JP2013071903A - Blood sugar level improving composition by citrus sudachi aromatic component - Google Patents
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Abstract
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本発明はスダチ芳香成分を有効成分とする血糖値改善組成物に関する発明である。 The present invention relates to a blood sugar level improving composition containing a sudachi fragrance component as an active ingredient.
近年、アロマテラピーとして、植物から抽出した精油をかいだり、塗ったりして、生理機能を整える療法がよく新聞紙上で紹介されている。また、精油には鎮静効果やストレス緩和効果などが知られている（特許文献１）。また、その精油の香りの効果は、芳香物質がきゅう覚を刺激し、交感神経系に対する活性化や副交感神経系に対する活性化によるものであるとされている（特許文献２、３）。
そして、これらの香り（香料）を利用して、肥満改善（痩身）に利用されたり（特許文献４）、脂肪蓄積抑制に使用されている（特許文献５）。更には、ホルモンバランスを改善し、エストロゲンの分泌促進の治療にも効果があると報告されている（特許文献６）。
これら以外にも皮膚免疫機能改善のためにも香料が使用されている（特許文献７）。このように植物から抽出した精油（香料）は、多くの疾患の症状改善や治療に利用されている。
しかしながら、このようなアロマテラピーにおいて、スダチ由来の精油が有効とする報告はなく、生活習慣病の症状改善や治療に有効であるとする報告も見出されていない。
In recent years, as aromatherapy, therapies that improve the physiological function by sprinkling and painting essential oil extracted from plants are often introduced on newspapers. In addition, essential oils are known to have a sedative effect and a stress relieving effect (Patent Document 1). In addition, the effect of the scent of the essential oil is said to be due to the activation of the sympathetic nervous system and the activation of the parasympathetic nervous system by the fragrance substance stimulating the olfactory sense (Patent Documents 2 and 3).
And these fragrances (fragrance | flavor) are utilized for obesity improvement (slimming) (patent document 4), and are used for fat accumulation suppression (patent document 5). Furthermore, it has been reported that it improves the hormone balance and is effective in promoting the promotion of estrogen secretion (Patent Document 6).
In addition to these, fragrances are also used to improve skin immune function (Patent Document 7). Essential oils (fragrances) extracted from plants in this way are used for symptom improvement and treatment of many diseases.
However, in such aromatherapy, there is no report that Sudachi-derived essential oil is effective, and there is no report that it is effective in improving symptoms or treatment of lifestyle-related diseases.
本発明の課題は、スダチ由来の精油（芳香成分）による生活習慣病の改善用芳香組成物を提供することにある。特に、スダチ由来の芳香成分による、新たな血糖値改善用芳香組成物を提供することにある。 The subject of this invention is providing the fragrance composition for improvement of the lifestyle-related disease by the essential oil (fragrance | flavor component) derived from Sudachi. In particular, it is to provide a new fragrance composition for improving blood glucose level by using a fragrance component derived from Sudachi.
本発明者らが、スダチの搾汁残渣あるいはスダチの果皮から得られた精油（芳香成分）に関する研究を進めていたところ、スダチの芳香成分が糖尿病モデルマウスの血糖値を改善あるいは降下させることを見出した。そこで、更に検討を進めたところ、スダチの芳香が消えると、改善されていた血糖値が上昇することを見出した。即ち、スダチ芳香成分には、血糖値改善（血糖値降下）作用を示す芳香成分が存在することが明らかとなった。そこで、他の柑橘類と同様に共通して含有される成分として、リナロール、ｐ−シメンの血糖降下作用を個別に確認したが、具体的にこれらの成分に関して血糖降下作用を見出すことはできなかった。また、この血糖降下作用は、柚子の精油成分には見出すことができなかった。このことから、本発明者らは、スダチの精油成分に含まれる特有の成分（ｐ−シメン、リナロール以外の精油成分)に、血糖降下作用があることを見出した。本発明は、これらの知見に基き完成したものである。 The present inventors have been conducting research on the essential oil (fragrance component) obtained from the juice residue of Sudachi or the skin of Sudachi, and it has been found that the fragrance component of Sudachi improves or lowers the blood glucose level of diabetes model mice. I found it. As a result of further investigation, it was found that when the scent of Sudachi disappeared, the improved blood sugar level increased. That is, it has been clarified that the Sudachi aroma component has an aroma component exhibiting an action of improving blood glucose level (lowering blood glucose level). Thus, as components commonly contained in other citrus fruits, the blood glucose lowering action of linalool and p-cymene was individually confirmed, but specifically, the blood sugar lowering action could not be found for these ingredients. . Moreover, this hypoglycemic effect could not be found in the essential oil component of eggplant. From these facts, the present inventors have found that specific components (essential oil components other than p-cymene and linalool) contained in the essential oil component of Sudachi have a hypoglycemic effect. The present invention has been completed based on these findings.
本発明の要旨は以下の通りである。
（１）スダチ精油成分を有効成分とする、血糖値改善・血糖降下を促進するための芳香組成物。
（２）上記スダチ精油成分が、蒸留法又は溶媒抽出法で分離されたものであることを特徴とする、上記（１）に記載の芳香組成物。
（３）上記蒸留法又は溶媒抽出法がスダチ果皮をエタノール水溶液抽出するものであることを特徴とする、上記（１）または（２）に記載の芳香組成物。
（４）上記蒸留法又は溶媒抽出法が超音波霧化分留法であることを特徴とする、上記（１）〜（３）のいずれかに記載の芳香組成物。
（５）上記芳香組成物が、上記精油成分を混入した香水や石鹸、ジャンプー、風呂の入浴剤、ローションのいずれかであることを特徴とする、上記（１）〜（４）のいずれかに記載の芳香組成物。
The gist of the present invention is as follows.
(1) A fragrance composition for promoting blood glucose level improvement and blood glucose lowering, comprising a Sudachi essential oil component as an active ingredient.
(2) The fragrance composition according to (1) above, wherein the Sudachi essential oil component is separated by a distillation method or a solvent extraction method.
(3) The fragrance composition as described in (1) or (2) above, wherein the distillation method or solvent extraction method is a method in which sudachi peel is extracted with an aqueous ethanol solution.
(4) The fragrance composition according to any one of (1) to (3) above, wherein the distillation method or solvent extraction method is an ultrasonic atomization fractionation method.
(5) The fragrance composition is any one of (1) to (4), characterized in that the fragrance composition is any of perfume, soap, jumpo, bathing agent, and lotion mixed with the essential oil component. A fragrance composition as described.
本発明の芳香組成物は、血糖値を改善し、血糖値を低下させる作用を有するため、糖尿病患者の生活環境の改善の一助として、本発明の芳香組成物を用いたアロマテラピーにより、糖尿病の治療支援を行うことが出る。この目的のために、本発明の芳香組成物は、香料として多くの製品に使用される。特に、血糖値改善（血糖値降下）の目的のために、香水や石鹸、ジャンプー、風呂の入浴剤、ローション等の製品として使用することができる。 Since the fragrance composition of the present invention has the action of improving blood glucose level and lowering blood glucose level, as an aid to the improvement of living environment of diabetic patients, aromatherapy using the fragrance composition of the present invention can be used to prevent diabetes. It is possible to provide treatment support. For this purpose, the fragrance composition of the present invention is used in many products as a fragrance. In particular, it can be used as a product such as perfume, soap, jumpo, bathing agent, lotion, etc. for the purpose of improving blood sugar level (lowering blood sugar level).
本発明の「スダチ精油」とは、スダチの果皮からエタノール水溶液で抽出された油状物質のことを言い、柑橘類に特有の芳香成分を有している。しかし、柚子の精油成分とスダチの精油成分は、ｄ−リモネンを多く含有することでは共通するが、それ以外の成分の組成は柑橘類の種類によって大きく異なっている。スダチの精油成分の組成、特に芳香成分の組成は、スダチの果皮からの抽出方法と分留方法の相違によって、揮発成分が飛散し易いために、揮発成分の含量に変動が生じ易い。そのため、本発明では、超音波霧化分留装置（松浦酒造場製）を用いて、スダチからのエタノール水溶液抽出物の濃縮、分離を行っている。なお、このスダチ精油には、抽出用のエタノールは含まれておらず、スダチの芳香成分が分離されている。そのため、本発明では「スダチ精油成分」として記載した。 The “sudachi essential oil” of the present invention refers to an oily substance extracted from the skin of Sudachi with an aqueous ethanol solution, and has an aromatic component peculiar to citrus fruits. However, the essential oil component of eggplant and the essential oil component of Sudachi are common in that they contain a large amount of d-limonene, but the composition of the other components is greatly different depending on the type of citrus fruit. The composition of the essential oil component of Sudachi, in particular the composition of the fragrance component, is likely to fluctuate in the content of the volatile component because the volatile component tends to scatter due to the difference between the extraction method from the peel of Sudachi and the fractionation method. Therefore, in the present invention, an aqueous ethanol extract from Sudachi is concentrated and separated using an ultrasonic atomization fractionator (manufactured by Matsuura Brewery). This Sudachi essential oil does not contain ethanol for extraction, and the Sudachi aromatic component is separated. Therefore, in this invention, it described as "Sudachi essential oil component."
本発明の「芳香組成物」とは、柑橘類の香りを拡散させるための組成物のことを言い、公知の手段を使用できる。例えば、皮膚や衣服に付ける香水、室内に香りを放散させる香料、線香など、更にはスダチ精油が香料として含有された石鹸、シャンプー、ローション、風呂の入浴剤、化粧品等を挙げることができる。 The “fragrance composition” of the present invention refers to a composition for diffusing the scent of citrus fruits, and known means can be used. For example, perfume to be applied to skin and clothes, fragrance to dissipate scent in the room, incense, and soap, shampoo, lotion, bathing agent for bath, cosmetics and the like containing sudachi essential oil as fragrance.
本発明の「蒸留法又は溶媒抽出法」とは、スダチの果皮から芳香成分（スダチ精油成分）を分離する方法のことであり、スダチ果皮からの精油成分の溶媒抽出液を蒸留すること、あるいはスダチ果皮そのものを乾留することを言う。溶媒抽出法に使用される溶媒としては、例えばヘキサン、ヘプタン、エーテル、酢酸エチル等の疎水性溶媒や、エタノール、メタノール等のアルコール系親水溶媒が使用できる。好ましい溶媒としてはヘキサンやエタノールを挙げることができる。エタノールは、更にエタノール水溶液として使用することができる。 The “distillation method or solvent extraction method” of the present invention is a method for separating an aromatic component (sudachi essential oil component) from the peel of Sudachi, and distillation of a solvent extract of the essential oil component from the peel of Sudachi, or Say that the Sudachi peel itself is carbonized. Examples of the solvent used in the solvent extraction method include hydrophobic solvents such as hexane, heptane, ether, and ethyl acetate, and alcoholic hydrophilic solvents such as ethanol and methanol. Preferred solvents include hexane and ethanol. Ethanol can be further used as an aqueous ethanol solution.
本発明の「エタノール水溶液」とは、エタノール濃度が３〜１５％の水溶液を言う。スダチ果皮からの抽出効率がエタノール濃度３〜１５％の間で最大となることから、好ましいエタノール濃度としては、約５％を挙げることができる。 The “ethanol aqueous solution” of the present invention refers to an aqueous solution having an ethanol concentration of 3 to 15%. Since the extraction efficiency from the Sudachi peel becomes maximum between 3 to 15% ethanol concentration, a preferable ethanol concentration can be about 5%.
本発明の「超音波霧化分留法」とは、液体に超音波を当てると霧が発生する現象を利用し、揮発成分を取り出す方法であり、この方法を用いた装置は本家松浦酒造場（鳴門市）、ナノミストテクノロジーズ社から販売されている。 The “ultrasonic atomization fractionation method” of the present invention is a method of taking out a volatile component using a phenomenon that mist is generated when ultrasonic waves are applied to a liquid, and an apparatus using this method is the Honke Matsuura Brewery. (Naruto City), sold by Nanomist Technologies.
次に実施例を挙げて本発明を更に説明するが、本発明はこれらに限定されるものではない。 EXAMPLES Next, although an Example is given and this invention is further demonstrated, this invention is not limited to these.
（実施例１）スダチ由来の精油（芳香成分）の調製
１）エタノール抽出法：
スダチ果皮に対して、２倍量のアルコール水溶液（５％エタノール水溶液）を使用して、香気成分の抽出を行い、初期抽出液を得た。この抽出液を超音波霧化分留装置（松浦酒造製）による霧化分離を２回行うことにより、スダチ精油（回収油：１００％）を分離した。分離条件は，溶液温度５０℃，冷却部温度−２０℃（１回目のみ−６℃）とした。１回目は、初期抽出液５０００ｍｌ（回収油：０．１８％）を霧化分離することで，分離液１０００ｍｌ（回収油：０．７４％）を得た。１回目の初期抽出液と分離液の品質比較を行い，分離液中の屈折示度および総酸が低値であることから，初期抽出液中の糖および有機酸は分離液中に移行しないことを確認した。続いて，一回目分離液の一部３５０ｍｌを用いて、霧化分離することで，２回目の分離液７０ｍ（回収油：３．２％）を得た。この分離液を静置すると油水分離を生じ，上澄のスダチ精油分２ｍｌを分離できた。上澄の精油分は水分，エタノールをほとんど含まず，無色透明でスダチの新鮮な香りを保持したスダチ精油であった。
上記スダチ精油分をガスクロマトグラフィー（ヒューレット・パッカード社、ＨＰ−５８９０Ａ）で分析した。ＤＢ−ＷＡＸカラムを用い、オーブン温度を初期温度４０℃３分、昇温速度５℃／分、到達温度２１０℃５分の条件で実施した。その結果を以下の表１（組成比）に示す。
(Example 1) Preparation of Sudachi-derived essential oil (fragrance component) 1) Ethanol extraction method:
The aroma component was extracted from the sudachi peel using an alcohol aqueous solution (5% ethanol aqueous solution) twice as much as the initial extract. Sudachi essential oil (recovered oil: 100%) was separated by subjecting this extract to atomization separation by an ultrasonic atomization fractionator (manufactured by Matsuura Shuzo) twice. The separation conditions were a solution temperature of 50 ° C. and a cooling part temperature of −20 ° C. (only the first time was −6 ° C.). The first time, the initial extract 5000 ml (recovered oil: 0.18%) was atomized and separated to obtain 1000 ml of a separated liquid (recovered oil: 0.74%). Compare the quality of the initial extract and the separated solution in the first round, and since the refraction index and total acid in the separated solution are low, sugar and organic acid in the initial extract should not move into the separated solution. It was confirmed. Subsequently, the second separation liquid 70m (recovered oil: 3.2%) was obtained by atomization separation using 350 ml of a part of the first separation liquid. When this separated liquid was allowed to stand, oil-water separation occurred, and 2 ml of the supernatant Sudachi essential oil could be separated. The supernatant essential oil contained almost no water and ethanol, and was colorless and transparent and had a fresh scent of Sudachi.
The Sudachi essential oil was analyzed by gas chromatography (Hewlett-Packard Company, HP-5890A). A DB-WAX column was used, and the oven temperature was set at an initial temperature of 40 ° C. for 3 minutes, a heating rate of 5 ° C./minute, and an ultimate temperature of 210 ° C. for 5 minutes. The results are shown in Table 1 (composition ratio) below.
（実施例２）ＧＫ−ラットを用いたスダチ芳香成分（スダチ精油）の血糖降下作用の評価
１）約１０％のスダチ精油を含有した霧化分離液の効果：
上記霧化分離液に水を加えて超音波拡散させ、５０倍希釈した希釈液（２００００ｐｐｍ）と５００倍希釈液（２０００ｐｐｍ）を作製した。上記希釈液と水（プラセボ）を用いて、ＧＫ−ラット（３０週令、雄性）の顔と手に、１日１回刷毛で塗布した。３週間の塗布試験後の結果を図１に示す。
図１に示されるように、５０倍希釈した希釈液（２００００ｐｐｍ）の場合に、有意な血糖値降下作用が示されることが分かった。また、５００倍希釈と比較し、その作用はスダチ精油の濃度依存性であった。
２）１００％スダチ精油の効果：
スダチ精油分に水を加えて５００倍に希釈した希釈液（２００００ｐｐｍ）を用いて、ＧＫ−ラット（３０週令、雄性）の鼻に１日１回、３週間塗布を行った。また、対照群として上記希釈液の代わりに水を塗布した。対照群（１群５匹）とスダチ精油塗布群（１群５匹）を同じ室内の隣接箇所で飼育した。スダチ精油による芳香が飼育室内に拡散しており、そのため、スダチ精油の芳香による効果が、隣接して飼育した対照群でも評価できる。即ち、ＧＫ−ラットの鼻にスダチ精油を塗布した群における直接的なスダチの芳香効果と、対照群における室内芳香の間接的な効果が評価できることになる。なお、評価期間３週間の上記ラットの血糖値の変化を測定し、塗布終了の１週間後の血糖値を測定した。その結果を図２に示す。
図２に示されるように、５００倍希釈液の場合に実施例１の場合と同様の血糖値降下の効果が得られることが明らかとなった。しかしも、スダチ塗布群だけでなく、対照群でも、図２に示されるように血糖値が有意に低下した。このことは、スダチの室内芳香によっても、血糖値降下が起こることを明らかにしたものである。更に、スダチ精油成分の塗布を中止したところ、血糖値が上昇に転じたことから、スダチ精油成分（芳香成分）による血糖値効果作用は明らかである。
Example 2 Evaluation of Hypoglycemic Action of Sudachi Fragrance Component (Sudachi Essential Oil) Using GK-Rat 1) Effect of Atomized Separation Solution Containing about 10% Sudachi Essential Oil:
Water was added to the atomized separation liquid and ultrasonically diffused to prepare a diluted solution (20000 ppm) diluted 50 times and a diluted solution (2000 ppm) 500 times. Using the diluted solution and water (placebo), the face and hands of GK-rats (30 weeks old, male) were applied once a day with a brush. The results after a 3-week application test are shown in FIG.
As shown in FIG. 1, it was found that a significant blood glucose lowering effect was exhibited in the case of a diluted solution (20000 ppm) diluted 50 times. In addition, the effect was dependent on the concentration of Sudachi essential oil as compared to 500-fold dilution.
2) Effect of 100% Sudachi essential oil:
Application was performed once a day for 3 weeks on the nose of GK-rats (30 weeks old, male) using a diluted solution (20000 ppm) diluted with Sudachi essential oil by adding water 500 times. As a control group, water was applied instead of the diluted solution. A control group (5 per group) and a Sudachi essential oil application group (5 per group) were bred at adjacent locations in the same room. The fragrance of Sudachi essential oil is diffused in the breeding room, so that the effect of the scent of Sudachi essential oil can be evaluated even in the control group bred adjacently. That is, it is possible to evaluate the direct fragrance effect of Sudachi in the group in which Sudachi essential oil is applied to the nose of GK-rat and the indirect effect of room fragrance in the control group. In addition, the change of the blood glucose level of the said rat for the evaluation period of 3 weeks was measured, and the blood glucose level 1 week after completion | finish of application | coating was measured. The result is shown in FIG.
As shown in FIG. 2, it was revealed that the same blood glucose level lowering effect as that in Example 1 can be obtained with the 500-fold diluted solution. However, as shown in FIG. 2, the blood glucose level significantly decreased not only in the Sudachi application group but also in the control group. This reveals that the blood sugar level is lowered by the indoor fragrance of Sudachi. Further, when the application of the Sudachi essential oil component was stopped, the blood sugar level started to rise, and thus the effect of the blood sugar level effect by the Sudachi essential oil component (fragrance component) is clear.
（実施例３）スダチと柚子の芳香成分の効果の相違
柚子もスダチも、香酸柑橘類の仲間であり、ｄ−リモネンが主要な成分であることでは一致する。その主要な成分を表２に示す。
(Example 3) Difference in effect of aromatic components of sudachi and citron Both citron and sudachi are members of perfume citrus, and agree that d-limonene is the main component. The main components are shown in Table 2.
主要成分のリモネンには、副交感神経刺激作用があり、肝臓強壮、腎臓刺激、消化管蠕動運動促進、血圧降下等の作用が公知である。また、副交感神経を刺激することで、膵臓からのインシュリン分泌が促進されるとの報告がある。
そこで、実施例１と同様の超音波霧化分留処理を行って得られた柚子の霧化分離液（約１０％の柚子精油含量）と実施例１で得られたスダチ霧化分離液（約１０％のスダチ精油含量）を使用した。各分離液を水で５０倍に希釈した水溶液（２００００ｐｐｍ）を作製した。ＧＫ−ラット（３０週令、雄性）を２群（１群５匹）に分けて、ラットの顔と手に上記水溶液を１日１回塗布した。３週間の塗布試験により、柚子とスダチの精油成分の効果の相違を検討した。その結果を図３に示す。
図３に示されるように、柚子精油成分では、血糖値は上昇傾向にあるが、スダチ精油分では僅かに血糖値が低下することが確認された。また、塗布開始から３週間後になるとスダチの方が柚子よりも有意に血糖値が低下する（ｐ＜０．０５）ことが示された。
以上のことから、スダチには、柚子と異なり、血糖効果に有効な精油成分を含有することが明らかになった。
The main component, limonene, has a parasympathomimetic action, and is known to have effects such as liver tonicity, kidney stimulation, gastrointestinal peristalsis, and blood pressure lowering. There is also a report that stimulation of parasympathetic nerves promotes insulin secretion from the pancreas.
Therefore, the atomization separation liquid (about 10% eggplant essential oil content) of the eggplant obtained by carrying out the same ultrasonic atomization fractionation treatment as in Example 1 and the Sudachi atomization separation liquid obtained in Example 1 ( About 10% Sudachi essential oil content) was used. An aqueous solution (20,000 ppm) was prepared by diluting each separation solution 50 times with water. GK-rats (30 weeks old, male) were divided into 2 groups (5 animals per group), and the above aqueous solution was applied to the faces and hands of the rats once a day. The difference in the effects of the essential oil components of eggplant and sudachi was examined by a 3-week application test. The result is shown in FIG.
As shown in FIG. 3, the blood sugar level tends to increase with the coconut essential oil component, but it was confirmed that the blood sugar level slightly decreased with the Sudachi essential oil component. In addition, it was shown that blood glucose level was significantly lower in Sudachi than in eggplant after 3 weeks from the start of application (p <0.05).
From the above, it has been clarified that Sudachi contains an essential oil component effective for the blood sugar effect, unlike eggplant.
（実施例４）スダチ精油成分のｐ−シメン、リナロールの効果確認
ｄ−リモネン以外の精油主要成分に関して、血糖値降下作用の有無を検証した。まず、柚子精油成分の第２主成分リナロール（３４％）とスダチの成分ｐ−シメン（４％）について、血糖値降下作用の有無を評価した。
ＧＫ−ラット（生後約１年、雄性）を１群５匹で３群（蒸留水塗布、リナロール塗布、ｐ−シメン塗布）に分けた。実験開始時の血糖値を測定した後、ラットの鼻に０．１％のリナロール、ｐ−シメン水溶液（蒸留水に市販のリナロール、ｐ−シメンを添加し、超音波で分散させた）を１日１回塗布した。１週間毎に血糖値を測定し、３週間連日塗布を行った。
その結果、３週間後の３群のいずれにおいても血糖値に有意な差は見られなかった。即ち、リナロールとｐ−シメンにおいては、血糖値降下作用を示さないことが分かった。
(Example 4) Confirmation of effect of p-cymene and linalool of Sudachi essential oil component With regard to essential oil main components other than d-limonene, the presence or absence of a blood glucose level lowering effect was verified. First, the second main component linalool (34%) of the eggplant essential oil component and the component p-cymene (4%) of Sudachi were evaluated for the blood glucose level lowering effect.
GK-rats (about 1 year after birth, male) were divided into 3 groups (distilled water application, linalool application, p-cymene application) with 5 animals per group. After measuring the blood glucose level at the start of the experiment, 0.1% linalool and p-cymene aqueous solution (commercially available linalool and p-cymene were added to distilled water and dispersed by ultrasonic waves) 1 It was applied once a day. The blood glucose level was measured every week and applied every day for 3 weeks.
As a result, there was no significant difference in blood glucose level in any of the three groups after 3 weeks. That is, it was found that linalool and p-cymene do not show a blood glucose lowering effect.
本発明では、スダチの精油部分に存在する芳香成分が直接的、間接的に作用して、血糖値を降下させることが見出された。その結果、香油成分を混入した、香水や石鹸、風呂の入浴剤、ローション等の化粧品が、血糖値を改善する効果を持つことが期待され、新たなアロマテラピーの可能性が見出された。
In the present invention, it has been found that the fragrance component present in the essential oil portion of Sudachi acts directly or indirectly to lower the blood glucose level. As a result, cosmetics such as perfumes and soaps, bath baths, and lotions mixed with perfume oil components are expected to have an effect of improving blood glucose levels, and new possibilities for aromatherapy have been found.
Claims (5)
The fragrance composition according to any one of claims 1 to 4, wherein the fragrance composition is any one of perfume, soap, jumpo, bath bath, and lotion mixed with the essential oil component.
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| CN103301037A (en) * | 2013-06-08 | 2013-09-18 | 上海巴方精细化工有限公司 | Lemon oil bath salt |
| WO2019159434A1 (en) * | 2018-02-15 | 2019-08-22 | 理恵 堤 | Yuko-containing composition |
| JP2020151615A (en) * | 2019-03-18 | 2020-09-24 | 株式会社アルビオン | Extraction device and extraction solvent removal method in extraction device |
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| CN103301036A (en) * | 2013-06-08 | 2013-09-18 | 上海巴方精细化工有限公司 | Sweet orange oil-bath salt |
| CN103301037A (en) * | 2013-06-08 | 2013-09-18 | 上海巴方精细化工有限公司 | Lemon oil bath salt |
| WO2019159434A1 (en) * | 2018-02-15 | 2019-08-22 | 理恵 堤 | Yuko-containing composition |
| JP2020151615A (en) * | 2019-03-18 | 2020-09-24 | 株式会社アルビオン | Extraction device and extraction solvent removal method in extraction device |
| JP7082078B2 (en) | 2019-03-18 | 2022-06-07 | 株式会社アルビオン | Extraction solvent removal method in extraction equipment and extraction equipment |
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