JP2011528718A5 - - Google Patents
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- Publication number
- JP2011528718A5 JP2011528718A5 JP2011520127A JP2011520127A JP2011528718A5 JP 2011528718 A5 JP2011528718 A5 JP 2011528718A5 JP 2011520127 A JP2011520127 A JP 2011520127A JP 2011520127 A JP2011520127 A JP 2011520127A JP 2011528718 A5 JP2011528718 A5 JP 2011528718A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- condition
- disease
- pain
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010013663 Drug dependence Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000002193 Pain Diseases 0.000 claims 2
- 208000007848 Alcoholism Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 206010011224 Cough Diseases 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 206010061173 Gastrointestinal motility disease Diseases 0.000 claims 1
- 208000003698 Heroin Dependence Diseases 0.000 claims 1
- 208000004454 Hyperalgesia Diseases 0.000 claims 1
- 208000007999 Hyperesthesia Diseases 0.000 claims 1
- 208000002551 Irritable Bowel Syndrome Diseases 0.000 claims 1
- 206010057852 Nicotine dependence Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 102000003840 Opioid Receptors Human genes 0.000 claims 1
- 108090000137 Opioid Receptors Proteins 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 206010038678 Respiratory depression Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 201000008286 diarrhea Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 230000003364 opioid Effects 0.000 claims 1
- 230000001575 pathological Effects 0.000 claims 1
Claims (4)
- オピオイド受容体の結合に関連する病態又は疾患を予防又は治療するための、請求項１〜２７のいずれか一項に記載の化合物の有効量を有効成分として含む、医薬製剤。
- 前記疾患又は病態が、痛み、かゆみ、下痢、過敏性腸症候群、胃腸運動障害、肥満症、呼吸抑制、痙攣、咳、痛覚過敏及び薬物嗜癖からなる群から選択される、請求項３１に記載の医薬製剤。
- 前記薬物嗜癖が、ヘロイン、コカイン、ニコチン及びアルコール嗜癖から選択される、請求項３２に記載の医薬製剤。
- 病態が痛みであり、組成物が更に、オピオイドの有効量を含む、請求項３２に記載の医薬製剤。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8225508P | 2008-07-21 | 2008-07-21 | |
| US61/082,255 | 2008-07-21 | ||
| PCT/US2009/051200 WO2010011619A1 (en) | 2008-07-21 | 2009-07-21 | Large substituent, non-phenolic amine opioids |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014204620A Division JP2015044819A (ja) | 2008-07-21 | 2014-10-03 | 大型置換基を有する非フェノール性アミンオピオイド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011528718A JP2011528718A (ja) | 2011-11-24 |
| JP2011528718A5 true JP2011528718A5 (ja) | 2012-01-12 |
| JP5727374B2 JP5727374B2 (ja) | 2015-06-03 |
Family
ID=41137538
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011520127A Active JP5727374B2 (ja) | 2008-07-21 | 2009-07-21 | 大型置換基を有する非フェノール性アミンオピオイド |
| JP2014204620A Pending JP2015044819A (ja) | 2008-07-21 | 2014-10-03 | 大型置換基を有する非フェノール性アミンオピオイド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014204620A Pending JP2015044819A (ja) | 2008-07-21 | 2014-10-03 | 大型置換基を有する非フェノール性アミンオピオイド |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100190817A1 (ja) |
| EP (1) | EP2318372B9 (ja) |
| JP (2) | JP5727374B2 (ja) |
| AU (1) | AU2009274147B2 (ja) |
| CA (1) | CA2731429C (ja) |
| ES (1) | ES2534055T3 (ja) |
| WO (1) | WO2010011619A1 (ja) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2318372B9 (en) * | 2008-07-21 | 2015-05-06 | Rensselaer Polytechnic Institute | Large substituent, non-phenolic amine opioids |
| AU2010326676B2 (en) | 2009-12-04 | 2013-03-14 | Alkermes Pharma Ireland Limited | Morphinan derivatives for the treatment of drug overdose |
| JP5964809B2 (ja) | 2010-03-22 | 2016-08-03 | レンセラール ポリテクニック インスティチュート | オピオイド受容体リガンドとしてのカルボキサミド基を含有するモルヒネ誘導体 |
| FI3446565T3 (fi) | 2010-08-23 | 2024-01-30 | Alkermes Pharma Ireland Ltd | Menetelmiä antipsykoottisten lääkkeiden aiheuttaman painonnousun hoitamiseksi |
| JP5981992B2 (ja) * | 2011-06-29 | 2016-08-31 | アルカーメス，インコーポレイテッド | 末梢作用オピオイド化合物 |
| US9211293B2 (en) | 2011-12-15 | 2015-12-15 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
| US9656961B2 (en) | 2013-05-24 | 2017-05-23 | Alkermes Pharma Ireland Limited | Methods for treating depressive symptoms |
| EP3004114B1 (en) | 2013-05-24 | 2019-12-25 | Alkermes Pharma Ireland Limited | Morphan and morphinan analogues, and methods of use |
| EP4243768A1 (en) | 2020-11-12 | 2023-09-20 | Alkermes Pharma Ireland Limited | Immediate release multilayer tablet |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002036573A2 (en) * | 2000-10-31 | 2002-05-10 | Rensselaer Polytechnic Institute | 8- substituted-2, 6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents |
| AU2003281060A1 (en) * | 2002-07-16 | 2004-02-02 | Rensselaer Polytechnic Institute | Process for conversion of phenols to carboxamides via the succinimide esters |
| CA2615774C (en) * | 2005-07-21 | 2014-12-09 | Rensselaer Polytechnic Institute | Large substituent, non-phenolic opioids |
| EP2318372B9 (en) * | 2008-07-21 | 2015-05-06 | Rensselaer Polytechnic Institute | Large substituent, non-phenolic amine opioids |
-
2009
- 2009-07-21 EP EP20090790652 patent/EP2318372B9/en active Active
- 2009-07-21 CA CA2731429A patent/CA2731429C/en active Active
- 2009-07-21 JP JP2011520127A patent/JP5727374B2/ja active Active
- 2009-07-21 US US12/506,354 patent/US20100190817A1/en not_active Abandoned
- 2009-07-21 ES ES09790652.3T patent/ES2534055T3/es active Active
- 2009-07-21 AU AU2009274147A patent/AU2009274147B2/en active Active
- 2009-07-21 WO PCT/US2009/051200 patent/WO2010011619A1/en active Application Filing
-
2014
- 2014-10-03 JP JP2014204620A patent/JP2015044819A/ja active Pending
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