JP2012139405A - Blood purifying apparatus and automatic priming method for blood circulation path thereof - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a blood purifying apparatus, which can check connection failures or the like of a blood circuit on priming, prevents air entertainments on automatic priming by a wet-type blood purifier, and is improved in a function to discharge filling liquid in the blood purifier.SOLUTION: The blood purifying apparatus includes the blood purifier 1, the blood circuit 2, a blood pump 3, an artery side valve V1 provided upstream of the blood pump 3, a priming liquid supply line 4 connected between the blood pump 3 and the artery side valve V1, a liquid discharge line 6 equipped with a valve V7, an artery chamber 24, a vein chamber 25, and a valve V2 provided downstream of the vein chamber 25, in which an air induction line 5 is provided so as to connect the vein chamber 25 and the artery chamber 24, and a Y-tube 61 is provided so as to intercommunicatably connect an artery side puncture needle connection end 27 and a vein side puncture needle connection end 28 to the liquid discharge line 6 and be connectable to a liquid discharge path 62.

Description

The present invention relates to a blood purification apparatus, and in a wet type blood purification apparatus, it is possible to automatically prime a blood circulation path (hereinafter referred to as a blood circulation path) including a blood flow path of the blood purification apparatus. It is characterized by that. The present invention also relates to an automatic priming method performed using the blood purification apparatus.

  Conventionally, hemodialysis and blood filtration using a blood purification apparatus have been performed in order to improve a serious condition such as a patient with renal failure or a patient with hyperhydration due to postoperative surgical fluid injection. In general, when the blood purification apparatus is used, a priming solution (generally, physiological saline) is introduced and filled into the blood circuit to remove foreign substances and air in the circuit (referred to as priming). And about the automatic priming method and processing apparatus of a blood purification apparatus, an arterial side blood circuit and a venous side blood circuit are connected, a blood circulation path is formed, a blood pump is operated, and a priming liquid is circulated to the blood circulation path At the same time, by supplying the priming liquid from the priming liquid storage container to the blood circulation path at a predetermined flow rate, the artificial dialysis apparatus is configured to discharge a part of the priming liquid from the overflow tube provided in the drip chamber. (For example, Patent Document 1) and the apparatus of Patent Document 1 overflow the priming liquid from the priming liquid supply system from the arterial circuit portion upstream of the blood pump through the venous circuit using its own head. Venous side washing and draining process to flow into the system and the priming liquid supply system The arterial side washing and discharging process in which the blood fluid flows from the arterial side circuit portion downstream of the blood pump to the overflow system using the blood head, and the staying liquid in the blood circulation circuit by the above two steps A liquid level adjustment line is provided in the automatic priming method and apparatus (for example, Patent Document 2) including a whole washing circulation process that is circulated through the blood circulation path by a pump, and a venous drip chamber, and blood is collected in an arterial blood collection unit A connector that can be connected to the blood collection side connector is provided on the liquid level adjustment line, and an open / close means is provided on the arterial blood circuit upstream from the connection portion with the priming liquid supply line. By opening this opening / closing means and connecting the connector of the liquid level adjustment line and the blood collection side connector, the priming liquid line A blood purification device (Patent Document 3) capable of priming an arterial blood circuit upstream of a connecting portion and a venous blood circuit downstream of a venous drip chamber, a blood purifier and a blood circuit, a blood pump, A priming fluid supply line connected to the arterial blood circuit upstream of the blood pump, a venous trap provided in the venous blood circuit, and a bubble sensor, and connected to the priming fluid supply line in the venous trap A blood purification device (Patent Document 4) provided with a possible line has been proposed.

However, the blood purification devices of Patent Document 1 and Patent Document 2 described above connect the arterial blood circuit and the venous blood circuit to form a blood circulation path, and require an overflow line for priming. This overflow line is formed by detachably connecting an overflow tube having a length of about 1 meter to the liquid level adjustment line of the venous drip chamber, and it is difficult to adjust the liquid level during treatment. During the treatment, it was necessary to remove the overflow tube. Therefore, it takes extra time to connect and disconnect, and the remaining spent priming solution attached to the tube is dirty because it adheres to the hand or drops on the floor. There is a problem.
Further, the blood purification device of Patent Document 3 does not require an overflow line at the time of priming. However, in order to fill the drip chamber with the priming solution (saline), the arterial drip chamber and the venous drip are used. It was necessary to invert the chamber and the blood purifier, which necessitated extra manual work during priming.
In addition, the blood purification device of Patent Document 4 solves the problems of Patent Documents 1 to 3, but prior to priming, it is confirmed that there is a connection failure or leakage in the blood circuit in the blood circuit. In addition, it is not compatible with wet type blood purifiers, and when automatic priming is performed, there is a disadvantage that air is bitten into the blood purifier, and the operator operates so as not to bite the air. There was a need. Further, the removal of the liquid filled in the blood purifier was not always satisfactory.

No. 5-19075 Japanese Patent No. 2659914 JP 2004-357957 A Japanese Patent Laid-Open No. 2007-190068

  The present invention can confirm the presence of a blood circuit connection failure or the like in the blood circulation path prior to priming, and in a wet type blood purifier, air can bite into the blood purifier even if automatic priming is performed. An object of the present invention is to provide a blood purifier having an improved function of draining the filling liquid from the blood purifier by automatic priming.

The blood purification apparatus of the present invention includes a blood purifier, a blood circuit, a blood pump, an on-off valve (arterial side on-off valve) provided in a blood circuit upstream of the blood pump, the arterial side on-off valve, and the blood pump. A priming liquid supply line connected to the blood circuit, a drain line including an on-off valve, an air trap (venous chamber) provided in the blood circuit downstream of the blood purifier, and the venous chamber In a blood purification apparatus including an on-off valve (venous side on-off valve) provided in a blood circuit on the downstream side, the vein chamber and a blood circuit between the blood purifier and the blood pump are connected. In addition, the air introduction line is provided, and the drainage line is provided with a connector capable of communicating the arterial puncture needle connection end and the venous side puncture needle connection end with each other and to the drainage path. Characterized in that it comprises Te.
Here, the air introduction line is provided with an air filter, an air introduction part provided with an air pump downstream from the air filter, a vein side connection part branched from the air introduction part and connected to the vein chamber, blood An arterial side connection part connected to the blood circuit between the purifier and the blood pump, and an open / close valve provided on each of the arterial side connection part and the venous side connection part are employed, and An on-off valve may be provided in parallel with the air pump. The connector may be a Y-shaped tube or a T-shaped tube. In short, any connector may be used as long as the arterial puncture needle connecting end and the venous puncture needle connecting end can communicate with each other and be connected to the drainage channel. If necessary, an air trap (arterial chamber) may be provided between the blood pump and the blood purifier, and the arterial connection portion of the air introduction line may be connected to the arterial chamber.
As the priming solution supply line, a method of supplying dialysate online or a method using reverse filtration is also possible.

Further, the priming method of the blood purification apparatus of the present invention comprises connecting an arterial puncture needle connecting end and a venous puncture needle connecting end to a drainage line connector, an air introduction line on / off valve, and a drainage line on / off valve. In a state where the artery side opening / closing valve is closed, the air pump is driven to introduce outside air into the blood circulation path, and after checking the connection of the blood circuit, priming is performed.
Here, when the arterial chamber is not employed, (1) the arterial side opening / closing valve, the drainage line opening / closing valve, and the priming liquid supply line opening / closing valve are opened, and the priming liquid supply line is utilized by utilizing the head. Filling the blood circuit between the valve and the arterial side on-off valve and checking the connection of the priming liquid supply line, and (2) the venous side on-off valve, the arterial side connection on-off valve, and the priming liquid Close the supply line on-off valve, open the on-off valve on the venous side connection part and the on-off valve on the air introduction line, and drive the blood pump to connect the connection part between the arterial side connection part and the blood purifier. A step of filling the blood circuit with a part of the filling liquid in the blood purifier, (3) opening the opening / closing valve of the priming liquid supply line and the opening / closing valve of the artery side connection portion, and opening the opening / closing valve of the artery side , And venous side The connecting valve is closed and the blood pump is driven to connect the priming fluid supply line and the blood circuit, and the connection between the connection portion downstream of the connection portion and the artery side connection portion and the blood pump. Filling the blood circuit with priming fluid, (4) driving the blood pump to return the priming fluid to the priming fluid supply line, and forming a liquid surface in the air trap of the priming fluid supply line, (5) Close the open / close valve of the arterial connection, open the open / close valve of the vein, and drive the blood pump to supply the priming fluid to the blood circulation path downstream from the connection between the priming fluid supply line and the blood circuit. Washing the filling liquid in the blood purifier, (6) opening the on-off valve of the venous side connection part, closing the venous side on-off valve, and driving the blood pump, Filling the blood circuit between the connection part of the blood circuit and the venous side opening / closing valve with a priming solution to form the liquid level of the venous chamber, (7) closing the opening / closing valve of the venous side connection part And (8) arterial side opening and closing, in which a blood pump is driven to fill a blood circulation path between a connection portion between the priming liquid supply line and the blood circuit and the venous side opening / closing valve; The valve is opened, the blood pump is driven, and the blood circuit upstream of the connection portion between the priming liquid supply line and the blood circuit is filled with the set amount of the priming liquid filled in the blood circuit in the previous step (7). (9) The step of repeating (7) and (8) above, (10) The arterial side on-off valve is closed, the priming fluid supply line on-off valve and the venous side on-off valve are opened, and blood The pump is driven at high speed and blood Each step includes introducing a priming liquid into the liquid circulation path and washing the blood circulation path downstream from the connection portion between the priming liquid supply line and the blood circuit.
However, during the steps (9) and (10), the drain line open / close valve is closed, the blood pump is driven, and the priming liquid is circulated in the blood circulation path. A step of removing the attached air may be added.

When an arterial chamber is employed, (1) open the on-off valve of the arterial side on-off valve, drainage line, and on-off valve of the priming liquid supply line, and use the head to Filling the blood circuit between the arterial side on-off valve with the priming liquid and checking the connection of the priming liquid supply line; (2) the venous side valve closing, the on-off valve of the arterial side connection part, and the priming liquid supply The line open / close valve is closed, the open / close valve of the venous side connection part and the air introduction line open / close valve are opened, the blood pump is driven, and the blood purifier is connected to the blood circuit between the arterial chamber and the blood purifier. (3) Opening the opening / closing valve of the priming liquid supply line and the opening / closing valve of the artery side connection portion, and opening the opening / closing valve of the artery side opening / closing valve, vein side opening / closing valve, and vein side connection portion Close the on-off valve And a step of filling the blood circuit between the priming fluid supply line and the blood circuit by driving the blood pump and the blood circuit between the arterial chamber and (4) priming by driving the blood pump. The step of returning the priming liquid to the liquid supply line and forming the liquid level in the air trap of the priming liquid supply line, (5) driving the blood pump to supply the priming liquid to the arterial chamber and forming the liquid level in the arterial chamber (6) closing the on-off valve of the arterial side connection portion, opening the venous side on-off valve, and driving the blood pump to circulate the blood circulation path downstream from the connection portion between the priming fluid supply line and the blood circuit Supplying the priming solution to the blood purifier and washing out the filling solution in the blood purifier, (7) opening the on-off valve of the venous side connection portion, closing the venous side on-off valve, and blood pump A step of driving to fill the blood circulation path between the priming liquid supply line and the blood circuit and the venous side opening / closing valve to form the liquid level of the venous chamber; (8) veins The on-off valve of the side connection is closed and the blood pump is driven to fill the blood circulation path between the connection portion between the priming fluid supply line and the blood circuit and the venous-side on-off valve with a predetermined amount of priming fluid. Step (9) Open the arterial valve and open the blood pump to drive the blood pump to the blood circuit upstream of the connection portion between the priming fluid supply line and the blood circuit, and to the blood circuit in the previous step (8). A step of supplying a filled set amount of the priming solution, (10) a step of repeating steps (8) and (9), (11) closing the artery side on-off valve, and opening and closing valves and veins of the priming solution supply line Open side open / close valve The blood pump is driven at a high speed, the priming liquid is introduced into the blood circulation path, and the blood circulation path downstream of the connection portion between the priming liquid supply line and the blood circuit is washed. It becomes.
However, during the steps (10) and (11), the drain line open / close valve is closed, the blood pump is driven, and the priming liquid is circulated in the blood circulation path. A step of removing the attached air may be added.

The priming step is performed in this order except for the step (2). However, the step (2) is performed in the air trap of the priming solution supply line (4) when the arterial chamber is not employed. It may be performed after the step of forming the surface, and in the case of employing an arterial chamber, it may be performed after the step of forming the liquid surface of the arterial chamber in (5).
Although the present invention has been generally described above, a better understanding can be obtained by reference to certain specific embodiments. These examples are provided herein for illustrative purposes only and are not limiting unless otherwise specified.

According to the present invention, the following effects can be expected. That is, the blood purification apparatus of the present invention does not require the inversion operation of the arterial chamber, the vein chamber, and the blood purification device at the time of priming, so that the priming operation can be automated. Further, in the step (3), the blood pump is driven in a state where the air introduction line connected to the blood circuit on the artery side is released to the atmosphere, and a connection portion between the priming fluid supply line and the blood circuit, Since the priming liquid is filled in the blood circuit downstream from the connecting portion and between the arterial chamber and the blood pump, the liquid level of the filling liquid filled in the step (2) may move. Therefore, air does not bite into the blood purifier. In the step of washing out the filling liquid in the blood purifier, the arterial puncture needle connection end and the venous side puncture needle connection end are connected to the drainage line so as to drain from the lower side. It is easy to wash out substances having a high specific gravity, and therefore, the function of draining the filling liquid from the blood purifier by automatic priming is good.

It is a schematic explanatory drawing which shows the Example of the blood purification apparatus of this invention. It is explanatory drawing of the connection check of the blood circuit performed before the priming operation in the blood purification apparatus shown in FIG. It is explanatory drawing of the priming method of the blood circulation path in the blood purification apparatus shown in FIG. It is explanatory drawing of the priming method of the blood circulation path in the blood purification apparatus shown in FIG. It is explanatory drawing of the priming method of the blood circulation path in the blood purification apparatus shown in FIG. It is explanatory drawing of the priming method of the blood circulation path in the blood purification apparatus shown in FIG. It is explanatory drawing of the priming method of the blood circulation path in the blood purification apparatus shown in FIG. It is explanatory drawing of the priming method of the blood circulation path in the blood purification apparatus shown in FIG. It is explanatory drawing of the priming method of the blood circulation path in the blood purification apparatus shown in FIG. It is explanatory drawing of the priming method of the blood circulation path in the blood purification apparatus shown in FIG. It is explanatory drawing of the priming method of the blood circulation path in the blood purification apparatus shown in FIG. It is explanatory drawing of the priming method of the blood circulation path in the blood purification apparatus shown in FIG. It is explanatory drawing of the priming method of the blood circulation path in the blood purification apparatus shown in FIG. It is a flowchart of the priming operation of this invention. It is a flowchart of the priming operation of this invention.

DESCRIPTION OF SYMBOLS 1 Blood purifier 21 Arterial side blood circuit 22 Venous side blood circuit 23 Bubble sensor 24 Arterial chamber V1 Arterial side opening / closing valve 25 Vein chamber 26 Bubble sensor V2 Vein side opening / closing valve 27 Arterial side puncture needle connection end 28 Vein side puncture needle connection end DESCRIPTION OF SYMBOLS 3 Blood pump 4 Priming liquid supply line 41 Priming liquid container 42 Air tap 43 Air bubble sensor V3 On-off valve 5 Air introduction line 51 Air introduction part 511 Air filter 512 Air pump 52 Arterial side connection part 53 Venous side connection part V4, V5, V6 On-off valve 61 Drainage line 61 Y tube 62 Drainage path

  Blood purifier and blood circuit, blood pump, on-off valve provided in the blood circuit upstream of the blood pump, priming liquid supply line connected to the blood circuit between the on-off valve and the blood pump, on-off valve A blood purification apparatus comprising: a drainage line including: an arterial chamber; a venous chamber; and an on-off valve provided in a blood circuit downstream from the venous chamber, wherein the venous chamber and the arterial chamber are connected to each other. In addition, an air introduction line is provided, and a Y-tube is provided in the drainage line so that the arterial puncture needle connection end and the venous side puncture needle connection end can communicate with each other and can be connected to the drainage path. . The air introduction line includes an air filter provided with an air filter and an air pump provided downstream from the air filter, a vein side connection part branched from the air introduction part and connected to the venous chamber, and a blood purifier An arterial side connection part connected to the blood circuit between the blood pump and the on / off valve provided respectively on the arterial side connection part and the venous side connection part, and further, an on / off valve is provided in parallel with the air pump. Yes.

Example 1
Next, Example 1 of the present invention will be described with reference to FIG.
FIG. 1 is a schematic explanatory view of a blood purification apparatus showing one embodiment of the present invention (the dialysate side is omitted).
As shown in FIG. 1, the blood purification apparatus of the present invention comprises a blood purification device 1 and a blood circuit 2 (consisting of an arterial blood circuit 21 upstream from the blood purification device 1 and a venous blood circuit 22 downstream). The blood pump 3, the arterial side on-off valve V1 provided in the arterial side blood circuit 21 on the upstream side of the blood pump 3, and the priming connected to the arterial side blood circuit 21 between the blood pump 3 and the arterial side on-off valve V1 A fluid supply line 4; a drainage line 6 having an on-off valve V7; an arterial chamber 24; a venous chamber 25; and an on-off valve V2 provided in the venous blood circuit 22 downstream from the venous chamber 25. In the blood purification apparatus, an air introduction line 5 is provided so as to connect the venous chamber 25 and the arterial chamber 24, and an arterial puncture needle connection end 27 and a venous puncture needle connection are connected to the drainage line 6. The 28, Y-shaped tube 61 can be connected to communicatively and drains 62 with each other is provided.

In FIG. 1, the blood circulation path includes a blood passage of blood purifier 1, an arterial blood circuit 21, and a venous blood circuit 22. The arterial blood circuit 21 is provided with an arterial open / close valve V1, a bubble sensor 23, a blood pump 3, and an arterial chamber 24 in order from the upstream side. The priming fluid supply line 4 is connected to the arterial blood circuit 21 between the blood pump 23 and the opening / closing means V 1, and the bubble sensor 23 is connected to the priming fluid supply line 4 and the arterial blood circuit 21. It is provided upstream from the connection portion 29. The priming liquid supply line 4 is provided with a priming liquid container 41, an air trap 42, a bubble sensor 43, and an on-off valve V3 in this order from the upstream side. If necessary, the priming liquid supply line 3 may be provided with a priming liquid injection means (not shown) downstream of the opening / closing means V3. Note that an ultrasonic sensor is usually employed as the bubble sensor.
On the other hand, the venous side blood circuit 22 is provided with a venous chamber 25, a bubble sensor 26, and a venous side on-off valve V2 in order from the upstream side, and the venous chamber 25 is connected to the arterial side arterial chamber 24. An air introduction line 5 is provided. The air introduction line 5 includes an air filter 511, an air introduction part 51 provided with an air pump 512 downstream from the air filter 511, and a vein side branched from the air introduction part 51 and connected to the venous chamber 25. The connection part 53 includes open / close valves V6 and V5 provided in the blood purifier 152 and the vein side connection part 53, respectively, and an open / close valve V4 is provided in parallel with the air pump 512.

The drainage line 6 can drain at a position below the blood purification device, and has an open valve V7 and a drainage passage 62. A Y-tube 61 is provided at one end of the drainage line 6. It has been. This Y-shaped tube 61 can communicate the arterial puncture needle connection end 27 and the venous side puncture needle connection end 28 with each other, and can also be connected to the drainage passage 62 by opening the on-off valve V7. Yes. The connector may be a Y-shaped tube or a T-shaped tube. In short, the connector can connect the arterial puncture needle connection end 27 and the venous side puncture needle connection end 28 to each other and to the drainage passage 62. That's fine.
Further, the arterial chamber 24 between the blood pump 3 and the blood purifier 1 may be omitted. The on-off valve V4 of the air introduction line 5 can be omitted, but if it is omitted, the operation of the air pump 512 is synchronized with the operation of the blood pump 3 when the on-off valve V5 and / or V6 of the air introduction line 5 is open during priming. It has the disadvantage of having to be made.
PA and PV are pressure sensors.

(Example 2)
Next, priming of the blood purifier according to Example 2 of the present invention will be described with reference to FIGS.
3 to 13 are explanatory diagrams of priming when the arterial chamber 24 is employed and the air introduction line 5 is provided with the on-off valve V4 in parallel with the air pump 512. FIG.
Before the priming operation, first, as shown in FIG. 2, it is necessary to check the connection of the blood circuit 2 by introducing air into the blood circulation path.
First, after connecting the arterial puncture needle connection end 27 and the venous side puncture needle connection end 28 to the Y-shaped tube 61 of the drainage line 6, the on-off valve V4 of the air introduction line 5 and the on-off valve V7 of the drainage line 6; With the artery side opening / closing valve V1 closed, the air pump 512 is driven to introduce outside air into the blood circulation path. At this time, if it is confirmed that there is no leak in the pressure sensors PA and PV (the pressure rises if there is no leak), the operation proceeds to the priming operation. If a leak is confirmed, the connection state of the blood circuit 2 is confirmed. If a leak is further confirmed after confirming the connection state of the blood circuit 2, the vein-side on-off valve V2 is further closed, and the air pump 512 is driven again to introduce outside air into the blood circulation path. If a leak is confirmed by this operation, the blood circuit 2 or the blood purifier 3 is defective. Usually, the blood circuit 2 and the blood purifier 3 are not examined at this stage without checking which is defective. Have both replaced.

At the time of priming, first, the on-off valves V1, V3, V7 are opened, and a blood circuit between the priming fluid supply line 4 and the arterial side on-off valve V1 is utilized using a drop (usually setting time of about 2 to 3 seconds). 21 is filled with the priming liquid, and the connection of the priming liquid supply line 4 is checked (S1, S2). At this time, it is necessary to confirm that the bubble sensors 23 and 43 are working. Next, the on-off valves V2, V3, V6 are closed, the on-off valves V5, V7 are opened, the blood pump 3 is driven (reversely rotated), and the space between the arterial chamber 24 and the (wet type) blood purifier 1 is reached. The blood circuit 21 is filled with a part of the filling liquid in the blood purifier 1 (S3, S4). Next, the on-off valves V3 and V6 are opened, the on-off valves V1, V2 and V5 are closed, the blood pump is driven (forward rotation), and a connection portion 29 between the priming fluid supply line 4 and the blood circuit 2; The blood circuit 21 between the arterial chamber 24 is filled with a priming solution (S5, S6). In this case, it is necessary to set the rotation amount of the blood pump 3 so that the priming solution does not enter the arterial chamber 24.
Next, the blood pump 3 is driven (reversely rotated), the priming liquid is returned to the priming liquid supply line 4, and a liquid level is formed on the air trap 42 of the priming liquid supply line 4 (S7, S8). Next, the blood pump 3 is driven (forward rotation) to supply the priming solution to the arterial chamber 24 and form a liquid level in the arterial chamber 24 (S9, S10). Next, the on-off valve V6 is closed, the on-off valve V2 is opened, the blood pump 3 is driven (forward rotation), and the blood circulation path downstream of the connection portion between the priming fluid supply line 4 and the blood circuit 21 is placed. A priming solution is supplied, and the filling solution in the blood purifier 1 is washed out (S11, S12). Next, the on-off valve V5 is opened, the on-off valve V2 is closed, the blood pump is driven (forward rotation), the connection portion 29 between the priming fluid supply line 4 and the blood circuit 2, the venous side on-off valve 26, The blood circulation path between is filled with priming solution to form the liquid level of the venous chamber 25 (S13, S14).

Next, the on-off valve V5 is closed, the blood pump 3 is driven (forward rotation), and the bulging of the blood circuit 2 is used to open and close the connection portion 29 between the priming fluid supply line 4 and the blood circuit 2 and the venous side opening / closing. A set amount of priming liquid (usually 4 to 5 mL) is filled into the blood circulation path to the valve 26 (S15, S16). Next, the on-off valve V1 is opened, the blood pump 3 is driven (reversely rotated), and the blood circuit 21 upstream of the connection portion 29 between the priming fluid supply line 4 and the blood circuit 2 is connected to the front S15, S16. A set amount of the priming solution filled in the blood circulation path in the process is supplied (S17, S18). Next, the steps S15 to S18 are repeated (S19), and after the priming of the blood circuit upstream of the arterial on-off valve V1 is completed (S20) (for example, in the case of a set amount of 4 mL, it is repeated 4 to 5 times) Complete), the on-off valve V7 is closed, the blood pump 3 is driven, the priming liquid is circulated in the blood circulation path, and the air adhering to the header portion of the blood purifier is removed (S21). In this case, if the blood pump 3 repeats forward / reverse rotation alternately a plurality of times, the efficiency of bleeding is good. Finally, the on-off valve V1 is closed, the on-off valves V2 and V3 are opened, the blood pump 3 is driven at a high speed, the priming liquid is introduced into the blood circulation path, the priming liquid supply line 4 and the blood circuit 2 The blood circulation path downstream of the connecting portion 29 is washed (S22).
The operation of S21 can be omitted.

Claims (10)

Blood purifier, blood circuit, blood pump, arterial side on-off valve provided in the blood circuit upstream of the blood pump, and priming fluid connected to the blood circuit between the arterial side on-off valve and the blood pump A supply line, a drain line provided with an open / close valve, a venous chamber provided in the blood circuit downstream of the blood purifier, and a venous open / close valve provided in the blood circuit downstream of the venous chamber In the blood purification apparatus, an air introduction line is provided so as to connect the venous chamber and a blood circuit between the blood purification device and the blood pump, and an arterial puncture needle connection end is connected to the drainage line. And a vein-side puncture needle connecting end are provided with a connector that can communicate with each other and that can be connected to a drainage path. An air introduction line provided with an air filter and provided with an air pump downstream from the air filter; a venous side connection part branched from the air introduction part and connected to a venous chamber; a blood purifier; The blood purification apparatus according to claim 1, comprising an arterial side connection part connected to a blood circuit between blood pumps, and an on-off valve provided at each of the arterial side connection part and the venous side connection part. The blood purification apparatus according to claim 2, wherein an open / close valve is provided in parallel with the air pump in the air introduction part. The blood purification apparatus according to any one of claims 1 to 3, wherein the connector is a Y-shaped tube or a T-shaped tube. The blood purifier according to any one of claims 1 to 4, wherein an arterial chamber is provided between the blood pump and the blood purifier, and an arterial connection portion of an air introduction line is connected to the arterial chamber. With the arterial puncture needle connection end and the venous side puncture needle connection end connected to the connector of the drainage line, with the open / close valve of the air introduction line, the drainage line open / close valve, and the arterial side open / close valve closed, A priming method for a blood purification apparatus, comprising: driving an air pump to introduce outside air into a blood circulation path, checking a connection of a blood circuit, and performing priming. Open the open / close valve on the arterial side, drainage line, and open / close valve on the priming liquid supply line, and fill the blood circuit between the priming liquid supply line and the arterial open / close valve using the drop. The first step of checking the connection of the priming liquid supply line,
Close the venous side on / off valve, the on / off valve on the arterial side connection, and the on / off valve on the priming fluid supply line, open the on / off valve on the venous side connection and the on / off valve on the air introduction line, and drive the blood pump, A second step of filling the blood circuit between the connection portion with the arterial side connection portion and the blood purifier with a part of the filling liquid in the blood purifier,
Open the open / close valve of the priming liquid supply line and the open / close valve of the arterial side connection, close the open / close valve of the arterial side open / close valve, the venous side open / close valve, and the venous side connection, and drive the blood pump to drive the priming liquid A third step of filling the blood circuit between the connection portion between the supply line and the blood circuit and the blood pump between the connection portion downstream of the connection portion and the arterial side connection portion and the blood pump;
A fourth step of driving the blood pump to return the priming liquid to the priming liquid supply line and forming a liquid level in the air trap of the priming liquid supply line;
Close the open / close valve of the arterial connection, open the open / close valve of the vein, and drive the blood pump to supply the priming fluid to the blood circulation path downstream from the connection between the priming fluid supply line and the blood circuit. The fifth step of washing out the filling liquid in the blood purifier,
Open the on-off valve of the venous side connection, close the venous side on-off valve, and drive the blood pump to connect the priming fluid supply line and the blood circuit, and the blood circulation path between the venous side on-off valve A sixth step of filling the priming solution to form a liquid level in the venous chamber;
Close the on-off valve of the venous side connection and drive the blood pump to fill the blood circulation path between the connection part of the priming fluid supply line and the blood circuit and the venous side on-off valve with a set amount of priming liquid The seventh step,
Open the artery side on-off valve, drive the blood pump, and set the priming amount set in the blood circuit in the seventh step to the blood circuit upstream from the connection part between the priming fluid supply line and the blood circuit An eighth step of supplying liquid,
A ninth step of repeating the seventh step and the eighth step,
And the arterial side on-off valve is closed, the on-off valve and the venous side on-off valve of the priming fluid supply line are opened, the blood pump is driven at high speed, the priming fluid is introduced into the blood circulation path, and the priming fluid supply line A tenth step of cleaning the blood circulation path downstream from the connection portion between the blood circuit and the blood circuit;
The priming method of the blood purification apparatus according to claim 4, comprising the steps of: Between the ninth step and the tenth step, the drain line open / close valve was closed, the blood pump was driven, the priming liquid was circulated in the blood circulation path, and it adhered to the header part of the blood purifier The priming method according to claim 9, further comprising a step of removing air. Open the open / close valve on the arterial side, drainage line, and open / close valve on the priming liquid supply line, and fill the blood circuit between the priming liquid supply line and the arterial open / close valve using the drop. The first step of checking the connection of the priming liquid supply line,
Close the venous side on / off valve, the on / off valve on the arterial side connection, and the on / off valve on the priming fluid supply line, open the on / off valve on the venous side connection and the on / off valve on the air introduction line, and drive the blood pump, A second step of filling the blood circuit between the arterial chamber and the blood purifier with a portion of the filling liquid in the blood purifier,
Open the open / close valve of the priming liquid supply line and the open / close valve of the arterial side connection, close the open / close valve of the arterial side open / close valve, the venous side open / close valve, and the venous side connection, and drive the blood pump to drive the priming liquid A third step of filling the blood circuit between the supply line and the blood circuit and the blood circuit between the arterial chamber,
A fourth step of driving the blood pump to return the priming liquid to the priming liquid supply line and forming a liquid level in the air trap of the priming liquid supply line;
A fifth step of driving the blood pump to supply priming fluid to the arterial chamber and forming a liquid surface in the arterial chamber;
Close the open / close valve of the arterial connection, open the open / close valve of the vein, and drive the blood pump to supply the priming fluid to the blood circulation path downstream from the connection between the priming fluid supply line and the blood circuit. The sixth step of washing out the filling liquid in the blood purifier,
Open the on-off valve of the venous side connection, close the venous side on-off valve, and drive the blood pump to connect the priming fluid supply line and the blood circuit, and the blood circulation path between the venous side on-off valve Filling a priming solution to form a liquid level in the venous chamber,
Close the on-off valve of the venous side connection and drive the blood pump to fill the blood circulation path between the connection part of the priming fluid supply line and the blood circuit and the venous side on-off valve with a set amount of priming liquid The eighth step,
Open the artery side on-off valve and drive the blood pump to prime the blood circuit upstream of the connecting portion between the priming fluid supply line and the blood circuit into the blood circuit in the eighth step. The ninth step of supplying the liquid,
A tenth step for repeating the eighth step and the ninth step;
And the arterial side on-off valve is closed, the on-off valve and the venous side on-off valve of the priming fluid supply line are opened, the blood pump is driven at high speed, the priming fluid is introduced into the blood circulation path, and the priming fluid supply line An eleventh step of washing the blood circulation path downstream of the connection portion between the blood circuit and the blood circuit;
The priming method of the blood purification apparatus according to claim 5, comprising the steps of: Between the tenth and eleventh steps, the drain line open / close valve is closed and the blood pump is driven to circulate the priming fluid in the blood circulation path and adhere to the header of the blood purifier The priming method according to claim 9, further comprising a step of removing the air.

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