JP2012521551A5 - - Google Patents
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- Publication number
- JP2012521551A5 JP2012521551A5 JP2012501376A JP2012501376A JP2012521551A5 JP 2012521551 A5 JP2012521551 A5 JP 2012521551A5 JP 2012501376 A JP2012501376 A JP 2012501376A JP 2012501376 A JP2012501376 A JP 2012501376A JP 2012521551 A5 JP2012521551 A5 JP 2012521551A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- endogenous
- endogenous metabolites
- biological sample
- metabolic profile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002207 metabolite Substances 0.000 claims 25
- 238000000034 method Methods 0.000 claims 18
- 239000012472 biological sample Substances 0.000 claims 11
- 230000002503 metabolic effect Effects 0.000 claims 10
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 10
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 6
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 3
- 239000004471 Glycine Substances 0.000 claims 3
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 3
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 3
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 3
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 3
- 239000004472 Lysine Substances 0.000 claims 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 3
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 3
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 3
- 239000004473 Threonine Substances 0.000 claims 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 3
- 229960001230 asparagine Drugs 0.000 claims 3
- 235000009582 asparagine Nutrition 0.000 claims 3
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 3
- 229960000310 isoleucine Drugs 0.000 claims 3
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 3
- 238000005259 measurement Methods 0.000 claims 3
- 229930182817 methionine Natural products 0.000 claims 3
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 3
- FGEWTNKUNGVHKT-UHFFFAOYSA-N 2-[(2-chloro-3,4-dimethoxyphenyl)methylideneamino]guanidine Chemical compound COC1=CC=C(C=NNC(N)=N)C(Cl)=C1OC FGEWTNKUNGVHKT-UHFFFAOYSA-N 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000004611 spectroscopical analysis Methods 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 239000013060 biological fluid Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 239000013068 control sample Substances 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 238000001212 derivatisation Methods 0.000 claims 1
- 230000006866 deterioration Effects 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 150000003839 salts Chemical group 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 210000001179 synovial fluid Anatomy 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0905096.4 | 2009-03-24 | ||
| GB0905090.7 | 2009-03-24 | ||
| GB0905090A GB0905090D0 (en) | 2009-03-24 | 2009-03-24 | Biomarkers |
| GB0905096A GB0905096D0 (en) | 2009-03-24 | 2009-03-24 | Biomarkers |
| GB0905098.0 | 2009-03-24 | ||
| GB0905098A GB0905098D0 (en) | 2009-03-24 | 2009-03-24 | Use of biomarkers |
| PCT/GB2010/000557 WO2010109192A1 (en) | 2009-03-24 | 2010-03-24 | Metabolic profiles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012521551A JP2012521551A (ja) | 2012-09-13 |
| JP2012521551A5 true JP2012521551A5 (https=) | 2013-05-09 |
| JP5607719B2 JP5607719B2 (ja) | 2014-10-15 |
Family
ID=42228305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012501376A Expired - Fee Related JP5607719B2 (ja) | 2009-03-24 | 2010-03-24 | 代謝プロファイル |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20120108668A1 (https=) |
| EP (1) | EP2411812B1 (https=) |
| JP (1) | JP5607719B2 (https=) |
| ES (1) | ES2432534T3 (https=) |
| GB (1) | GB2470803A (https=) |
| WO (1) | WO2010109192A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011012868A1 (en) * | 2009-07-31 | 2011-02-03 | Anamar Ab | Compounds for treatment of inflammation |
| JP6198377B2 (ja) * | 2012-09-14 | 2017-09-20 | キヤノン株式会社 | 表示制御装置、表示制御方法、及びプログラム |
| US20160061812A1 (en) * | 2013-03-15 | 2016-03-03 | The University Of Birmingham | Diagnosis and Treatment of Arthritic Conditions |
| CN103675181A (zh) * | 2013-12-05 | 2014-03-26 | 陈东 | 气相色谱-质谱检测细胞内外液中有机酸、氨基酸、糖的方法 |
| CN106175684B (zh) * | 2016-07-13 | 2018-12-21 | 华南师范大学 | 基于激光光谱技术的人体股骨头病变早期诊断设备及其操作方法 |
| CN109115905A (zh) * | 2018-07-31 | 2019-01-01 | 苏州旭辉检测有限公司 | 一种血液样本中鸟氨酸的检测方法 |
| CN111307792A (zh) * | 2020-02-20 | 2020-06-19 | 江苏大学 | 一种猪肉食源性致病菌挥发性代谢物的色敏仿生传感检测方法 |
| GB202102105D0 (en) * | 2021-02-15 | 2021-03-31 | Novabiotics Ltd | Prognostic method |
| CN115290797A (zh) * | 2022-09-13 | 2022-11-04 | 贵州医科大学 | 基于气质联用技术的黑骨藤抗类风湿性关节炎代谢组学研究方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| GB0019357D0 (en) * | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel phenyl guanidines |
| JP4717810B2 (ja) | 2003-06-20 | 2011-07-06 | ユニバーシティ オブ フロリダ リサーチ ファウンデーション インコーポレイテッド | １型糖尿病と２型糖尿病を識別するためのバイオマーカー |
| US7700364B2 (en) * | 2004-10-12 | 2010-04-20 | Quest Diagnostics Investments Incorporated | Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry |
| US20070026458A1 (en) | 2004-12-17 | 2007-02-01 | Entelos, Inc. | Assessing insulin resistance using biomarkers |
| EP2369346B1 (en) | 2006-03-24 | 2014-08-27 | Metanomics GmbH | Method for diagnosing diabetes type II |
| DE102006026173A1 (de) | 2006-06-06 | 2007-12-20 | Fachhochschule Südwestfalen | Verfahren zur nichtinvasiven Diagnose von Diabetes |
| AU2007298649B2 (en) | 2006-07-28 | 2012-08-09 | Al-Saqqaf, Lamya | Prediction and prophylactic treatment of type 1 diabetes |
| CN101529248A (zh) | 2006-09-14 | 2009-09-09 | 佐拉生物科学有限公司 | 作为用于早期预测自身免疫和1型糖尿病风险之工具的生物流体代谢物谱分析 |
| EP3067692B1 (en) * | 2007-06-29 | 2019-04-17 | Quest Diagnostics Investments Incorporated | Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry (lc-ms) |
-
2010
- 2010-03-24 EP EP10710609.8A patent/EP2411812B1/en not_active Not-in-force
- 2010-03-24 ES ES10710609T patent/ES2432534T3/es active Active
- 2010-03-24 GB GB1004994A patent/GB2470803A/en not_active Withdrawn
- 2010-03-24 US US13/259,733 patent/US20120108668A1/en not_active Abandoned
- 2010-03-24 WO PCT/GB2010/000557 patent/WO2010109192A1/en not_active Ceased
- 2010-03-24 JP JP2012501376A patent/JP5607719B2/ja not_active Expired - Fee Related
-
2015
- 2015-07-24 US US14/807,920 patent/US20160018407A1/en not_active Abandoned
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