JP2012254941A - Skin care preparation for external use and method for accelerating volatilization of perfume by using the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin care preparation for external use that expresses excellent rising of fragrance while exhibiting good warming effects and a method for accelerating volatilization of a perfume by using the same.SOLUTION: The skin care preparation for external use comprises the following components (A) and (B): (A) 0.2-3 mass% of a perfume having an ester content of 25 mass% or lower; (B) 0.001-0.5 mass% of a warm feeling agent represented by formula (I).

Description

  The present invention relates to an external preparation for skin and a method for promoting perfume volatilization using the same.

  Traditionally, the skin has a variety of effects, such as giving the skin a warm feeling, improving blood circulation and improving cooling, activating metabolism, draining waste products and making it easier for nutrients to be absorbed. It is known that the warming sensation agent brought into the skin is extremely useful as a compound for external preparations for skin. As a warming agent, 4-vanillyl alkyl ether as described in Patent Document 1 is also known.

JP 61-9293 A

  However, the present inventors have found that when a fragrance is used in combination with a warming agent, the effect of the warming agent may be inhibited depending on the type of the flavoring.

  Therefore, the subject of this invention is providing the skin external preparation which can express the outstanding fragrance, exhibiting a warm feeling effect favorably, and the fragrance | flavor volatilization promotion method using the same.

  That is, the present inventors have found that the inhibitory action on a specific warming sensation is greatly different depending on the ester content in the fragrance, and as a result of further investigation, the fragrance having a low ester content and the specific warming sensation By using each in a specific amount, the warming sensation provided by the warming agent is not inhibited by the fragrance, and the volatilization of the fragrance is effectively promoted by the warming sensation. As a result, the present invention has been completed.

That is, the present invention includes the following components (A) and (B):
(A) Perfume with an ester content of 25% by mass or less 0.2-3% by mass,
(B) 0.001 to 0.5 mass% of a warming agent represented by the following formula (I),
An external preparation for skin containing the above is provided.

(In formula (I), X represents —O— or —NH—, and R represents an alkyl group having 1 to 6 carbon atoms or an alkanoyl group having 4 to 9 carbon atoms.)

The present invention also includes the following components (A) and (B):
(A) Perfume with an ester content of 25% by mass or less 0.2-3% by mass,
(B) 0.001 to 0.5 mass% of a warming agent represented by the following formula (I),
The present invention provides a method for promoting perfume volatilization, which comprises applying a skin external preparation containing the composition to the skin.

(In formula (I), X represents —O— or —NH—, and R represents an alkyl group having 1 to 6 carbon atoms or an alkanoyl group having 4 to 9 carbon atoms.)

According to the skin external preparation of the present invention, the warming effect brought about by the warming agent is not inhibited by the fragrance, and the volatilization of the fragrance is effectively promoted by the warming agent. You can feel standing.
Therefore, if it is the fragrance | flavor volatilization acceleration | stimulation method of this invention using the said skin external preparation, the warming effect which a warming sensation brings about is not inhibited by a fragrance | flavor, and volatilization of a fragrance | flavor is effectively accelerated | stimulated by a warming sensation agent. It is possible to realize a good warm feeling effect and excellent fragrance.

Hereinafter, the present invention will be described in detail.
The skin external preparation of this invention contains 0.2-3 mass% of fragrance | flavors whose ester content is 25 mass% or less as a component (A). Examples of such fragrances include fragrances including ester fragrances having an ester skeleton such as esters of fatty acids, esters of aromatic acids, tiglic acid, angelic acid and other esters. The ester content in the fragrance of the component (A) is not likely to inhibit the action of the warming agent of the component (B) described later, and is used together with such warming agent while exhibiting a good warming effect. From the viewpoint of effectively releasing a scent, it is 25% by mass or less, preferably 0.1 to 20% by mass, and more preferably 0.5 to 8% by mass.

  In addition, the ester content in the fragrance | flavor of a component (A) means the value measured by a gas chromatograph mass spectrometry. Specifically, the value measured by gas chromatograph mass spectrometry first, the perfume of component (A) is peak-separated by gas chromatography to obtain a gas chromatogram. Subsequently, each peak component of the obtained gas chromatogram is identified with a mass spectrometer. For identification, for example, using a commercially available or public institution database (Wiley, NIST: National Institute of Standard Technology) that comprehensively lists volatile components, the total amount of perfume in the total amount of peaks identified as ester components The ratio value is the ester content.

  The content of the fragrance of the component (A) is preferably 0.3 to 2.5% by mass, more preferably 0.4 to 2.5% in the total amount of the external preparation for skin, from the viewpoint of realizing sufficient fragrance formation. 2% by mass.

  The skin external preparation of this invention contains 0.001-0.5 mass% of warming agents represented by following formula (I) as a component (B). Such warming sensation brings warming action to the skin and promotes blood flow, thereby increasing the skin temperature and promoting the volatilization of the fragrance of component (A), and realizing a good fragrance. it can.

In the formula (I), X represents —O— or —NH—, and is preferably —O—.
R is an alkyl group having 1 to 6 carbon atoms, preferably 4 to 5 carbon atoms, or an alkanoyl group having 6 to 12 carbon atoms, preferably 8 to 10 carbon atoms. These may be linear or branched, and may be saturated or unsaturated. Here, examples of the alkyl group include a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, an isobutyl group, a sec-butyl group, a tert-butyl group, an n-amyl group, and an isoamyl group. , N-hexyl group. Of these, n-propyl group, n-butyl group, n-amyl group, isoamyl group and n-hexyl group are preferable, and n-butyl is particularly preferable from the viewpoint of warming action.

  Examples of the alkanoyl group include saturated or unsaturated groups such as a hexanoyl group, a heptanoyl group, an octanoyl group, a nonanoyl group, a decanoyl group, an undecanoyl group, and a dodecanoyl group. Of these, a nonanoyl group and a decanoyl group are preferable from the viewpoint of warming action, and an unsaturated decanoyl group is particularly preferable.

  Specific examples of the warming agent represented by the above formula (I) include 4-vanillyl butyl ether, capsaicin, and vanillyl nonanamide. Of these, 4-vanyl butyl ether is preferable from the viewpoint of the balance between the warming effect and the mildness to the skin.

  The content of the warming agent of the component (B) is preferably 0.002 to 0.4% by mass in the total amount of the external preparation for skin, and more preferably from the viewpoint of providing a sufficient warming effect. 003 to 0.3% by mass.

  The external preparation for skin of the present invention preferably further contains an acrylic acid / alkyl methacrylate copolymer as component (C). Component (C) is a copolymer in which a constituent unit part derived from an alkyl methacrylate monomer in the molecule can act as a lipophilic group and a constituent unit part derived from an acrylic acid monomer can act as a hydrophilic group. . Therefore, while embedding the fragrance | flavor of a component (A) effectively by the effect | action of a lipophilic group, the component (C) which formed the gel phase around by the effect | action of a hydrophilic group, and embedded the component (A), and each component Can be uniformly dispersed. In addition, since the formed gel phase is instantaneously condensed by the salt existing on the skin when the external preparation for skin of the present invention is applied to the skin, the fragrance of the embedded component (A) is the component (C). It is released immediately from the inside and can release a good scent instantly.

  Ratio of structural unit derived from acrylic monomer of component (C) to structural unit derived from alkyl methacrylate monomer (constituent unit derived from acrylic acid monomer: structural unit derived from alkyl methacrylate monomer) ) Is preferably 1:99 to 99: 1 from the viewpoint of exerting a good balance between the action of the lipophilic group and the action of the hydrophilic group. In addition, the alkyl moiety of the alkyl methacrylate monomer preferably has 10 to 30 carbon atoms from the viewpoint of effectively exerting the action as a lipophilic group. As such acrylic acid / alkyl methacrylate copolymer, specifically, for example, commercially available products such as “Pemlen TR-1” and “Pemlen TR-2” (both manufactured by Lubrizol) are used. Can do.

  The content of the acrylic acid / alkyl methacrylate copolymer of the component (C) is preferably 0.01 to 0.5% by mass in the total amount of the external preparation for skin, from the viewpoint of more uniformly dispersing each component. More preferably, it is 0.05-0.4 mass%.

  The external preparation for skin of the present invention preferably further contains a polyhydric alcohol as component (D). Such polyhydric alcohols generate heat of hydration upon contact with water, and this heat of hydration can bring warmth to the skin. Therefore, when the topical skin preparation of the present invention is applied to the skin, particularly skin wet with water, the component (D) reacts with moisture present on the skin to generate heat of hydration, and the temperature of the component (B). Combined with the sensitizer, it can effectively bring a warm feeling effect to the skin.

  Specific examples of such a polyhydric alcohol of component (D) include 1,3-butanediol, ethylene glycol, propylene glycol, glycerin, diglycerin, triglycerin, polyglycerin, diethylene glycol, dipropylene glycol. , Diethylene glycol monoalkyl ether, polyethylene glycol, polypropylene glycol, polyethylene glycol / polypropylene glycol, polyoxyalkylene such as polyoxyethylene hydrogenated castor oil (10E.O., 20E.O., 30E.O. or 40E.O.) Examples include hydrogenated castor oil and sorbitol. These may be used alone or in combination of two or more.

  Of these, liquids are preferred at room temperature (25 ° C.) from the viewpoint of uniformly dispersing the other components while favorably dissolving the component (B) warming agent. It is preferably non-volatile from the viewpoint that it cannot be lowered to give a sufficient warm feeling. From such a viewpoint, the number of hydroxyl groups per molecule of (D) polyhydric alcohol is preferably 2 to 4, more preferably 2 to 3. Such preferable (D) polyhydric alcohols include ethylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol, polyethylene glycol / polypropylene glycol, diethylene glycol monoalkyl ether, glycerin, diglycerin, triglycerin, polyglycerin, diethylene glycol, dipropylene glycol. Among them, glycerin, dipropylene glycol, and polyethylene glycol are more preferable, and glycerin and polyethylene glycol are particularly preferable. In particular, the polyethylene glycol is more preferably from 200 to 800, particularly preferably from 200 to 600, in terms of average molecular weight by GPC, from the viewpoint of imparting warmth.

  The content of the polyhydric alcohol of the component (D) is effective in utilizing the heat of hydration to bring the skin to a good warming effect combined with the action of the warming agent of the component (B). The total amount of the external preparation is preferably 90 to 99.7% by mass, more preferably 96 to 99.5% by mass.

  In addition, when mix | blending the polyhydric alcohol of the said component (D) with the skin external preparation of this invention, content of a water | moisture content in the skin external preparation whole quantity becomes like this. Preferably it is 7 mass% or less, More preferably, it is 4 mass%. It is particularly preferred that it is as follows and is substantially free of moisture. “Substantially not contained” means that water is not intentionally added, and includes those that are inevitably mixed in production. However, it is more preferable that no water is contained. By doing in this way, the heat of hydration can be utilized effectively and the good warmth effect combined with the action of the warming agent of the component (B) can be brought to the skin.

  In order to form a gel phase more effectively with the above-mentioned component (C) acrylic acid / methacrylic acid copolymer, after dispersing component (C) in component (D), an appropriate neutralizing agent is added. It is good to add. By adding a neutralizing agent, a gel phase having an appropriate viscosity can be formed. Specific examples of such a neutralizing agent include inorganic alkali compounds and organic alkali compounds. More specifically, in addition to inorganic alkali compounds such as sodium hydroxide and potassium hydroxide, (mono, di, tri) ethanolamine, (mono, di, tri) isopropanolamine, 2-amino-2-methyl-1 And organic alkali compounds such as -propanol, 2-amino-2-methyl-1,3-propanediol, and 2-amino-2-hydroxymethyl-1,3-propanediol. Among these, from the viewpoint of forming a better gel phase, sodium hydroxide, potassium hydroxide, triethanolamine, 2-amino-2-methyl-1-propanol, 2-amino-2-methyl-1,3- Propanediol is preferred. The content of the neutralizing agent is preferably 0.003 to 0.3% by mass, more preferably 0.01 to 0.2% by mass in the total amount of the external preparation for skin.

  In the present invention, in addition to the above components, any components used for cosmetics and external preparations for skin can be used within a range not impairing the effects of the present invention, depending on the purpose of use. For example, fats and oils, waxes, hydrocarbon oils, higher fatty acids, alcohols other than component (D), silicone, metal sequestering agents, thickeners other than component (C), powder components, colorants, solvents, astringents, Inflammatory agents, moisturizers, pH adjusters, plant extracts and the like can be mentioned.

  Examples of the product form of the external preparation for skin of the present invention include liquid, gel, solid, cream, water-oil two-layer separation system, aerosol, and the like. As a method of use, direct application, spraying, or impregnation in a cloth, non-woven fabric, paper or the like may be applied. Especially, it is desirable to use for the skin wet with water, and when it contains the above-mentioned component (D), an effective warm feeling effect | action can be brought about. In addition, when used on the skin where the number of stratum corneum is less than 20 such as the neck, shoulders, chest, inner upper arm, inner forearm, outer upper arm, etc., it has a good warm feeling and a comfortable scent. You can feel it.

  EXAMPLES Hereinafter, although this invention is demonstrated concretely based on an Example, this invention is not limited to these Examples.

[Examples 1-4, Comparative Examples 1-4]
Each external preparation for skin was prepared according to the formulation shown in Table 1, and the following Test Examples 1 to 6 were performed. In addition, content of each component shown in Table 1 is a value which made the whole quantity of each skin external preparation 100 mass%.

[Test Example 1]
The skin external preparations obtained in Example 1 and Comparative Example 1 were compared. First, the forearm was immersed in a 5 L water bath at 40 ° C. for 5 minutes. Next, after measuring the skin temperature inside the forearm in a wet state with an infrared thermometer, 3 g of each external preparation for skin was applied onto the inner skin of the forearm of each of the right and left arms, and towel-dried. Next, the skin temperature at the time of 1 to 20 minutes after application was measured with an infrared thermometer, and the sensory evaluation was performed for the warm feeling, the intensity of the fragrance, and the skin irritation. The results are shown in Table 2.
In addition, about the intensity of fragrance, ten panelists chose one with a strong fragrance, and adopted the evaluation with the larger number of persons.

  From the above results, it can be seen that Example 1 exhibits superior scenting compared to Comparative Example 1 that does not include the warming agent of component (B).

[Test Example 2]
The skin external preparations obtained in Example 1 and Comparative Example 2 were compared. That is, according to the method of Test Example 1, measurement of skin temperature, sensory evaluation of warmth and skin hypoallergenicity were performed. The results are shown in Table 3. In addition, since the fragrance | flavor contained in Example 1 and the fragrance | flavor contained in the comparative example 2 differed in the kind of fragrance, sensory evaluation of the intensity | strength of fragrance was not performed here.

  From the above results, it can be seen that Example 1 exhibits an excellent warm feeling effect as compared with Comparative Example 2 containing a fragrance having an ester amount exceeding 25 mass%.

[Test Example 3]
Instead of performing sensory evaluation of the scent strength in Test Example 2, the skin external preparations obtained in Comparative Example 2 and Comparative Example 3 were compared. That is, according to the method of Test Example 1, measurement of skin temperature and sensory evaluation of warmth, fragrance intensity and skin hypoallergenicity were performed. The results are shown in Table 4.

  From the above results, when the fragrance containing an ester amount of more than 25% by mass includes the warming agent of component (B) as in Comparative Example 2, the comparative example does not contain the warming agent of component (B). It can be seen that the warming effect is weakened to the same extent as 3.

[Test Example 4]
The skin external preparations obtained in Example 2 and Comparative Example 4 were compared. That is, according to the method of Test Example 1, measurement of skin temperature and sensory evaluation of warmth, fragrance intensity and skin hypoallergenicity were performed. The results are shown in Table 5.

  From the above results, it can be seen that Example 2 also exhibits superior scenting compared to Comparative Example 4 that does not contain the component (B) warming agent.

[Test Example 5]
The skin external preparations obtained in Example 3 and Comparative Example 1 were compared. That is, according to the method of Test Example 1, measurement of skin temperature and sensory evaluation of warmth, fragrance intensity and skin hypoallergenicity were performed. The results are shown in Table 6.

  From the above results, it can be seen that although the skin irritation is somewhat, Example 3 also exhibits superior fragrance as compared with Comparative Example 1 that does not contain the warming agent of component (B).

[Test Example 6]
The skin external preparations obtained in Example 1 and Example 4 were compared. That is, according to the method of Test Example 1, measurement of skin temperature and sensory evaluation of warmth, fragrance intensity and skin hypoallergenicity were performed. The results are shown in Table 7.

  From the above results, it can be seen that Example 4 containing 7% of water also shows excellent fragrance although not as much as Example 1.

Claims (7)

The following components (A) and (B):
(A) Perfume with an ester content of 25% by mass or less 0.2-3% by mass,
(B) 0.001 to 0.5 mass% of a warming agent represented by the following formula (I),
A method for promoting perfume volatilization, which comprises applying a skin external preparation containing the composition to the skin.

(In formula (I), X represents —O— or —NH—, and R represents an alkyl group having 1 to 6 carbon atoms or an alkanoyl group having 4 to 9 carbon atoms.) The fragrance | flavor volatilization promotion method of Claim 1 applied to the skin of the site | part whose number of stratum corneum is 20 or less. The following components (A) and (B):
(A) Perfume with an ester content of 25% by mass or less 0.2-3% by mass,
(B) 0.001 to 0.5 mass% of a warming agent represented by the following formula (I),
An external preparation for skin.

(In formula (I), X represents —O— or —NH—, and R represents an alkyl group having 1 to 6 carbon atoms or an alkanoyl group having 4 to 9 carbon atoms.)   Furthermore, the skin external preparation of Claim 3 which contains 0.01-0.5 mass% of component (C) acrylic acid and the alkyl methacrylate copolymer.   Furthermore, the skin external preparation of Claim 3 or 4 which contains 90-99.7 mass% of component (D) polyhydric alcohol.   The skin external preparation according to any one of claims 3 to 5, which is used for skin wet with water.   The skin external preparation according to any one of claims 3 to 6, which is used for skin of a site having 20 or less stratum corneum.