JP2013013640A - Tissue sample collecting system for biopsy - Google Patents

Tissue sample collecting system for biopsy Download PDF

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JP2013013640A
JP2013013640A JP2011149757A JP2011149757A JP2013013640A JP 2013013640 A JP2013013640 A JP 2013013640A JP 2011149757 A JP2011149757 A JP 2011149757A JP 2011149757 A JP2011149757 A JP 2011149757A JP 2013013640 A JP2013013640 A JP 2013013640A
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needle
instrument
biopsy
vibration applying
tissue
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Hiroaki Hattori
裕昭 服部
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HATTORI MISAKI
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Abstract

PROBLEM TO BE SOLVED: To provide a system capable of securing an amount of tissue collected by using a relatively thick needle-like tool even when an object tissue to be collected is hard.SOLUTION: The tissue sample collecting system for biopsy includes: the needle-like tool for collecting a biological tissue sample; a biopsy device holding the needle-like tool for controlling collection operation of the biological tissue sample by the needle-like tool; and a vibration imparting unit for vibrating the needle-like tool at a predetermined frequency of vibration.

Description

本発明は、生検用の組織標本を採取するシステム(装置)の技術に関する。   The present invention relates to a technique of a system (device) for collecting a tissue specimen for biopsy.

生検とは、生体から組織の小切片を切り取って、病理学的に調べることをいい、医師による診断の確定のために行われ、特に悪性腫瘍の診断のためには不可欠である。また、穿刺針を用いて試料を採取することを針生検といい(広辞苑第六版)、針生検の対象となる臓器には、乳腺、リンパ節、甲状腺などがある。
近年、上記のような生検を行うことを目的としたシステム(装置)に関する技術の提案が多数なされている(特許文献1、2など)。
Biopsy refers to examining a pathologically by cutting a small section of tissue from a living body, and is performed for confirmation of diagnosis by a doctor, and is particularly essential for diagnosis of malignant tumor. Collecting a sample using a puncture needle is called needle biopsy (Kojien 6th edition), and organs to be subjected to needle biopsy include mammary gland, lymph node, thyroid gland and the like.
In recent years, many proposals have been made on technologies related to systems (devices) for the purpose of performing biopsy as described above (Patent Documents 1 and 2, etc.).

一方、人の組織は軟らかいものから硬いものまで種々のものがある。生検の対象を、例えば、乳腺組織とした場合、皮膚及び脂肪は軟らかいため問題は生じないが、乳腺組織そのものは繊維性の成分が多く、組織採取用の針状器具(生検針)を刺すことが困難なときもある。また、生検の対象を乳腺組織とした場合に、大きな腫瘤に対し生検針を刺すことは比較的容易であるが、問題となるのは、腫瘤の大きさが1cm以下、特に、0.5cm程度の場合であって、この大きさの腫瘤になると、硬い乳腺組織の中にある腫瘤に生検針を当てることが難しい。
他方、上記のような組織採取が難しいという事態を打開する対策としては、生検針を細くし抵抗を減らした上で組織採取を行うという方策が取られている。
On the other hand, there are various human tissues ranging from soft to hard. For example, when the target of biopsy is mammary gland tissue, there is no problem because the skin and fat are soft. Sometimes it is difficult. In addition, when the biopsy target is a mammary gland tissue, it is relatively easy to stab a biopsy needle into a large mass, but the problem is that the size of the mass is 1 cm or less, particularly 0.5 cm. In this case, it is difficult to apply a biopsy needle to a tumor in hard mammary gland tissue.
On the other hand, as a measure for overcoming the situation in which it is difficult to collect tissue as described above, a measure is taken to collect tissue after reducing the resistance by reducing the biopsy needle.

特開2011−104117号公報JP 2011-104117 A 特開2010−233858号公報JP 2010-233858 A

しかしながら、上記技術のように、生検針を細くすると採取される組織の量が少なくなり、もともと小さい腫瘤の採取を狙っていることとも相まって、採取される組織が少量であれば、病理診断が困難になるという問題点がある。   However, if the biopsy needle is made narrower as in the above technique, the amount of tissue collected is reduced, and coupled with the aim of collecting small tumors, pathological diagnosis is difficult if the collected tissue is small. There is a problem of becoming.

そこで本発明では、上記問題点に鑑み、生検用の採取対象組織が硬い場合であっても、比較的太い針状器具(生検針)を用いることによって、採取される組織の量を確保し、医師による診断率を向上させる生検用組織標本採取システムおよび当該システムの制御方法を提供することを目的とする。   Therefore, in the present invention, in view of the above problems, even when the tissue to be collected for biopsy is hard, the amount of tissue to be collected is ensured by using a relatively thick needle-like instrument (biopsy needle). An object of the present invention is to provide a biopsy tissue sample collection system that improves the diagnosis rate by a doctor and a control method of the system.

開示する生検用組織標本採取システムの一形態は、生体組織標本を採取するための針状器具と、前記針状器具を保持し、該針状器具による前記生体組織標本の採取動作を制御する生検装置と、前記針状器具を所定の振動数で振動させる振動付与手段と、を有することを特徴とする。   One form of the disclosed biopsy tissue specimen collection system includes a needle-like instrument for collecting a biological tissue specimen, and holding the needle-like instrument, and controlling an operation of collecting the biological tissue specimen by the needle-like instrument. It has a biopsy device and a vibration applying means for vibrating the needle-like instrument at a predetermined frequency.

開示する振動付与装置の一形態は、生体組織標本を採取するための針状器具と、前記針状器具を保持し、該針状器具による前記生体組織標本の採取動作を制御する生検装置と、を有する生検用組織標本採取システムに対し、前記針状器具を所定の振動数で振動させる振動付与手段を有することを特徴とする。   An embodiment of the disclosed vibration imparting device includes a needle-like instrument for collecting a biological tissue specimen, a biopsy device that holds the needle-like instrument and controls an operation of collecting the biological tissue specimen using the needle-like instrument, The biopsy tissue sampling system has a vibration applying means for vibrating the needle-like instrument at a predetermined frequency.

開示する生検用組織標本採取システムは、生検用の採取対象組織が硬い場合であっても、比較的口径の大きい針状器具を用いることによって、採取される組織の量を確保し、医師による診断率を向上させることができる。   The disclosed biopsy tissue sample collection system secures the amount of tissue to be collected by using a needle-like instrument having a relatively large diameter, even when the collection target tissue for biopsy is hard. Can improve the diagnosis rate.

従来の生検用組織標本採取システムの概要を説明する図である。It is a figure explaining the outline | summary of the conventional tissue sample collection system for biopsy. 本実施の形態に係る生検用組織標本採取システムの全体概要図である。1 is an overall schematic diagram of a tissue sample collection system for biopsy according to the present embodiment. 本実施の形態に係る振動付与手段の概要を説明する図である。It is a figure explaining the outline | summary of the vibration provision means which concerns on this Embodiment. 本実施の形態に係る針状器具による生検用組織標本の採取動作を説明する図(その1)である。It is a figure (the 1) explaining the collection | recovery operation | movement of the biopsy tissue sample by the needle-shaped instrument which concerns on this Embodiment. 本実施の形態に係る針状器具による生検用組織標本の採取動作を説明する図(その2)である。It is FIG. (2) explaining the collection | recovery operation | movement of the biopsy tissue sample by the needle-shaped instrument which concerns on this Embodiment. 本実施の形態に係る針状器具による生検用組織標本の採取動作を説明する図(その3)である。It is FIG. (3) explaining the collection | recovery operation | movement of the biopsy tissue sample by the needle-shaped instrument which concerns on this Embodiment.

図面を参照しながら、本発明を実施するための形態について説明する。
(本実施の形態に係る生検用組織標本採取システムの構造)
DESCRIPTION OF EMBODIMENTS Embodiments for carrying out the present invention will be described with reference to the drawings.
(Structure of tissue specimen collection system for biopsy according to the present embodiment)

図1及び図2を用いて、本実施の形態に係る生検用組織標本採取システム(以下、単に「生検システム」という。)100の構造について、従来の生検システム200の構造と比較しながら説明する。図1は、生検システム200の概要を説明する図であり、図2は、生検システム100の概要を説明する図である。   1 and 2, the structure of a biopsy tissue sampling system (hereinafter simply referred to as “biopsy system”) 100 according to the present embodiment is compared with the structure of a conventional biopsy system 200. While explaining. FIG. 1 is a diagram illustrating an outline of the biopsy system 200, and FIG. 2 is a diagram illustrating an outline of the biopsy system 100.

はじめに、従来の生検システム200について説明する。図1で示すように、生検システム200は、針状器具210、生検装置220、操作手段230を有する。針状器具210は、中空であって、細長い針のような形状をしており、生検用の組織標本を採取するために、患者に刺入して使用する。   First, a conventional biopsy system 200 will be described. As shown in FIG. 1, the biopsy system 200 includes a needle-like instrument 210, a biopsy device 220, and operation means 230. The needle-like instrument 210 is hollow and shaped like an elongated needle, and is inserted into a patient and used to collect a tissue specimen for biopsy.

生検装置220は、針状器具210を保持し、後述する操作手段230を介して、針状器具210の生検用組織標本の採取動作を制御する役割を果たす部位である。   The biopsy device 220 is a part that holds the needle-like instrument 210 and plays a role of controlling the operation of collecting the biopsy tissue specimen of the needle-like instrument 210 via the operation means 230 described later.

操作手段230は、生検装置220に含まれる部位であり、例えば、ユーザ(医師)による操作手段230の押下操作などが行われたことをトリガーとして、針状器具210による生検用組織標本の採取動作が開始されるなど、ユーザ(医師)と生検システム200とのインターフェース機能を発揮する部位である。   The operation means 230 is a part included in the biopsy device 220. For example, when the user (physician) depresses the operation means 230, the operation means 230 triggers the biopsy tissue specimen by the needle-like instrument 210. This is a part that exhibits an interface function between the user (physician) and the biopsy system 200, such as when a sampling operation is started.

生検システム200は、上記のような構成を有しており、針状器具210を患者に刺し入れ、針状器具210の中空部分に患者の組織標本を採取することで、医師による病理診断を可能にしている。   The biopsy system 200 has the above-described configuration. The needle-like instrument 210 is inserted into the patient, and a tissue specimen of the patient is collected in the hollow part of the needle-like instrument 210, so that a pathological diagnosis by a doctor can be performed. It is possible.

しかしながら、生検システム200においては、病理診断を行う部位の組織が硬い場合、生検針を細くし組織採取を行うが、生検針を細くすると採取される組織の量が少なくなり、病理診断が困難になる。   However, in the biopsy system 200, when the tissue of the site where the pathological diagnosis is performed is hard, the biopsy needle is thinned and the tissue is collected. However, if the biopsy needle is thinned, the amount of the collected tissue is reduced and the pathological diagnosis is difficult. become.

そこで、生検システム100は、患者(患部)に刺し入れる針状器具110が振動するように制御することによって、組織標本採取時の針状器具110の患部に対する抵抗を減らす。こうすることによって、生検システム100は、比較的口径の大きい(太い)針状器具110での微小病変の正確な穿刺を容易にし、より多くの組織採取を可能にする。   Therefore, the biopsy system 100 reduces the resistance of the needle-like instrument 110 to the affected part when collecting the tissue specimen by controlling the needle-like instrument 110 inserted into the patient (affected part) to vibrate. By doing so, the biopsy system 100 facilitates accurate puncture of a micro-lesion with a relatively large (thick) needle-like instrument 110 and allows more tissue collection.

図2で示すように、生検システム100は、針状器具110、生検装置120、操作手段130、振動付与手段140を有する。針状器具110は、中空であって、細長い針のような形状をしており、生検用の組織標本を採取するために、患者に刺入して使用する。   As shown in FIG. 2, the biopsy system 100 includes a needle-like instrument 110, a biopsy device 120, an operation unit 130, and a vibration applying unit 140. The needle-like instrument 110 is hollow and has a shape like an elongated needle, and is inserted into a patient for use in obtaining a tissue specimen for biopsy.

生検装置120は、針状器具110を保持し、後述する操作手段130を介して、針状器具110の生検用組織標本の採取動作を制御する役割を果たす部位である。   The biopsy device 120 is a part that holds the needle-like instrument 110 and plays a role of controlling the operation of collecting the tissue specimen for biopsy of the needle-like instrument 110 via the operation means 130 described later.

操作手段130は、生検装置120に含まれる部位であり、例えば、ユーザ(医師)による操作手段130の押下操作などが行われたことをトリガーとして、針状器具110による生検用組織標本の採取動作が開始されるなど、ユーザ(医師)と生検システム100とのインターフェース機能を発揮する部位である。   The operation means 130 is a part included in the biopsy device 120. For example, when the user (physician) depresses the operation means 130, the operation means 130 triggers the biopsy tissue sample by the needle-like instrument 110. This is a part that exhibits an interface function between the user (physician) and the biopsy system 100, such as the start of the collection operation.

振動付与手段140は、針状器具110を所定の振動数で振動させる機能を果たす器具である。振動付与手段140は、例えば、バイブレータ(Vibrator)と呼ばれる器具であって、モーターの軸に重心を偏らせた重りを取り付け、回転させることで振動を生むものである。   The vibration applying means 140 is an instrument that functions to vibrate the needle-like instrument 110 at a predetermined frequency. The vibration applying means 140 is, for example, an instrument called a vibrator, and generates vibration by attaching and rotating a weight with a biased center of gravity on the shaft of the motor.

振動付与手段140は、針状器具110に対し直接的に振動を付与する形態であっても良く、例えば、生検装置120を介して、針状器具110に対し間接的に振動を付与する形態であっても良い。従って、振動付与手段140は、図2で示すように、針状器具110に装着される形態であっても良く、生検装置120の側面に装着される形態であっても良い。また、振動付与手段は、図2で示すように、生検装置120に内蔵される形態であっても良い。   The vibration imparting means 140 may be configured to directly impart vibration to the needle-shaped instrument 110, for example, form configured to indirectly impart vibration to the needle-shaped instrument 110 via the biopsy device 120. It may be. Therefore, as shown in FIG. 2, the vibration applying means 140 may be mounted on the needle-like instrument 110 or may be mounted on the side surface of the biopsy device 120. Further, as shown in FIG. 2, the vibration applying means may be in a form built in the biopsy device 120.

図3で示すように、振動付与手段140は、針状器具110について、ランダムな方向に振動を付与する形態であっても良く、針状器具110の患部への刺し入れ方向に振動を付与する形態であっても良く、また、針状器具110の患部への刺し入れ方向と直交する方向に振動を付与する形態であっても良い。   As shown in FIG. 3, the vibration imparting means 140 may be configured to impart vibration in a random direction with respect to the needle-like instrument 110, and imparts vibration in the direction in which the needle-like instrument 110 is inserted into the affected area. The form may be sufficient, and the form which provides a vibration in the direction orthogonal to the insertion direction to the affected part of the needle-shaped instrument 110 may be sufficient.

上記のように、生検システム100は、患者に刺し入れる針状器具110が振動するように制御することによって、組織標本採取時の針状器具110の患部に対する抵抗を減らすことができる。こうすることによって、生検システム100は、比較的口径の大きい(太い)針状器具110での微小病変の正確な穿刺を容易にし、より多くの組織採取を可能にする。
(本実施の形態に係る生検用組織標本採取システムの使用方法)
As described above, the biopsy system 100 can reduce the resistance to the affected part of the needle-like instrument 110 during tissue sampling by controlling the needle-like instrument 110 inserted into the patient to vibrate. By doing so, the biopsy system 100 facilitates accurate puncture of a micro-lesion with a relatively large (thick) needle-like instrument 110 and allows more tissue collection.
(Usage method of tissue sample collection system for biopsy according to the present embodiment)

図2乃至図6を用いて、生検システム100の使用方法について説明する。図4は、採取する組織(病変組織)と生検システム100(又は針状器具110)との関係を示す図であり、図5及び図6は、針状器具110の拡大図である。   A method of using the biopsy system 100 will be described with reference to FIGS. 4 is a diagram showing the relationship between the tissue to be collected (lesioned tissue) and the biopsy system 100 (or the needle-like instrument 110), and FIGS. 5 and 6 are enlarged views of the needle-like instrument 110. FIG.

はじめに、ユーザ(医師)操作に従い振動付与手段140によって、直接的又は間接的に、針状器具110が振動するように制御する。このようにすることで、針状器具110の患部刺し入れ時の抵抗を減らすことができるため、患部が乳腺組織のように硬い場合でもあっても、比較的広口径の針状器具110を使用することができ、微小病変の正確な穿刺を可能とする。   First, it controls so that the needle-shaped instrument 110 may vibrate directly or indirectly by the vibration imparting means 140 according to a user (doctor) operation. By doing so, the resistance at the time of insertion of the affected part of the needle-shaped instrument 110 can be reduced, so that the needle-shaped instrument 110 having a relatively wide diameter is used even if the affected part is hard like breast tissue. And allows accurate puncture of microlesions.

次に、図4で示すように、ユーザ(医師)が、イメージ下(超音波、X線、CT等)で、患者の乳腺組織150の中に有る病変組織(採取対象組織)160の手前まで、生検システム100の針状器具110先端を刺し入れる。   Next, as shown in FIG. 4, the user (physician) moves to the front of the lesion tissue (collection target tissue) 160 in the mammary gland tissue 150 of the patient under the image (ultrasound, X-ray, CT, etc.) The tip of the needle-like instrument 110 of the biopsy system 100 is inserted.

さらに、ユーザ(医師)が、例えば、操作手段130の押下操作を行うと、針状器具110による生検用組織標本の採取動作が開始される。ここで生検用組織標本の採取動作について説明する。図5で示すように、針状器具110の根元部位にあった外筒112が、操作手段130の押下操作をトリガーにして、図6で示すように、針状器具110の先端部位へ移動する。そうすると、外筒112及び内針114によって病変組織160が切り取られ、試料ノッチ116内に生検用の採取対象組織(病変組織)160が採取される。
最後に、ユーザ(医師)が、試料ノッチ116に採取された組織を顕微鏡などで観察することによって、患者に対する診断の確定を行う。
Further, when the user (doctor) performs, for example, a pressing operation of the operation means 130, the biopsy tissue specimen collection operation by the needle-like instrument 110 is started. Here, an operation of collecting a biopsy tissue specimen will be described. As shown in FIG. 5, the outer cylinder 112 at the base part of the needle-like instrument 110 moves to the tip part of the needle-like instrument 110 as shown in FIG. 6, using the pressing operation of the operation means 130 as a trigger. . Then, the diseased tissue 160 is cut out by the outer cylinder 112 and the inner needle 114, and a tissue to be collected (lesioned tissue) 160 for biopsy is collected in the sample notch 116.
Finally, the user (doctor) confirms the diagnosis for the patient by observing the tissue collected in the sample notch 116 with a microscope or the like.

以上、本発明の実施の形態について詳述したが、本発明は係る特定の実施の形態に限定されるものではなく、特許請求の範囲に記載された本発明の要旨の範囲において、種々の変形・変更が可能である。   Although the embodiment of the present invention has been described in detail above, the present invention is not limited to the specific embodiment, and various modifications are possible within the scope of the gist of the present invention described in the claims.・ Change is possible.

100 生検用組織標本採取システム
110 針状器具
112 外筒
114 内針
116 試料ノッチ
120 生検装置
130 操作手段
140 振動付与手段(振動付与装置)
150 乳腺組織
160 採取対象組織(病変組織)
200 従来の生検用組織標本採取システム
210 従来の針状器具
220 従来の生検装置
230 従来の操作手段
DESCRIPTION OF SYMBOLS 100 Biopsy tissue sample collection system 110 Needle-shaped instrument 112 Outer cylinder 114 Inner needle 116 Sample notch 120 Biopsy device 130 Operation means 140 Vibration imparting means (vibration imparting apparatus)
150 Breast tissue 160 Collection target tissue (lesion tissue)
200 Conventional tissue sampling system for biopsy 210 Conventional needle-like instrument 220 Conventional biopsy device 230 Conventional operating means

Claims (15)

生体組織標本を採取するための針状器具と、
前記針状器具を保持し、該針状器具による前記生体組織標本の採取動作を制御する生検装置と、
前記針状器具を所定の振動数で振動させる振動付与手段と、を有することを特徴とする生検用組織標本採取システム。
A needle-like instrument for collecting a biological tissue specimen;
A biopsy device that holds the needle-like instrument and controls the sampling operation of the biological tissue specimen by the needle-like instrument;
And a vibration applying means for vibrating the needle-like instrument at a predetermined frequency.
前記振動付与手段が、前記針状器具に装着されていることを特徴とする請求項1に記載の生検用組織標本採取システム。   The tissue sample collection system for biopsy according to claim 1, wherein the vibration applying means is attached to the needle-like instrument. 前記振動付与手段が、前記生検装置に装着されていることを特徴とする請求項1に記載の生検用組織標本採取システム。   The tissue sample collection system for biopsy according to claim 1, wherein the vibration applying means is attached to the biopsy device. 前記振動付与手段が、前記針状器具を、患部への刺し入れ方向に振動させることを特徴とする請求項1乃至3の何れか一に記載の生検用組織標本採取システム。   The tissue sample collection system for biopsy according to any one of claims 1 to 3, wherein the vibration applying unit vibrates the needle-like instrument in a direction of insertion into an affected area. 前記振動付与手段が、前記針状器具を、患部への刺し入れ方向と直交する方向に振動させることを特徴とする請求項1乃至3の何れか一に記載の生検用組織標本採取システム。   The tissue sample collection system for biopsy according to any one of claims 1 to 3, wherein the vibration applying means vibrates the needle-like instrument in a direction orthogonal to a direction of insertion into the affected area. 生体組織標本を採取するための針状器具と、前記針状器具を保持し、該針状器具による前記生体組織標本の採取動作を制御する生検装置と、を有する生検用組織標本採取システムの制御方法であって、
振動付与手段が、前記針状器具を所定の振動数で振動させるステップを備えることを特徴とする制御方法。
A biopsy tissue sample collection system comprising: a needle-like instrument for collecting a biological tissue specimen; and a biopsy device that holds the needle-like instrument and controls the collection operation of the biological tissue specimen by the needle-like instrument. Control method,
A control method, wherein the vibration applying means includes a step of vibrating the needle-like instrument at a predetermined frequency.
前記振動付与手段が、前記針状器具に装着されていることを特徴とする請求項6に記載の制御方法。   The control method according to claim 6, wherein the vibration applying unit is attached to the needle-like instrument. 前記振動付与手段が、前記生検装置に装着されていることを特徴とする請求項6に記載の制御方法。   The control method according to claim 6, wherein the vibration applying unit is attached to the biopsy device. 前記振動付与手段が、前記針状器具を、患部への刺し入れ方向に振動させることを特徴とする請求項6乃至8の何れか一に記載の制御方法。   The control method according to any one of claims 6 to 8, wherein the vibration applying unit vibrates the needle-like instrument in a direction of insertion into an affected area. 前記振動付与手段が、前記針状器具を、患部への刺し入れ方向と直交する方向に振動させることを特徴とする請求項6乃至8の何れか一に記載の制御方法。   The control method according to any one of claims 6 to 8, wherein the vibration applying unit vibrates the needle-like instrument in a direction orthogonal to a direction of insertion into the affected area. 生体組織標本を採取するための針状器具と、前記針状器具を保持し、該針状器具による前記生体組織標本の採取動作を制御する生検装置と、を有する生検用組織標本採取システムに関し、前記針状器具を所定の振動数で振動させる振動付与装置。   A biopsy tissue sample collection system comprising: a needle-like instrument for collecting a biological tissue specimen; and a biopsy device that holds the needle-like instrument and controls the collection operation of the biological tissue specimen by the needle-like instrument. In regard to the above, a vibration applying device that vibrates the needle-like instrument at a predetermined frequency. 前記針状器具に装着されていることを特徴とする請求項11に記載の振動付与装置。   The vibration applying apparatus according to claim 11, wherein the vibration applying apparatus is attached to the needle-like instrument. 前記生検装置に装着されていることを特徴とする請求項11に記載の振動付与装置。   The vibration applying device according to claim 11, wherein the vibration applying device is attached to the biopsy device. 前記針状器具を、患部への刺し入れ方向に振動させることを特徴とする請求項11乃至13の何れか一に記載の振動付与装置。   The vibration applying device according to any one of claims 11 to 13, wherein the needle-like instrument is vibrated in a direction of insertion into an affected area. 前記針状器具を、患部への刺し入れ方向と直交する方向に振動させることを特徴とする請求項11乃至13の何れか一に記載の振動付与装置。
The vibration applying apparatus according to any one of claims 11 to 13, wherein the needle-like instrument is vibrated in a direction orthogonal to a direction of insertion into an affected area.
JP2011149757A 2011-07-06 2011-07-06 Tissue sample collecting system for biopsy Pending JP2013013640A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08509145A (en) * 1993-04-20 1996-10-01 アドヴァンスド サイトメトリックス インコーポレイテッド Aspiration cytology device, kit and method
US5916229A (en) * 1996-02-07 1999-06-29 Evans; Donald Rotating needle biopsy device and method
JP2002538919A (en) * 1999-03-23 2002-11-19 エフエヌエイ・コンセプツ,リミテッド・ライアビリティ・カンパニー Biopsy needle device
JP2006192267A (en) * 2005-01-10 2006-07-27 Ethicon Endo Surgery Inc Biopsy instrument with improved needle penetration

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08509145A (en) * 1993-04-20 1996-10-01 アドヴァンスド サイトメトリックス インコーポレイテッド Aspiration cytology device, kit and method
US5916229A (en) * 1996-02-07 1999-06-29 Evans; Donald Rotating needle biopsy device and method
JP2002538919A (en) * 1999-03-23 2002-11-19 エフエヌエイ・コンセプツ,リミテッド・ライアビリティ・カンパニー Biopsy needle device
JP2006192267A (en) * 2005-01-10 2006-07-27 Ethicon Endo Surgery Inc Biopsy instrument with improved needle penetration

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