JP2012515002A - ピルビン酸およびその塩を含有する愛玩動物用組成物ならびにその使用方法 - Google Patents
ピルビン酸およびその塩を含有する愛玩動物用組成物ならびにその使用方法 Download PDFInfo
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- A—HUMAN NECESSITIES
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Abstract
【選択図】なし
Description
[004] したがって本発明は、ペットの通常の栄養要求を満たす、有効量のピルビン酸またはその塩あるいは有効量のリポ酸またはその塩およびピルビン酸またはその塩を含む、愛玩動物用ペットフード組成物を包含する。
[006] 他の態様は、愛玩動物において健全な身体組成を維持または増進するための、たとえば体重または体脂肪を減少させ、除脂肪筋量の割合を増大させるための方法であって、健全な身体組成を増進または維持するのに有効な量のピルビン酸またはその塩あるいはリポ酸またはその塩およびピルビン酸またはその塩を含む組成物を動物に給餌することを含む方法を包含する。
[007] 本発明は一般に、ピルビン酸またはその塩あるいはリポ酸またはその塩およびピルビン酸またはその塩を含む組成物を包含する。
[009] 特定の態様において、ピルビン酸またはその塩は組成物中に10ppm〜10000ppmの量で存在する。
[0011] 特定の態様において、ピルビン酸またはその塩は組成物中に100ppm〜2500ppmの量で存在する。
[0013] 特定の態様において、リポ酸またはその塩は組成物中に10ppm〜4000ppmの量で存在する。
[0015] 特定の態様において、リポ酸またはその塩は組成物中に100ppm〜2000ppmの量で存在する。
[0017] 特定の態様において、組成物はさらにタンパク質、脂肪、炭水化物、繊維、およびその組合わせを含む。
[0019] 特定の態様において、組成物はキャットフードである。
[0020] 特定の態様において、組成物は食物、栄養食、サプリメント、動物用のおやつまたは玩具である。
[0022] 特定の態様において、組成物は乾燥食物の形態である。
[0023] 特定の態様において、本発明は、愛玩動物において体重を管理するための方法であって、有効量のピルビン酸またはその塩あるいは有効量のリポ酸またはその塩およびピルビン酸またはその塩を含む組成物を愛玩動物に投与することを含む方法を包含する。
[0025] 本発明の他の態様は、愛玩動物において健全な身体組成を維持または増進するための方法であって、有効量のピルビン酸またはその塩あるいは有効量のリポ酸またはその塩およびピルビン酸またはその塩を含有する本発明組成物を愛玩動物に給餌することを含む方法を包含する。
[0029] 用語“げっ歯類”にはハムスター、マウス、ラット、モルモット、ジャービル(アレチネズミ、gerbil)、うさぎ、ハリネズミ(hedge hog)、フェレット(ferret)、チンチラ(chinchilla)などが含まれるが、これらに限定されない。
本発明の組成物
[0031] 本発明の1態様は、ピルビン酸またはその塩あるいはリポ酸またはその塩およびピルビン酸またはその塩を含む、愛玩動物用組成物を包含する。
[0047] 特定の態様において、栄養調整剤は、当業者に既知の多様な供給源、たとえばビタミンおよび無機質のサプリメントおよび食物成分から得られる。ビタミンおよび無機質は、欠乏を避けて健康を維持するために要求される量で含有させることができる。これらの量は当技術分野で容易に入手できる。The National Research Council (NRC)は、農場動物についてそのような栄養素の推奨量を提示している。たとえばNutrient Requirements of Swine(ブタの栄養素要求量)(10th Rev. Ed., Nat’l Academy Press, ワシントンD.C., 1998)、Nutrient Requirements of Poultry(家禽の栄養素要求量)(9th Rev. Ed., Nat’l Academy Press, ワシントンD.C., 1994)、Nutrient Requirements of Horses(ウマの栄養素要求量)(5th Rev. Ed., Nat’l Academy Press, ワシントンD.C., 1989)を参照。The American Feed Control Officials (AAFCO)は、イヌおよびネコについてそのような栄養素の推奨量を提示している。American Feed Control Officials, Inc., Official publication, pp. 129-137 (2004)を参照。一般に食物添加物として有用なビタミンには、ビタミンA、ビタミンB1、ビタミンB2、ビタミンB6、ビタミンB12、ビタミンD、ビオチン、ビタミンK、葉酸、イノシトール、ナイアシンおよびパントテン酸が含まれる。食物添加物として有用な無機質および微量元素には、カルシウム、リン、ナトリウム、カリウム、マグネシウム、銅、亜鉛、塩化物、鉄、セレン、ヨウ素および鉄が含まれる。
(a)0%〜75%の炭水化物、
(b)2%〜50%の脂肪、
(c)0%〜40%の食物繊維、および
(d)0%〜15%の1種類以上の栄養調整剤。
[0056] 本発明の組成物は、当業者に既知の一般的な食物製造方法を用いて缶詰め形態または湿潤形態で調製できる。一般に、粉砕した動物タンパク質組織を他の成分、たとえば魚油、穀粒、調整用成分、特殊な目的の添加剤(たとえば、ビタミンおよび無機質の混合物、無機塩類、セルロースおよびてん菜パルプ、増量剤など)、リポ酸またはその塩およびピルビン酸またはその塩、ならびに加工するのに十分な量の水と混合する。構成要素をブレンディングしながら加熱するのに適した容器内でこれらの成分を混合する。混合物の加熱はいずれか適切な方法、たとえば直接蒸気注入を用いて、または熱交換器を備えた容器を用いて行なわれる。最終成分の添加に続いて、混合物を約50°F〜約212°Fの温度に加熱する。この範囲外の温度も許容できるが、他の加工助剤を用いなければ商業上は実用的でない可能性がある。適切な温度に加熱した場合、材料は一般に粘稠な液体の形態であろう。この粘稠な液体を缶に充填する。蓋をし、容器をハーメチックシールする。シールした缶を次いで内容物の殺菌のために設計された一般的な装置に入れる。殺菌は通常は約230°Fより高い温度に、用いる温度、組成物およびこれらに類する要因に応じて適宜な時間、加熱することにより達成される。本発明の組成物は、食物組成物に製造の前、途中または後に添加できる。
本発明の組成物により障害を治療または予防する方法
[0059] 本発明は、治療または予防に有効な量の、ピルビン酸またはその塩あるいはリポ酸またはその塩およびピルビン酸またはその塩を含む組成物を、それが必要な愛玩動物に投与することにより、特定の障害を治療または予防する方法をも包含する。
[0066] 32匹のイヌを体重減少試験に用いた。すべてのイヌを34.8%より高い体脂肪%(総体重の)で試験開始した。より早く最適体重(20%の体脂肪)を達成しない限り4ヶ月間、イヌの体重減少試験を続けた。イヌを4種類の処置のうちの1つに割り当てた(処置当たり8匹のイヌ;表1、2および3)。各食物をキブル状にし、Association of American Feed Control Officials(2005)のイヌのための栄養素指針に従って配合し、成体維持要求を満たすように調整した。体重減少試験中に、すべてのイヌにつき0、1、2、3および4ヶ月目に二重エネルギーx線吸収測定(DEXA)を行なった。体重が減少した後、イヌを4ヶ月間同じ食物のまま飼育して、その食物が体重再増加を阻止するかを判定した。試験のこの維持部分において、イヌにつき0、2および4ヶ月目にDEXAを行なった。すべてのDEXA時点で血液化学的スクリーニング分析も行なった。
[0072] 表5は、リポ酸およびピルビン酸カルシウムを含有する例示ペットフード組成物が、その例示ペットフード組成物を与えたイヌにおいて除脂肪体重を4カ月間にわたって減少させたことを示す。
[0076] 表9は、リポ酸およびピルビン酸カルシウムを含有する例示ペットフード組成物が、その例示ペットフード組成物を与えたイヌにおいて血清アラニンアミノトランスフェラーゼレベルを4カ月間にわたって減少させたことを示す。
Claims (45)
- ピルビン酸またはその塩を含む組成物。
- さらにリポ酸またはその塩を含む、請求項1に記載の組成物。
- ピルビン酸またはその塩が組成物中に5ppm〜20000ppmの量で存在する、請求項1または2に記載の組成物。
- ピルビン酸またはその塩が組成物中に10ppm〜10000ppmの量で存在する、前記請求項のいずれか1項に記載の組成物。
- ピルビン酸またはその塩が組成物中に50ppm〜5000ppmの量で存在する、前記請求項のいずれか1項に記載の組成物。
- ピルビン酸またはその塩が組成物中に100ppm〜2500ppmの量で存在する、前記請求項のいずれか1項に記載の組成物。
- リポ酸またはその塩が組成物中に約5ppm〜約5000ppmの量で存在する、請求項2〜5のいずれか1項に記載の組成物。
- リポ酸またはその塩が組成物中に10ppm〜4000ppmの量で存在する、請求項2〜6のいずれか1項に記載の組成物。
- リポ酸またはその塩が組成物中に50ppm〜3000ppmの量で存在する、請求項2〜7のいずれか1項に記載の組成物。
- リポ酸またはその塩が組成物中に100ppm〜2000ppmの量で存在する、請求項2〜8のいずれか1項に記載の組成物。
- リポ酸またはその塩が組成物中に500ppm〜1000ppmの量で存在する、請求項2〜9のいずれか1項に記載の組成物。
- 組成物がさらにタンパク質、脂肪、炭水化物、繊維、およびその組合わせを含む、前記請求項のいずれか1項に記載の組成物。
- 組成物がドッグフードである、前記請求項のいずれか1項に記載の組成物。
- 組成物がキャットフードである、前記請求項のいずれか1項に記載の組成物。
- 組成物が食物、栄養食、サプリメント、動物用のおやつまたは玩具である、前記請求項のいずれか1項に記載の組成物。
- 湿潤食物の形態である、前記請求項のいずれか1項に記載の組成物。
- 乾燥食物の形態である、前記請求項のいずれか1項に記載の組成物。
- リポ酸またはその塩およびピルビン酸またはその塩を含む組成物。
- 愛玩動物において肥満症を予防または治療するための方法であって、有効量のピルビン酸またはその塩を含む組成物を愛玩動物に投与することを含む方法。
- さらに有効量のリポ酸またはその塩を含む、請求項18に記載の方法。
- ピルビン酸またはその塩が組成物中に5ppm〜20000ppmの量で存在する、請求項18または19に記載の方法。
- ピルビン酸またはその塩が組成物中に10ppm〜10000ppmの量で存在する、請求項18〜20のいずれか1項に記載の方法。
- ピルビン酸またはその塩が組成物中に50ppm〜5000ppmの量で存在する、請求項18〜21のいずれか1項に記載の方法。
- ピルビン酸またはその塩が組成物中に100ppm〜2500ppmの量で存在する、請求項18〜22のいずれか1項に記載の方法。
- 組成物がさらにタンパク質、脂肪、炭水化物、繊維、およびその組合わせを含む、請求項18〜23のいずれか1項に記載の方法。
- リポ酸またはその塩が組成物中に5ppm〜5000ppmの量で存在する、請求項19〜24のいずれか1項に記載の方法。
- リポ酸またはその塩が組成物中に10ppm〜4000ppmの量で存在する、請求項19〜25のいずれか1項に記載の方法。
- リポ酸またはその塩が組成物中に50ppm〜3000ppmの量で存在する、請求項19〜26のいずれか1項に記載の方法。
- リポ酸またはその塩が組成物中に100ppm〜2000ppmの量で存在する、請求項19〜27のいずれか1項に記載の方法。
- リポ酸またはその塩が組成物中に500ppm〜1000ppmの量で存在する、請求項19〜28のいずれか1項に記載の方法。
- 組成物がさらにタンパク質、脂肪、炭水化物、繊維、およびその組合わせを含む、請求項18〜29のいずれか1項に記載の方法。
- 組成物がドッグフードである、請求項18〜30のいずれか1項に記載の方法。
- 組成物がキャットフードである、請求項18〜31のいずれか1項に記載の方法。
- 組成物が食物、栄養食、サプリメント、動物用のおやつまたは玩具である、請求項18〜32のいずれか1項に記載の方法。
- 湿潤食物の形態である、請求項18〜33のいずれか1項に記載の方法。
- 乾燥食物の形態である、請求項18〜34のいずれか1項に記載の方法。
- 愛玩動物がイヌである、請求項18〜35のいずれか1項に記載の方法。
- 愛玩動物がネコである、請求項18〜36のいずれか1項に記載の方法。
- 投与が経口給餌である、請求項18〜37のいずれか1項に記載の方法。
- 愛玩動物において体重を管理するための方法であって、有効量のピルビン酸またはその塩を含む組成物を愛玩動物に投与することを含む方法。
- さらに有効量のリポ酸またはその塩を含む、請求項39に記載の方法。
- 愛玩動物において体脂肪を減少させるための方法であって、有効量のピルビン酸またはその塩を含む組成物を愛玩動物に投与することを含む方法。
- さらに有効量のリポ酸またはその塩を含む、請求項41に記載の方法。
- 愛玩動物において除脂肪体重を増加させるための方法であって、有効量のピルビン酸またはその塩を含む組成物を愛玩動物に投与することを含む方法。
- さらに有効量のリポ酸またはその塩を含む、請求項43に記載の方法。
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JP2020501503A (ja) * | 2016-12-15 | 2020-01-23 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | コンパニオンアニマルにおけるリン又は酵素を調節する組成物及び方法 |
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