JP2012532613A - Ｓｐａｒｃアンチセンス組成物及びその使用 - Google Patents

Ｓｐａｒｃアンチセンス組成物及びその使用 Download PDF

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JP2012532613A
JP2012532613A JP2012519786A JP2012519786A JP2012532613A JP 2012532613 A JP2012532613 A JP 2012532613A JP 2012519786 A JP2012519786 A JP 2012519786A JP 2012519786 A JP2012519786 A JP 2012519786A JP 2012532613 A JP2012532613 A JP 2012532613A
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sparc
cancer
rna
lna
seq
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チェウ、ヴォン
ファン、ラーン
デサイ、ニール
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アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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JP2012519786A 2009-07-09 2010-07-09 Ｓｐａｒｃアンチセンス組成物及びその使用 Withdrawn JP2012532613A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22443109P 2009-07-09 2009-07-09
US61/224,431 2009-07-09
PCT/US2010/041600 WO2011006121A2 (en) 2009-07-09 2010-07-09 Sparc antisense compositions and uses thereof

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JP2012532613A true JP2012532613A (ja) 2012-12-20

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JP2012519786A Withdrawn JP2012532613A (ja) 2009-07-09 2010-07-09 Ｓｐａｒｃアンチセンス組成物及びその使用

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US (1) US20120183538A1 (enExample)
EP (1) EP2451952A4 (enExample)
JP (1) JP2012532613A (enExample)
KR (1) KR20120048613A (enExample)
CN (1) CN102625839A (enExample)
AU (1) AU2010271226A1 (enExample)
BR (1) BR112012001102A2 (enExample)
CA (1) CA2767621A1 (enExample)
IL (1) IL217428A0 (enExample)
IN (1) IN2012DN00451A (enExample)
MX (1) MX2012000468A (enExample)
WO (1) WO2011006121A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2018008749A1 (ja) * 2016-07-08 2019-10-10 ＴＡＫ−Ｃｉｒｃｕｌａｔｏｒ株式会社 Ｍｅｘ３ｂ遺伝子の発現を抑制する核酸、ｍｅｘ３ｂ遺伝子発現抑制剤、ｍｅｘ３ｂ遺伝子発現を抑制する方法及びｍｅｘ３ｂ遺伝子発現に起因する疾病の予防又は治療剤
US11279935B2 (en) 2016-07-08 2022-03-22 Tak-Circulator Co, Ltd Method for screening prophylactic or therapeutic agents for diseases caused by interleukin 6, interleukin 13, TNF, G-CSF, CXCL1, CXCL2, or CXCL5 and agent for the prevention or treatment of diseases caused by interleukin 6, interleukin 13, TNF, G-CSF, CXCL1, CXCL2, or CXCL5
WO2022270071A1 (ja) * 2021-06-24 2022-12-29 国立大学法人北海道大学 肝線維化抑制のための剤及び医薬組成物

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102935239B (zh) * 2012-11-14 2013-09-25 中国人民解放军第三军医大学第二附属医院 用于预防或治疗肺癌的制剂及其制备方法与应用
GB201315747D0 (en) * 2013-09-04 2013-10-16 Cambridge University Hospitals Nhs Foundation Trust Biomarkers associated with diabetes and firosis
SMT202100562T1 (it) * 2014-03-19 2021-11-12 Ionis Pharmaceuticals Inc Composizioni per modulare l'espressione di ataxina 2
WO2015143245A1 (en) 2014-03-19 2015-09-24 Isis Pharmaceuticals, Inc. Methods for modulating ataxin 2 expression
WO2017117496A1 (en) 2015-12-31 2017-07-06 Ionis Pharmaceuticals, Inc. Methods for reducing ataxin-2 expression
WO2018191153A1 (en) * 2017-04-09 2018-10-18 The Cleveland Clinic Foundation Cancer treatment by malat1 inhibition
US10550388B2 (en) 2017-08-15 2020-02-04 The Board Of Trustees Of The Leland Stanford Junior University Targeting pleiotrophin signaling to limit high-grade glioma invasion
SG11202100077PA (en) 2018-07-25 2021-02-25 Ionis Pharmaceuticals Inc Compounds and methods for reducing atxn2 expression

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020119158A1 (en) * 1998-12-17 2002-08-29 Corixa Corporation Compositions and methods for the therapy and diagnosis of ovarian cancer
US20040018188A9 (en) * 1999-01-20 2004-01-29 Incyte Genomics, Inc. Sparc-related proteins
US20020072503A1 (en) * 2000-03-28 2002-06-13 Jiangchun Xu Compositions and methods for the therapy and diagnosis of ovarian cancer
EP1514929A1 (en) * 2003-09-12 2005-03-16 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Antisense oligonucleotides for prevention of metastasis formation of cancer cells
JP4682152B2 (ja) * 2003-12-31 2011-05-11 ザ・ペン・ステート・リサーチ・ファンデーション 卵巣がんの化学療法に対する抵抗性を予測および克服するための方法ならびに結腸がんの発生を予測するための方法
US7564154B2 (en) * 2006-07-19 2009-07-21 Papst Licensing Gmbh & Co. Kg Disk storage device with brushless DC drive motor and slide bearing assembly

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2018008749A1 (ja) * 2016-07-08 2019-10-10 ＴＡＫ−Ｃｉｒｃｕｌａｔｏｒ株式会社 Ｍｅｘ３ｂ遺伝子の発現を抑制する核酸、ｍｅｘ３ｂ遺伝子発現抑制剤、ｍｅｘ３ｂ遺伝子発現を抑制する方法及びｍｅｘ３ｂ遺伝子発現に起因する疾病の予防又は治療剤
US11279935B2 (en) 2016-07-08 2022-03-22 Tak-Circulator Co, Ltd Method for screening prophylactic or therapeutic agents for diseases caused by interleukin 6, interleukin 13, TNF, G-CSF, CXCL1, CXCL2, or CXCL5 and agent for the prevention or treatment of diseases caused by interleukin 6, interleukin 13, TNF, G-CSF, CXCL1, CXCL2, or CXCL5
US11312956B2 (en) 2016-07-08 2022-04-26 Tak-Circulator Co., Ltd Nucleic acid inhibiting expression of the MEX3B gene, MEX3B gene expression inhibitor, method for inhibiting MEX3B gene expression, and prophylactic or therapeutic agent for disease caused by MEX3B gene expression
JP7106788B2 (ja) 2016-07-08 2022-07-27 ＴＡＫ－Ｃｉｒｃｕｌａｔｏｒ株式会社 Ｍｅｘ３ｂ遺伝子の発現を抑制する核酸、ｍｅｘ３ｂ遺伝子発現抑制剤、ｍｅｘ３ｂ遺伝子発現を抑制する方法及びｍｅｘ３ｂ遺伝子発現に起因する疾病の予防又は治療剤
WO2022270071A1 (ja) * 2021-06-24 2022-12-29 国立大学法人北海道大学 肝線維化抑制のための剤及び医薬組成物

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US20120183538A1 (en) 2012-07-19
EP2451952A2 (en) 2012-05-16
IN2012DN00451A (enExample) 2015-05-15
AU2010271226A1 (en) 2012-02-02
IL217428A0 (en) 2012-02-29
MX2012000468A (es) 2012-03-07
WO2011006121A3 (en) 2011-03-03
CA2767621A1 (en) 2011-01-13
CN102625839A (zh) 2012-08-01
WO2011006121A2 (en) 2011-01-13
BR112012001102A2 (pt) 2015-09-01
KR20120048613A (ko) 2012-05-15
EP2451952A4 (en) 2013-11-06

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