JP2012518671A5 - - Google Patents
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- Publication number
- JP2012518671A5 JP2012518671A5 JP2011551479A JP2011551479A JP2012518671A5 JP 2012518671 A5 JP2012518671 A5 JP 2012518671A5 JP 2011551479 A JP2011551479 A JP 2011551479A JP 2011551479 A JP2011551479 A JP 2011551479A JP 2012518671 A5 JP2012518671 A5 JP 2012518671A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- iii
- pharmaceutical composition
- alkyl chain
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims description 21
- 125000000217 alkyl group Chemical group 0.000 claims description 16
- 239000008194 pharmaceutical composition Substances 0.000 claims description 16
- 208000023275 Autoimmune disease Diseases 0.000 claims description 8
- 206010052779 Transplant rejections Diseases 0.000 claims description 8
- 230000004968 inflammatory condition Effects 0.000 claims description 8
- 201000006417 multiple sclerosis Diseases 0.000 claims description 8
- 210000000056 organ Anatomy 0.000 claims description 8
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 claims description 6
- 230000002265 prevention Effects 0.000 claims description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 4
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims description 4
- KKGQTZUTZRNORY-UHFFFAOYSA-N fingolimod Chemical compound CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 KKGQTZUTZRNORY-UHFFFAOYSA-N 0.000 claims description 4
- 229960000556 fingolimod Drugs 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 239000001301 oxygen Substances 0.000 claims description 4
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 claims description 2
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 239000012074 organic phase Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000012071 phase Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09153550.0 | 2009-02-24 | ||
| EP09153550 | 2009-02-24 | ||
| PCT/EP2010/052231 WO2010097371A1 (en) | 2009-02-24 | 2010-02-23 | Ceramide-analogous metabolites |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012518671A JP2012518671A (ja) | 2012-08-16 |
| JP2012518671A5 true JP2012518671A5 (https=) | 2013-03-28 |
Family
ID=40447014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011551479A Pending JP2012518671A (ja) | 2009-02-24 | 2010-02-23 | セラミド類似体代謝物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8673982B2 (https=) |
| EP (1) | EP2400960B1 (https=) |
| JP (1) | JP2012518671A (https=) |
| KR (1) | KR20110126631A (https=) |
| CN (1) | CN102333530A (https=) |
| AU (1) | AU2010217605B2 (https=) |
| BR (1) | BRPI1007994A2 (https=) |
| CA (1) | CA2752003A1 (https=) |
| ES (1) | ES2411138T3 (https=) |
| MX (1) | MX2011008876A (https=) |
| PL (1) | PL2400960T3 (https=) |
| PT (1) | PT2400960E (https=) |
| RU (1) | RU2011138963A (https=) |
| WO (1) | WO2010097371A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2888634C (en) * | 2012-10-19 | 2019-10-08 | Ruth Perez | Compositions and methods for the treatment of parkinson's disease |
| EP2927211A4 (en) * | 2012-11-30 | 2016-07-20 | Amorepacific Corp | NEW PSEUDOCERAMIDE COMPOUND AND METHOD OF MANUFACTURING THEREOF |
| US9815772B2 (en) * | 2013-03-05 | 2017-11-14 | Biocon Limited | Process for the preparation of 2-amino-1,3-propane diol compounds and salts thereof |
| KR101510683B1 (ko) * | 2013-09-03 | 2015-04-10 | (주)네오팜 | 카나비노이드 수용체에 길항작용을 가지는 신규한 유사 세라마이드 유도체 및 이를 포함하는 약학 또는 화장품 조성물 |
| EP3118621A1 (en) | 2015-07-14 | 2017-01-18 | Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Methods and compositions for the diagnosis and for the treatment of adrenoleukodystrophy |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69321823T2 (de) * | 1992-10-21 | 1999-06-02 | Taito Co., Ltd., Tokio/Tokyo | 2-amino-1, 3- propandiolverbindung und immunosuppressium |
| US5948820A (en) * | 1994-08-22 | 1999-09-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzene compound and pharmaceutical use thereof |
| EP0778263B1 (en) * | 1994-08-22 | 2002-01-09 | Welfide Corporation | Benzene compound and medicinal use thereof |
| PL1773307T3 (pl) * | 2004-07-30 | 2015-03-31 | Novartis Ag | Preparaty 2-amino-1,3-propanodioli i ich analogów |
| GT200600350A (es) * | 2005-08-09 | 2007-03-28 | Formulaciones líquidas | |
| BRPI0619894B8 (pt) * | 2005-12-15 | 2021-05-25 | Mitsubishi Tanabe Pharma Corp | composto de amina e composição farmacêutica |
| CN101240002B (zh) * | 2007-02-07 | 2011-01-26 | 首都医科大学 | 脂肪酰氨基酰阿糖胞苷缀合物、其制备方法和应用 |
-
2010
- 2010-02-23 JP JP2011551479A patent/JP2012518671A/ja active Pending
- 2010-02-23 KR KR1020117019540A patent/KR20110126631A/ko not_active Withdrawn
- 2010-02-23 PL PL10705160T patent/PL2400960T3/pl unknown
- 2010-02-23 BR BRPI1007994A patent/BRPI1007994A2/pt not_active IP Right Cessation
- 2010-02-23 CN CN2010800089918A patent/CN102333530A/zh active Pending
- 2010-02-23 US US13/202,939 patent/US8673982B2/en not_active Expired - Fee Related
- 2010-02-23 WO PCT/EP2010/052231 patent/WO2010097371A1/en not_active Ceased
- 2010-02-23 PT PT107051609T patent/PT2400960E/pt unknown
- 2010-02-23 RU RU2011138963/15A patent/RU2011138963A/ru not_active Application Discontinuation
- 2010-02-23 EP EP10705160.9A patent/EP2400960B1/en not_active Not-in-force
- 2010-02-23 MX MX2011008876A patent/MX2011008876A/es not_active Application Discontinuation
- 2010-02-23 ES ES10705160T patent/ES2411138T3/es active Active
- 2010-02-23 AU AU2010217605A patent/AU2010217605B2/en not_active Ceased
- 2010-02-23 CA CA2752003A patent/CA2752003A1/en not_active Abandoned
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