JP2012149090A - 水晶体の変化による老眼治療 - Google Patents
水晶体の変化による老眼治療 Download PDFInfo
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- JP2012149090A JP2012149090A JP2012093632A JP2012093632A JP2012149090A JP 2012149090 A JP2012149090 A JP 2012149090A JP 2012093632 A JP2012093632 A JP 2012093632A JP 2012093632 A JP2012093632 A JP 2012093632A JP 2012149090 A JP2012149090 A JP 2012149090A
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- lens
- pharmaceutical composition
- accommodation
- presbyopia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/013—Instruments for compensation of ocular refraction ; Instruments for use in cornea removal, for reshaping or performing incisions in the cornea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
【解決手段】本発明は、ヒト水晶体の遠近調節能力を変化させる様々な還元剤の使用を介して、および/またはヒト水晶体の遠近調節能力の変化に影響するエネルギーを適用することにより、老眼になったヒト水晶体の遠近調節に作用する。本発明は、老眼の発症を予防する及びそれを治療する。水晶体の硬化を生じる水晶体線維を互いに接着させる結合の形成を切断および/または予防することにより、本発明は、水晶体および/または水晶体嚢の弾性および伸展性を増加させる。
【選択図】なし
Description
Claims (14)
- チオール トランスフェラーゼ、ニコチンアデニンジヌクレオチドリン酸、還元性チオール誘導体、又は、これらの組み合わせを含む、老眼の治療及び/又は予防用薬学的組成物。
- 前記還元性チオール誘導体がグルタチオンを含む、請求項1記載の薬学的組成物。
- 生体適合性の担体を更に含む、請求項1記載の薬学的組成物。
- ウイルスファージに入れ込まれた(encased)、請求項1記載の薬学的組成物。
- 局所的に投与される、請求項1記載の薬学的組成物。
- 全身投与される、請求項1記載の薬学的組成物。
- 光反応性の化合物を更に含む、請求項1記載の薬学的組成物。
- レーザー光エネルギーにより活性化される、請求項1記載の薬学的組成物。
- 前記チオール トランスフェラーゼが、0〜20重量%の量で存在する、請求項1記載の薬学的組成物。
- 前記グルタチオンが、0〜20重量%の量で存在する、請求項2記載の薬学的組成物。
- 前記ニコチンアデニンジヌクレオチドリン酸が、0〜20重量%の量で存在する、請求項1記載の薬学的組成物。
- 前記グルタチオンが、S−グルタチオンである、請求項1記載の薬学的組成物。
- グルコース−6リン酸を更に含む、請求項1記載の薬学的組成物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26242301P | 2001-01-19 | 2001-01-19 | |
US60/262,423 | 2001-01-19 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002557315A Division JP2005506096A (ja) | 2001-01-19 | 2002-01-18 | 水晶体の変化による老眼治療 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015033723A Division JP2015145374A (ja) | 2001-01-19 | 2015-02-24 | 水晶体の変化による老眼治療 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2012149090A true JP2012149090A (ja) | 2012-08-09 |
JP5740343B2 JP5740343B2 (ja) | 2015-06-24 |
Family
ID=22997442
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002557315A Pending JP2005506096A (ja) | 2001-01-19 | 2002-01-18 | 水晶体の変化による老眼治療 |
JP2012093632A Expired - Fee Related JP5740343B2 (ja) | 2001-01-19 | 2012-04-17 | 水晶体の変化による老眼治療 |
JP2015033723A Pending JP2015145374A (ja) | 2001-01-19 | 2015-02-24 | 水晶体の変化による老眼治療 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002557315A Pending JP2005506096A (ja) | 2001-01-19 | 2002-01-18 | 水晶体の変化による老眼治療 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015033723A Pending JP2015145374A (ja) | 2001-01-19 | 2015-02-24 | 水晶体の変化による老眼治療 |
Country Status (4)
Country | Link |
---|---|
EP (2) | EP1370237A2 (ja) |
JP (3) | JP2005506096A (ja) |
CA (1) | CA2435374A1 (ja) |
WO (1) | WO2002056804A2 (ja) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8647612B2 (en) | 2008-03-05 | 2014-02-11 | Encore Health, Llc | Dithiol compounds, derivatives, and treatment of presbyopia |
US8697109B2 (en) | 2000-08-16 | 2014-04-15 | Encore Health, Llc | Caged mercaptan and seleno-mercaptan compounds and methods of using them |
US7935332B2 (en) | 2000-08-16 | 2011-05-03 | Encore Health, Llc | Presbyopia treatment by lens alteration |
US20050112113A1 (en) * | 2000-08-16 | 2005-05-26 | Till Jonathan S. | Presbyopia treatment by lens alteration |
EP1370237A2 (en) * | 2001-01-19 | 2003-12-17 | Newlens, LLC | Presbyopia treatment by lens alteration |
US8186357B2 (en) * | 2004-01-23 | 2012-05-29 | Rowiak Gmbh | Control device for a surgical laser |
US9044439B2 (en) | 2008-03-05 | 2015-06-02 | Encore Health, Llc | Low dose lipoic and pharmaceutical compositions and methods |
WO2009111635A2 (en) | 2008-03-05 | 2009-09-11 | Encore Health, Llc | Dithiol compounds, derivatives, and uses therefor |
US8410162B2 (en) | 2009-06-15 | 2013-04-02 | Encore Health Llc | Choline esters |
DK2442647T3 (en) | 2009-06-15 | 2016-05-30 | Encore Health Llc | Dithiolforbindelser, derivatives thereof, and the uses of these |
US8518028B2 (en) * | 2009-09-30 | 2013-08-27 | Abbott Medical Optics Inc. | Methods for enhancing accommodation of a natural lens of an eye |
RU2735790C2 (ru) | 2014-03-03 | 2020-11-09 | Энкор Вижн, Инк. | Композиции и способы применения холинового эфира липоевой кислоты |
EP3668521A4 (en) * | 2017-08-14 | 2021-05-05 | The Regents of the University of Colorado, a body corporate | INHIBITION OF OXIDIZING STRESS, GLYCATION AND PROTEIN CROSS-LINKING |
EA202191683A1 (ru) | 2018-12-18 | 2021-09-01 | Сантен Фармасьютикал Ко., Лтд. | Средство, содержащее 4-фенилбутират, для профилактики или лечения пресбиопии |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005506096A (ja) * | 2001-01-19 | 2005-03-03 | ニューレンズ、エルエルシー | 水晶体の変化による老眼治療 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5459133A (en) * | 1992-06-05 | 1995-10-17 | Telor Ophthalmic Pharmaceuticals, Inc. | Methods and products for treating presbyopia |
US5395356A (en) * | 1993-06-04 | 1995-03-07 | Summit Technology, Inc. | Correction of presbyopia by photorefractive keratectomy |
US5665770A (en) * | 1993-11-05 | 1997-09-09 | Gakko Hojin Kinki Daigaku | Method for treatment of cataract with radical scavenger |
US5906996A (en) * | 1996-08-21 | 1999-05-25 | Murphy; Michael A. | Tetramine treatment of neurological disorders |
US5817630A (en) * | 1997-03-18 | 1998-10-06 | Austin Nutriceutical Corporation | Glutathione antioxidant eye drops |
AU2001283386A1 (en) * | 2000-08-16 | 2002-02-25 | Refocus, Llc. | Presbyopia treatment by lens alteration |
-
2002
- 2002-01-18 EP EP02709084A patent/EP1370237A2/en not_active Withdrawn
- 2002-01-18 WO PCT/US2002/001404 patent/WO2002056804A2/en active IP Right Grant
- 2002-01-18 EP EP06024024A patent/EP1808158A3/en not_active Withdrawn
- 2002-01-18 CA CA002435374A patent/CA2435374A1/en not_active Abandoned
- 2002-01-18 JP JP2002557315A patent/JP2005506096A/ja active Pending
-
2012
- 2012-04-17 JP JP2012093632A patent/JP5740343B2/ja not_active Expired - Fee Related
-
2015
- 2015-02-24 JP JP2015033723A patent/JP2015145374A/ja active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005506096A (ja) * | 2001-01-19 | 2005-03-03 | ニューレンズ、エルエルシー | 水晶体の変化による老眼治療 |
Non-Patent Citations (1)
Title |
---|
JPN6013038207; Exp.Eye.Res.,1999,Vol.69,p.663-669 * |
Also Published As
Publication number | Publication date |
---|---|
JP2005506096A (ja) | 2005-03-03 |
WO2002056804A2 (en) | 2002-07-25 |
JP2015145374A (ja) | 2015-08-13 |
EP1808158A3 (en) | 2008-06-18 |
EP1808158A2 (en) | 2007-07-18 |
JP5740343B2 (ja) | 2015-06-24 |
CA2435374A1 (en) | 2002-07-25 |
WO2002056804A3 (en) | 2003-10-16 |
EP1370237A2 (en) | 2003-12-17 |
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