JP2013063090A5 - - Google Patents
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- Publication number
- JP2013063090A5 JP2013063090A5 JP2012282502A JP2012282502A JP2013063090A5 JP 2013063090 A5 JP2013063090 A5 JP 2013063090A5 JP 2012282502 A JP2012282502 A JP 2012282502A JP 2012282502 A JP2012282502 A JP 2012282502A JP 2013063090 A5 JP2013063090 A5 JP 2013063090A5
- Authority
- JP
- Japan
- Prior art keywords
- drug
- cell
- antibody
- agent
- response
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 33
- 210000004027 cell Anatomy 0.000 claims 18
- 229940079593 drug Drugs 0.000 claims 16
- 239000003814 drug Substances 0.000 claims 16
- 235000014113 dietary fatty acids Nutrition 0.000 claims 14
- 229930195729 fatty acid Natural products 0.000 claims 14
- 239000000194 fatty acid Substances 0.000 claims 14
- 150000004665 fatty acids Chemical class 0.000 claims 14
- 239000003795 chemical substances by application Substances 0.000 claims 10
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims 10
- 239000005483 tyrosine kinase inhibitor Substances 0.000 claims 10
- 150000004917 tyrosine kinase inhibitor derivatives Chemical group 0.000 claims 10
- 210000004413 cardiac myocyte Anatomy 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 230000001590 oxidative effect Effects 0.000 claims 8
- 231100000331 toxic Toxicity 0.000 claims 8
- 230000002588 toxic effect Effects 0.000 claims 8
- 231100000419 toxicity Toxicity 0.000 claims 8
- 230000001988 toxicity Effects 0.000 claims 8
- 206010048610 Cardiotoxicity Diseases 0.000 claims 5
- 231100000259 cardiotoxicity Toxicity 0.000 claims 5
- 229960000575 trastuzumab Drugs 0.000 claims 5
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77709606P | 2006-02-27 | 2006-02-27 | |
| US60/777,096 | 2006-02-27 | ||
| US82123006P | 2006-08-02 | 2006-08-02 | |
| US60/821,230 | 2006-08-02 | ||
| US82737206P | 2006-09-28 | 2006-09-28 | |
| US60/827,372 | 2006-09-28 | ||
| US82834506P | 2006-10-05 | 2006-10-05 | |
| US60/828,345 | 2006-10-05 | ||
| US86773606P | 2006-11-29 | 2006-11-29 | |
| US60/867,736 | 2006-11-29 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008556587A Division JP5539653B2 (ja) | 2006-02-27 | 2007-02-27 | 細胞脂肪を減少させるため、心毒性を予測するため、チロシンキナーゼ阻害剤による処置による組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013063090A JP2013063090A (ja) | 2013-04-11 |
| JP2013063090A5 true JP2013063090A5 (enExample) | 2013-10-24 |
Family
ID=38459790
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008556587A Expired - Fee Related JP5539653B2 (ja) | 2006-02-27 | 2007-02-27 | 細胞脂肪を減少させるため、心毒性を予測するため、チロシンキナーゼ阻害剤による処置による組成物および方法 |
| JP2012282502A Pending JP2013063090A (ja) | 2006-02-27 | 2012-12-26 | 細胞脂肪を減少させるため、心毒性を予測するため、チロシンキナーゼ阻害剤による処置による組成物および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008556587A Expired - Fee Related JP5539653B2 (ja) | 2006-02-27 | 2007-02-27 | 細胞脂肪を減少させるため、心毒性を予測するため、チロシンキナーゼ阻害剤による処置による組成物および方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8709738B2 (enExample) |
| EP (1) | EP1996939B1 (enExample) |
| JP (2) | JP5539653B2 (enExample) |
| KR (1) | KR101390625B1 (enExample) |
| CN (2) | CN101438155B (enExample) |
| AU (1) | AU2007220094B2 (enExample) |
| CA (1) | CA2643846A1 (enExample) |
| ES (1) | ES2475162T3 (enExample) |
| IL (1) | IL193715A (enExample) |
| NZ (2) | NZ571465A (enExample) |
| WO (1) | WO2007101191A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010036910A1 (en) * | 2008-09-26 | 2010-04-01 | Yoshikazu Ohta | Heart protection by administering an amp-activated protein kinase activator |
| WO2015027171A1 (en) * | 2013-08-23 | 2015-02-26 | Quintiles Transnational Corporation | Methods for predicting toxicity in response to treatment with a drug by assessing activation of the sterol regulatory binding protein (srebp) pathway |
| EP3739041A1 (en) | 2014-03-27 | 2020-11-18 | The Salk Institute for Biological Studies | Compositions and methods for treating type 1 and type 2 diabetes and related disorders |
| WO2016138464A1 (en) * | 2015-02-27 | 2016-09-01 | Salk Institute For Biological Studies | Reprogramming progenitor compositions and methods of use therefore |
| CA3025344A1 (en) | 2016-05-25 | 2017-11-30 | Salk Institute For Biological Studies | Compositions and methods for organoid generation and disease modeling |
| JP7032723B2 (ja) * | 2017-07-21 | 2022-03-09 | 公立大学法人福島県立医科大学 | 薬剤の心毒性評価方法及びそのための試薬又はキット |
| US11369608B2 (en) | 2017-10-27 | 2022-06-28 | University Of Virginia Patent Foundation | Compounds and methods for regulating, limiting, or inhibiting AVIL expression |
| TWI711458B (zh) * | 2019-07-08 | 2020-12-01 | 大江生醫股份有限公司 | 植物發酵物及其製備方法與用於胃臟保健的用途 |
| KR102493664B1 (ko) | 2020-01-29 | 2023-02-01 | 한국화학연구원 | 심장 독성 예측 모델링 시스템 및 모델링 방법 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9618420D0 (en) * | 1996-09-04 | 1996-10-16 | Scotia Holdings Plc | Fatty acid treatment |
| DE19932555A1 (de) * | 1999-07-13 | 2001-01-18 | Solvay Pharm Gmbh | Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen |
| US20020028826A1 (en) * | 2000-06-15 | 2002-03-07 | Robl Jeffrey A. | HMG-CoA reductase inhibitors and method |
| EP1438420B1 (en) * | 2001-09-24 | 2009-09-16 | Lipomics Technologies, Inc. | Methods of using quantitative lipid metabolome data |
| WO2004042360A2 (en) * | 2002-11-04 | 2004-05-21 | The Regents Of The Univeristy Of California | Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body |
| EP1980629A3 (en) * | 2003-08-28 | 2008-12-17 | Ipsogen | Identification of an erbb2 gene expression signature in breast cancers |
-
2007
- 2007-02-27 US US12/280,893 patent/US8709738B2/en not_active Expired - Fee Related
- 2007-02-27 NZ NZ571465A patent/NZ571465A/en not_active IP Right Cessation
- 2007-02-27 WO PCT/US2007/062871 patent/WO2007101191A2/en not_active Ceased
- 2007-02-27 CA CA002643846A patent/CA2643846A1/en not_active Abandoned
- 2007-02-27 NZ NZ594178A patent/NZ594178A/xx not_active IP Right Cessation
- 2007-02-27 JP JP2008556587A patent/JP5539653B2/ja not_active Expired - Fee Related
- 2007-02-27 KR KR1020087023650A patent/KR101390625B1/ko not_active Expired - Fee Related
- 2007-02-27 CN CN2007800136974A patent/CN101438155B/zh not_active Expired - Fee Related
- 2007-02-27 AU AU2007220094A patent/AU2007220094B2/en not_active Ceased
- 2007-02-27 EP EP07757542.1A patent/EP1996939B1/en not_active Not-in-force
- 2007-02-27 ES ES07757542.1T patent/ES2475162T3/es active Active
- 2007-02-27 CN CN2013101368247A patent/CN103217520A/zh active Pending
-
2008
- 2008-08-26 IL IL193715A patent/IL193715A/en not_active IP Right Cessation
-
2012
- 2012-12-26 JP JP2012282502A patent/JP2013063090A/ja active Pending
-
2013
- 2013-04-05 US US13/857,591 patent/US20130288285A1/en not_active Abandoned
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