JP2011530309A - 多価ワクチン - Google Patents
多価ワクチン Download PDFInfo
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- JP2011530309A JP2011530309A JP2011523001A JP2011523001A JP2011530309A JP 2011530309 A JP2011530309 A JP 2011530309A JP 2011523001 A JP2011523001 A JP 2011523001A JP 2011523001 A JP2011523001 A JP 2011523001A JP 2011530309 A JP2011530309 A JP 2011530309A
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- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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| JP2016533181A (ja) * | 2013-10-16 | 2016-10-27 | ニユー・イングランド・バイオレイブス・インコーポレイテツド | 強化された特性を有する逆転写酵素 |
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| AU2006283101B2 (en) | 2005-08-23 | 2013-03-07 | Beth Israel Deaconess Medical Center | Polyvalent vaccine |
| US7951377B2 (en) | 2005-08-23 | 2011-05-31 | Los Alamos National Security, Llc | Mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens |
| PT2358757T (pt) | 2008-11-18 | 2018-12-04 | Beth Israel Deaconess Medical Ct Inc | Vacinas antivirais com imunogenicidade celular melhorada |
| EP2739300B1 (en) | 2011-07-05 | 2019-06-19 | Duke University | N-terminal deleted gp120 immunogens |
| CA2850745C (en) * | 2011-10-03 | 2022-12-13 | Duke University | Vaccine |
| CN104955450A (zh) | 2012-12-13 | 2015-09-30 | 达拉斯贝勒研究院 | 用于治疗葡萄糖转运体1缺乏症的三庚酸甘油酯 |
| WO2015048785A2 (en) * | 2013-09-30 | 2015-04-02 | Los Alamos National Security, Llc | Mosaic conserved region hiv immunogenic polypeptides |
| EP3119890A4 (en) | 2014-03-19 | 2017-12-27 | Duke University | Swarm immunization with envelopes from ch505 |
| JP2017512499A (ja) * | 2014-03-25 | 2017-05-25 | デューク ユニバーシティ | モザイクｈｉｖ−１配列およびその使用 |
| EP3126502A4 (en) | 2014-03-31 | 2018-01-17 | Duke University | Compositions comprising ch848 envelopes and uses thereof |
| US10232034B2 (en) | 2014-09-28 | 2019-03-19 | Duke University | Compositions comprising CH505 envelopes, and trimers |
| WO2017151801A1 (en) | 2016-03-01 | 2017-09-08 | Duke University | Compositions comprising hiv envelopes to induce ch235 lineage antibodies |
| US11318197B2 (en) | 2016-03-03 | 2022-05-03 | Duke University | Compositions and methods for inducing HIV-1 antibodies |
| WO2017152146A2 (en) | 2016-03-03 | 2017-09-08 | Duke University | Compositions and methods for inducing hiv-1 antibodies |
| WO2018067580A1 (en) | 2016-10-03 | 2018-04-12 | Duke University | Methods to identify immunogens by targeting improbable mutations |
| WO2018075559A1 (en) | 2016-10-17 | 2018-04-26 | Beth Israel Deaconess Medical Center, Inc. | Signature-based human immunodeficiency virus (hiv) envelope (env) trimer vaccines and methods of using the same |
| EP3630174A4 (en) | 2017-05-25 | 2021-07-07 | Duke University | MODIFIED COMPOSITIONS CONTAINING HIV ENVELOPE PROTEINS |
| US12138304B2 (en) | 2018-10-01 | 2024-11-12 | Duke University | HIV-1 envelope stabilizing mutations |
| EP3999107A1 (en) | 2019-07-16 | 2022-05-25 | Gilead Sciences, Inc. | Hiv vaccines and methods of making and using |
| US12053517B2 (en) | 2021-01-14 | 2024-08-06 | Gilead Sciences, Inc. | HIV vaccines and methods of using |
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| WO2005028625A2 (en) * | 2003-09-17 | 2005-03-31 | Duke University | Consensus/ancestral immunogens |
| US20050137387A1 (en) * | 2000-02-18 | 2005-06-23 | University Of Washington Office Of Technology Licensing | Ancestral and COT viral sequences, proteins and immunogenic compositions |
Family Cites Families (19)
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| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US6139843A (en) * | 1991-04-02 | 2000-10-31 | Albert Einstein College Of Medicine Of Yeshiva University | Peptide compositions for the treatment of HIV |
| US6541011B2 (en) * | 1998-02-11 | 2003-04-01 | Maxygen, Inc. | Antigen library immunization |
| US6503753B1 (en) * | 1998-02-13 | 2003-01-07 | Adan Rios | Method for the development of an HIV vaccine |
| US20030180314A1 (en) * | 1998-07-10 | 2003-09-25 | Degroot Anne | Immunogenic, cross-clade, HIV peptides |
| US7935805B1 (en) * | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
| US6710173B1 (en) * | 1999-06-25 | 2004-03-23 | Progenics Pharmaceuticals, Inc. | Stabilized viral envelope proteins and uses thereof |
| US20040115621A1 (en) * | 2000-02-18 | 2004-06-17 | Allen Rodrigo | Ancestral viruses and vaccines |
| US6733993B2 (en) * | 2000-09-15 | 2004-05-11 | Merck & Co., Inc. | Enhanced first generation adenovirus vaccines expressing codon optimized HIV1-gag, pol, nef and modifications |
| US7195768B2 (en) | 2001-11-07 | 2007-03-27 | Duke University | Polyvalent immunogen |
| WO2003039470A2 (en) * | 2001-11-07 | 2003-05-15 | Duke University | Polyvalent immunogen of hiv |
| WO2005012502A2 (en) * | 2003-03-28 | 2005-02-10 | Idm Pharma, Inc. | Methods of identifying optimal variants of peptide epitopes |
| ATE520708T1 (de) * | 2003-03-28 | 2011-09-15 | Us Gov Health & Human Serv | Immunogenetische hiv-1 multi-klade, multivalente konstrukte und deren verwendung |
| EP1675613B1 (en) * | 2003-09-15 | 2012-05-23 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Hiv vaccines based on env of multiple clades of hiv |
| WO2005035555A1 (en) * | 2003-10-10 | 2005-04-21 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hiv/siv env chimeras that promote trimerization and maintain targets of neutralizing antibodies |
| US7951377B2 (en) | 2005-08-23 | 2011-05-31 | Los Alamos National Security, Llc | Mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens |
| AU2006283101B2 (en) | 2005-08-23 | 2013-03-07 | Beth Israel Deaconess Medical Center | Polyvalent vaccine |
| EP1954309A2 (en) | 2005-10-17 | 2008-08-13 | Novartis AG | Multiclade hiv vaccines |
| US20130273103A1 (en) | 2010-09-28 | 2013-10-17 | Los Alamos National Security, Llc | Polyvalent immunogen |
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2009
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- 2009-08-14 CN CN2009801404211A patent/CN102177175A/zh active Pending
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- 2009-08-14 AU AU2009282442A patent/AU2009282442B2/en not_active Ceased
- 2009-08-14 BR BRPI0917205A patent/BRPI0917205A2/pt not_active IP Right Cessation
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2011
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2017
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050137387A1 (en) * | 2000-02-18 | 2005-06-23 | University Of Washington Office Of Technology Licensing | Ancestral and COT viral sequences, proteins and immunogenic compositions |
| WO2005028625A2 (en) * | 2003-09-17 | 2005-03-31 | Duke University | Consensus/ancestral immunogens |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016533181A (ja) * | 2013-10-16 | 2016-10-27 | ニユー・イングランド・バイオレイブス・インコーポレイテツド | 強化された特性を有する逆転写酵素 |
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| US9044445B2 (en) | 2015-06-02 |
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| US9011873B2 (en) | 2015-04-21 |
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| WO2010019262A3 (en) | 2010-05-27 |
| CA2733898A1 (en) | 2010-02-18 |
| BRPI0917205A2 (pt) | 2015-11-10 |
| AU2009282442A1 (en) | 2010-02-18 |
| US20160067329A1 (en) | 2016-03-10 |
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| US20150265700A1 (en) | 2015-09-24 |
| EP2318430A2 (en) | 2011-05-11 |
| US20180185471A1 (en) | 2018-07-05 |
| US9821053B2 (en) | 2017-11-21 |
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