JP2012508251A5 - - Google Patents
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- Publication number
- JP2012508251A5 JP2012508251A5 JP2011535709A JP2011535709A JP2012508251A5 JP 2012508251 A5 JP2012508251 A5 JP 2012508251A5 JP 2011535709 A JP2011535709 A JP 2011535709A JP 2011535709 A JP2011535709 A JP 2011535709A JP 2012508251 A5 JP2012508251 A5 JP 2012508251A5
- Authority
- JP
- Japan
- Prior art keywords
- chloride
- dichloroamino
- chloroamino
- methylbutyl
- ammonium chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052757 nitrogen Inorganic materials 0.000 claims 92
- -1 chloroamino Chemical group 0.000 claims 52
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims 44
- 150000001875 compounds Chemical class 0.000 claims 21
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-M chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 8
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 125000004404 heteroalkyl group Chemical group 0.000 claims 7
- 125000005349 heteroarylcycloalkyl group Chemical group 0.000 claims 7
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000011780 sodium chloride Substances 0.000 claims 5
- 125000004429 atoms Chemical group 0.000 claims 4
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 claims 4
- 201000009910 diseases by infectious agent Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000000813 microbial Effects 0.000 claims 3
- BMYXRDWPFUUMAW-UHFFFAOYSA-M [6-(dichloroamino)-4-hydroxy-6-methylheptyl]-trimethylazanium;chloride Chemical compound [Cl-].ClN(Cl)C(C)(C)CC(O)CCC[N+](C)(C)C BMYXRDWPFUUMAW-UHFFFAOYSA-M 0.000 claims 2
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229910052698 phosphorus Inorganic materials 0.000 claims 2
- 210000002345 respiratory system Anatomy 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- HGAAUVBGQAGHDS-UHFFFAOYSA-M 1-[4-[2-(chloroamino)-2-methylpropyl]-4-methylpiperazin-4-ium-1-yl]ethanone;chloride Chemical compound [Cl-].CC(=O)N1CC[N+](C)(CC(C)(C)NCl)CC1 HGAAUVBGQAGHDS-UHFFFAOYSA-M 0.000 claims 1
- LVUGKWGVVMYQSW-UHFFFAOYSA-M 1-[4-[2-(dichloroamino)-2-methylpropyl]-4-methylpiperazin-4-ium-1-yl]ethanone;chloride Chemical compound [Cl-].CC(=O)N1CC[N+](C)(CC(C)(C)N(Cl)Cl)CC1 LVUGKWGVVMYQSW-UHFFFAOYSA-M 0.000 claims 1
- ROOGHAYNSNLPHN-UHFFFAOYSA-M 2-(1-methylpiperidin-1-ium-1-yl)ethyl 3-(chloroamino)-3-methylbutanoate;chloride Chemical compound [Cl-].ClNC(C)(C)CC(=O)OCC[N+]1(C)CCCCC1 ROOGHAYNSNLPHN-UHFFFAOYSA-M 0.000 claims 1
- SOMPTWPVLIXLKQ-UHFFFAOYSA-M 2-(1-methylpiperidin-1-ium-1-yl)ethyl 3-(dichloroamino)-3-methylbutanoate;chloride Chemical compound [Cl-].ClN(Cl)C(C)(C)CC(=O)OCC[N+]1(C)CCCCC1 SOMPTWPVLIXLKQ-UHFFFAOYSA-M 0.000 claims 1
- GYMMBUJBHHKGIU-UHFFFAOYSA-M 2-[4-[2-(chloroamino)propan-2-yl]triazol-1-yl]ethyl-trimethylazanium;chloride Chemical compound [Cl-].ClNC(C)(C)C1=CN(CC[N+](C)(C)C)N=N1 GYMMBUJBHHKGIU-UHFFFAOYSA-M 0.000 claims 1
- VMOFIUDZRYATRG-UHFFFAOYSA-M 2-[4-[2-(dichloroamino)propan-2-yl]triazol-1-yl]ethyl-trimethylazanium;chloride Chemical compound [Cl-].ClN(Cl)C(C)(C)C1=CN(CC[N+](C)(C)C)N=N1 VMOFIUDZRYATRG-UHFFFAOYSA-M 0.000 claims 1
- YSKRJBAMULWUJP-UHFFFAOYSA-N 3-[1-(chloroamino)cyclohexyl]propyl-trimethylazanium Chemical compound C[N+](C)(C)CCCC1(NCl)CCCCC1 YSKRJBAMULWUJP-UHFFFAOYSA-N 0.000 claims 1
- VVCKIVOMVZVYEZ-UHFFFAOYSA-N 3-[1-(chloroamino)cyclopentyl]propyl-trimethylazanium Chemical compound C[N+](C)(C)CCCC1(NCl)CCCC1 VVCKIVOMVZVYEZ-UHFFFAOYSA-N 0.000 claims 1
- IGWQDLSZEXSYKC-UHFFFAOYSA-N 3-[1-(dichloroamino)cyclohexyl]propyl-trimethylazanium Chemical compound C[N+](C)(C)CCCC1(N(Cl)Cl)CCCCC1 IGWQDLSZEXSYKC-UHFFFAOYSA-N 0.000 claims 1
- HJKLCECPSXTFMP-UHFFFAOYSA-N 3-[1-(dichloroamino)cyclopentyl]propyl-trimethylazanium Chemical compound C[N+](C)(C)CCCC1(N(Cl)Cl)CCCC1 HJKLCECPSXTFMP-UHFFFAOYSA-N 0.000 claims 1
- OFFRIFGMYLGRSS-UHFFFAOYSA-M 4-(1-azoniabicyclo[2.2.2]octan-1-yl)-N,N-dichloro-2-methylbutan-2-amine;methanesulfonate Chemical compound CS([O-])(=O)=O.C1CC2CC[N+]1(CCC(C)(C)N(Cl)Cl)CC2 OFFRIFGMYLGRSS-UHFFFAOYSA-M 0.000 claims 1
- WXXRALRSVOZVPF-UHFFFAOYSA-M 4-(1-azoniabicyclo[2.2.2]octan-1-yl)-N-chloro-2-methylbutan-2-amine;methanesulfonate Chemical compound CS([O-])(=O)=O.C1CC2CC[N+]1(CCC(C)(C)NCl)CC2 WXXRALRSVOZVPF-UHFFFAOYSA-M 0.000 claims 1
- 210000004209 Hair Anatomy 0.000 claims 1
- 210000001503 Joints Anatomy 0.000 claims 1
- 210000004400 Mucous Membrane Anatomy 0.000 claims 1
- GWIUGRDUEQIQFY-UHFFFAOYSA-M N,N-dichloro-2-methyl-1-(1-methylpiperidin-1-ium-1-yl)propan-2-amine;chloride Chemical compound [Cl-].ClN(Cl)C(C)(C)C[N+]1(C)CCCCC1 GWIUGRDUEQIQFY-UHFFFAOYSA-M 0.000 claims 1
- KPQXDCFELNBGME-UHFFFAOYSA-M N,N-dichloro-2-methyl-1-(4-methylmorpholin-4-ium-4-yl)propan-2-amine;chloride Chemical compound [Cl-].ClN(Cl)C(C)(C)C[N+]1(C)CCOCC1 KPQXDCFELNBGME-UHFFFAOYSA-M 0.000 claims 1
- LZUZTPFINSGXOC-UHFFFAOYSA-M N,N-dichloro-2-methyl-4-(1,4,4-trimethylpiperidin-1-ium-1-yl)butan-2-amine;chloride Chemical compound [Cl-].ClN(Cl)C(C)(C)CC[N+]1(C)CCC(C)(C)CC1 LZUZTPFINSGXOC-UHFFFAOYSA-M 0.000 claims 1
- IOQNJOJBJMUHOU-UHFFFAOYSA-M N,N-dichloro-2-methyl-4-(1-methylazepan-1-ium-1-yl)butan-2-amine;chloride Chemical compound [Cl-].ClN(Cl)C(C)(C)CC[N+]1(C)CCCCCC1 IOQNJOJBJMUHOU-UHFFFAOYSA-M 0.000 claims 1
- AXSBZJUXVPHFJT-UHFFFAOYSA-M N,N-dichloro-2-methyl-4-(1-methylpiperidin-1-ium-1-yl)butan-2-amine;chloride Chemical compound [Cl-].ClN(Cl)C(C)(C)CC[N+]1(C)CCCCC1 AXSBZJUXVPHFJT-UHFFFAOYSA-M 0.000 claims 1
- JQILRJNCGLBMHZ-UHFFFAOYSA-M N,N-dichloro-2-methyl-4-(1-methylpyrrolidin-1-ium-1-yl)butan-2-amine;chloride Chemical compound [Cl-].ClN(Cl)C(C)(C)CC[N+]1(C)CCCC1 JQILRJNCGLBMHZ-UHFFFAOYSA-M 0.000 claims 1
- CPNKVUSNCFZEEA-UHFFFAOYSA-M N,N-dichloro-2-methyl-4-(4-methylmorpholin-4-ium-4-yl)butan-2-amine;chloride Chemical compound [Cl-].ClN(Cl)C(C)(C)CC[N+]1(C)CCOCC1 CPNKVUSNCFZEEA-UHFFFAOYSA-M 0.000 claims 1
- QTDDBOJSIZFCCW-UHFFFAOYSA-M N,N-dichloro-2-methyl-4-pyridin-1-ium-1-ylbutan-2-amine;chloride Chemical compound [Cl-].ClN(Cl)C(C)(C)CC[N+]1=CC=CC=C1 QTDDBOJSIZFCCW-UHFFFAOYSA-M 0.000 claims 1
- PQGHVNAJBSUUIL-UHFFFAOYSA-M N,N-dichloro-2-methyl-5-pyridin-1-ium-1-ylpentan-2-amine;chloride Chemical compound [Cl-].ClN(Cl)C(C)(C)CCC[N+]1=CC=CC=C1 PQGHVNAJBSUUIL-UHFFFAOYSA-M 0.000 claims 1
- BOPJCCASSPUXJK-UHFFFAOYSA-M N,N-dichloro-4-(4,4-difluoro-1-methylpiperidin-1-ium-1-yl)-2-methylbutan-2-amine;chloride Chemical compound [Cl-].ClN(Cl)C(C)(C)CC[N+]1(C)CCC(F)(F)CC1 BOPJCCASSPUXJK-UHFFFAOYSA-M 0.000 claims 1
- SEHPLDLDSGWWRP-UHFFFAOYSA-M N-chloro-2-methyl-1-(1-methylpiperidin-1-ium-1-yl)propan-2-amine;chloride Chemical compound [Cl-].ClNC(C)(C)C[N+]1(C)CCCCC1 SEHPLDLDSGWWRP-UHFFFAOYSA-M 0.000 claims 1
- DRGSVJGJHXNWGM-UHFFFAOYSA-M N-chloro-2-methyl-1-(4-methylmorpholin-4-ium-4-yl)propan-2-amine;chloride Chemical compound [Cl-].ClNC(C)(C)C[N+]1(C)CCOCC1 DRGSVJGJHXNWGM-UHFFFAOYSA-M 0.000 claims 1
- CDWNOKXIWKZSJZ-UHFFFAOYSA-M N-chloro-2-methyl-4-(1,4,4-trimethylpiperidin-1-ium-1-yl)butan-2-amine;chloride Chemical compound [Cl-].ClNC(C)(C)CC[N+]1(C)CCC(C)(C)CC1 CDWNOKXIWKZSJZ-UHFFFAOYSA-M 0.000 claims 1
- UANXUGWCHRDJRK-UHFFFAOYSA-M N-chloro-2-methyl-4-(1-methylazepan-1-ium-1-yl)butan-2-amine;chloride Chemical compound [Cl-].ClNC(C)(C)CC[N+]1(C)CCCCCC1 UANXUGWCHRDJRK-UHFFFAOYSA-M 0.000 claims 1
- KHIJMPPAFXTZBN-UHFFFAOYSA-M N-chloro-2-methyl-4-(1-methylpiperidin-1-ium-1-yl)butan-2-amine;chloride Chemical compound [Cl-].ClNC(C)(C)CC[N+]1(C)CCCCC1 KHIJMPPAFXTZBN-UHFFFAOYSA-M 0.000 claims 1
- YORYNNDOULFLHR-UHFFFAOYSA-M N-chloro-2-methyl-4-(1-methylpyrrolidin-1-ium-1-yl)butan-2-amine;chloride Chemical compound [Cl-].ClNC(C)(C)CC[N+]1(C)CCCC1 YORYNNDOULFLHR-UHFFFAOYSA-M 0.000 claims 1
- HFAHZCBSSBAXKS-UHFFFAOYSA-M N-chloro-2-methyl-4-(4-methylmorpholin-4-ium-4-yl)butan-2-amine;chloride Chemical compound [Cl-].ClNC(C)(C)CC[N+]1(C)CCOCC1 HFAHZCBSSBAXKS-UHFFFAOYSA-M 0.000 claims 1
- RUWVTHNZUNILSN-UHFFFAOYSA-M N-chloro-2-methyl-4-pyridin-1-ium-1-ylbutan-2-amine;chloride Chemical compound [Cl-].ClNC(C)(C)CC[N+]1=CC=CC=C1 RUWVTHNZUNILSN-UHFFFAOYSA-M 0.000 claims 1
- SMYCFEODAWBRCO-UHFFFAOYSA-M N-chloro-2-methyl-5-pyridin-1-ium-1-ylpentan-2-amine;chloride Chemical compound [Cl-].ClNC(C)(C)CCC[N+]1=CC=CC=C1 SMYCFEODAWBRCO-UHFFFAOYSA-M 0.000 claims 1
- SHROQRXTRFLCGW-UHFFFAOYSA-M N-chloro-4-(4,4-difluoro-1-methylpiperidin-1-ium-1-yl)-2-methylbutan-2-amine;chloride Chemical compound [Cl-].ClNC(C)(C)CC[N+]1(C)CCC(F)(F)CC1 SHROQRXTRFLCGW-UHFFFAOYSA-M 0.000 claims 1
- 210000000282 Nails Anatomy 0.000 claims 1
- 210000003491 Skin Anatomy 0.000 claims 1
- ZLJAXCLKUOMAKP-UHFFFAOYSA-M [2-(chloroamino)-2-methylpropyl]-(3-fluorophenyl)-dimethylazanium;chloride Chemical compound [Cl-].ClNC(C)(C)C[N+](C)(C)C1=CC=CC(F)=C1 ZLJAXCLKUOMAKP-UHFFFAOYSA-M 0.000 claims 1
- AVVXXYCPMYUMEO-UHFFFAOYSA-M [2-(chloroamino)-2-methylpropyl]-dimethylsulfanium;chloride Chemical compound [Cl-].C[S+](C)CC(C)(C)NCl AVVXXYCPMYUMEO-UHFFFAOYSA-M 0.000 claims 1
- IKSMEWQZHQUKMI-UHFFFAOYSA-M [2-(chloroamino)-2-methylpropyl]-trimethylphosphanium;chloride Chemical compound [Cl-].ClNC(C)(C)C[P+](C)(C)C IKSMEWQZHQUKMI-UHFFFAOYSA-M 0.000 claims 1
- MWKZQMZJZJGZNK-UHFFFAOYSA-M [2-(dichloroamino)-2-methylpropyl]-(3-fluorophenyl)-dimethylazanium;chloride Chemical compound [Cl-].ClN(Cl)C(C)(C)C[N+](C)(C)C1=CC=CC(F)=C1 MWKZQMZJZJGZNK-UHFFFAOYSA-M 0.000 claims 1
- ZCOWIFNURMQKJU-UHFFFAOYSA-M [2-(dichloroamino)-2-methylpropyl]-dimethylsulfanium;chloride Chemical compound [Cl-].C[S+](C)CC(C)(C)N(Cl)Cl ZCOWIFNURMQKJU-UHFFFAOYSA-M 0.000 claims 1
- UQHOHEWYSKFDSF-UHFFFAOYSA-M [2-(dichloroamino)-2-methylpropyl]-trimethylphosphanium;chloride Chemical compound [Cl-].ClN(Cl)C(C)(C)C[P+](C)(C)C UQHOHEWYSKFDSF-UHFFFAOYSA-M 0.000 claims 1
- ZVJWWOBMZRNVSX-UHFFFAOYSA-M [3-(chloroamino)-3-methylbutyl]-(3-fluorophenyl)-dimethylazanium;chloride Chemical compound [Cl-].ClNC(C)(C)CC[N+](C)(C)C1=CC=CC(F)=C1 ZVJWWOBMZRNVSX-UHFFFAOYSA-M 0.000 claims 1
- BAHLGONMYOSODQ-UHFFFAOYSA-M [3-(chloroamino)-3-methylbutyl]-dimethyl-(3,3,3-trifluoropropyl)azanium;chloride Chemical compound [Cl-].ClNC(C)(C)CC[N+](C)(C)CCC(F)(F)F BAHLGONMYOSODQ-UHFFFAOYSA-M 0.000 claims 1
- DEMXNHBOCAWHNN-UHFFFAOYSA-M [3-(chloroamino)-3-methylbutyl]-dimethylsulfanium;chloride Chemical compound [Cl-].C[S+](C)CCC(C)(C)NCl DEMXNHBOCAWHNN-UHFFFAOYSA-M 0.000 claims 1
- SESVNIKJCJAPIH-UHFFFAOYSA-M [3-(chloroamino)-3-methylbutyl]-dodecyl-dimethylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CCC(C)(C)NCl SESVNIKJCJAPIH-UHFFFAOYSA-M 0.000 claims 1
- SVUVQIMSAULGJO-UHFFFAOYSA-M [3-(chloroamino)-3-methylbutyl]-ethyl-dimethylazanium;chloride Chemical compound [Cl-].CC[N+](C)(C)CCC(C)(C)NCl SVUVQIMSAULGJO-UHFFFAOYSA-M 0.000 claims 1
- MZCFFKJRGKYHCO-UHFFFAOYSA-M [3-(chloroamino)-3-methylbutyl]-hexyl-dimethylazanium;chloride Chemical compound [Cl-].CCCCCC[N+](C)(C)CCC(C)(C)NCl MZCFFKJRGKYHCO-UHFFFAOYSA-M 0.000 claims 1
- OKDIYPHBJZLDAJ-UHFFFAOYSA-M [3-(chloroamino)-3-methylbutyl]-trimethylphosphanium;chloride Chemical compound [Cl-].ClNC(C)(C)CC[P+](C)(C)C OKDIYPHBJZLDAJ-UHFFFAOYSA-M 0.000 claims 1
- XWFRLXJWPFPONW-UHFFFAOYSA-M [3-(dichloroamino)-3-methylbutyl]-(3-fluorophenyl)-dimethylazanium;chloride Chemical compound [Cl-].ClN(Cl)C(C)(C)CC[N+](C)(C)C1=CC=CC(F)=C1 XWFRLXJWPFPONW-UHFFFAOYSA-M 0.000 claims 1
- XIUQMQXEFNRYOC-UHFFFAOYSA-M [3-(dichloroamino)-3-methylbutyl]-dimethyl-(3,3,3-trifluoropropyl)azanium;chloride Chemical compound [Cl-].ClN(Cl)C(C)(C)CC[N+](C)(C)CCC(F)(F)F XIUQMQXEFNRYOC-UHFFFAOYSA-M 0.000 claims 1
- KBLRUVQWMJXUBL-UHFFFAOYSA-M [3-(dichloroamino)-3-methylbutyl]-dimethylsulfanium;chloride Chemical compound [Cl-].C[S+](C)CCC(C)(C)N(Cl)Cl KBLRUVQWMJXUBL-UHFFFAOYSA-M 0.000 claims 1
- QAWAWLVJBACXTO-UHFFFAOYSA-M [3-(dichloroamino)-3-methylbutyl]-dodecyl-dimethylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CCC(C)(C)N(Cl)Cl QAWAWLVJBACXTO-UHFFFAOYSA-M 0.000 claims 1
- IJPUUSDBVWHITG-UHFFFAOYSA-M [3-(dichloroamino)-3-methylbutyl]-ethyl-dimethylazanium;chloride Chemical compound [Cl-].CC[N+](C)(C)CCC(C)(C)N(Cl)Cl IJPUUSDBVWHITG-UHFFFAOYSA-M 0.000 claims 1
- WJSRTBBOKZRWGU-UHFFFAOYSA-M [3-(dichloroamino)-3-methylbutyl]-hexyl-dimethylazanium;chloride Chemical compound [Cl-].CCCCCC[N+](C)(C)CCC(C)(C)N(Cl)Cl WJSRTBBOKZRWGU-UHFFFAOYSA-M 0.000 claims 1
- CRZAYEIDVJMNNC-UHFFFAOYSA-M [3-(dichloroamino)-3-methylbutyl]-trimethylphosphanium;chloride Chemical compound [Cl-].ClN(Cl)C(C)(C)CC[P+](C)(C)C CRZAYEIDVJMNNC-UHFFFAOYSA-M 0.000 claims 1
- ICVCXWDNNTUJIO-UHFFFAOYSA-M [4-(chloroamino)-4-methylpentyl]-trimethylphosphanium;chloride Chemical compound [Cl-].ClNC(C)(C)CCC[P+](C)(C)C ICVCXWDNNTUJIO-UHFFFAOYSA-M 0.000 claims 1
- GXQIEAGJYKTDKP-UHFFFAOYSA-N [4-(chloroamino)-4-propylheptyl]-trimethylazanium Chemical compound CCCC(CCC)(NCl)CCC[N+](C)(C)C GXQIEAGJYKTDKP-UHFFFAOYSA-N 0.000 claims 1
- AXRFRMUBAWDOHG-UHFFFAOYSA-M [4-(dichloroamino)-4-methylpentyl]-trimethylphosphanium;chloride Chemical compound [Cl-].ClN(Cl)C(C)(C)CCC[P+](C)(C)C AXRFRMUBAWDOHG-UHFFFAOYSA-M 0.000 claims 1
- XLKGTTMXFXLSQF-UHFFFAOYSA-N [4-(dichloroamino)-4-propylheptyl]-trimethylazanium Chemical compound CCCC(CCC)(N(Cl)Cl)CCC[N+](C)(C)C XLKGTTMXFXLSQF-UHFFFAOYSA-N 0.000 claims 1
- KBPAHRDAQXEKDT-UHFFFAOYSA-M [5-(chloroamino)-3-hydroxy-5-methylhexyl]-trimethylazanium;chloride Chemical compound [Cl-].ClNC(C)(C)CC(O)CC[N+](C)(C)C KBPAHRDAQXEKDT-UHFFFAOYSA-M 0.000 claims 1
- SUMZYZAOISWYGN-UHFFFAOYSA-M [5-(dichloroamino)-3-hydroxy-5-methylhexyl]-trimethylazanium;chloride Chemical compound [Cl-].ClN(Cl)C(C)(C)CC(O)CC[N+](C)(C)C SUMZYZAOISWYGN-UHFFFAOYSA-M 0.000 claims 1
- QFAPUQKCUJDUKS-UHFFFAOYSA-M [6-(chloroamino)-4-fluoro-6-methylheptyl]-trimethylazanium;chloride Chemical compound [Cl-].ClNC(C)(C)CC(F)CCC[N+](C)(C)C QFAPUQKCUJDUKS-UHFFFAOYSA-M 0.000 claims 1
- RVYIEGPUNPWWSO-UHFFFAOYSA-M [6-(dichloroamino)-4-fluoro-6-methylheptyl]-trimethylazanium;chloride Chemical compound [Cl-].ClN(Cl)C(C)(C)CC(F)CCC[N+](C)(C)C RVYIEGPUNPWWSO-UHFFFAOYSA-M 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 230000000844 anti-bacterial Effects 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atoms Chemical group C* 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 125000006448 cycloalkyl cycloalkyl group Chemical group 0.000 claims 1
- 239000004053 dental implant Substances 0.000 claims 1
- 230000000249 desinfective Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 239000000082 organ preservation Substances 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 0 CC(C)(C*(*)*)*C(C)(C)CC(*)(N(*)*)[Al] Chemical compound CC(C)(C*(*)*)*C(C)(C)CC(*)(N(*)*)[Al] 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11267408P | 2008-11-07 | 2008-11-07 | |
| US61/112,674 | 2008-11-07 | ||
| PCT/US2009/063652 WO2010054269A1 (en) | 2008-11-07 | 2009-11-06 | Antimicrobial n-chlorinated compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012508251A JP2012508251A (ja) | 2012-04-05 |
| JP2012508251A5 true JP2012508251A5 (US07981874-20110719-C00313.png) | 2012-12-20 |
| JP5599808B2 JP5599808B2 (ja) | 2014-10-01 |
Family
ID=42153282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011535709A Expired - Fee Related JP5599808B2 (ja) | 2008-11-07 | 2009-11-06 | 抗菌性ｎ−塩素化組成物 |
Country Status (5)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012054521A2 (en) * | 2010-10-19 | 2012-04-26 | Novabay Pharmaceuticlas, Inc. | Antimicrobial polyether and polyol compounds |
| US9028807B2 (en) | 2012-04-05 | 2015-05-12 | Ues, Inc. | Synthesis models for antimicrobial agents via the halogenation of organic/inorganic composites |
| AU2013265971A1 (en) * | 2012-05-17 | 2014-12-18 | Exigence Technologies Inc. | Biocidal compounds and methods for using same |
| US9145352B2 (en) * | 2012-05-30 | 2015-09-29 | Universidad De Caldas | Quaternary N-(halomethyl) ammonium salts as therapeutic agents |
| RU2644554C2 (ru) | 2013-03-15 | 2018-02-13 | Джензим Корпорейшн | Амин-функциональные полиамиды |
| US9468654B1 (en) | 2014-04-02 | 2016-10-18 | Ali Razavi | Drug delivery compositions and methods |
| JP6478775B2 (ja) * | 2014-05-15 | 2019-03-06 | キヤノン株式会社 | アミン化合物及びイオン導電剤、導電性樹脂組成物 |
| CN107935892B (zh) * | 2017-11-24 | 2020-06-02 | 万华化学集团股份有限公司 | 一种制备乙二胺基乙磺酸钠的方法 |
| WO2022178005A1 (en) | 2021-02-17 | 2022-08-25 | Oxion Dental, Llc | Stabilized active oxygen-generating antiseptic compositions, irrigation solutions, and articles |
| CN113851683B (zh) * | 2021-08-27 | 2023-10-20 | 重庆大学 | 一种咔唑类聚芳烃哌啶阴离子交换膜的制备方法 |
| WO2023200968A1 (en) * | 2022-04-13 | 2023-10-19 | Ohio State Innovation Foundation | Compositions and methods of making and use thereof |
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| US4981926A (en) * | 1990-02-06 | 1991-01-01 | The Dow Chemical Company | Composition of epoxy resin, amino group-containing phosphonium catalyst and curing agent |
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| CA2320556A1 (en) | 1999-09-29 | 2001-03-29 | Queen's University At Kingston | N,n-dichlorinated omega amino acids and uses thereof |
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| TWI386201B (zh) | 2005-01-25 | 2013-02-21 | Novabay Pharmaceuticals Inc | Ｎ-鹵化胺基酸、ｎ，ｎ-二鹵化胺基酸與其衍生物；以及使用其之組合物與方法 |
| TW200843787A (en) * | 2006-12-29 | 2008-11-16 | Novabay Pharmaceuticals Inc | N-halogenated amino compounds and derivatives; compositions and methods of using them |
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| WO2010124237A1 (en) * | 2009-04-24 | 2010-10-28 | Novabay Pharmaceuticals Inc. | Methods of treating infections of the nail |
| CA2787461A1 (en) * | 2010-02-04 | 2011-08-11 | Novabay Pharmaceuticals, Inc. | Polysaccharide based antimicrobial formulations |
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2009
- 2009-11-06 CA CA2741667A patent/CA2741667A1/en not_active Abandoned
- 2009-11-06 US US12/614,347 patent/US8278482B2/en active Active - Reinstated
- 2009-11-06 EP EP09825526.8A patent/EP2341886B1/en not_active Not-in-force
- 2009-11-06 JP JP2011535709A patent/JP5599808B2/ja not_active Expired - Fee Related
- 2009-11-06 WO PCT/US2009/063652 patent/WO2010054269A1/en active Application Filing
