JP2011525169A5 - - Google Patents
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- Publication number
- JP2011525169A5 JP2011525169A5 JP2010546793A JP2010546793A JP2011525169A5 JP 2011525169 A5 JP2011525169 A5 JP 2011525169A5 JP 2010546793 A JP2010546793 A JP 2010546793A JP 2010546793 A JP2010546793 A JP 2010546793A JP 2011525169 A5 JP2011525169 A5 JP 2011525169A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- subject
- poly
- microorganism
- tlr3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 claims 18
- 206010028980 Neoplasm Diseases 0.000 claims 13
- 102000008230 Toll-like receptor 3 Human genes 0.000 claims 13
- 108010060885 Toll-like receptor 3 Proteins 0.000 claims 13
- 244000005700 microbiome Species 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 230000028993 immune response Effects 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 239000000556 agonist Substances 0.000 claims 2
- 230000000139 costimulatory effect Effects 0.000 claims 2
- 230000016396 cytokine production Effects 0.000 claims 2
- 210000004443 dendritic cell Anatomy 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 108090000944 RNA Helicases Proteins 0.000 claims 1
- 102000004409 RNA Helicases Human genes 0.000 claims 1
- 102000002689 Toll-like receptor Human genes 0.000 claims 1
- 108020000411 Toll-like receptor Proteins 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000004041 dendritic cell maturation Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 230000015788 innate immune response Effects 0.000 claims 1
- 238000010255 intramuscular injection Methods 0.000 claims 1
- 239000007927 intramuscular injection Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 210000003300 oropharynx Anatomy 0.000 claims 1
- 230000000770 proinflammatory effect Effects 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 229920002477 rna polymer Polymers 0.000 claims 1
- 210000003437 trachea Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2930708P | 2008-02-15 | 2008-02-15 | |
| US61/029,307 | 2008-02-15 | ||
| US5160608P | 2008-05-08 | 2008-05-08 | |
| US61/051,606 | 2008-05-08 | ||
| PCT/US2009/000959 WO2009102496A2 (en) | 2008-02-15 | 2009-02-17 | Selective agonist of toll-like receptor 3 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011525169A JP2011525169A (ja) | 2011-09-15 |
| JP2011525169A5 true JP2011525169A5 (enExample) | 2012-05-17 |
Family
ID=40957440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010546793A Withdrawn JP2011525169A (ja) | 2008-02-15 | 2009-02-17 | Ｔｏｌｌ様受容体３の選択的アゴニスト |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100310600A1 (enExample) |
| EP (1) | EP2249845A4 (enExample) |
| JP (1) | JP2011525169A (enExample) |
| KR (1) | KR20100126390A (enExample) |
| CN (1) | CN101990435A (enExample) |
| AU (1) | AU2009215128A1 (enExample) |
| BR (1) | BRPI0907515A2 (enExample) |
| CA (1) | CA2715293A1 (enExample) |
| NZ (1) | NZ587371A (enExample) |
| WO (1) | WO2009102496A2 (enExample) |
| ZA (1) | ZA201005826B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2740011A1 (en) * | 2008-10-10 | 2010-04-15 | Hemispherx Biopharma, Inc. | Treatment of chronic fatigue syndrome using selective agonists of toll-like receptor 3 (tlr3) |
| US8722874B2 (en) | 2008-10-23 | 2014-05-13 | Hemispherx Biopharma, Inc. | Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity |
| US20100160413A1 (en) * | 2008-10-23 | 2010-06-24 | Hemispherx Biopharma, Inc. | Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity |
| WO2011072871A1 (en) * | 2009-12-18 | 2011-06-23 | Bavarian Nordic A/S | Production of ifn-lambda by conventional dendritic cells and uses thereof |
| CN108853144A (zh) * | 2017-05-16 | 2018-11-23 | 科济生物医药（上海）有限公司 | Toll样受体激动剂与免疫效应细胞的联用 |
| CN108498362A (zh) * | 2018-04-17 | 2018-09-07 | 睿欧生物科技（上海）有限公司 | 预防及治疗口腔溃疡的Toll样受体激动剂漱口水 |
| US20240216364A1 (en) | 2021-04-28 | 2024-07-04 | Enyo Pharma | Strong potentiation of tlr3 agonists effects using fxr agonists as a combined treatment |
| CN115487302A (zh) * | 2022-11-09 | 2022-12-20 | 吉林大学 | Toll样受体3在治疗华支睾吸虫性肝纤维化的用途 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4024222A (en) * | 1973-10-30 | 1977-05-17 | The Johns Hopkins University | Nucleic acid complexes |
| US6130206A (en) * | 1980-07-07 | 2000-10-10 | Hem Research, Inc. | Treating viral infections associated with chronic fatigue with dsRNA |
| US6080726A (en) * | 1985-08-12 | 2000-06-27 | University Of Maryland | Anti-viral and immuno stimulator polynucleotide duplex and use thereof |
| US4795744A (en) * | 1986-07-17 | 1989-01-03 | Hem Research, Inc. | Modulation of AIDS virus-related events by double-stranded RNAS |
| US5063209A (en) * | 1985-08-26 | 1991-11-05 | Hem Research, Inc. | Modulation of aids virus-related events by double-stranded RNAs |
| US4950652A (en) * | 1987-03-23 | 1990-08-21 | Hem Research, Inc. | dsRNAs for combination therapy in the treatment of viral diseases |
| ZA883887B (en) * | 1987-06-10 | 1990-02-28 | Lilly Co Eli | Chromatographic purification process |
| US5258369A (en) * | 1988-08-29 | 1993-11-02 | Hem Pharmaceuticals Corporation | Treatment of chronic cerebral dysfunction by dsRNA methodology |
| GB0119346D0 (en) * | 2001-08-08 | 2001-10-03 | Bioclones Proprietary Ltd | Process for the maturation of dendritic cells |
| WO2003037323A2 (en) * | 2001-10-26 | 2003-05-08 | MEDIGENE AG Gesellschaft für Molekularbiologische Kardiologie und Onkologie | Inhibitors of the fatty acid oxidation for prophylaxis and treatment of diseases related to mitochondrial dysfunction |
| WO2006054129A1 (en) * | 2004-11-19 | 2006-05-26 | Institut Gustave Roussy | Improved treatment of cancer by double-stranded rna |
| US7834064B2 (en) * | 2005-01-03 | 2010-11-16 | Andres Mario Salazar | Clinical method for the immunomodulatory and vaccine adjuvant use of poly-ICLC and other dsRNAs |
| AU2006322073A1 (en) * | 2005-12-07 | 2007-06-14 | Hemispherx Biopharma, Inc. | dsRNAs as influenza virus vaccine adjuvants or immuno-stimulants |
| US20070166800A1 (en) * | 2006-01-13 | 2007-07-19 | Haixiang Lin | Immunogenic substances comprising a polyinosinic acid-polycytidilic acid based adjuvant |
| JP2010507361A (ja) * | 2006-07-31 | 2010-03-11 | キュアバック ゲーエムベーハー | 具体的には免疫刺激剤／アジュバントとしての、一般式（Ｉ）：ＧｌＸｍＧｎ、または一般式（ＩＩ）：ＣｌＸｍＣｎで表される核酸 |
| AU2008223446B2 (en) * | 2007-03-05 | 2012-02-02 | Utah State University | Restrictive agonist of Toll-like receptor 3 (TLR3) |
| AU2009215795A1 (en) * | 2008-02-21 | 2009-08-27 | University Of Kentucky Research Foundation | Ultra-small RNAs as toll-like receptor-3 antagonists |
| CA2740011A1 (en) * | 2008-10-10 | 2010-04-15 | Hemispherx Biopharma, Inc. | Treatment of chronic fatigue syndrome using selective agonists of toll-like receptor 3 (tlr3) |
| US8722874B2 (en) * | 2008-10-23 | 2014-05-13 | Hemispherx Biopharma, Inc. | Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity |
| US20100160413A1 (en) * | 2008-10-23 | 2010-06-24 | Hemispherx Biopharma, Inc. | Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity |
| WO2010104571A2 (en) * | 2009-03-13 | 2010-09-16 | Hemispherx Biopharma, Inc. | Treating chronic fatigue syndrome and prolonged qt interval |
-
2009
- 2009-02-17 AU AU2009215128A patent/AU2009215128A1/en not_active Abandoned
- 2009-02-17 WO PCT/US2009/000959 patent/WO2009102496A2/en not_active Ceased
- 2009-02-17 JP JP2010546793A patent/JP2011525169A/ja not_active Withdrawn
- 2009-02-17 EP EP09710652A patent/EP2249845A4/en not_active Withdrawn
- 2009-02-17 BR BRPI0907515-1A patent/BRPI0907515A2/pt not_active IP Right Cessation
- 2009-02-17 CN CN2009801126292A patent/CN101990435A/zh active Pending
- 2009-02-17 US US12/735,755 patent/US20100310600A1/en not_active Abandoned
- 2009-02-17 CA CA2715293A patent/CA2715293A1/en not_active Abandoned
- 2009-02-17 KR KR1020107020663A patent/KR20100126390A/ko not_active Withdrawn
- 2009-02-17 NZ NZ587371A patent/NZ587371A/xx not_active IP Right Cessation
-
2010
- 2010-08-16 ZA ZA2010/05826A patent/ZA201005826B/en unknown
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