JP2012517965A5 - - Google Patents

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Publication number
JP2012517965A5
JP2012517965A5 JP2011549472A JP2011549472A JP2012517965A5 JP 2012517965 A5 JP2012517965 A5 JP 2012517965A5 JP 2011549472 A JP2011549472 A JP 2011549472A JP 2011549472 A JP2011549472 A JP 2011549472A JP 2012517965 A5 JP2012517965 A5 JP 2012517965A5
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JP
Japan
Prior art keywords
formula
reaction
above meanings
compound
dmf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2011549472A
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English (en)
Japanese (ja)
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JP5667085B2 (ja
JP2012517965A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/EP2010/000717 external-priority patent/WO2010091824A1/en
Publication of JP2012517965A publication Critical patent/JP2012517965A/ja
Publication of JP2012517965A5 publication Critical patent/JP2012517965A5/ja
Application granted granted Critical
Publication of JP5667085B2 publication Critical patent/JP5667085B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2011549472A 2009-02-13 2010-02-05 Ａｋｔインヒビターとしての融合されたピリミジン Expired - Fee Related JP5667085B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09152805 2009-02-13
EP09152805.9 2009-02-13
PCT/EP2010/000717 WO2010091824A1 (en) 2009-02-13 2010-02-05 Fused pyrimidines as akt inhibitors

Publications (3)

Publication Number Publication Date
JP2012517965A JP2012517965A (ja) 2012-08-09
JP2012517965A5 true JP2012517965A5 (https=) 2014-09-04
JP5667085B2 JP5667085B2 (ja) 2015-02-12

Family

ID=42019301

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011549472A Expired - Fee Related JP5667085B2 (ja) 2009-02-13 2010-02-05 Ａｋｔインヒビターとしての融合されたピリミジン

Country Status (7)

Country Link
US (1) US20130310362A1 (https=)
EP (1) EP2396331B1 (https=)
JP (1) JP5667085B2 (https=)
CN (1) CN102361872B (https=)
CA (1) CA2752114C (https=)
ES (1) ES2435804T3 (https=)
WO (1) WO2010091824A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2897279C (en) * 2013-01-23 2020-12-29 Astrazeneca Ab Aminopyrazine derivatives and pharmaceutical compositions thereof for use in the treatment of cancer
AU2014318614B2 (en) 2013-09-12 2021-01-07 Dana-Farber Cancer Institute Inc. Methods for evaluating and treating Waldenstrom's macroglobulinemia
JP6602779B2 (ja) 2014-02-13 2019-11-06 インサイト・コーポレイション Ｌｓｄ１阻害剤としてのシクロプロピルアミン類
EP3105218B1 (en) 2014-02-13 2019-09-25 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
EP2907811A1 (en) 2014-02-14 2015-08-19 Actelion Pharmaceuticals Ltd. Process for manufacturing pyrimidine sulfamide derivatives
WO2016007731A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyridines and imidazopyrazines as lsd1 inhibitors
US9695167B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors
US9695180B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
EP3277689B1 (en) 2015-04-03 2019-09-04 Incyte Corporation Heterocyclic compounds as lsd1 inhibitors
MY189367A (en) 2015-08-12 2022-02-08 Incyte Corp Salts of an lsd1 inhibitor
US10968200B2 (en) 2018-08-31 2021-04-06 Incyte Corporation Salts of an LSD1 inhibitor and processes for preparing the same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050008691A (ko) * 2002-04-19 2005-01-21 셀룰러 지노믹스 아이엔씨 이미다조[1,2-ａ]피라진-8-일 아민, 그의 제조방법 및사용방법
CN1809354A (zh) * 2003-04-24 2006-07-26 麦克公司 Akt活性抑制剂
CA2561311A1 (en) 2004-04-09 2005-10-27 Merck & Co., Inc. Inhibitors of akt activity
EP1784175A4 (en) 2004-08-23 2009-07-22 Merck & Co Inc INHIBITORS OF ACT ACTIVITY
EP1812439B2 (en) * 2004-10-15 2017-12-06 Takeda Pharmaceutical Company Limited Kinase inhibitors
US7910561B2 (en) * 2004-12-15 2011-03-22 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
AU2006216998B2 (en) 2005-02-14 2010-12-23 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
EP1898903B8 (en) 2005-06-10 2013-05-15 Merck Sharp & Dohme Corp. Inhibitors of akt activity
DE102007012645A1 (de) * 2007-03-16 2008-09-18 Bayer Healthcare Ag Substituierte Imidazo- und Triazolopyrimidine
WO2009021990A1 (en) * 2007-08-14 2009-02-19 Bayer Schering Pharma Aktiengesellschaft Fused imidazoles for cancer treatment
NZ583267A (en) * 2007-08-14 2012-03-30 Bayer Schering Pharma Ag Fused bicyclic pyrimidines

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