JP2012514994A - 非コードｒｎａ発現アッセイを用いた方法 - Google Patents

非コードｒｎａ発現アッセイを用いた方法 Download PDF

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JP2012514994A
JP2012514994A JP2011545794A JP2011545794A JP2012514994A JP 2012514994 A JP2012514994 A JP 2012514994A JP 2011545794 A JP2011545794 A JP 2011545794A JP 2011545794 A JP2011545794 A JP 2011545794A JP 2012514994 A JP2012514994 A JP 2012514994A
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expression
coding rna
intervention
interventions
biological
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JP2012514994A5 (enExample
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エスティベイロ，ジャシント・ピーター
ゴードン，ジョン・フランシス
ヒリアー，クリストファー・ロバート
オブライエン，ビンセント
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Sistemic Scotland Ltd
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Sistemic Scotland Ltd
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Priority claimed from GB0900809A external-priority patent/GB0900809D0/en
Priority claimed from GB0917708A external-priority patent/GB0917708D0/en
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Publication of JP2012514994A publication Critical patent/JP2012514994A/ja
Publication of JP2012514994A5 publication Critical patent/JP2012514994A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/142—Toxicological screening, e.g. expression profiles which identify toxicity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
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  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2011545794A 2009-01-19 2010-01-19 非コードｒｎａ発現アッセイを用いた方法 Pending JP2012514994A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0900809.5 2009-01-19
GB0900809A GB0900809D0 (en) 2009-01-19 2009-01-19 Methods employing non-coding RNA expression assays
GB0917708.0 2009-10-09
GB0917708A GB0917708D0 (en) 2009-10-09 2009-10-09 Methods employing non-coding rna expression assays
PCT/GB2010/000076 WO2010082039A1 (en) 2009-01-19 2010-01-19 Methods employing non-coding rna expression assays

Publications (2)

Publication Number Publication Date
JP2012514994A true JP2012514994A (ja) 2012-07-05
JP2012514994A5 JP2012514994A5 (enExample) 2013-03-07

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JP2011545794A Pending JP2012514994A (ja) 2009-01-19 2010-01-19 非コードｒｎａ発現アッセイを用いた方法

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US (3) US9074241B2 (enExample)
EP (2) EP2387617B1 (enExample)
JP (1) JP2012514994A (enExample)
KR (1) KR20110138341A (enExample)
CN (1) CN102356163A (enExample)
AU (1) AU2010205493A1 (enExample)
CA (1) CA2787218A1 (enExample)
IL (1) IL214154A (enExample)
SG (2) SG196843A1 (enExample)
WO (1) WO2010082039A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201014049D0 (en) * 2010-08-23 2010-10-06 Sistemic Uk Cell characterisation
CN108319814B (zh) * 2018-01-29 2018-12-14 中国科学院生物物理研究所 基于染色体空间相互作用预测长非编码rna生物学功能的方法
CN111899788B (zh) * 2020-07-06 2023-08-18 李霞 一种非编码rna调控疾病风险靶通路的识别方法及系统
CN113593700B (zh) * 2021-08-06 2024-02-27 江苏师范大学 分析肺癌进展的方法、装置、设备、介质及程序产品

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002528095A (ja) * 1998-10-27 2002-09-03 ロゼッタ・インファーマティクス・インコーポレーテッド 同時調節された遺伝子セットを使用して遺伝子発現パターンの検出および分類を向上させる方法
JP2007532100A (ja) * 2004-04-07 2007-11-15 エクシコン・アクティーゼルスカブ ｍｉｃｒｏＲＮＡおよび低分子干渉ＲＮＡの定量化のための新規方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005056761A2 (en) * 2003-12-05 2005-06-23 Massachusetts Institute Of Technology REAGENTS AND METHODS FOR IDENTIFICATION OF RNAi PATHWAY GENES AND CHEMICAL MODULATORS OF RNAi
US20100310583A1 (en) 2007-01-31 2010-12-09 Immune Disease Institute Let-7 microrna and mimetics thereof as therapeutics for cancer
CA2678919A1 (en) 2007-03-27 2008-10-02 Ranit Aharonov Gene expression signature for classification of cancers
WO2008154098A2 (en) * 2007-06-07 2008-12-18 Wisconsin Alumni Research Foundation Reagents and methods for mirna expression analysis and identification of cancer biomarkers
US8367318B2 (en) * 2007-07-23 2013-02-05 Dharmacon, Inc. Screening of micro-RNA cluster inhibitor pools
CA2676113C (en) * 2007-07-25 2014-07-08 University Of Louisville Research Foundation, Inc. Exosome-associated microrna as a diagnostic marker
JP2011505143A (ja) * 2007-11-30 2011-02-24 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション マイクロｒｎａ発現プロファイリング及び肺癌における末梢血ターゲティング

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002528095A (ja) * 1998-10-27 2002-09-03 ロゼッタ・インファーマティクス・インコーポレーテッド 同時調節された遺伝子セットを使用して遺伝子発現パターンの検出および分類を向上させる方法
JP2007532100A (ja) * 2004-04-07 2007-11-15 エクシコン・アクティーゼルスカブ ｍｉｃｒｏＲＮＡおよび低分子干渉ＲＮＡの定量化のための新規方法

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JPN5012007881; ＫＲＵＴＺＦＥＬＤＴ　Ｊ: 'ＳＩＬＥＮＣＩＮＧ　ＯＦ　ＭＩＣＲＯＲＮＡＳ　ＩＮ　ＶＩＶＯ　ＷＩＴＨ　ＡＮＴＡＧＯＭＩＲＳ' ＮＡＴＵＲＥ , 20051201, Ｐ６８５-６８９, ＮＡＴＵＲＥ　ＰＵＢＬＩＳＨＩＮＧ　ＧＲＯＵＰ *
JPN5012007882; ＭＯＳＣＨＯＳ　ＳＴＥＲＧＨＩＯＳ　Ａ: 'ＥＸＰＲＥＳＳＩＯＮ　ＰＲＯＦＩＬＩＮＧ　ＩＮ　ＶＩＶＯ　ＤＥＭＯＮＳＴＲＡＴＥＳ　ＲＡＰＩＤ　ＣＨＡＮＧＥＳ　ＩＮ　ＬＵＮＧ　ＭＩＣＲＯＲＮＡ　ＬＥＶＥＬＳ　以下備考' ＢＭＣ　ＧＥＮＯＭＩＣＳ Ｖ８, 200707 *
JPN6014028405; ＲＮＡ，　２００８　［Ａｖａｉｌａｂｌｅ　ｏｎｌｉｎｅ　２００８．０３．２０］，　Ｖｏｌ．　１４，　Ｎｏ．　５，　ｐｐ．　８３６-８４３ *
JPN6014028408; Ｃａｎｃｅｒ　Ｃｅｌｌ，　２００６，　Ｖｏｌ．　９，　Ｎｏ．　６，　ｐｐ．　４３５-４４３ *
JPN6014028411; Ｊ．　Ｃｅｌｌ．　Ｍｏｌ．　Ｍｅｄ．，　２００８，　Ｖｏｌ．　１２，　Ｎｏ．　１，　ｐｐ．　２２７-２４０ *

Also Published As

Publication number Publication date
WO2010082039A1 (en) 2010-07-22
EP2492357A1 (en) 2012-08-29
US20110312524A1 (en) 2011-12-22
KR20110138341A (ko) 2011-12-27
US20160002722A1 (en) 2016-01-07
US20170058346A1 (en) 2017-03-02
EP2492357B1 (en) 2015-09-23
IL214154A0 (en) 2011-08-31
SG196843A1 (en) 2014-02-13
EP2387617B1 (en) 2014-10-29
EP2387617A1 (en) 2011-11-23
CN102356163A (zh) 2012-02-15
IL214154A (en) 2016-10-31
CA2787218A1 (en) 2010-07-22
SG173042A1 (en) 2011-08-29
AU2010205493A1 (en) 2011-09-08
US9074241B2 (en) 2015-07-07

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