JP2012517430A - 外部からの合図によるオンデマンドで可逆的な薬物放出 - Google Patents

外部からの合図によるオンデマンドで可逆的な薬物放出 Download PDF

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Publication number
JP2012517430A
JP2012517430A JP2011549205A JP2011549205A JP2012517430A JP 2012517430 A JP2012517430 A JP 2012517430A JP 2011549205 A JP2011549205 A JP 2011549205A JP 2011549205 A JP2011549205 A JP 2011549205A JP 2012517430 A JP2012517430 A JP 2012517430A
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Prior art keywords
polymer matrix
bioactive agent
ultrasound
polymer
matrix
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Pending
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JP2011549205A
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Japanese (ja)
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JP2012517430A5 (enExample
Inventor
シュエンホァ チャオ
ナザニエル ディー． ヒュービッシュ
デイビッド ジェイ． ムーニー
ジガン スオ
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プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ
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Publication of JP2012517430A publication Critical patent/JP2012517430A/ja
Publication of JP2012517430A5 publication Critical patent/JP2012517430A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
JP2011549205A 2009-02-10 2010-02-01 外部からの合図によるオンデマンドで可逆的な薬物放出 Pending JP2012517430A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15127709P 2009-02-10 2009-02-10
US61/151,277 2009-02-10
PCT/US2010/022769 WO2010093528A2 (en) 2009-02-10 2010-02-01 On-demand and reversible drug release by external cue

Publications (2)

Publication Number Publication Date
JP2012517430A true JP2012517430A (ja) 2012-08-02
JP2012517430A5 JP2012517430A5 (enExample) 2013-03-21

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JP2011549205A Pending JP2012517430A (ja) 2009-02-10 2010-02-01 外部からの合図によるオンデマンドで可逆的な薬物放出

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Country Link
US (1) US20120035531A1 (enExample)
EP (1) EP2395981A4 (enExample)
JP (1) JP2012517430A (enExample)
CN (1) CN102316855A (enExample)
WO (1) WO2010093528A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8753309B2 (en) 2011-06-24 2014-06-17 The Invention Science Fund I, Llc Device, system, and method including micro-patterned cell treatment array
US9387276B2 (en) 2012-01-05 2016-07-12 President And Fellows Of Harvard College Interpenetrating networks with covalent and Ionic Crosslinks
JP7137213B2 (ja) 2016-03-22 2022-09-14 プレジデント アンド フェローズ オブ ハーバード カレッジ 生体適合性接着剤およびその使用の方法
WO2021174021A1 (en) * 2020-02-27 2021-09-02 Fred Hutchinson Cancer Research Center Tunable extended release hydrogels
CN114681437A (zh) * 2020-12-30 2022-07-01 苏州百迈生物医药有限公司 一种米托蒽醌组合物及其制备方法
WO2022268284A1 (en) * 2021-06-21 2022-12-29 Sorbonne Universite Sonosensitive composition

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4657543A (en) * 1984-07-23 1987-04-14 Massachusetts Institute Of Technology Ultrasonically modulated polymeric devices for delivering compositions
AU6419899A (en) * 1998-10-09 2000-05-01 Regents Of The University Of Michigan, The Hydrogels and water soluble polymeric carriers for drug delivery
US6748954B2 (en) * 2000-10-27 2004-06-15 The Regents Of The University Of Michigan Drug release from polymer matrices through mechanical stimulation
NL1023720C2 (nl) * 2003-06-23 2004-12-28 Univ Eindhoven Tech Werkwijze voor het wijzigen van de transporteigenschappen van een materiaal, werkwijze voor het vrijmaken van een werkstof uit een implantaat, evenals implantaat met werkstof.
WO2007024972A2 (en) * 2005-08-22 2007-03-01 Quick-Med Technologies, Inc. Non-leaching absorbent wound dressing

Also Published As

Publication number Publication date
WO2010093528A3 (en) 2011-03-31
US20120035531A1 (en) 2012-02-09
EP2395981A2 (en) 2011-12-21
CN102316855A (zh) 2012-01-11
EP2395981A4 (en) 2013-08-14
WO2010093528A2 (en) 2010-08-19

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