JP2012036120A - Undiluted gargle composition and usage of the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an undiluted gargle composition having bactericidal effect and anti-inflammatory effect, little foaming, good portability, and further, a good feeling of use without bitter taste or irritation, and to provide a method for using the same.SOLUTION: The undiluted gargle composition contains: at least any (component (A)) of a quaternary ammonium salt type bactericide and dipotassium glycyrrhizinate; and at least one (component (B)) selected from methyl butyrate, ethyl butyrate, ethyl acetate, pentyl acetate, and hexyl acetate, wherein the content of the component (B) is 0.01-0.1 mass%, and the mass ratio of the component (B) to the component (A), (B)/(A), is 1-5.

Description

  The present invention relates to an undiluted gargle composition and a method of using the same.

  The gargle composition is generally used for the purpose of imparting bactericidal action or anti-inflammatory action to the oral cavity or throat for disinfection, treatment of various inflammations, and prevention of infectious diseases such as colds. A grade ammonium salt type bactericide and an anti-inflammatory agent such as dipotassium glycyrrhizinate are blended. These components have the property of foaming due to the surface activity.

In addition to gargle compositions, oral compositions include toothpastes and mouthwashes used as substitutes for toothpastes, and these toothpastes and mouthwashes also have quaternary ammonium salt fungicides. Or dipotassium glycyrrhizinate may be added.
As for the dentifrice, the thing excellent in foaming property is liked (for example, refer patent document 1), and the mouthwash which wash | cleans an intraoral cavity in the state which closed the mouth improves the feeling of use similarly. Therefore, foaming is required (for example, refer to Patent Document 2). Therefore, foaming due to a quaternary ammonium salt type fungicide or dipotassium glycyrrhizinate does not cause a problem.

  On the other hand, gargle is a problem in that bubbles are spilled from the mouth when foamed, unlike buffing agents and mouthwashes, because bubbling is performed in the oral cavity with the mouth open.

  In the technical field of cosmetics, it is generally known to add ethanol in order to obtain an antifoaming effect. However, it is unsuitable for people and children who are sensitive to ethanol, which may cause irritation and hot flashes.

  In addition, gargle compositions that are used in a diluted form are widely used, and when they are at home, preparation of gargles and the like is easy and the oral cavity can be washed frequently and easily. However, it was difficult to prepare a mouthwash because it was difficult to prepare a mouthwash even if it wanted to be cleaned, and it was difficult to clean the oral cavity, which was a problem in terms of poor portability.

  Furthermore, for the purpose of continuous use, the gargle composition is required to be easy to use not only from feeling of use such as foaming and portability but also from the point of taste.

As an oral composition with improved flavor, a caries fungus growth inhibitor (see Patent Document 3) using linalool or the like as a fragrance component in the oral composition, for the purpose of improving unpleasant aftertaste due to sodium chloride and sodium bicarbonate. An oral composition using a chain terpene, which is a fragrance component (see Patent Document 4), and an oral composition using a fragrance component having a specific structure for the purpose of enhancing the cooling effect of menthol (Patent Document 5) For example, a composition for oral cavity using vanillin or the like as a fragrance component is disclosed for the purpose of improving the bitterness and odor derived from the surfactant (see Patent Document 6).
However, these have a flavor improving action and a bactericidal action, but are not capable of suppressing foaming.

  Therefore, it is desired to provide an undiluted gargle composition having a bactericidal action and an anti-inflammatory action, less foaming, good portability, and good use feeling without bitterness and irritation, and a method for using the same. Currently.

See JP2009-155240A JP 2006-347987 A JP-A-63-30409 JP-A-8-99847 JP 2000-247859 A JP 2003-81797 A

  An object of the present invention is to solve the above-described problems and achieve the following objects. That is, the present invention provides an undiluted gargle composition having a bactericidal action and an anti-inflammatory action, less foaming, good portability, and good use feeling without bitterness and irritation, and a method for using the same. Objective.

  In order to solve the above-mentioned problems, the present inventors have made extensive studies and as a result, obtained the following findings. That is, at least one selected from quaternary ammonium salt type fungicides and dipotassium glycyrrhizinate (component (A)) and methyl butyrate, ethyl butyrate, ethyl acetate, pentyl acetate, and hexyl acetate (( B) component), the content of the component (B) is 0.01% by mass to 0.1% by mass, and the mass ratio of the component (A) to the component (B) is ( B) / (A) = 1-5 undiluted gargle composition has bactericidal action and anti-inflammatory action, less foaming, good portability, and no bitterness or irritation The inventors found that the feeling of use was good and completed the present invention.

The present invention is based on the above findings by the present inventors, and means for solving the above problems are as follows. That is,
<1> At least one selected from quaternary ammonium salt type fungicides and dipotassium glycyrrhizinate (component (A)) and methyl butyrate, ethyl butyrate, ethyl acetate, pentyl acetate, and hexyl acetate ( (B) component), the content of the component (B) is 0.01% by mass to 0.1% by mass, and the mass ratio of the component (A) to the component (B) is It is an undiluted gargle composition characterized by being (B) / (A) = 1-5.
<2> The undiluted gargle according to <1>, further containing an alkanediol having 2 to 6 carbon atoms (component (C)), wherein the content of the component (C) is 1% by mass to 20% by mass. Agent composition.
<3> At least one of a polyhydric alcohol and a sugar alcohol (component (D)) and hydroxyethyl cellulose (component (E)) are further contained, and the polyhydric alcohol is polyethylene glycol and at least tripolymerization. <Polypropylene glycol, glycerin, and polyglycerin, wherein the content of the component (D) is 5% by mass to 20% by mass, and the viscosity at 25 ° C. is 10 mPa · s to 100 mPa · s < The undiluted gargle composition according to any one of <1> to <2>.
<4> A method of using the undiluted gargle composition according to any one of <1> to <3> without being diluted.

  According to the present invention, it is possible to solve the above-mentioned problems in the prior art, achieve the object, have bactericidal action and anti-inflammatory action, have less foaming, have good portability, and have no bitterness or irritation A pleasant undiluted gargle composition and a method of using the same can be provided.

(Undiluted gargle composition and method of use thereof)
The undiluted gargle composition of the present invention is selected from quaternary ammonium salt-type fungicides and / or dipotassium glycyrrhizinate (component (A)), methyl butyrate, ethyl butyrate, pentyl acetate, and hexyl acetate. And at least one of alkanediol having 2 to 6 carbon atoms (component (C)), polyhydric alcohol and sugar alcohol (( D) component), hydroxyethyl cellulose (component (E)), and other components.
The method of use of the present invention is a method of using the undiluted gargle composition of the present invention without dilution.
Hereinafter, the usage method of the said undiluted gargle composition is demonstrated with description of the said undiluted gargle composition.

<(A) component>
At least one of the quaternary ammonium salt type fungicide and dipotassium glycyrrhizinate as the component (A) is blended for the purpose of imparting at least one of a bactericidal action and an anti-inflammatory action.

-Quaternary ammonium salt type fungicide-
There is no restriction | limiting in particular as said quaternary ammonium salt type fungicide, According to the objective, it can select suitably, For example, the compound represented by following General formula (1), represented by following General formula (2) And the like. These may be used alone or in combination of two or more.
In the general formula (1) and the general formula (2), R ¹ and R ² each represent a hydrocarbon group having 8 to 184 carbon atoms or a hydrocarbon group having an ether bond. Z ¹⁻ and Z ²⁻ each represent a halogen atom, an amino acid, or an aliphatic fatty acid. Among these, a halogen atom is preferable.

  Specific examples of the component (A) include cetylpyridinium chloride, benzethonium chloride, and benzalkonium chloride. Among these, cetylpyridinium chloride and benzethonium chloride are preferable.

  The method for obtaining the component (A) is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include a synthesis method and a commercially available method.

-Dipotassium glycyrrhizinate-
The dipotassium glycyrrhizinate is a compound having an anti-inflammatory action represented by C ₄₂ H ₆₀ K ₂ O ₁₆ .
The method for obtaining the dipotassium glycyrrhizinate is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include a synthesis method, a method for extracting from a plant, and a method using a commercially available product.

-Content-
There is no restriction | limiting in particular as content of the said (A) component in the said undiluted gargle composition, Although it can select suitably according to the objective, 0.001 mass%-0.02 mass% are preferable, 0.002 mass%-0.01 mass% is more preferable. When the content of the component (A) is less than 0.001% by mass, at least one of the bactericidal action and the anti-inflammatory action may be lowered.
When the component (A) is a quaternary ammonium salt type fungicide, if the content of the quaternary ammonium salt type fungicide exceeds 0.02% by mass, the bitterness becomes strong and the use becomes difficult. There is.
When the component (A) is dipotassium glycyrrhizinate, when the content of dipotassium glycyrrhizinate exceeds 0.02% by mass, sweetness becomes strong and it may be difficult to use.

<(B) component>
The component (B), at least one selected from methyl butyrate, ethyl butyrate, ethyl acetate, pentyl acetate, and hexyl acetate, is blended for the purpose of suppressing foaming. Among these, the component (B) is preferably ethyl butyrate, pentyl acetate, and hexyl acetate.

  The method for obtaining the component (B) is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include a synthesis method and a commercially available method.

  Although content of the said (B) component is 0.01 mass%-0.1 mass%, 0.02 mass%-0.05 mass% are preferable at a point with a foaming suppression effect and a bitterness suppression effect high. . If the content of the component (B) is less than 0.01% by mass, foaming may not be sufficiently suppressed, and if it exceeds 0.1% by mass, the bitterness becomes strong and difficult to use. May be.

<(B) / (A) (mass ratio)>
The mass ratio of the component (A) and the component (B) is (B) / (A) = 1 to 5, but it has a high effect of suppressing foaming and suppressing bitterness. ~ 4 is preferred. When the mass ratio is less than 1, foaming may not be sufficiently suppressed. When the mass ratio exceeds 5, the bitterness may become strong and use may be difficult.

<(C) component>
It is preferable that the undiluted gargle composition further contains an alkanediol having 2 to 6 carbon atoms, which is the component (C), in terms of enhancing the effect of suppressing foaming.

The component (C) is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include propylene glycol, dipropylene glycol, 1,3-butylene glycol, hexylene glycol and 1,2-pentanediol. , 3-methyl-1,3-butanediol and the like. These may be used alone or in combination of two or more.
Among these, as for the said (C) component, propylene glycol is preferable at the point which the effect | action which suppresses foaming is high.

  The content of (C) in the undiluted gargle composition is 1% by mass to 20% by mass, but preferably 5% by mass to 15% by mass. If the content of the component (C) is less than 1% by mass, foaming may not be sufficiently suppressed, and if it exceeds 20% by mass, the bitterness may become strong and difficult to use. .

<(D) component>
The undiluted gargle composition can further add moisture to the oral cavity by blending at least one of the polyhydric alcohol and sugar alcohol as component (D). In the use of a person having a dry mouth condition such as), it is preferable in that a moisturizing effect can be obtained by gargle.

When the component (D) is a polyhydric alcohol, the type thereof is at least one of polyethylene glycol, polypropylene glycol that is at least tripolymerized, glycerin, and polyglycerin.
When the component (D) is a sugar alcohol, the type thereof is not particularly limited and may be appropriately selected depending on the purpose. For example, erythritol, pentaerythritol, dipentaerythritol, maltitol, xylitol, inositol And sorbitol. These may be used alone or in combination of two or more.
Among these, the (D) component is preferably glycerin or sorbitol from the viewpoint of imparting flavor and moisturizing feeling.

  In the case where the component (D) is polyethylene glycol, the polyethylene glycol is defined in Cosmetic Raw Material Standards Second Edition Comment, Quasi-drug Raw Material Standard 2006, Japanese Pharmacopoeia Pharmaceutical Standard 2002, 15th Revised Japanese Pharmacopoeia Polyethylene glycol is preferable, and specific examples thereof include polyethylene glycol 200 (average molecular weight 190 to 210), polyethylene glycol 300 (average molecular weight 280 to 320), polyethylene glycol 400 (average molecular weight 380 to 420), polyethylene glycol 600 (average molecular weight). 570-630), polyethylene glycol 1,500 (equal mixture of polyethylene glycol 300 and polyethylene glycol 1,540), polyethylene glycol 1,540 (average molecular weight 1,290-1,650), poly Ethylene glycol 4,000 (average molecular weight 2,600-3,800), polyethylene glycol 6,000 (average molecular weight 7,300-9,300), polyethylene glycol 20,000 (average molecular weight 15,500-25,000) Macrogol 400 (average molecular weight 380-420), Macrogol 1,500 (equal mixture of polyethylene glycol 300 and polyethylene glycol 1,540), Macrogol 4,000 (average molecular weight 2,600-3,800) Macrogol 6,000 (average molecular weight 7,300 to 9,300), macrogol 20,000 (average molecular weight 15,500 to 25,000), and the like.

  Specific examples of the polyethylene glycol include PEG # 200 corresponding to polyethylene glycol 200, PEG # 300 corresponding to polyethylene glycol 300, PEG # 400 corresponding to polyethylene glycol 400, Macrogol 400, and PEG corresponding to polyethylene glycol 600. # 600, PEG # 1000 equivalent to polyethylene glycol 1,000, PEG # 1500 equivalent to polyethylene glycol 1,500, Macrogol 1500, PEG # 1540 equivalent to polyethylene glycol 1,540, equivalent to polyethylene glycol 4,000 PEG # 4000, Macrogol 4000, equivalent to polyethylene glycol 6,000, PEG # 6000, Macrogol 6000, polyethylene glycol PEG # 20000 or macro goal 20000 (manufactured by Nippon Oil Co., Ltd.), which corresponds to 20,000 and the like.

  The content of the component (D) in the undiluted gargle composition is 5% by mass to 20% by mass, but preferably 10% by mass to 15% by mass. When the content of the component (D) is less than 5% by mass, a sufficient moisturizing feeling may not be realized, and when it exceeds 20% by mass, the stickiness becomes strong and the usability may deteriorate. is there.

<(E) component>
It is preferable that the undiluted gargle composition further contains hydroxyethyl cellulose as component (E) in terms of imparting a moisturizing feeling to the oral cavity.

There is no restriction | limiting in particular as a weight average molecular weight of the said (E) component, Although it can select suitably according to the objective, 100,000-1.6 million are preferable and 100,000-400,000 are more preferable. Those having a weight average molecular weight of less than 100,000 are difficult to obtain, and even if they are blended, a sufficient thickening effect cannot be obtained and a sufficient moisturizing feeling may not be realized. When the weight average molecular weight exceeds 1.6 million, foaming may occur during gargle, and stickiness may become strong, resulting in poor usability.
On the other hand, when the weight average molecular weight is in the preferred range, it is preferable in that the feeling of foaming and stickiness at the time of gargling is small and the usability can be improved.

  Specific examples of the component (E) include SP200 (weight average molecular weight (Mw) 120,000, viscosity of 5% by mass aqueous solution 60 mPa · s to 110 mPa · s), SP400 and SE400 (weight average molecular weight (Mw) 250,000, 2 mass% aqueous solution viscosity 80 mPa · s to 130 mPa · s), SP500 and SE500 (weight average molecular weight (Mw) 380,000, 2 mass% aqueous solution viscosity 300 mPa · s to 400 mPa · s), SP550 and SE550 (weight average molecular weight) (Mw) Viscosity of 500,000 and 2% by weight aqueous solution, 1,000 to 2,000 mPa · s), SP600 and SE600 (weight average molecular weight (Mw) of 1020,000, viscosity of 2% by weight aqueous solution of 4,800 mPa · s to 6, 000 mPa · s), SP750 and SE750 (weight average molecular weight (Mw) 1,210,000, 2% by weight aqueous solution 1,000 mPa · s to 1,500 mPa · s) SP850 and SE850 (weight average molecular weight (Mw) 1,480,000, viscosity of 2 mass% aqueous solution 2,400 mPa · s to 3,000 mPa · s), SP900 and SE900 (weight) And an average molecular weight (Mw) of 1,560,000, and a viscosity of 4,000 mPa · s to 5,500 mPa · s of a 2 mass% aqueous solution (above, manufactured by Daicel Chemical Industries, Ltd.).

  The method for measuring the weight average molecular weight of the component (E) is not particularly limited and can be appropriately selected from commonly used measurement methods according to the purpose. For example, a commonly used measurement method Among them, there is a method of measuring with a SEC-MALLS-RI system. When measuring with the SEC-MALLS-RI system, specific examples of measurement conditions are as follows.

Apparatus: SEC-MALLS-RI system autosampler (model 123, manufactured by System Instruments)
Pump (DS-4, manufactured by Showa Denko KK)
Column oven (SSC-2100, manufactured by Senshu Kagaku Co., Ltd.)
Multi-angle light scattering detector (MALLS: detection wavelength 632.8 nm) (DAWN DSP-F, manufactured by Wyatt Technology)
Differential refractometer (RI-71: D2 lamp, manufactured by Showa Denko KK)
Column: α-M + α-2500 (manufactured by Tosoh Corporation)
Sample concentration: 1,000 ppm
Sample solvent, mobile phase: 0.1 mol / L sodium chloride Temperature: 40 ° C
Flow rate: 0.5 mL / min Standard substance: Pullulan (SHODEX P-50 (molecular weight 50,000), Showa Denko KK)

There is no restriction | limiting in particular as a measuring method of the viscosity of the said (E) component, According to the objective, it can select suitably from the measuring methods generally used, For example, it is a measuring method generally used. Examples include a method of measuring with a BM viscometer.
When the viscosity of the component (E) is 10 mPa · s or more and less than 1,000 mPa · s when measured with the BM type viscometer, the rotor no. 2. It is preferable to measure the viscosity after 1 minute at 30 rpm.
When the viscosity of the component (E) is 1,000 mPa · s or more and less than 10,000 mPa · s, the sample temperature is 25 ° C. and the rotor No. 4. It is preferable to measure the viscosity after 1 minute at 60 rpm.

  There is no restriction | limiting in particular as content of the said (E) component in the said undiluted gargle composition, Although it can select suitably according to the objective, The viscosity of the said undiluted gargle composition is 10 mPa * s. It is preferable to mix | blend so that it may become -100mPa * s, 0.3 mass%-5 mass% are more preferable, 0.3 mass%-3 mass% are still more preferable. When the content of the component (E) is less than 0.3% by mass, a sufficient thickening effect cannot be obtained and a sufficient moisturizing feeling may not be realized. If it exceeds, foaming may occur during gargle, and stickiness may become stronger and the feeling of use may worsen.

<Other ingredients>
There is no restriction | limiting in particular as said other component, According to the objective, it can select suitably, For example, pharmacologically acceptable carriers, such as water, starch, ethanol, various additives, etc. are mentioned.
There is no restriction | limiting in particular as content of the said other component in the said undiluted gargle composition, According to the objective, it can select suitably in the range which does not impair the effect of this invention.

  The additive is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include surfactants such as anionic surfactants, cationic surfactants, and zwitterionic surfactants, and inorganic powders. , Water-insoluble powders such as organic powders, polymer compounds, moisturizers excluding component (D) and component (E), vitamins, amino acids, anti-inflammatory agents excluding component (A), A) Bactericides excluding components, ultraviolet absorbers, cooling sensation agents, antioxidants, colorants, antiperspirants, deodorants, preservatives, inclusion compounds, solvents other than the component (B), etc. It is done. These may be used alone or in combination of two or more.

<Viscosity>
There is no restriction | limiting in particular as a viscosity of the said undiluted gargle composition, Although it can select suitably according to the objective, 10 mPa * s-100 mPa * s are preferable and 10 mPa * s-60 mPa * s are more preferable. When the viscosity is less than 10 mPa · s, it may not be possible to realize a sufficient moisturizing feeling, and when it exceeds 100 mPa · s, the stickiness may become strong and the usability may deteriorate.
In general, when such a thickening is imparted to the gargle composition, there is a problem in that foaming is enhanced, but the undiluted gargle composition of the present invention imparts a moisturizing feeling due to moisturizing by appropriate thickening. It is advantageous in that it can be produced and has less foaming.

  The method for measuring the viscosity of the undiluted gargle composition is not particularly limited, and can be appropriately selected according to the purpose from commonly used measurement methods. For example, a commonly used measurement Using a BM viscometer, which is the method, at a sample temperature of 25 ° C., the rotor No. 1, a method of measuring the viscosity after 60 rpm and 1 minute, and the like.

<Use>
The said undiluted gargle composition may be used individually by 1 type, and may be used in combination with the undiluted gargle composition which uses another component as an active ingredient. Moreover, you may use the said undiluted gargle composition in the state mix | blended with the undiluted gargle composition which uses another component as an active ingredient.

<Manufacturing method>
There is no restriction | limiting in particular as a manufacturing method of the said undiluted gargle composition, Although it can select suitably according to the objective, When adding the said (E) component, it mixes with the component except this (E) component. After preparing the liquid, a method in which the component (E) is added little by little while stirring the mixed liquid and swollen is preferable. Thereby, moderate viscosity can be provided to the undiluted gargle composition.

<How to use>
The undiluted gargle composition is used without being diluted. By using the undiluted gargle composition undiluted, each component in the undiluted gargle composition can act in the oral cavity at a high concentration, improve the moisturizing feeling, and maintain it. Can also be improved. Furthermore, since the water used for dilution is unnecessary, it can be used anytime, and it is preferable also from the point of being excellent in portability.

  There is no restriction | limiting in particular as the usage-amount of the said undiluted gargle composition, the usage time per time, and the frequency | count of usage, Although it can select suitably according to the objective, 50mL should be divided into several times and used. Is preferred.

<Application>
The undiluted gargle composition has a bactericidal action and an anti-inflammatory action, has less foaming, has good portability, has no bitterness or irritation, and has a good feeling of use, and thus can be suitably used as a gargle.
In addition, the method of using the undiluted gargle composition can be suitably used for gargle without selecting a place, and even if bubbling in the oral cavity with the mouth open, the oral cavity is sterilized without spilling from the mouth. Therefore, it can be suitably used as a method for suppressing inflammation.

  EXAMPLES The present invention will be specifically described below with reference to examples of the present invention, but the present invention is not limited to these examples. In the following examples, “%” represents “% by mass”, and all the component amounts described in Examples and Comparative Examples are in terms of pure content.

(Examples 1-5, Comparative Examples 2-5)
Under the temperature condition of about 40 ° C., according to the composition shown in Table 1 and Table 5, the components (A), (B) and purified water were added to a beaker and stirred with a stirrer, and Examples 1 to 5 and Undiluted gargle compositions of Comparative Examples 2 to 5 were prepared.

(Examples 6 to 20, Comparative Example 6)
Example (A), (B) component, (C) component, and purified water were added to a beaker under a temperature condition of about 40 ° C. according to the compositions shown in Tables 2 to 5 and stirred with a stirrer. Undiluted gargle compositions of 6 to 20 and Comparative Example 6 were prepared.

(Comparative Example 1)
In Examples 1-5 and Comparative Examples 2-5, according to the composition shown in Table 5, except that component (B) was not added, a comparison was made in the same manner as in Examples 1-5 and Comparative Examples 2-5. The undiluted gargle composition of Example 1 was prepared.

(Comparative Example 7)
In Examples 6 to 20 and Comparative Example 6, the same method as in Examples 6 to 20 and Comparative Example 6 except that the component (B ′) was added instead of the component (B) according to the composition shown in Table 5. The undiluted gargle composition of Comparative Example 7 was prepared.

  About the undiluted gargle composition of Examples 1-20 and Comparative Examples 1-7, sensory evaluation was performed about the foaming and bitterness at the time of gargling with the following method.

<Evaluation of foaming>
Using 10 g of the undiluted gargle composition of Examples 1 to 20 and Comparative Examples 1 to 7, and bubbling for 10 seconds with the mouth open, the following evaluation was conducted by 10 panelists on the foaming in the state of opening the mouth. Sensory evaluation was performed according to the standard. The average value of evaluation of 10 panelists was calculated, and the determination was made based on the following criteria. The results are shown in Tables 1-5.
[Evaluation criteria]
5 points: No foaming 4 points: Slightly foaming but not spilling from the mouth 3 points: Foaming, foam comes to the edge of the mouth, but does not spill from the mouth 2 points: Quite foaming, foam comes out of the edge of the mouth, Bubbles splash on the face 1 point: Very foamy, foam flows out of the edge of the mouth [Criteria]
A: 4.7 to 5.0 points B: 4.5 to less than 4.7 points C: 4.0 to 4.5 points D: 3.0 to less than 4.0 points E: 2 .0 or more and less than 3.0 points F: Less than 2.0 points

<Evaluation of bitterness>
Using 10 g of the undiluted gargle composition of Examples 1-20, gargle for 10 seconds with the mouth open, and perform a sensory evaluation on the bitter taste in the mouth after spitting out according to the following evaluation criteria by 10 panelists It was. The average value of evaluation of 10 panelists was calculated, and the determination was made based on the following criteria. The results are shown in Tables 1-5.
[Evaluation criteria]
5 points: no bitterness 4 points: slightly bitter 3 points: slightly bitter 2 points: bitterness 1 point: considerably bitter [Criteria]
A: 4.7 to 5.0 points B: 4.5 to less than 4.7 points C: 4.0 to 4.5 points D: 3.0 to less than 4.0 points E: 2 .0 or more and less than 3.0 points F: Less than 2.0 points

(Examples 21 to 42, Comparative Example 8)
Under a temperature condition of about 40 ° C., in accordance with the composition shown in Tables 5 to 8, add (A) component, (B) component, (C) component, (D) component, and purified water to the beaker, A mixed solution was prepared by stirring. Next, the undiluted gargle composition of Examples 21 to 42 and Comparative Example 8 was prepared by adding the component (E) to this mixed solution little by little and allowing it to swell.

(Example 43)
Under the temperature condition of about 40 ° C., according to the composition shown in Table 9, the components (A), (B), (C), and purified water were added to the beaker and stirred with a stirrer. An undiluted gargle composition was prepared.

  About the undiluted gargle composition of Examples 21-43 and Comparative Example 8, sensory evaluation was performed about the foaming and bitterness at the time of a gargling by the method similar to Examples 1-20. Moreover, the moisturizing feeling and greasy sensory evaluation after gargling, and the viscosity were measured by the following methods.

<Measurement of viscosity>
The viscosities of Examples 21 to 43 and Comparative Example 8 were measured using a BM viscometer (manufactured by Tokyo Keiki Co., Ltd.) at a sample temperature of 25 ° C. 1. Viscosity after 1 minute at 60 rpm. The results are shown in Tables 6-9.

<Evaluation of moisturizing feeling>
Using 10 g of the undiluted gargle composition of Examples 21 to 43 and Comparative Example 8, gargle for 10 seconds with the mouth open, and for the moist feeling in the mouth after vomiting, the following evaluation criteria were given by 10 panelists Sensory evaluation was performed according to The average value of evaluation of 10 panelists was calculated, and the determination was made based on the following criteria. The results are shown in Tables 6-9.
[Evaluation criteria]
5 points: feels very moist 4 points: feels very moist 3 points: feels moist 2 points: feels slightly moist 1 point: does not feel moist [Criteria]
A: 4.7 to 5.0 points B: 4.5 to less than 4.7 points C: 4.0 to 4.5 points D: 3.0 to less than 4.0 points E: 2 .0 or more and less than 3.0 points F: Less than 2.0 points

<Evaluation of stickiness>
Using 10 g of the undiluted gargle composition of Examples 21 to 43 and Comparative Example 8, gargle for 10 seconds with the mouth open, and the stickiness feeling in the mouth after spitting out, the following evaluation criteria were given by 10 panelists Sensory evaluation was performed according to The average value of evaluation of 10 panelists was calculated, and the determination was made based on the following criteria. The results are shown in Tables 6-9.
[Evaluation criteria]
5 points: No stickiness 4 points: Feels slightly sticky 3 points: Feels slightly sticky 2 points: Feels sticky 1 point: Feels sticky [Criteria]
A: 4.7 to 5.0 points B: 4.5 to less than 4.7 points C: 4.0 to 4.5 points D: 3.0 to less than 4.0 points E: 2 .0 or more and less than 3.0 points F: Less than 2.0 points

(Prescription Example 1)
In Examples 21-43 and Comparative Example 8, instead of the compositions in Tables 6-9, the non-formulation of Formulation Example 1 was performed in the same manner as in Examples 21-43 and Comparative Example 8, except that the following compositions were followed. A diluted gargle composition was obtained.
[composition]
Cetylpyridinium chloride (component (A)) 0.005%
Dipotassium glycyrrhizinate (component (A)) 0.005%
Glycerin 10.0%
Hydroxyethyl cellulose (weight average molecular weight 14.48 million) ((component E)) 0.3%
Propylene glycol (component (C)) 10.0%
Menthol 0.005%
Eucalyptus oil 0.0005%
Blue No. 1 0.04ppm
Ethyl butyrate (component (B)) 0.02%
Saccharin sodium hydrate 0.0005%
Purified water balance 100%
Viscosity 30mPa · s

  The raw materials used in Examples 1 to 43, Comparative Examples 1 to 8, and Formulation Example 1 are as shown in Table 10.

The undiluted gargle composition of the present invention has a bactericidal action and an anti-inflammatory action, has less foaming, has good portability, and has a good feeling of use without bitterness or irritation, and can be suitably used as a gargle. is there.
Further, the method of using the undiluted gargle composition of the present invention can be suitably used for gargle without selecting a place, and even if bubbling is carried out in the oral cavity with the mouth open, the foam does not spill from the mouth. Can be suitably used as a method of sterilizing and suppressing inflammation.

Claims (4)

At least one selected from quaternary ammonium salt type fungicides and dipotassium glycyrrhizinate (component (A)) and methyl butyrate, ethyl butyrate, ethyl acetate, pentyl acetate, and hexyl acetate ((B) Component), and
The content of the component (B) is 0.01% by mass to 0.1% by mass,
An undiluted gargle composition, wherein the mass ratio of the component (A) to the component (B) is (B) / (A) = 1-5.   The undiluted gargle composition according to claim 1, further comprising an alkanediol having 2 to 6 carbon atoms (component (C)), wherein the content of the component (C) is 1% by mass to 20% by mass. At least one of a polyhydric alcohol and a sugar alcohol (component (D)) and hydroxyethyl cellulose (component (E)),
The polyhydric alcohol is at least one of polyethylene glycol, polypropylene glycol that is at least three polymerizations, glycerin, and polyglycerin,
The content of the component (D) is 5% by mass to 20% by mass,
The undiluted gargle composition according to claim 1, which has a viscosity at 25 ° C. of 10 mPa · s to 100 mPa · s.   A method for using the undiluted gargle composition according to any one of claims 1 to 3 without dilution.