JP2012532317A - 充填床の形成の間における外部からの分取クロマトグラフィーカラムのモニタリング - Google Patents
充填床の形成の間における外部からの分取クロマトグラフィーカラムのモニタリング Download PDFInfo
- Publication number
- JP2012532317A JP2012532317A JP2012517866A JP2012517866A JP2012532317A JP 2012532317 A JP2012532317 A JP 2012532317A JP 2012517866 A JP2012517866 A JP 2012517866A JP 2012517866 A JP2012517866 A JP 2012517866A JP 2012532317 A JP2012532317 A JP 2012532317A
- Authority
- JP
- Japan
- Prior art keywords
- column
- strip
- axis
- preparative chromatography
- piston
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000004237 preparative chromatography Methods 0.000 title claims abstract description 20
- 238000012544 monitoring process Methods 0.000 title claims abstract description 13
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000012856 packing Methods 0.000 claims abstract description 22
- 239000011347 resin Substances 0.000 claims abstract description 12
- 229920005989 resin Polymers 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims description 13
- 239000012780 transparent material Substances 0.000 claims description 9
- 230000000007 visual effect Effects 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims 7
- 239000012539 chromatography resin Substances 0.000 claims 1
- 239000002002 slurry Substances 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 12
- 230000006378 damage Effects 0.000 abstract description 3
- 239000000203 mixture Substances 0.000 description 8
- 239000011521 glass Substances 0.000 description 7
- 229910000831 Steel Inorganic materials 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000012149 elution buffer Substances 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 239000010959 steel Substances 0.000 description 3
- 239000011534 wash buffer Substances 0.000 description 3
- 230000005526 G1 to G0 transition Effects 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000004642 Polyimide Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 238000012435 analytical chromatography Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000004323 axial length Effects 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 239000005388 borosilicate glass Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000005465 channeling Effects 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000005350 fused silica glass Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 239000005355 lead glass Substances 0.000 description 1
- 238000004460 liquid liquid chromatography Methods 0.000 description 1
- 238000004810 partition chromatography Methods 0.000 description 1
- 229920003055 poly(ester-imide) Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000012925 reference material Substances 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 229910052594 sapphire Inorganic materials 0.000 description 1
- 239000010980 sapphire Substances 0.000 description 1
- 239000005361 soda-lime glass Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
- B01D15/206—Packing or coating
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/22—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/50—Conditioning of the sorbent material or stationary liquid
- G01N30/56—Packing methods or coating methods
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6052—Construction of the column body
- G01N30/6082—Construction of the column body transparent to radiation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/50—Conditioning of the sorbent material or stationary liquid
- G01N30/56—Packing methods or coating methods
- G01N2030/562—Packing methods or coating methods packing
- G01N2030/565—Packing methods or coating methods packing slurry packing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6004—Construction of the column end pieces
- G01N30/6021—Adjustable pistons
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T137/00—Fluid handling
- Y10T137/0318—Processes
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22192609P | 2009-06-30 | 2009-06-30 | |
| US61/221,926 | 2009-06-30 | ||
| PCT/US2010/040450 WO2011002796A1 (en) | 2009-06-30 | 2010-06-29 | Monitoring a preparative chromatography column from the exterior during formation of the packed bed |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012532317A true JP2012532317A (ja) | 2012-12-13 |
| JP2012532317A5 JP2012532317A5 (https=) | 2013-06-13 |
Family
ID=43411410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012517866A Ceased JP2012532317A (ja) | 2009-06-30 | 2010-06-29 | 充填床の形成の間における外部からの分取クロマトグラフィーカラムのモニタリング |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20110139689A1 (https=) |
| EP (1) | EP2448646A4 (https=) |
| JP (1) | JP2012532317A (https=) |
| CA (1) | CA2766093C (https=) |
| WO (1) | WO2011002796A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140131275A1 (en) * | 2012-11-15 | 2014-05-15 | Bayer Intellectual Property Gmbh | Process for phase separation or extraction and device suitable therefor |
| JP6461930B2 (ja) | 2013-09-30 | 2019-01-30 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | スラリーの移送法 |
| CN104326528A (zh) * | 2014-11-19 | 2015-02-04 | 许天浩 | 新型树脂捕捉器 |
| US10881985B1 (en) * | 2016-12-08 | 2021-01-05 | Elemental Scientific, Inc. | System with reusable column with resin packing and unpacking procedures and sample analysis |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01199156A (ja) * | 1986-07-02 | 1989-08-10 | Amicon Wright Ltd | 調整可能な分配室装置 |
| US5141324A (en) * | 1990-12-26 | 1992-08-25 | Stranco, Inc. | Visual monitoring device for sludge conditioning system |
| JP2003279554A (ja) * | 2002-02-15 | 2003-10-02 | Novasep | 動的軸圧縮クロマトグラフィー装置におけるクロマトグラフィーベッドの保護 |
| JP2007500805A (ja) * | 2003-07-31 | 2007-01-18 | マットソン テクノロジイ インコーポレイテッド | 窓装置 |
| US20070193933A1 (en) * | 2004-02-23 | 2007-08-23 | Pierre Vidalinc | Method and devices for dry loading of chromatography resins |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3507076A (en) * | 1965-02-04 | 1970-04-21 | Milo O Rudd | Apparatus for processing of ophthalmic lens |
| US3492396A (en) * | 1967-03-13 | 1970-01-27 | Becton Dickinson Co | Agglutinate separation method and apparatus |
| US4192905A (en) * | 1977-08-05 | 1980-03-11 | Scheibal Thomas P | Imitation bevel edging |
| US4298466A (en) * | 1980-01-10 | 1981-11-03 | Phelps Dodge Corporation | Apparatus and method for visually monitoring an ion exchange fluidized bed |
| US4500793A (en) * | 1982-02-11 | 1985-02-19 | Ebara Corporation | Apparatus for monitoring inside of treating column |
| US4476017A (en) * | 1983-06-03 | 1984-10-09 | Beckman Instruments, Inc. | Removable synthesis column |
| US4797209A (en) * | 1986-07-02 | 1989-01-10 | Amicon Wright Ltd. | Adjustable distribution cell apparatus |
| DE3637916A1 (de) * | 1986-11-06 | 1988-05-19 | Labomatic Gmbh | Chromatographiesaeule |
| DE4014605A1 (de) * | 1990-05-07 | 1991-11-14 | Kronwald Separationstechnik Gm | Mehrteiliger chromatographiesaeulenanschluss |
| US5078493A (en) * | 1990-06-29 | 1992-01-07 | Conoco Inc. | Flow cell resistant to corrosive environments for fiber optic spectroscopy |
| DE4114766A1 (de) * | 1991-05-06 | 1992-11-12 | Kronwald Separationstechnik Gm | Kartuschensystem fuer chromatographiesaeulen |
| JPH07198701A (ja) * | 1993-11-26 | 1995-08-01 | Ngk Insulators Ltd | 低圧高速液体クロマトグラフィー用カラム、低圧高速液体クロマトグラフィー用カラム装置及び同カラム装置の使用方法 |
| FR2786885B1 (fr) * | 1998-12-03 | 2001-03-09 | Christian Dalloz Sunoptics | Ebauche d'oculaire non correcteur, et lunettes obtenues a partir de telles ebauches |
| US6451202B1 (en) * | 1999-06-21 | 2002-09-17 | Access Business Group International Llc | Point-of-use water treatment system |
| CA2468317A1 (en) * | 2001-11-27 | 2003-06-05 | Euroflow (Uk) Limited | Detection systems and methods |
| WO2003046545A1 (fr) * | 2001-11-29 | 2003-06-05 | Gl Sciences Incorporated | Tube de separation |
| US6561665B1 (en) * | 2002-03-14 | 2003-05-13 | Kim In-Chul | Lighting signboard having a curved structure |
| EP1606616B1 (en) * | 2003-03-21 | 2006-08-02 | Millipore Corporation | Chromatographic column seal |
| EP1972933A1 (en) * | 2007-03-23 | 2008-09-24 | Coöperatie AVEBE U.A. | Chromatographic column system |
| US7718058B2 (en) * | 2007-04-25 | 2010-05-18 | Bio-Rad Laboratories, Inc. | Chromatography column with pack, unpack, and clean-in-place features |
| MX2011000399A (es) * | 2008-07-10 | 2011-03-01 | Water Security Corp | Filtro con resina yodada e indicador de vida de filtro. |
-
2010
- 2010-06-10 US US12/797,986 patent/US20110139689A1/en not_active Abandoned
- 2010-06-29 WO PCT/US2010/040450 patent/WO2011002796A1/en not_active Ceased
- 2010-06-29 EP EP10794653.5A patent/EP2448646A4/en not_active Withdrawn
- 2010-06-29 JP JP2012517866A patent/JP2012532317A/ja not_active Ceased
- 2010-06-29 CA CA 2766093 patent/CA2766093C/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01199156A (ja) * | 1986-07-02 | 1989-08-10 | Amicon Wright Ltd | 調整可能な分配室装置 |
| US5141324A (en) * | 1990-12-26 | 1992-08-25 | Stranco, Inc. | Visual monitoring device for sludge conditioning system |
| JP2003279554A (ja) * | 2002-02-15 | 2003-10-02 | Novasep | 動的軸圧縮クロマトグラフィー装置におけるクロマトグラフィーベッドの保護 |
| JP2007500805A (ja) * | 2003-07-31 | 2007-01-18 | マットソン テクノロジイ インコーポレイテッド | 窓装置 |
| US20070193933A1 (en) * | 2004-02-23 | 2007-08-23 | Pierre Vidalinc | Method and devices for dry loading of chromatography resins |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2448646A4 (en) | 2013-07-10 |
| CA2766093A1 (en) | 2011-01-06 |
| CA2766093C (en) | 2013-12-17 |
| EP2448646A1 (en) | 2012-05-09 |
| WO2011002796A1 (en) | 2011-01-06 |
| US20110139689A1 (en) | 2011-06-16 |
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| A01 | Written decision to grant a patent or to grant a registration (utility model) |
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| A045 | Written measure of dismissal of application [lapsed due to lack of payment] |
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