JP2012016294A5 - - Google Patents
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- JP2012016294A5 JP2012016294A5 JP2010154096A JP2010154096A JP2012016294A5 JP 2012016294 A5 JP2012016294 A5 JP 2012016294A5 JP 2010154096 A JP2010154096 A JP 2010154096A JP 2010154096 A JP2010154096 A JP 2010154096A JP 2012016294 A5 JP2012016294 A5 JP 2012016294A5
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久保田哲朗、週刊医学のあゆみ ２１７巻９号、８６９−８７３頁（２００７年）
入野田崇ら、日本消化器外科学会誌 ３２巻７号、１９５５−１９６１頁（１９９９年）
Ｆａｋｈｒｅｊａｈａｎｉ Ｅ．ら、Ｃａｎｃｅｒ Ｃｈｅｍｏｔｈｅｒａｐｙ ａｎｄ Ｐｈａｒｍａｃｏｌｏｇｙ，６０，４３７−４４６（２００７）
Ｈｕａ Ｄ．ら、Ｗｏｒｌｄ Ｊｏｕｒｎａｌ ｏｆ Ｇａｓｔｒｏｅｎｔｒｏｌｏｇｙ，１３（３７），５０３０−５０３４（２００７）
Ｂｏｋｕ Ｎ．ら、Ｊａｐａｎｅｓｅ Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｏｎｃｏｌｏｇｙ，３７（４），２７５−２８１（２００７）
Ｎａｋａｊｉｍａ Ｔ．ら、Ｂｒｉｔｉｓｈ Ｊｏｕｒｎａｌ ｏｆ Ｓｕｒｇｅｒｙ，９４（１２），１４６８−１４７６（２００７）
Ｓａｋｕｒａｍｏｔｏ Ｓ．ら、Ｎｅｗ Ｅｎｇｌａｎｄ Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎｅ，３５７，１８１０−１８２０（２００７）
このｍｉＲＮＡセットへのｍｉＲＮＡの組み入れは、Ｗｉｌｃｏｘｏｎ検定のｐ値が小さい順に繰り返し、最大のＥｆｆｉｃａｃｙを得られた時点の遺伝子（ポリヌクレオチド）のセットを求めた。その結果を図３に示す。図３の縦軸は胃がんの補助化学療法感受性を判定できる確率を、横軸は表１に記載の配列番号の順に増やした、胃がんの補助化学療法感受性の有無の判定に必要なｍｉＲＮＡ（ポリヌクレオチド）の合計数をそれぞれ示す。例えば、横軸の数字が５のときは表１の配列番号１〜５のｍｉＲＮＡ（ポリヌクレオチド）の組み合わせで予測した結果を、２０のときは配列番号１〜２０のｍｉＲＮＡ（ポリヌクレオチド）の組み合わせで予測した結果がそれぞれ示されている。１３種類のｍｉＲＮＡ（ポリヌクレオチド）のセットの場合にＥｆｆｉｃａｃｙが最大であり、８１％であった。以上のとおり、５−ＦＵ系プロドラッグによる補助化学療法感受性の有無を非常に高い確率で判定できるｍｉＲＮＡ（ポリヌクレオチド）のセットが見出された。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010154096A JP5755849B2 (ja) | 2010-07-06 | 2010-07-06 | 胃がんの補助化学療法感受性判定用組成物又はキット |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010154096A JP5755849B2 (ja) | 2010-07-06 | 2010-07-06 | 胃がんの補助化学療法感受性判定用組成物又はキット |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012016294A JP2012016294A (ja) | 2012-01-26 |
| JP2012016294A5 true JP2012016294A5 (ja) | 2013-08-15 |
| JP5755849B2 JP5755849B2 (ja) | 2015-07-29 |
Family
ID=45602028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010154096A Expired - Fee Related JP5755849B2 (ja) | 2010-07-06 | 2010-07-06 | 胃がんの補助化学療法感受性判定用組成物又はキット |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP5755849B2 (ja) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2005007846A1 (ja) * | 2003-04-25 | 2006-08-31 | 財団法人癌研究会 | 腫瘍細胞の抗癌剤に対する感受性を判定する方法 |
| WO2007148235A2 (en) * | 2006-05-04 | 2007-12-27 | Rosetta Genomics Ltd | Cancer-related nucleic acids |
| EP2041309A1 (en) * | 2006-06-22 | 2009-04-01 | Oryzon Genomics, S.A. | Prognostic method in colorectal cancer |
| WO2008112283A2 (en) * | 2007-03-12 | 2008-09-18 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Microrna profiling of androgen responsiveness for predicting the appropriate prostate cancer treatment |
| WO2008138578A2 (en) * | 2007-05-11 | 2008-11-20 | Medical Prognosis Institute | Methods, kits, and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy |
| US20090263803A1 (en) * | 2008-02-08 | 2009-10-22 | Sylvie Beaudenon | Mirnas differentially expressed in lymph nodes from cancer patients |
| JP2012039876A (ja) * | 2008-12-26 | 2012-03-01 | Univ Of Tokushima | ＭｉｃｒｏＲＮＡによる直腸癌に対する術前化学放射線療法の効果予測 |
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2010
- 2010-07-06 JP JP2010154096A patent/JP5755849B2/ja not_active Expired - Fee Related
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