JP2013075894A5 - - Google Patents
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- Publication number
- JP2013075894A5 JP2013075894A5 JP2012202153A JP2012202153A JP2013075894A5 JP 2013075894 A5 JP2013075894 A5 JP 2013075894A5 JP 2012202153 A JP2012202153 A JP 2012202153A JP 2012202153 A JP2012202153 A JP 2012202153A JP 2013075894 A5 JP2013075894 A5 JP 2013075894A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- optionally substituted
- substituted
- saturated heterocyclic
- represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000623 heterocyclic group Chemical group 0.000 claims 33
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 18
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 16
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 15
- 125000005843 halogen group Chemical group 0.000 claims 14
- 125000001072 heteroaryl group Chemical group 0.000 claims 14
- 239000003814 drug Substances 0.000 claims 13
- 125000003118 aryl group Chemical group 0.000 claims 11
- 125000004432 carbon atom Chemical group C* 0.000 claims 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 11
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 9
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 8
- -1 C 3 substituted Chemical class 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 7
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 6
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 6
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 6
- 125000003710 aryl alkyl group Chemical group 0.000 claims 5
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 5
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 4
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims 4
- 125000005144 cycloalkylsulfonyl group Chemical group 0.000 claims 4
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 claims 4
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 claims 4
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims 4
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 3
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 3
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 3
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 3
- 125000004104 aryloxy group Chemical group 0.000 claims 3
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 3
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 claims 3
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims 3
- WSFSSNUMVMOOMR-BJUDXGSMSA-N methanone Chemical compound O=[11CH2] WSFSSNUMVMOOMR-BJUDXGSMSA-N 0.000 claims 3
- 125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 201000000980 schizophrenia Diseases 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000004434 sulfur atom Chemical group 0.000 claims 3
- QNBRIOXWQACPNP-DEOSSOPVSA-N (4-fluorophenyl)-[1-[2-[(2s)-1-(6-methyl-1h-indole-2-carbonyl)pyrrolidin-2-yl]ethyl]piperidin-4-yl]methanone Chemical compound C([C@@H]1CCCN1C(=O)C1=CC2=CC=C(C=C2N1)C)CN(CC1)CCC1C(=O)C1=CC=C(F)C=C1 QNBRIOXWQACPNP-DEOSSOPVSA-N 0.000 claims 2
- 125000006624 (C1-C6) alkoxycarbonylamino group Chemical group 0.000 claims 2
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 2
- IOCJGSXOVZSTBQ-NRFANRHFSA-N [1-[2-[(2s)-1-(3,6-difluoro-1h-indole-2-carbonyl)pyrrolidin-2-yl]ethyl]piperidin-4-yl]-(4-fluorophenyl)methanone Chemical compound C([C@@H]1CCCN1C(=O)C1=C(C2=CC=C(F)C=C2N1)F)CN(CC1)CCC1C(=O)C1=CC=C(F)C=C1 IOCJGSXOVZSTBQ-NRFANRHFSA-N 0.000 claims 2
- LXLZFQZQRGBWHW-NRFANRHFSA-N [1-[2-[(2s)-1-(3-fluoro-1h-indole-2-carbonyl)pyrrolidin-2-yl]ethyl]piperidin-4-yl]-(4-fluorophenyl)methanone Chemical compound C([C@@H]1CCCN1C(=O)C1=C(C2=CC=CC=C2N1)F)CN(CC1)CCC1C(=O)C1=CC=C(F)C=C1 LXLZFQZQRGBWHW-NRFANRHFSA-N 0.000 claims 2
- VAMONZHTNGAPAG-QHCPKHFHSA-N [1-[2-[(2s)-1-(6-fluoro-1h-indole-2-carbonyl)pyrrolidin-2-yl]ethyl]piperidin-4-yl]-(4-fluorophenyl)methanone Chemical compound C1=CC(F)=CC=C1C(=O)C1CCN(CC[C@H]2N(CCC2)C(=O)C=2NC3=CC(F)=CC=C3C=2)CC1 VAMONZHTNGAPAG-QHCPKHFHSA-N 0.000 claims 2
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 2
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims 2
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 2
- 125000004658 aryl carbonyl amino group Chemical group 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000005169 cycloalkylcarbonylamino group Chemical group 0.000 claims 2
- 125000005224 heteroarylcarbonylamino group Chemical group 0.000 claims 2
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 2
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 2
- WZFNUGOPNOBVRE-VWLOTQADSA-N (4-fluorophenyl)-[1-[2-[(2s)-1-(1-methylindole-5-carbonyl)pyrrolidin-2-yl]ethyl]piperidin-4-yl]methanone Chemical compound C([C@@H]1CCCN1C(=O)C=1C=C2C=CN(C2=CC=1)C)CN(CC1)CCC1C(=O)C1=CC=C(F)C=C1 WZFNUGOPNOBVRE-VWLOTQADSA-N 0.000 claims 1
- UTHWIOICGCUXQD-SANMLTNESA-N (4-fluorophenyl)-[1-[2-[(2s)-1-(6-propan-2-yl-1h-indole-2-carbonyl)pyrrolidin-2-yl]ethyl]piperidin-4-yl]methanone Chemical compound C([C@@H]1CCCN1C(=O)C1=CC2=CC=C(C=C2N1)C(C)C)CN(CC1)CCC1C(=O)C1=CC=C(F)C=C1 UTHWIOICGCUXQD-SANMLTNESA-N 0.000 claims 1
- HIOSXSLJQINPMZ-FQEVSTJZSA-N (4-fluorophenyl)-[1-[2-[(2s)-1-[3-fluoro-6-(trifluoromethoxy)-1h-indole-2-carbonyl]pyrrolidin-2-yl]ethyl]piperidin-4-yl]methanone Chemical compound C([C@@H]1CCCN1C(=O)C1=C(C2=CC=C(OC(F)(F)F)C=C2N1)F)CN(CC1)CCC1C(=O)C1=CC=C(F)C=C1 HIOSXSLJQINPMZ-FQEVSTJZSA-N 0.000 claims 1
- SIDLXAYALUAFFR-QFIPXVFZSA-N (4-fluorophenyl)-[1-[2-[(2s)-1-[6-(trifluoromethoxy)-1h-indole-2-carbonyl]pyrrolidin-2-yl]ethyl]piperidin-4-yl]methanone Chemical compound C1=CC(F)=CC=C1C(=O)C1CCN(CC[C@H]2N(CCC2)C(=O)C=2NC3=CC(OC(F)(F)F)=CC=C3C=2)CC1 SIDLXAYALUAFFR-QFIPXVFZSA-N 0.000 claims 1
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 claims 1
- XRUIIJREVLDYTG-UHFFFAOYSA-N 6-(trifluoromethyl)-1h-indole-2-carbaldehyde Chemical compound FC(F)(F)C1=CC=C2C=C(C=O)NC2=C1 XRUIIJREVLDYTG-UHFFFAOYSA-N 0.000 claims 1
- AWWLOYBXGYSTPT-UHFFFAOYSA-N 6-(trifluoromethylsulfanyl)-1H-indole-2-carbaldehyde Chemical compound FC(SC1=CC=C2C=C(NC2=C1)C=O)(F)F AWWLOYBXGYSTPT-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- LIFLLNHDTKBBJP-QFIPXVFZSA-N [(2s)-2-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]pyrrolidin-1-yl]-(3-phenyl-1h-pyrazol-5-yl)methanone Chemical compound C([C@H]1CCN2CCC(CC2)C=2C3=CC=C(C=C3ON=2)F)CCN1C(=O)C(NN=1)=CC=1C1=CC=CC=C1 LIFLLNHDTKBBJP-QFIPXVFZSA-N 0.000 claims 1
- ZHBRGKFUCWANDK-NRFANRHFSA-N [1-[2-[(2s)-1-(5-fluoro-4-methoxy-1h-indole-2-carbonyl)pyrrolidin-2-yl]ethyl]piperidin-4-yl]-(4-fluorophenyl)methanone Chemical compound C([C@@H]1CCCN1C(=O)C=1NC=2C=CC(F)=C(C=2C=1)OC)CN(CC1)CCC1C(=O)C1=CC=C(F)C=C1 ZHBRGKFUCWANDK-NRFANRHFSA-N 0.000 claims 1
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000006598 aminocarbonylamino group Chemical group 0.000 claims 1
- 125000004657 aryl sulfonyl amino group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000005419 heteroarylsulfonylamino group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 125000006296 sulfonyl amino group Chemical group [H]N(*)S(*)(=O)=O 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012202153A JP5715605B2 (ja) | 2011-09-14 | 2012-09-14 | Ｎ−アシル環状アミン誘導体またはその医薬上許容される塩からなる医薬 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011200374 | 2011-09-14 | ||
| JP2011200374 | 2011-09-14 | ||
| JP2012202153A JP5715605B2 (ja) | 2011-09-14 | 2012-09-14 | Ｎ−アシル環状アミン誘導体またはその医薬上許容される塩からなる医薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013075894A JP2013075894A (ja) | 2013-04-25 |
| JP2013075894A5 true JP2013075894A5 (OSRAM) | 2014-03-13 |
| JP5715605B2 JP5715605B2 (ja) | 2015-05-07 |
Family
ID=48479653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012202153A Expired - Fee Related JP5715605B2 (ja) | 2011-09-14 | 2012-09-14 | Ｎ−アシル環状アミン誘導体またはその医薬上許容される塩からなる医薬 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP5715605B2 (OSRAM) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000032987A (ja) * | 1998-07-16 | 2000-02-02 | Dai Ichi Seiyaku Co Ltd | Ｄｎａ |
| CN104140421B (zh) * | 2013-05-08 | 2017-04-05 | 上海医药工业研究院 | 苯并异噻唑类化合物及在制备抗精神分裂症药物中的应用 |
| CN105315267B (zh) * | 2014-07-30 | 2019-06-04 | 江苏恩华药业股份有限公司 | 一种酰胺类衍生物及其应用 |
| JP2019059672A (ja) * | 2015-12-28 | 2019-04-18 | 大日本住友製薬株式会社 | 治療抵抗性うつ病等の治療薬 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3133061A (en) * | 1962-11-13 | 1964-05-12 | Sterling Drug Inc | Piperidine carboxamides and derivatives thereof |
| FR2285883A1 (fr) * | 1974-09-30 | 1976-04-23 | Cerm Cent Europ Rech Mauvernay | Nouveaux composes chimiques a activite bronchospasmolytique et antitussive, et procede pour leur obtention |
| EP0663827A4 (en) * | 1992-10-07 | 1995-11-15 | Merck & Co Inc | TOKOLYTIC OXYTOCINE RECEPTOR ANTAGONISTS. |
| WO2003051869A1 (en) * | 2001-12-19 | 2003-06-26 | H. Lundbeck A/S | 3,4-dihydro-1h-isoquinoloin-2-yl-derivatives |
| MXPA06007654A (es) * | 2003-12-31 | 2006-09-04 | Warner Lambert Co | Derivados de piperidina n-sustituidos. |
-
2012
- 2012-09-14 JP JP2012202153A patent/JP5715605B2/ja not_active Expired - Fee Related
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