JP2012092065A - 歯磨剤 - Google Patents
歯磨剤 Download PDFInfo
- Publication number
- JP2012092065A JP2012092065A JP2010241727A JP2010241727A JP2012092065A JP 2012092065 A JP2012092065 A JP 2012092065A JP 2010241727 A JP2010241727 A JP 2010241727A JP 2010241727 A JP2010241727 A JP 2010241727A JP 2012092065 A JP2012092065 A JP 2012092065A
- Authority
- JP
- Japan
- Prior art keywords
- dentifrice
- mass
- component
- salt
- abrasive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000551 dentifrice Substances 0.000 title claims abstract description 42
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 23
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims abstract description 21
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims abstract description 21
- 150000003839 salts Chemical class 0.000 claims abstract description 21
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims abstract description 20
- 238000006266 etherification reaction Methods 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000003082 abrasive agent Substances 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 3
- 230000000638 stimulation Effects 0.000 abstract description 4
- 235000002639 sodium chloride Nutrition 0.000 description 22
- 229940105329 carboxymethylcellulose Drugs 0.000 description 18
- -1 alkali metal salts Chemical class 0.000 description 12
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- 230000000694 effects Effects 0.000 description 7
- 238000000034 method Methods 0.000 description 5
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- 229910019142 PO4 Inorganic materials 0.000 description 3
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- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
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- 125000000217 alkyl group Chemical group 0.000 description 2
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- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 229940043256 calcium pyrophosphate Drugs 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
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- 229940113118 carrageenan Drugs 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
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- 238000007796 conventional method Methods 0.000 description 2
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- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 2
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- 239000000194 fatty acid Substances 0.000 description 2
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- 235000003599 food sweetener Nutrition 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
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- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 2
- 239000001095 magnesium carbonate Substances 0.000 description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- AQMNWCRSESPIJM-UHFFFAOYSA-M sodium metaphosphate Chemical compound [Na+].[O-]P(=O)=O AQMNWCRSESPIJM-UHFFFAOYSA-M 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
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- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
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- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
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Abstract
【解決手段】成分(A)エーテル化度が0.1〜0.5のカルボキシメチルセルロース又はその塩0.1〜25質量%を含有し、かつ
成分(B)研磨剤1質量%未満含有する、又は成分(B)研磨剤を含有しない歯磨剤。
【選択図】なし
Description
一方、研磨剤として水不溶性のセルロースパウダーを配合したものは、市販の歯磨剤と比較して強い研磨力を有しないもので、ある一定の清掃効果を持つものではあるが、歯の狭小な領域に付着した歯垢や汚れを有効に除去する点については依然検討の余地があった(特許文献1参照)。
成分(B)研磨剤1質量%未満含有する、又は成分(B)研磨剤を含有しない歯磨剤を提供するものである。
本発明の歯磨剤は、(A)エーテル化度が0.1〜0.5のカルボキシメチルセルロース又はその塩を含む。一般的に、歯磨剤には粘結剤としてカルボキシメチルセルロース又はその塩が配合されるが、粘結剤として配合されるカルボキシメチルセルロース又はその塩のエーテル化度は1.0〜1.5であり、まれに用いられる低粘度のカルボキシメチルセルロース又はその塩でもそのエーテル化度は0.6〜0.8である。なお、例えば、エーテル化度が0.2〜0.3のカルボキシメチルセルロースナトリウムの1%水溶液の25℃における粘度は、BM型粘度計 ロータNO.1 回転数60で測定した場合に30〜100mPa・sであるため、粘結剤としての機能が極めて低く、歯磨剤に粘結剤として使用されない。
エーテル化度=(162×Y)/(10,000−80×Y)
表1〜2に示す処方に基づき、常法に従って歯磨剤を調製した。得られた歯磨剤について、以下に示す方法に従って各評価を行った。
歯垢又は汚れ除去の評価モデル及び歯垢又は汚れ除去率(%)の算出方法を下記に示す。
(1)φ4mmのガラス管を5本並べて接着剤(長時間固化タイプ)で固定し、歯間モデルを作成した。
(2)ガラス管の溝にモデル歯垢又は汚れとして赤い口紅(オーブ ルージュドレシャスRD305(花王))を塗り込む。
(3)余分な塗布口紅を食器用洗浄剤(研磨剤を含まない)でブラッシング洗浄(歯ブラシ「毛先が球」レギュラーサイズ、ふつう(花王))を赤色が出なくなるまで行う。
(4)各歯磨剤2gを口紅の上に塗布する。
(5)口紅が落ちなくなるまでブラッシング(歯ブラシは(3)と同じ)する。
(6)洗水で歯磨剤と口紅を落とす。
(7)エタノール100mLに歯間モデルを漬け、10分間超音波洗浄(モデル歯間部の奥より残存口紅溶出)する。
(8)(7)で得られたエタノール溶液について、540nmにて吸光度(Abs)を測定する。
なお、コントロール(初期値)は上記(3)の処理後、(7)(8)の処理を行ったものを用いた。評価モデルの歯垢又は汚れ除去率(%)は、コントロールの吸光度(A0)に対する各歯磨剤での評価後の吸光度(A)の減少率((A0−A)/A0)×100)から算出した。
各歯磨剤を粘度測定用の容器に詰め、25℃の恒温器で24時間保存した後、ヘリパス型粘度計を用いて、ロータC、2.5rpm、1分間の条件で粘度(dPa・s)を測定した。
Claims (5)
- 成分(A)エーテル化度が0.1〜0.5のカルボキシメチルセルロース又はその塩0.1〜25質量%を含有し、かつ
成分(B)研磨剤1質量%未満含有する、又は成分(B)研磨剤を含有しない歯磨剤。 - 更に水を含有する請求項1に記載の歯磨剤。
- 歯磨剤全量100質量%中における水の含有量と成分(A)の含有量との質量比(水分量/A)が、1.5〜150である請求項1又は2に記載の歯磨剤。
- 25℃における粘度が、2000〜4000dPa・sである請求項1〜3の何れか1項に記載の歯磨剤。
- 前記成分(A)が、平均粒径5〜150μmの粒子からなる請求項1〜4の何れか1項に記載の歯磨剤。
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JP2000229807A (ja) * | 1999-02-12 | 2000-08-22 | Kao Corp | 崩壊性粒子 |
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JP2004284956A (ja) * | 2003-03-19 | 2004-10-14 | Lion Corp | 練歯磨組成物 |
JP2008031187A (ja) * | 2007-10-25 | 2008-02-14 | Kao Corp | 崩壊性粒子 |
JP2011121916A (ja) * | 2009-12-11 | 2011-06-23 | Kao Corp | 歯磨剤組成物 |
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JPS5598111A (en) * | 1979-01-16 | 1980-07-25 | Lion Corp | Toothpaste composition |
JPH06336416A (ja) * | 1993-05-28 | 1994-12-06 | Sunstar Inc | 歯磨組成物 |
JPH10139642A (ja) * | 1996-11-13 | 1998-05-26 | Lion Corp | 歯磨組成物 |
JP2000119171A (ja) * | 1998-10-12 | 2000-04-25 | Kao Corp | 崩壊性粒子 |
JP2000229807A (ja) * | 1999-02-12 | 2000-08-22 | Kao Corp | 崩壊性粒子 |
JP2004284956A (ja) * | 2003-03-19 | 2004-10-14 | Lion Corp | 練歯磨組成物 |
JP2004002476A (ja) * | 2003-09-01 | 2004-01-08 | Sunstar Inc | 口腔用組成物 |
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JP2011121916A (ja) * | 2009-12-11 | 2011-06-23 | Kao Corp | 歯磨剤組成物 |
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