JP2012507278A - 短縮型ヒトｒｎａｓｅｔ２の大腸菌における効率的発現 - Google Patents

短縮型ヒトｒｎａｓｅｔ２の大腸菌における効率的発現 Download PDF

Info

Publication number
JP2012507278A
JP2012507278A JP2011533932A JP2011533932A JP2012507278A JP 2012507278 A JP2012507278 A JP 2012507278A JP 2011533932 A JP2011533932 A JP 2011533932A JP 2011533932 A JP2011533932 A JP 2011533932A JP 2012507278 A JP2012507278 A JP 2012507278A
Authority
JP
Japan
Prior art keywords
rnaset2
seq
truncated
human
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011533932A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012507278A5 (https=
Inventor
オデド ショセヨヴ，
ベティ シュワルツ，
レヴァヴァ ロイズ，
パトリシア スミルノフ，
リロン ナットマン，
Original Assignee
イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミテッド filed Critical イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミテッド
Publication of JP2012507278A publication Critical patent/JP2012507278A/ja
Publication of JP2012507278A5 publication Critical patent/JP2012507278A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2011533932A 2008-10-30 2009-10-29 短縮型ヒトｒｎａｓｅｔ２の大腸菌における効率的発現 Pending JP2012507278A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19313408P 2008-10-30 2008-10-30
US61/193,134 2008-10-30
PCT/IL2009/001012 WO2010049933A1 (en) 2008-10-30 2009-10-29 Efficient expression of truncated human rnaset2 in e. coli

Publications (2)

Publication Number Publication Date
JP2012507278A true JP2012507278A (ja) 2012-03-29
JP2012507278A5 JP2012507278A5 (https=) 2012-12-13

Family

ID=41694413

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011533932A Pending JP2012507278A (ja) 2008-10-30 2009-10-29 短縮型ヒトｒｎａｓｅｔ２の大腸菌における効率的発現

Country Status (8)

Country Link
US (1) US20110207667A1 (https=)
EP (1) EP2346993A1 (https=)
JP (1) JP2012507278A (https=)
AU (1) AU2009309277A1 (https=)
CA (1) CA2739705A1 (https=)
EA (1) EA201100610A1 (https=)
WO (1) WO2010049933A1 (https=)
ZA (1) ZA201102615B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016520318A (ja) * 2013-05-29 2016-07-14 セレクティスＣｅｌｌｅｃｔｉｓ Ｉｉ型ｃｒｉｓｐｒシステムにおける新規のコンパクトなｃａｓ９足場

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015508662A (ja) * 2012-02-29 2015-03-23 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ １→３リーディングフレームシフトを減少させるための方法
WO2015114633A1 (en) 2014-01-30 2015-08-06 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Ltd. Actin binding peptides and compositions comprising same for inhibiting angiogenes is and treating medical conditions associated with same
US11186872B2 (en) * 2016-03-17 2021-11-30 Cedars-Sinai Medical Center Methods of diagnosing inflammatory bowel disease through RNASET2
WO2020112890A1 (en) 2018-11-29 2020-06-04 Cedars-Sinai Medical Center Rnaset2 compositions and methods of treatment therewith

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008514224A (ja) * 2004-09-29 2008-05-08 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム 組換えヒトＴ２ＲＮａｓｅおよびその使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001021830A1 (en) * 1999-09-24 2001-03-29 Ambion, Inc. Nuclease inhibitor cocktail
US6436703B1 (en) * 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
US7608413B1 (en) * 2005-03-25 2009-10-27 Celera Corporation Kidney disease targets and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008514224A (ja) * 2004-09-29 2008-05-08 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム 組換えヒトＴ２ＲＮａｓｅおよびその使用

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JPN6014018411; ＩＮＴＥＲＮＡＴＩＯＮＡＬ　ＪＯＵＲＮＡＬ　ＯＦ　ＯＮＣＯＬＯＧＹ Ｖｏｌ．２６, 2005, ｐｐ．１１５９-１１６８ *
JPN6014018415; Ｊ．　Ｂｉｏｃｈｅｍ． Ｖｏｌ．２６９, 1990, ｐｐ．２６１-２６４ *
JPN6014018418; Ｊ．　Ｂｉｏｌ．　Ｃｈｅｍ． Ｖｏｌ．２７４，　Ｎｏ．１４, 1999, ｐｐ．９２７７-９２８２ *
JPN6014018421; Ｂｉｏｃｈｅｍ．　Ｂｉｏｐｈｙｓ．　Ｒｅｓ．　Ｃｏｍｍｕｎ． Ｖｏｌ．１９４，　Ｎｏ．１, 1993, ｐｐ．４２５-４３１ *
JPN6014018424; Ｊ．　Ｍｏｌ．　Ｂｉｏｌ． Ｖｏｌ．２５５, 1996, ｐｐ．３４９-３５５ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016520318A (ja) * 2013-05-29 2016-07-14 セレクティスＣｅｌｌｅｃｔｉｓ Ｉｉ型ｃｒｉｓｐｒシステムにおける新規のコンパクトなｃａｓ９足場

Also Published As

Publication number Publication date
AU2009309277A8 (en) 2011-05-12
EP2346993A1 (en) 2011-07-27
EA201100610A1 (ru) 2011-10-31
AU2009309277A1 (en) 2010-05-06
ZA201102615B (en) 2012-03-28
US20110207667A1 (en) 2011-08-25
CA2739705A1 (en) 2010-05-06
WO2010049933A1 (en) 2010-05-06

Similar Documents

Publication Publication Date Title
US20220403024A1 (en) Conditionally active polypeptides
JP7224352B2 (ja) 標的特異的伝達のためのエクソソーム及びこれを製造及び伝達する方法
DK2040728T3 (en) FKBP-L and uses thereof such as angiogenesis inhibitors
CA3086040A1 (en) Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof
JP2022095641A (ja) 条件的活性型ポリペプチド及びそれを生成する方法
CN103228788B (zh) 抗癌融合蛋白
CN102300987A (zh) 膜型-1基质金属蛋白抑制剂及其用途
CN111499725A (zh) 结合IL-4受体α的泪脂质运载蛋白突变蛋白
KR20110136825A (ko) 미락 단백질
KR20170117089A (ko) 조건부 활성 생체 단백질
JP2012507278A (ja) 短縮型ヒトｒｎａｓｅｔ２の大腸菌における効率的発現
CN116284321B (zh) 一种细胞穿透肽及其应用
CN1798838B (zh) 一种蛋白酶的抑制剂蛋白及其用途
EP1869185B1 (en) Conjugate comprising p21 protein for the treatment of cancer
KR101651330B1 (ko) 세포투과성이 우수한 ｔａｔ－ａ２０ 융합단백질의 제조방법 및 이의 용도
CN101613410A (zh) 核糖核酸酶与毒蛋白膜转位结构域融合蛋白及其制备方法和用途
US12539325B2 (en) Exosomes for target specific delivery and methods for preparing and delivering the same
HK40081641A (en) Conditionally active polypeptides
HK1234103A1 (en) Discovering and producing conditionally active biologic proteins in the same eukaryotic cell production hosts

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121023

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20121023

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140502

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140704

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150203

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20150710