulsion composition of the present invention contains ceramide as an essential component. As ceramide, it is generally known that type 1 to type 7 exist, and any of them can be used. Among them, type 2 is particularly preferable, and N-stearoyl dihydroxysphingosine is particularly preferable. Such ceramide has a commercial item, and such a commercial item can be purchased and used. Among such commercially available products, “Ceramide I” (manufactured by Cosmo Farm), which is a type 1, N- (27-octadecanoyloxy-heptacosanoyl-)-phytosphingosine, is preferred. “Ceramide TIC-001” (manufactured by Takasago Kagaku Kogyo Co., Ltd.) containing N-stearoyl dihydroxysphingosine, which is type 2, and “Ceramide III” (Cosmo Farm, Inc.) containing N-stearoyl phytosphingosine, type 3. "Ceramide IIIA" (manufactured by Cosmo Farm), N-oleoyl phytosphingosine, "Ceramide IIIB" (manufactured by Cosmo Farm), type 6 “Ceramide VI, which contains N-2-hydroxystearoyl phytosphingosine” (Cosmo Pharm, Ltd.) can be preferably exemplified. These can contain only the seed | species, and can also be made to contain in combination of 2 or more type. The preferable content of the ceramide in the external preparation of the present invention is preferably 0.01 to 5% by mass, more preferably 0.1 to 2% by mass, based on the total amount of the emulsion composition. If the amount is too small, the preferable effect of ceramide will not be exhibited. If the amount is too large, an insoluble substance of ceramide may be formed.

<Phospholipids essential for the present invention>
The emulsified composition of the present invention is characterized by containing phospholipid as an essential component. In the emulsified composition of the present invention, phospholipids usually used for cosmetics and the like can be used without particular limitation. Preferred examples of such phospholipids include those selected from lecithin, phosphatidylglycerol, phosphatidylserine, phosphatidylinositol, phosphatidylethanolamine, phosphatidylic acid, and lyso forms thereof. Here, lecithin is a common name for phospholipids containing phosphatidylcholine as a main component. Instead of lecithin, phosphatidylcholine as a main component can also be used. As the base source, soybean, egg yolk and the like can be preferably exemplified, and soybean can be particularly preferably exemplified. In the composition for external use of the present invention, such a phospholipid may contain only one species or may contain two or more species in combination. The preferable content of such phospholipids in the external composition of the present invention is the total amount, preferably 0.01 to 5.0% by mass, more preferably 0.5 to 3%, based on the total amount of the emulsified composition. 0.0% by mass. This is because if the amount is too small, a stable emulsified composition cannot be obtained, and if it is too much, the feeling of use becomes very bad.

<Isostearic acid essential for the present invention>
The emulsion composition of the present invention contains isostearic acid. Such isostearic acid is preferably contained in an amount of 0.1 to 10.0% by mass, and more preferably 1.0 to 5.0% by mass. By containing in this amount range, the emulsion stability can be enhanced. Further, isostearic acid may be neutralized and in the form of a salt, and any neutralizing agent that is usually used in cosmetics can be used without any particular limitation. For example, alkali metal salts such as sodium salt and potassium salt, alkaline earth metal salts such as calcium salt and magnesium salt, organic amine salts such as ammonium salt, triethylamine salt, triethanolamine salt and monoethanolamine salt, lysine salt, Preferred examples include basic amino acid salts such as arginate. Particularly preferred is the potassium salt.

<Hydroxyalkyl (C12-18) hydroxy dimer linoleyl ether essential for the present invention>
The emulsified composition of the present invention contains hydroxyalkyl (C12-18) hydroxy dimer linoleyl ether. Both are raw materials for cosmetics, and there are already commercially available products such as Supermol PS (manufactured by Croda Japan Co., Ltd.) and Supermol LM (manufactured by Croda Japan Co., Ltd.). The component is preferably contained in an amount of 1.0 to 10.0% by mass, and more preferably 5.0 to 7.0% by mass.

<Emulsified composition of the present invention>
The emulsified composition of the present invention includes skin care cosmetics such as emulsions, creams, cosmetics, massages, packs, and makeup cosmetics such as liquid foundations, cleansing creams, facial cleansers such as body shampoos, shampoos, rinses, Includes hair compositions such as treatments and hair styling.

  The emulsified composition thus obtained can be a completely new emulsified composition excellently moisturizing effect, moisture transpiration inhibiting effect, feeling of use and formulation stability, in which ceramide is stably blended.

In the emulsified composition of the present invention, in addition to the above-mentioned components, optional components usually used in cosmetics and external medicine for skin can be contained. Examples of such optional ingredients include macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, and hardened coconut oil. Oil, wax, liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum, oil, wax, liquid wax, liquid paraffin, squalane, bean wax, candelilla wax, carnauba wax, ibotarou, lanolin, reduced lanolin, hard lanolin , Hydrocarbons such as microcrystalline wax, higher fatty acids such as oleic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, cetyl alcohol, stearyl alcohol, isostearyl alcohol, Higher alcohols such as alcohol, octyldodecanol, myristyl alcohol, cetostearyl alcohol, cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, diacid malate Isostearyl, ethylene glycol di-2-ethylhexanoate, neopentyl glycol dicaprate, glycerin di-2-heptylundecanoate, glycerin tri-2-ethylhexanoate, tri-2-ethylhexanoate trimethylolpropane, triisostearin Synthetic ester oils such as acid trimethylolpropane, tetra-2-ethylhexanoic acid pentane erythritol, dimethylpolysiloxane, methylphenylpolysiloxane, diphenyl Linear polysiloxanes such as polypolysiloxane, cyclic polysiloxanes such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexanesiloxane, amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified Oil agents such as silicone oils such as modified polysiloxanes such as polysiloxane, fatty acid soap (sodium laurate, sodium palmitate, etc.), anionic surfactants such as potassium lauryl sulfate, alkyl sulfate triethanolamine ether, stearyl trimethyl chloride Cationic surfactants such as ammonium, benzalkonium chloride, laurylamine oxide, betaine surfactants (alkyl betaines, amide betaines, sulfobetaines, etc.) ), Imidazoline-based amphoteric surfactants (2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), amphoteric surfactants such as acylmethyltaurine, sorbitan fatty acid esters (sorbitan monoester) Stearate, sorbitan sesquioleate, etc.)
Glycerin fatty acids (such as glyceryl monostearate), propylene glycol fatty acid esters (such as propylene glycol monostearate), hydrogenated castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, monostearic acid) Polyoxyethylene sorbitan, etc.), POE sorbite fatty acid esters (POE-sorbite monolaurate, etc.), POE glycerin fatty acid esters (POE-glycerin monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate). etc)
POE alkyl ethers (POE2-octyldodecyl ether, etc.), POE alkylphenyl ethers (POE nonylphenyl ether, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP2-decyltetradecyl ether, etc.), Te Tronics, POE castor oil / hardened castor oil derivatives (POE castor oil, POE hardened castor oil, etc.), nonionic surfactants such as sucrose fatty acid ester, alkyl glucoside, polyethylene glycol, glycerin, 1,3-butylene glycol Erythritol, sorbitol, xylitol, maltitol, propylene glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4-hexylene glycol, 1,2-he Polyhydric alcohols such as sundiol, 1,2-octanediol, moisturizing ingredients such as sodium pyrrolidonecarboxylate, lactic acid, sodium lactate, guar gum, quince seed, carrageenan, galactan, gum arabic, pectin, mannan, starch, xanthan gum , Curdlan, methylcellulose, hydroxyethylcellulose, carboxymethylcellulose, methylhydroxypropylcellulose, chondroitin sulfate, dermatan sulfate, glycogen, heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum, keratan sulfate, chondroitin, mucoitin sulfate, hydroxyethyl guar gum, carboxy Methyl guar gum, dextran, keratosulfate, locust bean gum, succinoglucan, caronic acid, chitin, Thickeners such as tosan, carboxymethyl chitin, agar, polyvinyl alcohol, polyvinyl pyrrolidone, carboxy vinyl polymer, alkyl-modified carboxy vinyl polymer, sodium polyacrylate, polyethylene glycol, bentonite, surface may be treated, mica, Powders such as talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride (silica), aluminum oxide, barium sulfate, surface may be treated, bengara, yellow iron oxide, black iron oxide, Cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide inorganic pigments, surface may be treated, pearlescent agents such as titanium mica, fish phosphorus foil, bismuth oxychloride, red may be raked 202, Red 228, Red 226, Yellow 4, Blue 40 No. 4, Yellow No. 5, Red No. 505, Red No. 230, Red No. 223, Orange No. 201, Red No. 213, Yellow No. 204, Yellow No. 203, Blue No. 1, Green No. 201, Purple No. 201, Red No. 204 Organic dyes such as polyethylene powder, polymethyl methacrylate, nylon powder, organic powders such as organopolysiloxane elastomers, paraaminobenzoic acid UV absorbers, anthranilic acid UV absorbers, salicylic acid UV absorbers, cinnamon Acid UV absorber, benzophenone UV absorber, sugar UV absorber, 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole, 4-methoxy-4′-t-butyldibenzoylmethane ultraviolet absorbing agents and the like, ethanol, lower alcohols such as isopropanol, vitamin a or a derivative thereof, vitamin B Hydrochloride, vitamin _{B 6} tripalmitate, vitamin _{B 6} dioctanoate, vitamin _{B 2} or derivatives thereof, vitamin _{B 12,} vitamin B such as vitamin _{B 15} or a derivative thereof, alpha-tocopherol, beta-tocopherol, .gamma.-tocopherol, Preferable examples include vitamin E such as vitamin E acetate, vitamin D, vitamin H, pantothenic acid, panthetin, pyrroloquinoline quinone and the like.

<Manufacture example 1> Manufacture of the emulsion composition of this invention The emulsion which is the emulsion composition of this invention was produced according to the prescription shown below (Example 1). That is, the components (A) were mixed and dissolved by heating at 90 ° C. On the other hand, each component of (B) was mixed and dissolved and heated to 90 ° C. (B) was added to the mixture of (A) and stirred to emulsify. Thereafter, the mixture was stirred and cooled to room temperature to obtain an emulsion. In Example 1, Example 2 in which ceramide TIC-001 was substituted with Ceramide III, Example 3 in which Ceramide VI was substituted, Example 4 in which lecithin was substituted with phosphatidylcholine, Example 5 in which lysolecithin was substituted, Super Example 6 was also prepared in which mol LM was replaced with supermol PS. Further, in Example 1, Comparative Example 1 in which ceramide TIC-001 was replaced with water, Comparative Example 2 in which isostearic acid was replaced with stearic acid, Comparative Example 3 in which lecithin was replaced with polyoxyethylene (10) monostearate, Comparative Examples 4 and 5 in which Supermol LM was replaced with glycerol trioleate were also prepared. Table 1 shows the composition.

<Test Example 1> The skin moisturizing effect test was conducted in a room at 20 ° C. and a relative humidity of 50% for five panelists. The measurement site was washed with warm water of 32 ° C. for 30 seconds, allowed to rest for 20 minutes, and then measured. For the skin on the inner side of the forearm, on the day before the scheduled test date (-1 day), the skin moisture content of the planned test site is measured in advance with SKICON-200EX (manufactured by IBS). Thereafter, gauze (2 cm × 2 cm) impregnated with a 5% sodium lauryl sulfate aqueous solution was contacted for 30 minutes. On the next day (day 0), skin moisture content was measured with SKICON-200EX, and then the test samples shown in Table 1 (Examples 1 to 6, Comparative Examples 1 to 5) were applied. The test sample was applied three times a day. The skin moisture content was measured again 1 day and 2 days after application. At the same time, an untreated control test in which no test sample was applied was also performed. The evaluation results are shown in Table 2.

<Test Example 2> Water transpiration suppression test A test paper (Examples 1 to 11 and Comparative Examples 1 to 5) prepared on a filter paper covered with filter paper on the upper surface of an acrylic cup filled with water. ) Was applied in the same amount. This was stored in a constant temperature room at 40 ° C. for 24 hours. The weight of the filter paper, the filter paper coated with a test sample, and the filter paper covered with the test sample were measured in advance. After storage, the weight was measured again in the same manner, and the amount of moisture dissipated from the entire system was calculated. The evaluation results are shown in Table 3. The amount of dissipation of the untreated control without application of the test sample was taken as 100%.

<Test Example 3> Evaluation of feeling of use of emulsion During the test of the moisturizing effect of the skin, a questionnaire was conducted regarding the feeling of use when the test sample was applied at the test site. The evaluation criteria are shown below. In addition, Table 4 shows the most frequent results among the five people.
1: No sticky feeling, very good feeling 2: Feeling somewhat sticky, but relatively good feeling 3: Feeling sticky, Bad feeling 4: Feeling quite sticky, very It is a bad feeling to use

<Test Example 4> Stability of the emulsion The stability of the emulsion was evaluated by storing the test samples shown in Table 1 at 5 ° C, 40 ° C and 60 ° C for 2 weeks, and comparing with 5 ° C. The results are shown in Table 5.
0 ... Same as 5 ° C.
1 ... Slightly poor emulsification is observed compared to 5 ° C (less than 1% of the total).
2 ... Compared with 5 ° C, emulsification failure is observed (less than 10% of the total).
3 ... Emulsification is broken and oil is separated.

From the results of Table 2-5, it can be seen that according to the present invention, a new emulsified composition having good moisturizing effect, moisture transpiration inhibiting effect, feeling of use, and formulation stability can be provided.

  INDUSTRIAL APPLICABILITY The present invention can be applied to a new emulsified composition having good moisturizing effect, moisture transpiration inhibiting effect, feeling of use and formulation stability.

Claims (4)

An emulsified composition comprising 1) ceramide, 2) phospholipid, 3) isostearic acid, and 4) hydroxyalkyl (C12-18) hydroxydimeryl linoleyl ether. The emulsified composition according to claim 1, wherein the ceramide is ceramide type 2. The emulsified composition according to claim 1 or 2, wherein the content of the ceramide is 0.01 to 5% by mass. The emulsified composition according to any one of claims 1 to 3, wherein the phospholipid content is 0.01 to 5 mass%.