JP2012224609A - Novel antibacterial, antifungal, moisturizing and anti-inflammatory agent causing no skin irritation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an antibacterial, antifungal, moisturizing and anti-inflammatory agent that exhibits preventive and therapeutic effects on hand chapping of a beautician caused by shampooing or hair-dyeing.SOLUTION: The novel antibacterial, antifungal, moisturizing and anti-inflammatory agent is composed of glycerine, ethyl alcohol, catechin, glycerine fatty acid ester C10 and a guaiazulenesulfonate salt. The novel antibacterial, antifungal, moisturizing and anti-inflammatory agent exhibits not only remarkable effects on hand chapping of a beautician but also specific effects on diseases and conditions caused by many kinds of bacteria and mold.

Description

The present invention relates to a novel bactericidal antifungal moisturizer with anti-inflammatory properties.
The present inventor has previously filed a novel sterilizing, antifungal and moisturizing agent that exerts a dramatic preventive and therapeutic effect when applied to rough hands by a beautician. In the present invention, it is a novel bactericidal, antifungal, moisturizing and anti-inflammatory agent in which an anti-inflammatory action is added to the bactericidal, antifungal and moisturizing agent.

The present inventor has developed and provided a bactericidal antifungal agent to the market for many years. For example, the power anti developed by the present inventor is composed of a grapefruit seed extract and a component containing polylysine (international application number PCT / JP99 / 04642) without using an alcohol component, and all the components are food additives. It is continuously used for sterilization of sandboxes, which are children's playgrounds, and in-flight meals for international flights. Also, as another invention of the present inventor, an alcoholic disinfectant "Tsuyahando" in which glycerin is contained in 4%, which is a higher concentration than usual, in an alcohol disinfectant for the purpose of preventing hand-off due to alcohol in food factories. (Japanese Patent Application No. 2006-337308) was also developed. By introducing “TSUYAHANDO” to the market, food factories that use it will be able to prevent the handset caused by alcohol, and this will prevent the food factory from being contaminated by Staphylococcus aureus. did it.

Based on the experience of developing antibacterial / antifungal or anti-wetting agents over the years, we have attempted to develop antiseptic / antifungal / humidifying agents that are effective for the hairdressers' hands. The hand of a hairdresser is something that most hairdressers experience, and it is very strange that no countermeasures have been taken so far in the present state of science and technology, but it can be said that it is a difficult problem to solve. . The cause is caused by shampoo, hair dyeing and the like. In order to prevent or treat, moisturizing properties are required in addition to strong sterilization and antifungal properties, and low irritation is required so as not to hurt even when applied to bleeding skin. In particular, there is no known product that has added moisture retention to strong bactericidal properties. Therefore, what satisfies all these requirements is not currently known at all.

By the way, in general, many types of antibacterial agents and / or antifungal agents are known. The following is an overview of the background art in consideration of the above problems.
First, hypochlorous acid is known as a bactericidal / antifungal agent. Hypochlorous acid, which has a high concentration, is known as mold killer, and is used to remove mold in bathrooms, toilets, and kitchens. It is used in many places such as sterilization in breeding rooms. Although these are frequently used, they have carcinogenicity to the human body, skin irritation, and a strong irritating odor. Especially after spraying with a mild killer, they cannot be approached for a while due to the strong irritating odor. Moreover, after the odor disappears and disappears, the effect disappears. No one will get close to a beauty salon full of hypochlorous acid. Hypochlorous acid is not moisturizing.

Next, about 70% alcohol preparations are often used. Strong irritation to the skin caused by alcohol, flammability, temporary effects only for a few minutes, no effect after volatilization. There is no moisture retention.

Inverted soaps such as benzalkonium chloride are often used in hospitals as disinfectants, but they are not effective enough to remove white bacteria and are not strong enough to be used to prevent the hairdressers from touching. There is no added moisturizing property.

In addition, an alcohol preparation is known in which glycerin fatty acid ester C10 contained in coconut is mixed with an alcohol preparation to enhance the effect. However, glycerin fatty acid ester C10 is not used alone, but only dissolved in high-concentration alcohol (50% or more). Of course, there is nothing that adds moisture retention.

Catechin is known as another sterilizing / antifungal component. Catechin has no skin irritation and persistence and exerts a strong bactericidal action against Escherichia coli and many bacteria, but is less effective against general bacteria. There is a large unevenness in germicidal properties against bacteria. The effect on the hairdresser's hand alone cannot be expected. Of course, there is no moisture retention.

As for the moisturizing component, glycerin is known, has no irritation, but does not have strong bactericidal and antifungal properties. Hyaluronic acid and collagen are also known as skin moisturizers but are not bactericidal.
Based on the above, the inventors have invented and filed an application of a bactericidal, antifungal and moisturizing agent having no skin irritation that can be expected to be effective for a beautician.
By the previous invention, a therapeutic effect was obtained for the rough hands of many hairdressers for the first time. However, some beauticians are accompanied by inflammation. In this case, the appearance of the therapeutic effect was delayed. For this reason, it was desirable to add an anti-inflammatory effect to the previous invention.

The present inventor has added anti-inflammatory action to a sterilization / anti-mold / humectant with strong sterilization / anti-mold / moisturizing properties without skin irritation that can be effective for rough skin disorder of the beautician filed earlier The issue is to develop.

The above-mentioned sterilizing / antifungal / humectant has a feature that a water-soluble sterilizing component and an oily sterilizing component are dissolved without using a surfactant. For this reason, the said solution is very unstable, and even if it tries to add an anti-inflammatory component newly, most components will isolate | separate into the oil-based component and water-soluble component of the whole solution by adding. For this reason, many components could not be mixed. However, only guaiazulene sulfonate can be added without causing the separation, thus completing the present invention.
The present invention comprises glycerin, ethyl alcohol, catechin, glycerin fatty acid ester, water, and guaiazulene sulfonate.
In a preferred embodiment, 40% to 85% high-concentration glycerin is mixed with 1 to 15% ethyl alcohol, and then catechin is added to 0.001 to 5% catechin, and 0.1 to 2% glycerin fatty acid. It consists of a mixed solution containing ester C10 and 0.005 to 0.5%.

The product of the present invention dissolves glycerin fatty acid ester C10, which is insoluble in water, in ethyl alcohol and adds high-concentration glycerin to lower the ethyl alcohol concentration to such an extent that the skin irritation of alcohol can be suppressed. Further, the high concentration of glycerin complements the decrease in solubility of glycerin fatty acid ester C10 due to the effect of reducing the concentration of ethyl alcohol. Catechin is added to the said density | concentration here, and the fatty acid glycerol ester C10 which has oiliness and strong bactericidal and antifungal property, and the water-soluble sterilizing and antifungal catechin contained in tea are mixed.
Finally, guaiazulene sulfonate is added.

The catechin may be a tea leaf extract containing catechin. The coexistence of antibacterial and antifungal agents with completely different properties makes the antibacterial spectrum extremely wide, exerts antibacterial and fungicidal effects from most bacteria to fungi, and sustains the disinfecting and fungicidal effects. It was also long lasting for several hours. Moreover, the high-concentration glycerin exhibited sufficient moisturizing properties for the damaged skin, and was hypoallergenic so as not to be irritating to the affected area in the bleeding state due to the presence of the high-concentration glycerin. Guaiazulen sulfonate acted very effectively at the site of inflammation. The balance between the presence and concentration of all these ingredients provides a sterilizing, antifungal, moisturizing and anti-inflammatory agent that is sufficiently effective against the rough hair of the beautician, including severe inflammation that has been impossible for a long time. We were able to.

The new antiseptic, anti-mold, moisturizing and anti-inflammatory agents that are not irritating to the skin and exhibit strong antiseptic, anti-fungal, moisturizing and anti-inflammatory properties are not limited to the prevention of rough hands by the original hairdresser. It is effective against diseases caused by bacteria and fungi or to the situation. These include hand-care treatment, rough skin treatment, skin treatment for atopic patients, athlete's foot treatment, removal of caries fungus, removal of bad breath, acne treatment, scalp dandruff and itching, removal of aging odor. And toothpaste.

In a preferred embodiment, 40% to 85%, preferably 50% to 70% high concentration glycerin is mixed with ethyl alcohol at 1 to 15%, preferably 3 to 7%, and then catechin is added at 0.001 to 5%. Preferably containing 0.01 to 0.5% catechin, 0.1 to 2%, preferably 0.2 to 1% glycerin fatty acid ester C10, and 0.001 to 0.5% of guaiazulen sulfonate Preferably, it is a novel sterilizing, antifungal, moisturizing and anti-inflammatory agent comprising 0.01 to 0.1%. Sometimes cellulose gum is added as a thickener to the ingredients.

Again, the role of each component is
1) Glycerin is moisturizing and suppression of skin irritation by ethyl alcohol, promotes solubility of glycerin fatty acid ester C10, and increases blood flow in capillaries of affected skin. 2) Ethyl alcohol is used to dissolve oily glycerin fatty acid ester C10 in an aqueous solution. This mixes with water-soluble catechins. 3) Catechin has water-soluble bactericidal and antifungal effects, and its spectrum of action complements the bactericidal and antifungal spectrum of oily glycerin fatty acid esters. 4) Glycerin fatty acid ester C10 has a strong oily fungicidal and antifungal action. 5) Guaiazulene sulfone san salt has anti-inflammatory action.

The following ingredients were prepared as bactericidal, antifungal and moisturizing agents.
Glycerin 68% (v / v)
Water 16.5% (v / v)
Tea leaf extract 10% (v / v)
Ethyl alcohol 5% (v / v)
Glycerin fatty acid ester 0.5% (v / v)
Cellulose gum 0.5% (w / v)
Guaiazulene sulfone sodium
0.05% (w / v)

The composition is a thin green, viscous liquid with a weak tea scent and a sweet taste. The new bactericidal, antifungal and moisturizing agent of this composition exerted a strong healing power against the rough hair of the hairdresser. The effectiveness of 120 hairdressers with rough hands was confirmed and 100 were effective in 1 to 2 weeks. After 1 to 2 months, 95 people were cured.

There is no skin irritation and the new antibacterial, antifungal, moisturizing, antibacterial and antifungal actions are safe and powerful, and when applied to the ringworm of the foot, that is, the athlete's foot, the athlete's foot disappears within a few days. There were no side effects. Again, 10 of 10 subjects showed complete healing in 1 week. Furthermore, since dandruff and itching of the scalp are also considered to be bacterial growth at the site of inflammation caused by shampoo, 7 out of 7 dandruff itch disappeared completely within a few days. Surprisingly, a patient who did not heal dandruff for nearly 30 years was completely cured within a few days, and then did not develop dandruff itch again without applying the above.
Those that did not contain guaiazulene sulfonate had no effect on inflammation of human lips, but when this new bactericidal, antifungal, moisturizing and antiinflammatory agent was applied, it healed within a few days.

Even for children with atopic patients, the affected area was coated with a large amount of bacteria such as Staphylococcus aureus, and the symptoms disappeared when applied. Currently applied to 5 children with atopic patients and 5 have been cured. In addition, when toothpaste was used as a toothpaste, the bad breath disappeared and the mouth was refreshed. In addition, acne disappeared in one day when applied to the affected area for acne.
The new antiseptic, anti-fungal, moisturizing and anti-inflammatory agents with no skin irritation, high safety, strong bactericidal and anti-fungal properties, and moisturizing and anti-inflammatory properties were the original beauty This was effective not only for preventing teachers from roughing hands, but also for situations caused by various bacteria and fungi. In addition to the above, for example, the aging odor of an elderly man could be removed by thinly applying to the body.

In addition to the synergistic effect of the bactericidal / antifungal action of fatty acid glycerin ester, an oily bactericidal and antifungal ingredient, and water-soluble catechin contained in tea leaves, it also has a moisturizing effect on the skin that is possessed by high concentrations of glycerin. It was realized by the skin irritation inhibitory effect of glycerin and the anti-inflammatory effect of guaiazulene sulfonate.

The new antibacterial, antifungal, moisturizing and anti-inflammatory agents that are not irritating to the skin and can be produced with only food additives and exhibit strong disinfecting, antifungal and moisturizing properties have been known. Since it was not, it can be used not only for preventing the rough hair of the original hairdresser but also for diseases caused by many bacteria and fungi. These include hand-care treatment, rough skin treatment, skin treatment for atopic patients, athlete's foot treatment, removal of caries fungus, removal of bad breath, acne treatment, scalp dandruff and itching, removal of aging odor. And toothpaste. Furthermore, since it has no irritating odor and high safety, it can be used for baths such as mildew killer and purax made of hypochlorous acid, kitchen and toilet.

Claims (13)

40% or more and 85% or less, preferably 50% to 70% high concentration glycerin mixed with ethyl alcohol 1 to 15%, preferably 3 to 7%, and oily prepared using the mixture of glycerin and ethyl alcohol A new bactericidal, antifungal, moisturizing and anti-inflammatory agent containing glycerin fatty acid ester, water-soluble catechin and guaiazulene sulfonate. 40% or more and 85% or less, preferably 50% to 70% high concentration glycerin, ethyl alcohol is mixed to 1 to 15%, preferably 3 to 7%, then catechin is 0.001 to 1%, preferably 0.00. Including 01 to 0.5% catechin, and finally 0.1 to 2%, preferably 0.2 to 1% glycerin fatty acid ester C10, and further guaiazulen sulfonate 0.001 to 0.5%, A novel bactericidal, antifungal, moisturizing and anti-inflammatory agent preferably containing 0.005 to 0.1%. [Claim 1] An agent for preventing or treating rough hair of a beautician A novel toothpaste according to claim 1 [1] A household anti-wetting agent according to claim 1 Disinfectant after surgery according to claim 1 The atopy treatment agent according to claim 1 [Claim 1] Toothpaste for a new hairdresser The athlete's foot treatment agent according to claim 1 [Claim 1] The therapeutic agent for nail fungus The agent for treating swelling of the lips according to claim 1 [Claim 1] The agent for treating itching of dry skin The acupuncture agent according to claim 1