JP2012533303A - ポリ不飽和脂肪酸に富む油を産生するための新規δ9−エロンガーゼ - Google Patents

ポリ不飽和脂肪酸に富む油を産生するための新規δ9−エロンガーゼ Download PDF

Info

Publication number
JP2012533303A
JP2012533303A JP2012520732A JP2012520732A JP2012533303A JP 2012533303 A JP2012533303 A JP 2012533303A JP 2012520732 A JP2012520732 A JP 2012520732A JP 2012520732 A JP2012520732 A JP 2012520732A JP 2012533303 A JP2012533303 A JP 2012533303A
Authority
JP
Japan
Prior art keywords
plant
acid
elongase
polyunsaturated fatty
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012520732A
Other languages
English (en)
Japanese (ja)
Inventor
ペレイラ,シユゼツト
ダス,タパス
クリシユナン,パツドマバテイー
ムケルジ,プラデイツプ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of JP2012533303A publication Critical patent/JP2012533303A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93Ligases (6)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Edible Oils And Fats (AREA)
  • Fats And Perfumes (AREA)
JP2012520732A 2009-07-17 2010-07-14 ポリ不飽和脂肪酸に富む油を産生するための新規δ9−エロンガーゼ Pending JP2012533303A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/505,293 US8188335B2 (en) 2009-07-17 2009-07-17 Δ9-elongase for production of polyunsaturated fatty acid-enriched oils
US12/505,293 2009-07-17
PCT/US2010/041893 WO2011008803A2 (en) 2009-07-17 2010-07-14 Novel δ9-elongase for production of polyunsaturated fatty acid-enriched oils

Publications (1)

Publication Number Publication Date
JP2012533303A true JP2012533303A (ja) 2012-12-27

Family

ID=42651221

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012520732A Pending JP2012533303A (ja) 2009-07-17 2010-07-14 ポリ不飽和脂肪酸に富む油を産生するための新規δ9−エロンガーゼ

Country Status (15)

Country Link
US (1) US8188335B2 (enExample)
EP (1) EP2454365A2 (enExample)
JP (1) JP2012533303A (enExample)
CN (1) CN102782124B (enExample)
AR (1) AR077763A1 (enExample)
AU (1) AU2010273508B2 (enExample)
BR (1) BR112012001125A2 (enExample)
CA (1) CA2768318A1 (enExample)
IN (1) IN2012DN00469A (enExample)
MX (1) MX2012000825A (enExample)
MY (1) MY160166A (enExample)
NZ (1) NZ597679A (enExample)
RU (1) RU2558302C2 (enExample)
UA (1) UA107468C2 (enExample)
WO (1) WO2011008803A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016163454A1 (ja) * 2015-04-08 2016-10-13 株式会社ユーグレナ 関節リウマチ抑制剤,関節リウマチ予防剤,関節リウマチ治療剤及び関節リウマチ抑制用食品

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103451246B (zh) * 2004-04-22 2018-02-16 联邦科学技术研究组织 用重组细胞合成长链多不饱和脂肪酸
CA3023314C (en) 2004-04-22 2019-12-10 Commonwealth Scientific And Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
EP2059588A4 (en) 2006-08-29 2010-07-28 Commw Scient Ind Res Org FATTY ACID SYNTHESIS
US8809559B2 (en) 2008-11-18 2014-08-19 Commonwelath Scientific And Industrial Research Organisation Enzymes and methods for producing omega-3 fatty acids
GB0907413D0 (en) 2009-04-29 2009-06-10 Equateq Ltd Novel methods
US8293790B2 (en) 2011-10-19 2012-10-23 Dignity Sciences Limited Pharmaceutical compositions comprising DGLA and benzoyl peroxide and methods of use thereof
KR20140113921A (ko) * 2011-11-29 2014-09-25 디그너티 사이언스 리미티드 20-탄소 지방산을 포함하는 조성물 및 이를 제조 및 사용하는 방법
BR122019026149A8 (pt) 2012-06-15 2022-06-28 Commw Scient Ind Res Org Célula hospedeira, processo de produzir um lipídio de planta extraído, método de produzir semente, farinha de semente, método para produzir um produto alimentício, uso e processo para produzir ésteres de etila
PE20170253A1 (es) 2013-12-18 2017-04-14 Nuseed Pty Ltd Lipido que comprende acidos grasos poliinsaturados de cadena larga
AU2015281791A1 (en) 2014-06-27 2017-01-12 Commonwealth Scientific And Industrial Research Organisation Lipid comprising docosapentaenoic acid
CN109563517A (zh) 2016-06-01 2019-04-02 加拿大国家研究委员会 菟葵脂肪酸延伸酶及其在脂肪酸生产中的用途
US20210315851A1 (en) 2020-04-03 2021-10-14 Afimmune Limited Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008128241A1 (en) * 2007-04-16 2008-10-23 E. I. Du Pont De Nemours And Company Delta 9 elongases and their use in making polyunsaturated fatty acids

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57501692A (enExample) 1980-09-24 1982-09-16
US4582788A (en) 1982-01-22 1986-04-15 Cetus Corporation HLA typing method and cDNA probes used therein
ATE53862T1 (de) 1982-01-22 1990-06-15 Cetus Corp Verfahren zur charakterisierung von hla und die darin benutzten cdns-testmittel.
US4683194A (en) 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5420034A (en) 1986-07-31 1995-05-30 Calgene, Inc. Seed-specific transcriptional regulation
US4943674A (en) 1987-05-26 1990-07-24 Calgene, Inc. Fruit specific transcriptional factors
GB8507058D0 (en) 1985-03-19 1985-04-24 Efamol Ltd Pharmaceutical & dietary compositions
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
GB8524276D0 (en) 1985-10-02 1985-11-06 Efamol Ltd Pharmaceutical & dietary compositions
GB8524275D0 (en) 1985-10-02 1985-11-06 Efamol Ltd Pharmaceutical & dietary compositions
CA1284931C (en) 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US5107065A (en) 1986-03-28 1992-04-21 Calgene, Inc. Anti-sense regulation of gene expression in plant cells
US5188958A (en) 1986-05-29 1993-02-23 Calgene, Inc. Transformation and foreign gene expression in brassica species
CA1338457C (en) 1986-08-22 1996-07-16 Henry A. Erlich Purified thermostable enzyme
US5004863B2 (en) 1986-12-03 2000-10-17 Agracetus Genetic engineering of cotton plants and lines
US5416011A (en) 1988-07-22 1995-05-16 Monsanto Company Method for soybean transformation and regeneration
IE63225B1 (en) 1988-09-13 1995-04-05 Efamol Holdings Use of fatty acids in the treatment of myalgic encephalomyelitis
US5231020A (en) 1989-03-30 1993-07-27 Dna Plant Technology Corporation Genetic engineering of novel plant phenotypes
US5106739A (en) 1989-04-18 1992-04-21 Calgene, Inc. CaMv 355 enhanced mannopine synthase promoter and method for using same
US5175095A (en) 1989-07-19 1992-12-29 Calgene, Inc. Ovary-tissue transcriptional factors
AU659087B2 (en) 1990-05-25 1995-05-11 E.I. Du Pont De Nemours And Company Nucleotide sequence of soybean stearoyl-ACP desaturase gene
US5518908A (en) 1991-09-23 1996-05-21 Monsanto Company Method of controlling insects
PH31293A (en) 1991-10-10 1998-07-06 Rhone Poulenc Agrochimie Production of y-linolenic acid by a delta6-desaturage.
JPH07501701A (ja) 1991-12-04 1995-02-23 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー 植物由来の脂肪酸不飽和化酵素遺伝子
ATE204606T1 (de) 1991-12-06 2001-09-15 Genentech Inc Prohormon konvertase transformierte zellen.
US5912120A (en) 1992-04-09 1999-06-15 The United States Of America As Represented By The Department Of Health And Human Services, Cloning, expression and diagnosis of human cytochrome P450 2C19: the principal determinant of s-mephenytoin metabolism
DE69333025T2 (de) 1992-11-17 2004-04-29 E.I. Du Pont De Nemours And Co., Wilmington Für mikrosom delta 12 fettsäuredesaturase kodierende gene und verwandte enzyme von pflanzen
DE69424861T2 (de) 1993-02-26 2000-12-28 Calgene Llc., Davis Geminivirus-basiertes-genexpressionsystem
AU694181B2 (en) 1994-03-09 1998-07-16 Abbott Laboratories Humanized milk
WO1995024488A1 (en) 1994-03-09 1995-09-14 Abbott Laboratories Transgenic animals producing oligosaccharides and glycoconjugates
US5750176A (en) 1994-03-09 1998-05-12 Abbott Laboratories Transgenic non-human mammal milk comprising 2'-fucosyl-lactose
US5631152A (en) 1994-10-26 1997-05-20 Monsanto Company Rapid and efficient regeneration of transgenic plants
US5654402A (en) 1994-10-26 1997-08-05 Michigan State University Methods and compositions relating to plant Δ6 palmitoyl-acyl carrier protein desaturase
KR20080071190A (ko) 2005-11-23 2008-08-01 이 아이 듀폰 디 네모아 앤드 캄파니 델타-9 일롱가제, 및 다중불포화 지방산 생성에 있어서의이들의 용도
US7678560B2 (en) * 2006-05-17 2010-03-16 E.I. Du Pont De Nemours And Company Δ 5 desaturase and its use in making polyunsaturated fatty acids
UA102063C2 (uk) 2007-02-12 2013-06-10 Е. І. Дю Пон Де Немур Енд Компані Трансгенна соєва рослина, що продукує арахідонову кислоту
MX2009010574A (es) 2007-04-03 2009-10-22 Du Pont Multienzimas y su uso en la fabricacion de acidos grasos poliinsaturados.
EP2358869B1 (en) 2008-10-06 2014-03-26 Abbott Laboratories Delta-8 desaturase genes, enzymes encoded thereby and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008128241A1 (en) * 2007-04-16 2008-10-23 E. I. Du Pont De Nemours And Company Delta 9 elongases and their use in making polyunsaturated fatty acids

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016163454A1 (ja) * 2015-04-08 2016-10-13 株式会社ユーグレナ 関節リウマチ抑制剤,関節リウマチ予防剤,関節リウマチ治療剤及び関節リウマチ抑制用食品
JPWO2016163454A1 (ja) * 2015-04-08 2017-11-24 株式会社ユーグレナ 関節リウマチ抑制剤,関節リウマチ予防剤,関節リウマチ治療剤及び関節リウマチ抑制用食品
US10456433B2 (en) 2015-04-08 2019-10-29 Euglena Co., Ltd. Suppressive agent for rheumatoid arthritis, prophylactic agent for rheumatoid arthritis, therapeutic agent for rheumatoid arthritis, and food for suppressing rheumatoid arthritis

Also Published As

Publication number Publication date
CN102782124A (zh) 2012-11-14
EP2454365A2 (en) 2012-05-23
RU2012103248A (ru) 2013-08-27
AR077763A1 (es) 2011-09-21
RU2558302C2 (ru) 2015-07-27
MY160166A (en) 2017-02-28
UA107468C2 (uk) 2015-01-12
AU2010273508A1 (en) 2012-02-09
MX2012000825A (es) 2012-04-19
WO2011008803A2 (en) 2011-01-20
NZ597679A (en) 2013-06-28
US20110016585A1 (en) 2011-01-20
WO2011008803A3 (en) 2011-04-07
BR112012001125A2 (pt) 2015-09-01
IN2012DN00469A (enExample) 2015-06-05
US8188335B2 (en) 2012-05-29
CA2768318A1 (en) 2011-01-20
AU2010273508B2 (en) 2015-02-05
CN102782124B (zh) 2015-04-22

Similar Documents

Publication Publication Date Title
US8188335B2 (en) Δ9-elongase for production of polyunsaturated fatty acid-enriched oils
JP4916886B2 (ja) 油性植物および酵母中の多価不飽和脂肪酸レベルを変更するのに適したδ15デサチュラーゼ
RU2644241C2 (ru) Получение дгк и других дц-пнжк в растениях
JP5123861B2 (ja) Δ9エロンガーゼおよびそれらの多価不飽和脂肪酸製造における使用
ES2323644T3 (es) Desaturasas de acidos grasos procedentes de primula.
US7368552B2 (en) Genes involved in polyketide synthase pathways and uses thereof
US20110269983A1 (en) Production of very long chain polyunsaturated fatty acids in oilseed plants
US20060117414A1 (en) Fad4, Fad5, Fad5-2, and Fad6, novel fatty acid desaturase family members and uses thereof
US8084074B2 (en) Production of very long chain polyunsaturated fatty acids in oil seed plants
WO1998046764A9 (en) Methods and compositions for synthesis of long chain polyunsaturated fatty acids in plants
EP0996732A1 (en) Methods and compositions for synthesis of long chain polyunsaturated fatty acids in plants
US8916361B2 (en) Elongase gene and uses thereof
WO2008064096A2 (en) Elongase gene and uses thereof
US8247653B2 (en) Delta-8 desaturase genes, enzymes encoded thereby and uses thereof
HK1176973A (en) Novel △9-elongase for production of polyunsaturated fatty acid-enrichted oils

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20130711

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20141202

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150224

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150317

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150901

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20160705