JP2012100852A - Biological tissue adhesive applicator - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a biological tissue adhesive applicator capable of preventing a drug solution in a drug solution flow tube from accidentally advancing due to recovery of a check valve.SOLUTION: The biological tissue adhesive applicator 100 includes: a nozzle body 1; a gas injection port 2 for injecting gas into the nozzle body 1; drug solution injection ports 3a and 3b; drug solution discharge ports 4a and 4b; the drug solution flow tubes 5a and 5b for making the drug solution injection ports 3a and 3b and the drug solution discharge ports 4a and 4b communicate with each other, respectively; a gas jetting port 6 for spraying the drug solution in a misty state; the check valves 7a and 7b which are provided in the drug solution flow tubes 5a and 5b, which allow the drug solution to flow into the drug solution flow tubes 5a and 5b from the drug solution injection ports 3a and 3b, and which regulate the outflow of the drug solution in a drug solution injection port direction from the insides of the drug solution flow tubes 5a and 5b; and support means 19a and 19b for supporting the check valves 7a and 7b so as to prevent deformation in the direction of regulating the outflow of the drug solution by the check valves 7a and 7b.

Description

  The present invention relates to a biological tissue adhesive applicator for spraying and applying a chemical solution for tissue adhesion to an affected part of a living body, and in particular, spraying a plurality of chemical solutions at the same time to remove a liver or lung excision stump or digestive tract. The present invention relates to a biological tissue adhesive application tool suitable for hemostasis closure of a suture part.

  As a biological tissue adhesive applicator, a fibrinogen solution and a thrombin solution each filled as a chemical solution in two syringe bodies are simultaneously discharged from a nozzle and mixed with the two discharged chemical solutions using aseptic gas. Spray application methods for spraying have become widespread. By this method, the fibrinogen solution reacts with the thrombin solution to change into fibrous fibrin, and hemostasis of a sutured portion such as a digestive tract after injury is performed. At this time, intermittent use is performed in which the discharge of the chemical liquid is temporarily stopped and then discharged and sprayed again. At the time of this interruption, the atomized fine particles of the fibrinogen solution and the thrombin solution which have been sprayed may flow backward and adhere to the tip of the nozzle, and the two liquids may come into contact with each other. As a result, there has been a problem that the chemical solution is solidified at the discharge port of the chemical solution and the tip portion in the chemical solution distribution tube, and the tip of the nozzle is clogged.

  In order to eliminate this clogging, in the invention described in Patent Document 1, a switching device for switching the flow path of this sterile gas to the flow path of the chemical solution is provided at the sterile gas inlet. When the discharge of the chemical liquid is stopped, the switching device is communicated with the supply source of the sterile gas, but is switched so as not to communicate with the supply source of the chemical liquid, and the sterile gas is injected. Thus, an invention is disclosed in which the chemical liquid remaining on the distal end side of the chemical liquid flow path is discharged. Further, in the invention described in Patent Document 1, the chemical solution is allowed to flow into the flow channel at the inlet of each chemical solution, but the reverse for preventing the chemical solution and gas in the flow channel from flowing backward. A stop valve is provided. Therefore, when the residual chemical solution is discharged by the above gas pressure, the gas is also prevented from flowing toward the chemical supply source. On the other hand, in the invention described in Patent Document 2, the chemical solution flow pipe is provided with a communication port penetrating the tube wall surface from the inner wall to the outer wall obliquely rearward from the upstream side to the downstream side of the flow of the chemical solution. The invention is disclosed. The communication port is closed when the chemical solution is discharged, but the communication port is opened by the gas pressure at the moment when the discharge of the chemical solution is stopped during the intermittent spraying of the chemical solution. Aseptic gas flows into the flow pipe from the open communication port, and the chemical solution remaining on the front end side of the flow pipe is discharged to the outside, thereby preventing clogging of the nozzle tip.

Japanese Patent Laid-Open No. 2001-238887 JP 2007-252880 A

  However, in Patent Document 1, the check valve is deformed by the reverse flow of the atmospheric pressure or the gas pressure by releasing the pressing force of the piston or the like, and the chemical liquid may flow into the chemical liquid circulation pipe at the time of restoration. Moreover, in Patent Document 2, there is no description of a check valve, but when the piston is released, the chemical liquid pressed and compressed by the piston may be restored and moved forward in the distal direction. Therefore, there is a demand for the development of a technology that can better prevent such unexpected advance of the chemical solution in the chemical solution distribution pipe.

  The biological tissue adhesive applicator of the present invention includes a nozzle body having a space inside, a gas inlet for filling a gas in the space inside the nozzle body, a chemical liquid inlet provided in the nozzle body, and a nozzle A chemical solution discharge port provided at the tip of the main body, a chemical solution distribution pipe that is housed in the nozzle body and communicates with the chemical solution injection port and the chemical solution discharge port, and provided in the vicinity of the chemical solution discharge port, from the gas injection port to the nozzle body A gas outlet that sprays the gas filled inside and sprays the chemical liquid discharged from the chemical liquid outlet in a mist, and the chemical liquid distribution pipe is provided with the chemical liquid from the chemical injection port to the inside of the chemical liquid distribution pipe. A check valve that allows inflow and restricts the outflow of the chemical solution from the inside of the chemical solution distribution pipe in the direction of the chemical solution inlet, and a deformation in a direction that supports the check valve and restricts the outflow of the chemical solution by the check valve Supporting means for preventing

  Therefore, in the biological tissue adhesive applicator of the present invention, the check valve prevents the unexpected return to the allowable direction of the inflow of the chemical solution by the support means preventing the deformation in the regulation direction by the check valve. Can do. Therefore, it is possible to satisfactorily prevent the distal end surface of the chemical liquid in the chemical liquid flow pipe after stopping the discharge of the chemical liquid from advancing in the direction of the chemical liquid discharge port. As a result, leakage of the chemical solution from the nozzle body and solidification on the tip side due to contact with the outside air or other chemical solution can be prevented better. In other words, since the check valve is generally formed of a soft member, when the pressing force of the piston or the like is released when the discharge of the chemical liquid due to intermittent use is stopped, the check valve is reversed due to the return of atmospheric pressure or gas pressure. The stop valve is easily deformed in the upstream direction. After that, the deformed check valve is gradually restored to its original position and shape.For example, even if the chemical solution is discharged from the tip of the chemical solution circulation pipe, the chemical solution flows into the chemical solution flow path by restoring the check valve. was there. Even without such a chemical solution discharging means, the chemical solution may leak from the tip of the nozzle due to the advance of the chemical solution, and may solidify in contact with the outside air or other chemical solutions. However, in the present invention, since the check means is prevented from being deformed by the support means, solidification due to unexpected advance of the chemical liquid can be prevented more favorably. Such a product excellent in preventing solidification can be obtained easily and inexpensively by simply providing a check valve support means.

  In the biological tissue adhesive applicator of the present invention, the check valve is opened by applying pressure to the inner surface and closed by applying pressure to the outer surface; And a base provided on the surface.

  Further, in the biological tissue adhesive applicator of the present invention, the base portion has a protruding portion that protrudes in the direction of the supporting means, and the supporting means has an engaging portion that contacts and supports the protruding portion of the base portion. There may be.

  In the living tissue adhesive applicator of the present invention, the base has a stepped engagement step perpendicular to the axial direction on the inner or outer surface of the protrusion, and the support means engages the protrusion. Corresponding to the stepped portion, a stepped portion receiving portion to which the engaging stepped portion is applied may be provided on the outer surface or the inner surface.

  In the biological tissue adhesive applicator of the present invention, the check valve has a pair of opposed valve bodies, and a thin wall portion extending in the axial direction is formed on at least one opposed inner side of the valve body. It may be.

  In the living tissue adhesive applicator of the present invention, the support means projects the tip of the engaging portion to the inside of the pair of valve bodies facing the check valve, and the outer surface faces the valve body. You may form in the shape substantially the same as the shape of an inner surface.

  In the biological tissue adhesive applicator of the present invention, the nozzle body has a valve mounting portion for mounting the check valve on the side of the chemical injection port, and the support means holds the valve mounting portion from the inner surface side and the outer surface side. A clamping part for fixing may be formed protruding from the tip.

  Moreover, in the biological tissue adhesive applicator of the present invention, the chemical solution flow tube may be formed of a material that allows passage of gas but restricts passage of liquid.

  Moreover, in the biological tissue adhesive applicator of the present invention, the chemical solution distribution tube may be formed of a soft plastic tube.

  The biological tissue adhesive applicator of the present invention may further include a syringe body that is filled with a chemical solution and is connected to a chemical solution inlet of the chemical solution distribution pipe.

  In the biological tissue adhesive applicator of the present invention, the chemical fluid distribution pipe communicates with the chemical fluid circulation pipe provided with the check valve between the nozzle body and the chemical fluid circulation pipe, and the gas inside the nozzle body is discharged. It may have at least one communication port introduced in the outlet direction.

  Moreover, in the biological tissue adhesive applicator of the present invention, a plurality of communication ports may be formed in the longitudinal direction of the wall surface of the drug solution distribution tube.

  The biological tissue adhesive applicator of the present invention may have a plurality of chemical solution distribution pipes, and the communication ports may have different sums of opening areas of the communication ports for each chemical solution distribution tube.

  In the biological tissue adhesive applicator of the present invention, the syringe body having a plurality of syringe bodies filled with different liquid chemicals, and the syringe body filled with a higher viscosity liquid chemical, the sum of the opening areas of the communication ports is greater. A check valve and a support means may be provided in a chemical liquid distribution pipe that is connected to a wide chemical liquid distribution pipe and at least the chemical liquid having a higher viscosity flows.

  Moreover, the biological tissue adhesive applicator of the present invention may further include an identification means for identifying a drug solution distribution pipe connecting a syringe body filled with drug solutions having different viscosities.

  Moreover, in the biological tissue adhesive applicator of the present invention, a plurality of nozzle bodies each having a space therein may be provided individually for a plurality of drug solution distribution tubes.

  The various components of the present invention do not necessarily have to be independent of each other. A plurality of components are formed as a single member, and a single component is formed of a plurality of members. It may be that a certain component is a part of another component, a part of a certain component overlaps with a part of another component, or the like. In addition, the upstream side in the present invention means a chemical solution inlet side and a chemical solution supply side for injecting a chemical solution into the chemical solution distribution pipe, and the downstream side means a chemical solution outlet side and a nozzle body for discharging the chemical solution to the outside. Means the tip side of

  According to the living tissue adhesive applicator of the present invention, the support valve is satisfactorily prevented from deforming and restoring the check valve, and the chemical solution is prevented from advancing to the tip end side of the nozzle body in the chemical solution distribution pipe. A biological tissue adhesive applicator that can be used is provided. As a result, the contact of the chemical solution with the outside air and the mixing with the other chemical solution are well suppressed, the clogging of the nozzle tip due to the solidification of the chemical solution is prevented, and the chemical solution can be smoothly discharged.

BRIEF DESCRIPTION OF THE DRAWINGS It is the schematic of the state which shows an example of the biological tissue adhesive application tool concerning 1st embodiment of this invention, and the syringe main body each filled with two different chemical | medical solutions was connected to the nozzle main body, (a) It is the top view which looked at the said biological tissue adhesive application tool from the band (fixing means) side, (b) is a side view, (c) is the sectional view on the AA line of (b). It is a perspective view of the biological tissue adhesive application tool concerning 1st embodiment. In the biological tissue adhesive application tool concerning 1st embodiment, it is a partial expanded sectional view of a check valve part. In the biological tissue adhesive applicator according to the first embodiment, it is a partially enlarged perspective view of a drug solution circulation pipe provided with a slit-shaped communication port. It is a partial enlarged view of the nozzle body side for explaining the use state of the biological tissue adhesive application tool according to the first embodiment, (a) is a diagram showing a state in which a chemical solution is discharged, b) is a diagram illustrating a state in which the discharge of the chemical liquid is stopped and the chemical liquid is discharged from the inside of the chemical liquid circulation pipe provided with the communication port. It is an expanded sectional view near the check valve and the support means of the biological tissue adhesive application tool according to the second embodiment.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings. In all the drawings, the same reference numerals are given to the same components, and the description will be omitted as appropriate.

  In the present embodiment, description will be made by defining the front-rear, left-right, up-down directions as shown. However, this is provided for convenience in order to simply explain the relative relationship of the components, and does not limit the direction during the manufacture or use of the product implementing the present invention.

<First embodiment>
Fig.1 (a) is a plane schematic diagram which shows an example of the biological tissue adhesive application tool concerning 1st embodiment of this invention, FIG.1 (b) is a side view of the biological tissue adhesive application tool. FIG. 1C is a cross-sectional view taken along line AA in FIG.

  First, an outline of the biological tissue adhesive applicator of the present embodiment will be described with reference to FIGS. 1 (a) to 1 (c). In this specification, in FIG.1 (b), the upper direction in a figure is called the top of a bioadhesive application tool, and the downward direction in a figure is called the down. Further, in FIG. 1 (b), the front direction in the figure is called left, and the back direction in the figure is called right (that is, in FIG. 1 (a), the downward direction in the figure is called left, The up direction is called right). In FIG. 1, the left direction in the drawing is referred to as the front side or the front end side, and the right direction in the drawing is referred to as the rear side or the rear end side.

  As shown in FIG. 1 (a) to FIG. 1 (c), the biological tissue adhesive applicator 100 of the present embodiment is a chemical solution with different viscosities, and by contact with outside air or mixing with other drugs, It is used for adhering a diseased part by applying a drug solution that easily solidifies instantaneously, for example, a fibrinogen solution and a thrombin solution. That is, a nozzle body 1 having a space 1c therein, a gas inlet 2 for filling a gas in the space 1c inside the nozzle body 1, and two chemical liquid inlets 3a and 3b provided in the nozzle body 1 The two chemical liquid discharge ports 4a and 4b provided at the tip of the nozzle body 1 and the two chemical liquid injection ports 3a and 3b and the two chemical liquid discharge ports 4a and 4b that are housed in the nozzle body 1 and communicate with each other. Two chemical liquid distribution pipes 5a and 5b and two chemical liquid discharge ports 4a and 4b are provided in the vicinity of the gas injection port 2 to inject a gas filled in the nozzle body 1 and from the chemical liquid discharge ports 4a and 4b. A gas outlet 6 for spraying the discharged chemical liquid in the form of a mist and the chemical liquid distribution pipes 5a and 5b, allowing the chemical liquid to flow into the chemical liquid distribution pipes 5a and 5b from the chemical liquid injection ports 3a and 3b; Inside of the chemical solution distribution pipes 5a and 5b Check valves 7a and 7b for restricting the outflow of the chemical liquid from the liquid chemical inlets 3a and 3b, and support for preventing the deformation in the direction for regulating the outflow of the chemical liquid by supporting the check valves 7a and 7b. Means 19a, 19b. Therefore, for example, even when the discharge of the chemical solution is stopped during intermittent use of the biological tissue adhesive applicator, the leading end surface of the chemical solution in the chemical solution flow pipes 5a and 5b is unforeseen. Can be prevented well.

  In the biological tissue adhesive applicator 100 of the present embodiment, the chemical solution flow pipes 5a and 5b are further formed of a soft plastic tube having air tightness and liquid tightness. Two slit-like communication ports 8a that communicate the inside of the nozzle body 1 and the inside of the chemical solution circulation tube 5b with one of the chemical solution circulation tubes 5b and introduce gas in the nozzle body 1 in the direction of the chemical solution discharge port 4b. 8b is provided parallel to the longitudinal direction. For this reason, for example, even when the discharge of the chemical liquid is stopped during intermittent use of the biological tissue adhesive applicator, even a highly viscous chemical liquid can be easily externalized by the gas pressure of the gas flowing in from the communication ports 8a and 8b. Can be discharged. Therefore, it becomes difficult for the chemical solutions to come into contact with each other, the solidification of the chemical solution can be prevented well, and intermittent use of the biological tissue adhesive applicator can be performed smoothly.

  Moreover, since the chemical | medical solution distribution pipes 5a and 5b of this embodiment are formed with the soft plastic tube, the notch for slit-shaped communication ports 8a and 8b can be made easily. Although there is no restriction | limiting in particular as this plastic material, For example, it is desirable to use a polyvinyl chloride resin, a polyurethane resin, a silicone resin etc. As described above, in this embodiment, the chemical solution distribution tubes 5a and 5b are formed of soft plastic tubes, but the present invention is not limited to this, and may be formed of metal or other materials. .

  In addition, the biological tissue adhesive applicator 100 according to the present embodiment includes two syringe bodies 10a and 10b for filling medicine solutions having different viscosities, and each medicine solution filled in the syringe bodies 10a and 10b. Pistons 12a and 12b having functions as pressing means for injecting into the flow pipes 5a and 5b and identification means 9a and 9b for identifying a chemical solution and the pistons 12a and 12b are connected and pressed simultaneously. The piston connecting means 13, the syringe body connecting means 20 for connecting the syringe bodies 10 a, 10 b, and the identifying means 9 a provided in the vicinity of the two chemical liquid injection ports 3 a, 3 b of the nozzle body 1 and provided in the syringe bodies 10 a, 10 b. , 9b corresponding to the identification means 11a, 11b, and the fixing means for fixing the syringe body connecting means 20 and the nozzle body 1; A gas supply pipe 15 connected to the gas injection port 2 for supplying gas, a gas filtration filter 16 disposed on the upstream side of the gas injection port 2 of the gas supply pipe 15, It has further. As will be described later, the band 14 is also provided with identification means 14a and 14b.

  In the present embodiment, the syringe body filled with a fibrinogen solution having a relatively high viscosity is provided in the drug solution flow tube 5b provided with the communication ports 8a and 8b, that is, the drug solution flow tube 5b having a wide sum of the opening areas of the communication ports. 10b is connected. On the other hand, a syringe body 10a filled with a thrombin solution having a relatively low viscosity is connected to the chemical solution flow pipe 5a that is not provided with the communication ports 8a and 8b.

  Next, the nozzle body 1 of this embodiment will be described in detail. As shown in FIG. 1, the nozzle body 1 is airtightly connected to the rear end side of the nozzle body 1, and a column 1 b protrudes from the wall surface of the lid body 1 a in the front end direction of the nozzle body 1. . As shown in FIG. 1C, the support column 1 b is formed to protrude to the tip of the nozzle body 1. The support body 1b supports the nozzle body 1 and the chemical solution discharge ports 4a and 4b, thereby enhancing the resistance to the spray pressure of the chemical solution and the gas. Further, a gap is formed between the outer peripheral surface of the support column 1b and the inner peripheral surface of the nozzle body 1 and the outer peripheral surface of the chemical solution discharge ports 4a and 4b. In addition, this gas jet nozzle 6 is formed between the two chemical liquid discharge ports 4a and 4b and on the rear end side from these so as to perform good mixing and injection of the chemical liquid. A gas inlet 2 for injecting gas into the nozzle body 1 is opened in the lower bottom wall 1d of the nozzle body 1 as shown in FIG.

  Further, as shown in FIG. 1B, a gas supply pipe 15 that communicates with a supply means (not shown) such as a gas tank for supplying gas is formed protrudingly at the gas inlet 2 of the nozzle body 1. . Further, a filter 16 for gas filtration is connected to the gas supply pipe 15 on the upstream side of the gas inlet 2, and communicates with a gas supply source via the filter 16. With this configuration, impurities such as dust in the gas are removed by the filter 16, and the purified gas can be supplied to the space 1c of the nozzle body 1. Therefore, a cleaner chemical solution can be sprayed onto the affected area. Furthermore, when the discharge of the chemical liquid is stopped, dust or the like is mixed when gas flows into the chemical liquid flow pipe 5b from the communication ports 8a and 8b and discharges the chemical liquid on the tip side from the communication ports 8a and 8b. It is also possible to prevent clogging or the like inside the chemical solution distribution pipe 5b due to Therefore, smooth distribution and discharge of the chemical solution are possible.

  Further, as shown in the enlarged views of FIGS. 3 and 5, the lid body 1 a of the nozzle body 1 has communication holes 1 e 1 and 1 e 2 for communicating the drug solution flow pipes 5 a and 5 b with the syringe bodies 10 a and 10 b. Has been. In addition, a cylindrical valve mounting portion 1f1 is provided in the lid 1a so as to continuously insert and fix the chemical solution flow pipes 5a and 5b in the direction of the space 1c of the nozzle body 1 in succession to the communication holes 1e1 and 1e2. 1f2 is formed to protrude. The valve mounting portions 1f1 and 1f2 are connected to supporting means 19a and 19b for supporting the check valves 7a and 7b mounted inside and preventing deformation to the rear end side. Further, engagement receiving portions 1f11, 1f21 for engaging the engagement step portions 7c2, 7d2 of the check valves 7a, 7b are formed on the inner periphery of the valve mounting portions 1f1, 1f2. Details of the engagement step portions 7c2, 7d2 of the check valves 7a, 7b and the support means 19a, 19b will be described later.

  The nozzle body 1 may be formed of a translucent or opaque material, for example, for light shielding or the like, or transparent for easy internal confirmation, etc. You may form with a material. In addition, the biological tissue adhesive applicator of this embodiment, such as the nozzle body 1, and the chemical solution discharge ports 4a and 4b, the chemical solution flow pipes 5a and 5b, the gas supply pipe 15 and the check valves 7a and 7b, are used for medical purposes. It is desirable to form with a plastic material. However, the present application is not limited to this and may be formed of other medical materials. Moreover, it is desirable to form with the material which does not affect a chemical | medical solution.

  Next, the check valves 7a and 7b and the supporting means 19a and 19b will be described in detail. First, the check valves 7a and 7b allow the chemical solution to flow into the chemical solution flow pipes 5a and 5b from the chemical solution injection ports 3a and 3b, and the chemical solution injection ports 3a and 3b from the chemical solution flow pipes 5a and 5b. There is no particular limitation as long as it regulates the outflow of the chemical solution in the direction, and any ordinary one may be used. In the present embodiment, as shown in the enlarged view of FIG. 3, on the restricting side of the outflow of the chemical solution, that is, on the rear end side, base portions 7c and 7d formed in a cylindrical shape in the support means 19a and 19b direction, A so-called duckbill valve having a pair of opposing valve bodies 7e and 7f that are opened by application of pressure to and closed by application of pressure to the outer surface is used. In the check valve 7a, 7b of the present embodiment, the inner angle (hereinafter, each pair of valve bodies 7e, 7f may be referred to as [beak]) of the valve bodies 7e, 7f facing each other. The angle formed by the center lines in the thickness direction of the opposing valve bodies 7e and 7f. The same applies hereinafter.) The angle of the valve bodies 7e and 7f is made smaller by reducing the angle of the valve bodies 7e and 7f. It is small. By adopting this configuration, the deformation at the time of receiving pressure in the regulation direction is minimized.

  However, by reducing the beak in order to reduce the angle of the valve bodies 7e and 7f in this way, even when the valve bodies 7e and 7f of the check valves 7a and 7b are open, the resistance of the highly viscous chemical solution It may be difficult for chemicals to flow. In order to prevent this, the substantially central part in the width direction inside the beak of each of the pair of valve bodies 7e, 7f is in the axial direction (the same direction as the discharge direction of the chemical solution is called the axial direction; the same applies hereinafter). A pair of thin portions 7g and 7h extending in the axial direction are formed by scooping out in a semi-conical shape, and a flow path for the chemical solution is secured. With this configuration, the thin-walled portions 7g and 7h exhibit an effect like a hinge, and when the chemical solution is discharged, the beveled surfaces of the valve bodies 7e and 7f are deformed in a direction of opening around the axis, and when the valve is opened. There is also an effect that it is easy to secure the flow path. Moreover, since the effect of reducing the resistance of the flow generated when the chemical solution opens the check valves 7a and 7b when the chemical solution is discharged can be obtained, the chemical solution can flow more smoothly. The base portions 7c and 7d of the check valves 7a and 7b are provided with protrusions 7c1 and 7d1 provided with stepped engagement steps (engagement portions) 7c11 and 7d11 perpendicular to the axial direction. Projected in the direction.

  As shown in the enlarged view of FIG. 3, the support means 19a, 19b are doubled in the direction of the nozzle body 1 in order to sandwich and fix the check valves 7a, 7b and the valve mounting portions 1f1, 1f2 of the nozzle body 1. The cylindrical sandwiching portions 19c1, 19c2, 19d1, and 19d2 are formed to protrude. Further, cylindrical syringe connection portions 19e and 19f for liquid-tightly connecting the syringe main bodies 10a and 10b to the inside are protruded from the rear end. The holding portions 19c1 and 19d1 formed on the inner surfaces of the support means 19a and 19b are inserted into the check valves 7a and 7b, and protrude into the engagement step portions 7c1 and 7d1 formed on the check valves 7a and 7b. Step receiving portions 19c11 and 19d11 (engaging portions) that are supported by contact are provided.

  On the other hand, as described above, the nozzle body 1 has the valve mounting portions 1f1 and 1f2 for mounting the check valves 7a and 7b at the rear end. At the rear ends of the valve mounting portions 1f1 and 1f2, cylindrical valve mounting portions 1f1 and 1f2 for connecting the support means 19a and 19b are formed protrudingly. The support means 19a and 19b are formed by double cylindrical clamping parts 19c1, 19c2, 19d1 and 19d2, and the support means connection parts 1f1 and 1f2 and the protruding parts 7c1 and 7d1 of the base parts 7c and 7d of the check valves 7a and 7b. Are clamped and fixed from the inner surface side and the outer surface side. By this clamping, the check valves 7a and 7b and the nozzle body 1 are firmly connected. Further, at the time of this clamping, the tips of the step receiving portions 19c11 and 19d11 which are the holding portions on the inner surface side abut against the inner surfaces of the engagement step portions 7c11 and 7d11 provided on the base portions 7c and 7d of the check valves 7a and 7b. . Furthermore, the check valves 7a and 7b are more effectively deformed in the upstream direction when the engagement receiving portions 1f11 and 1f21 of the valve mounting portions 1f1 and 1f2 abut against the outer surfaces of the engagement step portions 7c11 and 7d11. Can be prevented.

  As described above, since the support means 19a and 19b support the check valves 7a and 7b, for example, when the discharge of the chemical liquid is stopped, the upstream side of the check valve due to the backflow of atmospheric pressure or gas pressure. Can be satisfactorily prevented. Therefore, the chemical solution in the chemical solution flow pipes 5a and 5b is prevented from advancing unexpectedly toward the tip side of the nozzle body 1, and leakage of the chemical solution, contact with the outside air, or mixing of the chemical solutions can be prevented. It is possible to prevent the solidification of the nozzle body 1 on the tip side.

  Support means covers 21a and 21b are attached to the outer periphery of the support means 19a and 19b. These are color-coded red and blue, respectively, and have an identification function when the syringe bodies 10a and 10b are connected to the nozzle body 1 via support means 19a and 19b, as will be described later. Further, by attaching the support means covers 21a and 21b in this way, the double cylindrical sandwiching portions 19c1, 19c2, 19d1 and 19d2 are prevented from spreading outward, and the support means 19a and 19b are dropped off. It is also possible to improve prevention, air tightness, and liquid tightness.

  Moreover, in this embodiment, injection | pouring of the chemical | medical solution to the chemical | medical solution distribution pipes 5a and 5b is performed by syringe main body 10a, 10b connected to each chemical | medical solution injection port 3a, 3b. Therefore, as described above, connecting portions 19d1 and 19d2 for connecting the syringe main bodies 10a and 10b project from the support means 19a and 19b. On the other hand, double cylindrical portions (10c1, 10c2, 10d1, 10d2) are formed at the tips of the syringe bodies 10a, 10b. The syringe main bodies 10a and 10b can be connected to the nozzle main body 1 by inserting the inner cylindrical portions 10c2 and 10d2 into the connection portions 19d1 and 19d2 of the support means 19a and 19b in a liquid-tight manner. In addition, what provided the double cylinder part at the front end in this way is a so-called “Lure lock” standard syringe body, and originally a female or male screw (internally formed on the inner surface of the outer cylinder part 10c1, 10d2) (Lure lock) is engaged with the male or female screw on the other side to prevent the syringe body from falling off. However, in the present embodiment, as described above, the cylindrical portions 10c2 and 10d2 inside the syringe bodies 10a and 10b are inserted and fixed to the connection portions 19d1 and 19d2 of the support means 19a and 19b, so that they easily fall off. Never do. Therefore, the syringe body of the present application is not limited to the "Lure lock" standard, and if it has cylindrical portions 10c2, 10d2 that are liquid-tightly inserted inside or outside of the syringe bodies 10a, 10b, Any other standard may be used. In addition, liquid medicines having different viscosities can flow from the syringe bodies 10a and 10b through the check valves 7a and 7b and the chemical liquid inlets 3a and 3b into the chemical liquid flow pipes 5a and 5b, respectively.

  The syringe bodies 10a, 10b are also provided with chemical liquid identifying means 9a, 9b for filling. In the present embodiment, the piston 12a that is inserted into the syringe body 10a formed of a transparent material and pushes the internal chemical liquid is red, and the piston 12b that is inserted into the syringe body 10b is blue, and has the functions of the identification means 9a and 9b. It is As shown in FIG. 1 (a), the red circle identification means 11a and the blue circle identification means are also connected to the nozzle body 1 to which the syringe bodies 10a and 10b identified by the red and blue pistons 12a and 12b are connected. An identification sticker 11 printed with 11b is attached. As shown in FIG. 1A, the band 14 as a fixing means for fixing the nozzle body 1 and the two syringe bodies 10a and 10b to each other is also provided with an identification means. That is, the identification means 14a is formed by embossing the letter "red" on the band 14 and the arrow indicating the mounting direction of the syringe body 10a. In addition, a letter “blue” and an arrow indicating the mounting direction of the syringe body 10b are highlighted on the band 14 to form the identification means 14b. Thereby, the error of the connection position to the nozzle main body 1 of syringe main body 10a, 10b can be prevented more. Furthermore, as described above, the support means cover 21a is red and the support means cover 21b is blue, and these are also provided with an identification function. With such a configuration, the two types of syringe bodies 10a and 10b can be more accurately connected to the nozzle body 1.

  Next, a method for fixing the nozzle body 1 and the syringe bodies 10a and 10b with the band 14 will be described. As shown in the overall view of FIG. 1A and the perspective view of FIG. 2, the tip of the band 14 is inserted and fixed in an insertion portion 1 g formed at the rear end of the nozzle body 1. A through hole 14c is opened at the rear end of the band 14. On the other hand, at the tip of the syringe main body connecting means 20 for connecting the syringe main bodies 10a and 10b, a protruding portion 20a for inserting into the through hole 14c is formed protruding upward. And after inserting syringe main body 10a, 10b in the support means 19a, 19b by the side of the nozzle main body 1, respectively, the band 14 is pushed down and the projection part 20a of the syringe main body connection means 20 is inserted in the through-hole 14c. In order to facilitate the push-down and insertion of the band, a pressing portion 14d for pressing with a finger is formed obliquely upward at the rear end of the band 14. The band 14 prevents the syringe bodies 10a and 10b from dropping off from the nozzle body 1 and prevents the syringe bodies 10a and 10b from moving in the front-rear direction and the up-down direction.

  As a result, the pistons 12a and 12b can be stably pressed, the drug solution can be smoothly discharged, and the biological tissue adhesive applicator 100 can be used stably. Further, as described above, the band 14 is provided with the identification means 14a in which the arrow indicating the connection side of the syringe body 10a and the “red” character are highlighted, and the arrow indicating the connection side of the syringe body 10b and “blue”. Is provided with identification means 14b embossed with the following characters. Therefore, it is possible to further prevent an error in connection of the syringe bodies 10a and 10b. In this embodiment, the letters “red” and “blue” are used. However, the present application is not limited to this, and the initial letter “R” of Red and the initial letter “B” of Blue are used. May be. Further, the color coding is not limited to red and blue, and an appropriate color may be used according to the color of the syringe bodies 10a and 10b, the type of the chemical solution, and the like.

  Next, the communication ports 8a and 8b provided in the chemical solution circulation pipe 5b will be described in detail. As shown in the enlarged view of FIG. 4, these connection ports 8a and 8b are formed by cutting the wall surface of the chemical solution circulation pipe 5b into a slit shape having a wide outer width and a narrow inner width. . Further, it is formed so as to incline from the upstream side to the downstream side in an intersecting direction with respect to the axial direction of the chemical solution circulation pipe 5b, and is arranged in parallel to the longitudinal direction. At the time of discharging the chemical liquid, as shown in FIG. 5A, since the discharge pressure of the chemical liquid is higher than the gas pressure, the gas does not flow into the chemical liquid flow pipe 5b from the communication ports 8a and 8b. . Therefore, it is possible to smoothly discharge the chemical liquid without hindering the discharge of the chemical liquid from the chemical liquid discharge port 4b. Further, the pistons 12a and 12b inserted into the syringe bodies 10a and 10b can be connected by the piston connecting means 13 and pressed simultaneously. Therefore, different chemical liquids flowing through the chemical liquid distribution pipes 5a and 5b can be discharged from the respective chemical liquid discharge ports 4a and 4b at a well-balanced discharge ratio and applied to the affected area, and the adhesiveness is also improved.

  Further, when the discharge of the chemical liquid is stopped, the connection ports 8a and 8b are opened by the gas pressure of the gas filled in the space 1c of the nozzle body 1 as shown in FIG. And gas flows in into the chemical | medical solution distribution pipe | tube 5b from these connection ports 8a and 8b, and the chemical | medical solution of the front end side rather than the connection ports 8a and 8b is discharged | emitted outside. Therefore, the chemical solution in the chemical solution distribution pipe 5b becomes difficult to come into contact with the outside air or the other chemical solution, and even when time elapses until the next chemical solution is discharged, clogging on the tip side can be prevented. In particular, as in the present embodiment, the check valve 7b is supported by the support means 19b, and due to the effect of preventing deformation, the check valve 7b is restored after the chemical liquid is discharged from the chemical liquid flow pipe 5b by gas pressure. Thereby, the unexpected advance of the chemical | medical solution to the front-end | tip direction rather than the communicating ports 8a and 8b can be prevented. Therefore, it is possible to better prevent the highly viscous chemical solution from coming into contact with the outside air or the other chemical solution, and improve the clogging prevention effect at the tip.

  In order to spray and apply to the affected part of the living body using the biological tissue adhesive applicator 100 configured as described above, first of the support means 19a and 19b connected to the rear end of the lid body 1a of the nozzle body 1 The syringe main bodies 10a and 10b are connected to the syringe connecting portions 19e and 19f. At this time, a syringe body 10b filled with a highly viscous drug solution (for example, a fibrinogen solution) is connected to the drug solution flow pipe 5b in which the communication ports 8a and 8b are formed. Further, the syringe body 10a filled with a relatively low-viscosity chemical solution (for example, thrombin solution) is connected to the chemical solution flow pipe 5a without the communication ports 8a and 8b. As described above, the identification means 9a, 9b are provided on the pistons 12a, 12b inserted into the syringe bodies 10a, 10b, the identification means 11a, 11b are provided on the nozzle body 1, and the identification means 14a, 14b are provided on the band 14, respectively. Yes. Therefore, the syringe main bodies 10a and 10b can be accurately connected without making a mistake in the connection positions. When the syringe bodies 10a and 10b are connected, the pressing portion 14d of the band 14 is pushed down, and the protruding portion 20a of the syringe body connecting means 20 is inserted into the through hole 14c, thereby fixing the syringe bodies 10a and 10b and the nozzle body 1 together. .

  This fixing prevents the syringe body 10a, 10b from being wobbled in the axial direction and the up-down direction during the spraying of the chemical liquid, and the chemical liquid spray can be performed smoothly. Next, an operation button (not shown) or the like is operated to fill the space 1c of the nozzle body 1 with gas from the gas supply unit and eject gas from the gas ejection port 6. At the same time, the piston connecting means 13 for connecting the pistons 12a and 12b is pressed to inject two kinds of chemical liquids into the chemical liquid flow pipes 5a and 5b, and discharge them from the chemical liquid discharge ports 4a and 4b. As shown in FIG. 5A, the chemical liquid discharged from the chemical liquid discharge ports 4a and 4b is mixed in the form of mist by the gas discharged from the gas outlet 6 and sprayed onto the affected part. During the spraying of the chemical solution, the pistons 12a and 12b can be simultaneously pressed by the piston connecting means 13. Accordingly, the two chemical solutions can be discharged smoothly, and can be applied to the affected area at a suitable mixing ratio with a good balance, thereby improving the adhesion effect.

  Note that due to intermittent use of the biological tissue adhesive applicator 100, when the discharge of the chemical liquid is stopped, the force applied to the chemical liquid is released by releasing the pressing force by the pistons 12a and 12b. Therefore, a force in the rear end direction acts on the check valves 7a and 7b by a force for returning the pistons 12a and 12b in a direction opposite to the pressing direction, a winding force of atmospheric pressure or gas pressure, or the like. For this reason, the check valve is normally deformed in the rear end direction, and this check valve is restored until the next discharge of the chemical solution, so that the chemical solution gradually flows into the chemical solution flow pipe. For this reason, the chemical solution may advance unexpectedly in the chemical solution distribution pipe, the chemical solution may come into contact with the outside air or other chemical solution, and the vicinity of the chemical solution discharge port may solidify. In particular, when bubbles are mixed in the chemical solution during the preparation of the chemical solution, the bubbles are compressed by the pressing force from the piston. Since the air bubbles are restored by releasing the pressing force of the piston, when the check valve is deformed, the restoring force of the air bubbles promotes the restoration of the check valve, and the chemical liquid is unexpectedly advanced in the chemical liquid circulation pipe. It was easy to occur.

  However, in this embodiment, it is supported by the support means 19a, 19b of the check valves 7a, 7b, and deformation of the check valves 7a, 7b is well prevented. That is, the engagement step portions 7c11, 7d11 of the check valves 7a, 7b are supported by the step receiving portions 19c11, 19d11 of the support means 19a, 19b and the engagement receiving portions 1f11, 1f21 of the valve mounting portions 1f1, 1f2. Yes. Further, the base portions 7c and 7d of the check valves 7a and 7b and the tips of the valve mounting portions 1f1 and 1f2 of the nozzle body 1 are both clamped and fixed by the clamping portions 19c1, 19c2, 19d1 and 19d2 of the support means 19a and 19b. Yes. Therefore, deformation and restoration of the check valves 7a and 7b when the discharge of the chemical liquid is temporarily stopped are prevented, and an unexpected advance of the chemical liquid can be prevented.

  Next, when the pressing of the pistons 12a and 12b is stopped, the gas flows into the chemical liquid flow pipe 5b provided with the communication ports 8a and 8b, and the chemical liquid remaining in the chemical liquid flow pipe 5b and the chemical liquid discharge port 4b is discharged to the outside. . Also in this case, since the deformation and restoration of the check valves 7a and 7b are prevented, the unexpected advance of the chemical solution is also prevented. Therefore, after the chemical solution is discharged from the chemical solution distribution tube 5b, The chemical solution does not advance to the tip side from the communication ports 8a and 8b. Therefore, solidification of the tip of the nozzle body 1 during intermittent use can be prevented satisfactorily, and the next chemical spray can be performed smoothly. In addition, a product excellent in preventing the solidification of the chemical solution can be obtained simply by providing the support means 19a, 19b of the check valves 7a, 7b, the number of parts is small, and fine adjustment between the parts is performed. Therefore, it can be provided easily and inexpensively with a simple configuration.

<Second embodiment>
FIG. 6 shows an example of the biological tissue adhesive application tool 110 according to the second embodiment of the present invention, and is an enlarged sectional view of the vicinity of the check valve 7b1 and the support means vicinity 19b1 of the embodiment. In addition, description is abbreviate | omitted about the part same as 1st embodiment by the structure of the biological tissue adhesive application tool 110 of 2nd embodiment.

  In the biological tissue adhesive applicator 110 of the second embodiment, the configuration of the support means 19b1 that supports the check valve 7b1 is different from that of the first embodiment, and therefore the details will be described below with the support means 19b1 as the center. . Also in the second embodiment, although not shown, there are two chemical liquid circulation pipes, and one chemical liquid circulation pipe 5b1 is provided with a slit-shaped communication port (not shown). The other non-illustrated chemical solution flow pipe is provided with a check valve and support means similar to those shown in FIG.

  Also in this embodiment, a duckbill valve having a base portion 7d12 and a pair of opposed valve bodies 7f1 is used as the check valve 7b1. The check valve 7b1 is mounted in a valve mounting portion 1f21 that is continuous with the communication hole 1e21 of the lid 1a1. The base 7d1 of the check valve 7b1 is provided with a protrusion 7d11 provided with a stepped engagement step (engagement portion) 7d111 perpendicular to the axial direction so as to protrude in the direction of the support means 19b1. An engagement receiving portion 1f211 for engaging the engagement step portion 7d111 of the check valve 7b1 is formed on the inner periphery of the valve mounting portion 1f21. Further, the internal angle of the beak portion of the valve body 7f1 is reduced to reduce the space of the valve body 7f1, and the substantially central portions in the width direction facing each other are scooped out in a semiconical shape and extended in the axial direction. A pair of thin-walled portions 7h1 is formed to make it easy to secure a flow path for the chemical solution.

  As shown in FIG. 6, the support means 19b1 is configured to sandwich and fix the check valve 7b1 and the valve mounting portion 1f21 of the nozzle body 1 so as to be double cylindrical holding portions 19d11 and 19d21 in the nozzle body 1 direction. The protrusion is formed. Further, a cylindrical syringe connection portion 19f1 for connecting the syringe main body 10b1 inside in a liquid-tight manner is formed at the rear end. Further, a step receiving portion 19d11 formed on the inner surface of the support means 19b1 is inserted into the check valve 7b1 and abutted against and supported by the engaging step 7d21 formed on the check valve 7b1. (Engagement portion) 19d111 is provided. Further, as a difference from the first embodiment, the tip of the clamping part 19d11 protrudes in the direction of the valve body 7f1 to form a tip protrusion 19d112. Further, the outer surface of the tip protrusion 19d112 is formed to have the same inclination as that of the inner surface facing the valve body 7b1, and the outer surface of the tip protrusion 19d111 is brought into contact with the inner surface of the valve body 7f1. With this configuration, the support force of the valve body 7f1 by the support means 19a1 is made stronger.

  As described above, the biological tissue adhesive applicator 110 according to the second embodiment can smoothly discharge a chemical solution by the check valve 7b1 having the above-described configuration when the chemical solution is discharged. Further, since the check means 7b1 is prevented from being deformed by the support means 19b1, the chemical liquid does not unexpectedly advance to the tip side from the communication port (not shown) in the chemical liquid flow pipe 5b1 when the discharge of the chemical liquid is stopped. . Therefore, solidification of the tip of the nozzle main body 101 during intermittent use can be satisfactorily prevented, and the next chemical spraying can be performed smoothly. In addition, a product excellent in preventing the solidification of the chemical solution can be obtained simply by providing the supporting means 19b1 such as the check valve 19b1, etc., the number of parts is small, and fine adjustment between the parts can be performed. Therefore, it can be provided easily and inexpensively with a simple configuration.

  Moreover, although each said embodiment has shown the example using two chemical | medical solution distribution pipes, this application is not limited to this. For example, as long as a check valve and its support means are provided, one type of chemical solution may be sprayed from one chemical solution outlet using one chemical solution flow pipe. Even in this case, the advance of the chemical solution can be satisfactorily prevented by preventing the check valve from being deformed by the support means. Moreover, it is good also as a structure which discharges three or more types of chemical | medical solutions from three or more chemical | medical solution discharge ports by providing a check valve and a support means in each using three or more chemical | medical solution distribution pipes. In this case, the same effect as described above can be obtained.

  Moreover, when providing a communicating port in a some chemical | medical solution distribution pipe, according to the viscosity of a chemical | medical solution, you may change the number of the communicating ports provided in each chemical | medical solution distribution pipe, and may change the sum of opening areas. And if the syringe main body filled with the high-viscosity chemical | medical solution is connected in order from the chemical | medical solution distribution pipe | tube with a wider opening area of a communicating port, the chemical | medical solution according to viscosity can be discharged | emitted efficiently.

  In each of the above embodiments, the communication port is formed so that gas does not flow from the communication port when the chemical solution is discharged. However, the gas may flow from the communication port even when the chemical solution is discharged. . In this case, the gas pressure can assist in the discharge of the highly viscous chemical solution. As a result, each chemical solution can be discharged at a well-balanced discharge ratio when, for example, a chemical solution having a viscosity lower than that of the chemical solution is discharged at the same time, and the variety of chemical solutions to be used can be widened.

  Further, in each of the above embodiments, for example, as in the first embodiment, the chemical liquid circulation pipe is formed of a plastic tube, and a communication port is provided to communicate the inside of the chemical liquid circulation pipe 5b and the inside of the nozzle body 1. . However, the present application is not limited to this. For example, even if the chemical liquid circulation pipe is formed of a material that allows passage of gas, such as Gore-Tex (registered trademark), but restricts passage of liquid. Good. With such a configuration, the chemical liquid does not leak into the nozzle main body, but the gas in the nozzle main body flows into the chemical liquid flow pipe, so that the discharge of the chemical liquid can be assisted by the gas pressure.

  Further, the chemical solution distribution pipe may be formed of a material having higher softness without forming a communication port and without using a material through which only gas passes. In this case, when the discharge of the chemical liquid is stopped, the highly flexible chemical liquid distribution pipe becomes flat due to the gas pressure in the nozzle body. Therefore, the chemical solution remaining in the chemical solution distribution pipe can be discharged to the outside. Alternatively, a chemical solution distribution tube may be formed of a material having low softness, and a balloon-like bulge having high flexibility may be formed in the middle of the chemical solution distribution tube. This balloon-like bulge swells when the chemical solution enters and does not hinder the flow of the chemical solution. Next, when the discharge of the chemical liquid is stopped, the chemical liquid on the tip side in the chemical liquid circulation pipe can be discharged because the gas pressure in the nozzle body 1 is deflated.

  In this way, a communication port is formed only in the chemical solution distribution pipe through which a highly viscous chemical solution flows, or a communication port is formed in a plurality of chemical solution distribution tubes, but the opening area of the communication port is changed depending on the difference in viscosity, Only when the chemical flow pipe where the highly viscous chemical liquid circulates is formed with a material that allows gas to pass but restricts the passage of liquid, or by providing a balloon in the chemical liquid flow pipe, etc. The chemical solution can be discharged from the tip of the chemical solution distribution pipe. In some cases, a plurality of chemical solutions having different viscosities can be discharged at a balanced discharge ratio. Furthermore, by providing a check valve and its support means in each chemical solution flow pipe and preventing the check valve from being deformed and restored by the support means, it is possible to prevent the chemical solution from advancing unexpectedly after the chemical solution is discharged. Therefore, the effect of preventing solidification of the tip of the nozzle body 1 can be improved.

  Moreover, in each said embodiment, although the some chemical | medical solution distribution pipes 8a and 8b are accommodated in one nozzle main body 1, this application is not limited to this. For example, as another different embodiment, a nozzle body having a space inside may be provided individually for a plurality of chemical liquid circulation pipes. That is, the biological tissue adhesive applicator may have a plurality of nozzle bodies. In the case of such an embodiment, although not illustrated, each nozzle body includes a gas inlet for filling a gas in the space inside the nozzle body, a chemical inlet provided in the nozzle body, and a nozzle body. The chemical solution discharge port provided at the tip and the chemical solution distribution pipe that is housed in the nozzle body and communicates with the chemical solution injection port and the chemical solution discharge port, respectively, and provided in the vicinity of the chemical solution discharge port, from the gas injection port to the inside of the nozzle body A gas outlet for spraying and mixing the chemical liquid discharged from the chemical liquid outlet and spraying and mixing it in the form of a mist, a communication port provided in at least one chemical liquid circulation pipe, and a chemical liquid provided with the communication port A check valve which is provided at least in the flow pipe, allows a chemical liquid to flow into the chemical liquid flow pipe from the chemical liquid inlet, and regulates the outflow of the chemical liquid from the chemical flow pipe toward the chemical discharge port. The configuration. Even with such a tissue adhesive application tool, when the discharge of the chemical solution is stopped during intermittent use, even a highly viscous chemical solution can be easily discharged to the outside by the gas pressure of the gas flowing in from the communication port. Can do. Therefore, solidification of a chemical | medical solution can be prevented favorably and intermittent use of a biological tissue adhesive application tool can be performed smoothly. In this case as well, the syringe body in which the gas in the medicinal flow pipe is connected to each nozzle body when the chemical liquid is discharged by the gas by providing a check valve provided with a support means in the medicinal liquid flow pipe provided with the communication port. It is possible to prevent inflow into

  Further, in the above-described other embodiments, one chemical solution circulation pipe is housed in each of the plurality of nozzle bodies, but the present application is not limited to this. In this case, a plurality of nozzle main bodies are used, and one or a plurality of nozzle main bodies may be provided with a plurality of chemical liquid circulation pipes. In this case, one nozzle is provided with a chemical flow pipe provided with a check valve provided with support means and a chemical liquid flow pipe provided with a check valve not provided with support means, or a chemical liquid flow pipe provided with no check valve itself. You may provide in a main body and you may provide a non-return valve provided with a support means in all the chemical | medical solution distribution pipes of each nozzle main body. Moreover, you may provide a communicating port in each chemical | medical solution distribution pipe. In any case, by providing a check valve with support means, it is possible to prevent the chemical liquid or gas from flowing back from the chemical liquid distribution pipe to the syringe body due to the return pressure when the injection of the chemical liquid is stopped. It becomes. As described above, if a chemical solution circulation pipe having a check valve provided with support means is included, whether or not a communication port is provided in the chemical solution flow pipe provided with the check valve provided with support means, and other chemical solutions It is optional whether or not a check valve provided with a communication port and support means or a check valve not provided with support means is provided in the flow pipe.

  Note that the present invention is not limited to the above-described embodiments, and includes various modifications and improvements as long as the object of the present invention is achieved.

DESCRIPTION OF SYMBOLS 1,101 Nozzle body 1f1, 1f2, 1f21 Valve mounting part 1f11, 1f21 Engagement receiving part 2 Gas inlet 3a, 3b, 3b1 Chemical inlet 4a, 4b Chemical outlet 5a, 5b, 5b1 Chemical outlet 6 Gas outlet 7a, 7b, 7b1 Check valve 7c, 7d, 7d12 Base 7c1, 7d1 Projection (cylindrical)
7c11, 7d11, 7d111 Engagement step (formed on the protrusion)
7e, 7f, 7f1 Valve body 7g, 7h, 7g1, 7h1 Thin portion 8a, 8b Communication port 9a, 9b Identification means (piston side)
10a, 10b, 10b1 Syringe body 11a, 11b Identification means (nozzle body side)
12a, 12b Piston (pressing means)
13 Piston connection means (connection means)
14 Band (fixing means)
14a, 14b Identification means (band side)
19a, 19b, 19b1 Support means 19c1, 19d1, 19d11 Inner surface side clamping portion (cylindrical)
19c11, 19d11, 19d111 Abutting part 19c2, 19d2, 19d21 Clamping part (cylindrical)
19e, 19f, 19f1 Syringe connection portion 20 Syringe body connecting means 21a, 21b, 21b1 Support means cover (identification means)
100, 110 Biological tissue adhesive applicator

Claims (16)

A nozzle body having a space inside;
A gas inlet for filling a gas in the space inside the nozzle body;
A chemical injection port provided in the nozzle body;
A chemical solution outlet provided at the tip of the nozzle body;
A chemical solution circulation pipe that is housed inside the nozzle body and communicates with the chemical solution inlet and the chemical solution outlet;
A gas outlet that is provided in the vicinity of the chemical liquid discharge port, injects a gas filled in the nozzle body from the gas injection port, and sprays the chemical liquid discharged from the chemical liquid discharge port in a mist form;
The reverse that is provided in the chemical solution distribution pipe, allows the chemical solution to flow into the chemical solution distribution pipe from the chemical solution injection port, and regulates the outflow of the chemical solution from the chemical solution distribution pipe toward the chemical solution injection port. A stop valve,
A biological tissue adhesive applicator having supporting means for supporting the check valve and preventing deformation in a direction of regulating the outflow of the drug solution by the check valve. The check valve is
The biological tissue according to claim 1, comprising: a valve body that opens when pressure is applied to the inner surface and closes when pressure is applied to the outer surface; and a base portion that is provided on a side of the valve body that restricts outflow of the chemical solution. Adhesive application tool. The base has a protruding portion protruding in the direction of the support means,
The biological tissue adhesive applicator according to claim 2, wherein the support means has an engaging portion that contacts and supports the protruding portion of the base portion. The base has a stepped engagement step perpendicular to the axial direction on the inner or outer surface of the protrusion,
The biological tissue adhesive applicator according to claim 3, wherein the support means has a step receiving portion on the outer surface or the inner surface for abutting the engagement step portion corresponding to the engagement step portion of the protrusion. The check valve has a pair of opposed valve bodies,
The biological tissue adhesive application tool according to any one of claims 2 to 4, wherein a thin-walled portion extending in the axial direction is formed inside at least one of the valve bodies facing each other.   The support means projects the distal end of the engaging portion to the inside of the pair of valve bodies opposed to the check valve, and has an outer surface substantially similar to the shape of the inner surface opposed to the valve body. The biological tissue adhesive application tool according to claim 5, wherein the biological tissue adhesive application tool is formed. The nozzle body has a valve mounting portion for mounting the check valve on the chemical injection port side,
The living tissue adhesive application according to any one of claims 1 to 6, wherein the support means has a clamping portion protruding from the tip for clamping and fixing the valve mounting portion from the inner surface side and the outer surface side. Tools.   The said chemical | medical solution distribution pipe | tube is a biological tissue adhesive application tool as described in any one of Claims 1-7 formed with the material which accept | permits passage of gas, but restrict | limits passage of a liquid.   The biological tissue adhesive applicator according to any one of claims 1 to 7, wherein the chemical solution circulation pipe is formed of a soft plastic tube.   The biological tissue adhesive application tool according to any one of claims 1 to 9, further comprising a syringe body that is filled with the chemical solution and is connected to a chemical solution inlet of the chemical solution distribution pipe.   The chemical liquid flow pipe communicates the inside of the nozzle body and the chemical liquid flow pipe with the chemical liquid flow pipe provided with the check valve, and introduces the gas inside the nozzle main body toward the chemical liquid discharge port. The biological tissue adhesive application tool according to any one of claims 1 to 10, which has at least one communication port.   The biological tissue adhesive application tool according to claim 11, wherein a plurality of the communication ports are formed in a longitudinal direction of a wall surface of the chemical solution circulation pipe.   The biological tissue adhesive applicator according to claim 11 or 12, wherein a plurality of the chemical solution distribution pipes are provided, and the communication ports have different sums of opening areas of the communication ports for each of the chemical solution distribution tubes.   A plurality of syringe bodies filled with chemical solutions having different viscosities are connected to the syringe main body filled with the higher-viscosity chemical solutions and connected to the chemical solution flow pipe having a wider sum of the opening areas of the communication ports. 14. The biological tissue adhesive applicator according to claim 13, wherein the check valve and the support means are provided at least in the chemical solution distribution pipe through which the chemical solution having higher viscosity flows.   The biological tissue adhesive application tool according to claim 14, further comprising identification means for identifying the chemical solution circulation pipe connecting the syringe body filled with the chemical solutions having different viscosities.   The biological tissue adhesive applicator according to any one of claims 1 to 14, wherein a plurality of the nozzle bodies having the space therein are individually provided with respect to the plurality of drug solution flow tubes.

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