JP2011528662A - ホジキン病の治療のためのｈｄａｃ阻害剤の使用 - Google Patents
ホジキン病の治療のためのｈｄａｃ阻害剤の使用 Download PDFInfo
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8180508P | 2008-07-18 | 2008-07-18 | |
| US61/081,805 | 2008-07-18 | ||
| PCT/US2009/050768 WO2010009280A1 (en) | 2008-07-18 | 2009-07-16 | Use of hdac inhibitors for the treatment of hodgkin's disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011528662A true JP2011528662A (ja) | 2011-11-24 |
| JP2011528662A5 JP2011528662A5 (enExample) | 2012-08-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2011518898A Pending JP2011528662A (ja) | 2008-07-18 | 2009-07-16 | ホジキン病の治療のためのｈｄａｃ阻害剤の使用 |
Country Status (15)
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| US (1) | US20110118309A1 (enExample) |
| EP (1) | EP2306996A1 (enExample) |
| JP (1) | JP2011528662A (enExample) |
| KR (1) | KR20110031980A (enExample) |
| CN (1) | CN102099021A (enExample) |
| AU (1) | AU2009270886A1 (enExample) |
| BR (1) | BRPI0915927A2 (enExample) |
| CA (1) | CA2730738A1 (enExample) |
| CL (1) | CL2011000100A1 (enExample) |
| IL (1) | IL210489A0 (enExample) |
| MA (1) | MA32482B1 (enExample) |
| MX (1) | MX2011000719A (enExample) |
| TW (1) | TW201006470A (enExample) |
| WO (1) | WO2010009280A1 (enExample) |
| ZA (1) | ZA201100165B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6082737B2 (ja) * | 2011-07-07 | 2017-02-15 | リサーチ キャンサー インスティテュート オブ アメリカＲｅｓｅａｒｃｈ Ｃａｎｃｅｒ Ｉｎｓｔｉｔｕｔｅ Ｏｆ Ａｍｅｒｉｃａ | がんを治療するためのシステム、方法、および製剤 |
| US8933078B2 (en) | 2011-07-14 | 2015-01-13 | Research Cancer Institute Of America | Method of treating cancer with combinations of histone deacetylase inhibitors (HDAC1) substances |
| WO2018157081A1 (en) | 2017-02-27 | 2018-08-30 | Research Cancer Institute Of America | Compositions, methods, systems and/or kits for preventing and/or treating neoplasms |
| WO2018170457A1 (en) | 2017-03-17 | 2018-09-20 | Research Cancer Institute Of America | Compositions, methods, systems and/or kits for preventing and/or treating neoplasms |
| CN109705057B (zh) * | 2017-10-25 | 2023-05-30 | 成都先导药物开发股份有限公司 | 组蛋白去乙酰化酶抑制剂及其制备方法与用途 |
| WO2019099750A1 (en) | 2017-11-17 | 2019-05-23 | Research Cancer Institute Of America | Compositions, methods, systems and/or kits for preventing and/or treating neoplasms |
| WO2021092153A1 (en) * | 2019-11-06 | 2021-05-14 | Dana-Farber Cancer Institute, Inc. | Selective dual histone deacetylase 6/8 (hdac6/8) degraders and methods of use thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004509105A (ja) * | 2000-09-01 | 2004-03-25 | ノバルティス アクチエンゲゼルシャフト | デアセチラーゼ阻害剤として有用なヒドロキサム酸誘導体 |
| WO2008002862A1 (en) * | 2006-06-26 | 2008-01-03 | Novartis Ag | Organic compounds |
| WO2008070011A2 (en) * | 2006-12-04 | 2008-06-12 | Novartis Ag | Combination of an hdac inhibitor and an antimetabolite |
-
2009
- 2009-07-16 EP EP09790500A patent/EP2306996A1/en not_active Withdrawn
- 2009-07-16 KR KR1020117003661A patent/KR20110031980A/ko not_active Withdrawn
- 2009-07-16 JP JP2011518898A patent/JP2011528662A/ja active Pending
- 2009-07-16 MX MX2011000719A patent/MX2011000719A/es not_active Application Discontinuation
- 2009-07-16 AU AU2009270886A patent/AU2009270886A1/en not_active Abandoned
- 2009-07-16 US US13/054,528 patent/US20110118309A1/en not_active Abandoned
- 2009-07-16 CA CA2730738A patent/CA2730738A1/en not_active Abandoned
- 2009-07-16 BR BRPI0915927A patent/BRPI0915927A2/pt not_active Application Discontinuation
- 2009-07-16 WO PCT/US2009/050768 patent/WO2010009280A1/en not_active Ceased
- 2009-07-16 CN CN2009801279739A patent/CN102099021A/zh active Pending
- 2009-07-17 TW TW098124315A patent/TW201006470A/zh unknown
-
2011
- 2011-01-06 IL IL210489A patent/IL210489A0/en unknown
- 2011-01-06 ZA ZA2011/00165A patent/ZA201100165B/en unknown
- 2011-01-14 MA MA33526A patent/MA32482B1/fr unknown
- 2011-01-17 CL CL2011000100A patent/CL2011000100A1/es unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004509105A (ja) * | 2000-09-01 | 2004-03-25 | ノバルティス アクチエンゲゼルシャフト | デアセチラーゼ阻害剤として有用なヒドロキサム酸誘導体 |
| WO2008002862A1 (en) * | 2006-06-26 | 2008-01-03 | Novartis Ag | Organic compounds |
| WO2008070011A2 (en) * | 2006-12-04 | 2008-06-12 | Novartis Ag | Combination of an hdac inhibitor and an antimetabolite |
Non-Patent Citations (6)
| Title |
|---|
| JPN5011009432; ＲＥＶＩＬＬ Ｐ: 'ＰＡＮＯＢＩＮＯＳＴＡＴ： ＨＩＳＴＯＮＥ ＤＥＡＣＥＴＹＬＡＳＥ （ＨＤＡＣ） ＩＮＨＩＢＩＴＯＲ ＡＰＯＰＴＯＳＩＳ ＩＮＤＵＣＥＲ ＯＮＣＯＬＹＴＩＣ' ＤＲＵＧＳ ＯＦ ＴＨＥ ＦＵＴＵＲＥ Ｖ３２ Ｎ４, 20070101, Ｐ３１５-３２２, ＰＲＯＵＳ ＳＣＩＥＮＣＥ * |
| JPN6013046733; Ｂｈａｌｌａ Ｓ， ｅｔ ａｌ．: 'Ｔｈｅ Ｂｒｏａｄ Ｓｐｅｃｔｒｕｍ ＨＤＡＣ Ｉｎｈｉｂｉｔｏｒ ＰＣＩ-２４７８１ Ｉｎｄｕｃｅｓ Ｃａｓｐａｓｅ- ａｎｄ ＲＯＳ-Ｄｅｐｅｎｄｅｎｔ Ａｐｏｐｔｏｓｉｓ ａｎｄ ｉｓ Ｓｙｎｅ' Ｎａｔｕｒｅ ｐｒｅｃｅｄｉｎｇｓ， ［ｏｎｌｉｎｅ］ , 20080712 * |
| JPN6013046735; Ｏ'Ｃｏｎｎｏｒ， ＯＡ: 'Ｃｌｉｎｉｃａｌ ｅｘｐｅｒｉｅｎｃｅ ｗｉｔｈ ｔｈｅ ｎｏｖｅｌ ｈｉｓｔｏｎｅ ｄｅａｃｅｔｙｌａｓｅ ｉｎｈｉｂｉｔｏｒ ｖｏｒｉｎｏｓｔａｔ （ｓｕｂｅｒｏｙｌａｎｉｌｉｄｅ ｈｙｄｒｏｘａ' Ｂｒｉｔｉｓｈ Ｊｏｕｒｎｌａ ｏｆ Ｃａｎｃｅｒ Ｖｏｌ．９５, 2006, ｐ．Ｓ７-Ｓ１２ * |
| JPN6013046736; Ｖｉｖｉａｎｉ Ｓ， ｅｔ ａｌ．: 'Ｐｈａｓｅ ＩＩ ｓｔｕｄｙ ｏｆ ｔｈｅ ｈｉｓｔｏｎｅ-ｄｅａｃｅｔｙｌａｓｅ ｉｎｈｉｂｉｔｏｒ ＩＴＦ２３５７ ｉｎ ｒｅｌａｐｓｅｄ／ｒｅｆｒａｃｔｏｒｙ Ｈｏｄｇｋｉｎ'ｓ ｌｙｍｐｈｏ' Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｏｎｃｏｌｏｇｙ， ２００８ ＡＳＣＯ Ａｎｎｕａｌ Ｍｅｅｔｉｎｇ Ｐｒｏｃｅｅｄｉｎｇｓ （Ｐｏｓｔ-Ｍｅｅｔｉｎｇ Ｅｄｉｔｉｏｎ）， ［ｏｎｌｉｎｅ］ Ｖｏｌ．２６， Ｎｏ．１５Ｓ, 20080520, ８５３２ * |
| JPN6013046738; Ｂｏｃｉｅｋ ＲＧ， ｅｔ ａｌ．: 'Ｉｓｏｔｙｐｅ-ｓｅｌｅｃｔｉｖｅ ｈｉｓｔｏｎｅ ｄｅａｃｅｔｙｌａｓｅ （ＨＤＡＣ） ｉｎｈｉｂｉｔｏｒ ＭＧＣＤ０１０３ ｄｅｍｏｎｓｔｒａｔｅｓ ｃｌｉｎｉｃａｌ ａｃｔｉｖｉｔｙ ａｎｄ ｓ' Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｏｎｃｏｌｏｇｙ， ２００８ ＡＳＣＯ Ａｎｎｕａｌ Ｍｅｅｔｉｎｇ Ｐｒｏｃｅｅｄｉｎｇｓ （Ｐｏｓｔ-Ｍｅｅｔｉｎｇ Ｅｄｉｔｉｏｎ）， ［ｏｎｌｉｎｅ］ Ｖｏｌ．２６， Ｎｏ．１５Ｓ, 20080520, ８５０７ * |
| JPN7013003503; Ｓｐｅｎｃｅｒ， Ａ， ｅｔ ａｌ．: 'ＯＲＡＬ ＰＡＮＯＢＩＮＯＳＴＡＴ （ＬＢＨ５８９）， Ａ ＮＯＶＥＬ ＤＥＡＣＥＴＹＬＡＳＥＩＮＨＩＢＩＴＯＲ （ＤＡＣＩ）， ＤＥＭＯＮＳＴＲＡＴＥＳ ＣＬＩＮＩＣＡＬ ＡＣＴＩＶＩＴＹ ＩＮＲＥ' Ａｎｎｕａｌｓ ｏｆ Ｏｎｃｏｌｏｇｙ Ｖｏｌ．１９， Ｓｕｐｐｌ．４, 200806, ｐ．ｉｖ１２８ * |
Also Published As
| Publication number | Publication date |
|---|---|
| CL2011000100A1 (es) | 2011-07-01 |
| TW201006470A (en) | 2010-02-16 |
| MA32482B1 (fr) | 2011-07-03 |
| EP2306996A1 (en) | 2011-04-13 |
| CA2730738A1 (en) | 2010-01-21 |
| MX2011000719A (es) | 2011-03-01 |
| KR20110031980A (ko) | 2011-03-29 |
| US20110118309A1 (en) | 2011-05-19 |
| CN102099021A (zh) | 2011-06-15 |
| AU2009270886A1 (en) | 2010-01-21 |
| WO2010009280A1 (en) | 2010-01-21 |
| ZA201100165B (en) | 2011-09-28 |
| BRPI0915927A2 (pt) | 2016-06-07 |
| IL210489A0 (en) | 2011-03-31 |
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