JP2012531900A5 - - Google Patents

Info

Publication number

JP2012531900A5

JP2012531900A5 JP2012517881A JP2012517881A JP2012531900A5 JP 2012531900 A5 JP2012531900 A5 JP 2012531900A5 JP 2012517881 A JP2012517881 A JP 2012517881A JP 2012517881 A JP2012517881 A JP 2012517881A JP 2012531900 A5 JP2012531900 A5 JP 2012531900A5

Authority

JP

Japan

Prior art keywords

medium

growth

supplement

antimicrobial

mycobacterial

Prior art date

2010-06-30

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims 15
• 239000002609 medium Substances 0.000 claims 13
• 230000000845 anti-microbial effect Effects 0.000 claims 10
• 239000013589 supplement Substances 0.000 claims 9
• 230000009670 mycobacterial growth Effects 0.000 claims 7
• 235000015872 dietary supplement Nutrition 0.000 claims 6
• 230000012010 growth Effects 0.000 claims 5
• KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 claims 4
• APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims 4
• 108010093965 Polymyxin B Proteins 0.000 claims 4
• APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 claims 4
• 229960003942 amphotericin b Drugs 0.000 claims 4
• 239000004599 antimicrobial Substances 0.000 claims 4
• 229960000308 fosfomycin Drugs 0.000 claims 4
• YMDXZJFXQJVXBF-STHAYSLISA-N fosfomycin Chemical compound C[C@@H]1O[C@@H]1P(O)(O)=O YMDXZJFXQJVXBF-STHAYSLISA-N 0.000 claims 4
• 229960000210 nalidixic acid Drugs 0.000 claims 4
• MHWLWQUZZRMNGJ-UHFFFAOYSA-N nalidixic acid Chemical compound C1=C(C)N=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 MHWLWQUZZRMNGJ-UHFFFAOYSA-N 0.000 claims 4
• 229920000024 polymyxin B Polymers 0.000 claims 4
• 229960005266 polymyxin b Drugs 0.000 claims 4
• 229960001082 trimethoprim Drugs 0.000 claims 4
• IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 claims 4
• 108010059993 Vancomycin Proteins 0.000 claims 3
• 239000000654 additive Substances 0.000 claims 3
• 230000000996 additive effect Effects 0.000 claims 3
• 239000003242 anti bacterial agent Substances 0.000 claims 3
• 229940088710 antibiotic agent Drugs 0.000 claims 3
• 238000001514 detection method Methods 0.000 claims 3
• 230000006698 induction Effects 0.000 claims 3
• 241000894007 species Species 0.000 claims 3
• 229960003165 vancomycin Drugs 0.000 claims 3
• MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 claims 3
• MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims 3
• 239000007640 basal medium Substances 0.000 claims 2
• 239000001963 growth medium Substances 0.000 claims 2
• 208000015181 infectious disease Diseases 0.000 claims 2
• 239000000126 substance Substances 0.000 claims 2
• 241000186359 Mycobacterium Species 0.000 claims 1
• 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
• 230000000844 anti-bacterial effect Effects 0.000 claims 1
• 230000001580 bacterial effect Effects 0.000 claims 1
• 238000011109 contamination Methods 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 230000035755 proliferation Effects 0.000 claims 1
• 230000000241 respiratory effect Effects 0.000 claims 1