JP2011523662A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011523662A5 JP2011523662A5 JP2011512657A JP2011512657A JP2011523662A5 JP 2011523662 A5 JP2011523662 A5 JP 2011523662A5 JP 2011512657 A JP2011512657 A JP 2011512657A JP 2011512657 A JP2011512657 A JP 2011512657A JP 2011523662 A5 JP2011523662 A5 JP 2011523662A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- cgmp
- seq
- group
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 17
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 claims description 11
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 8
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 7
- 230000001419 dependent effect Effects 0.000 claims description 7
- 206010061218 Inflammation Diseases 0.000 claims description 6
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 6
- 201000006549 dyspepsia Diseases 0.000 claims description 6
- 230000004054 inflammatory process Effects 0.000 claims description 6
- 239000002571 phosphodiesterase inhibitor Substances 0.000 claims description 6
- 108010078321 Guanylate Cyclase Proteins 0.000 claims description 5
- 102000014469 Guanylate cyclase Human genes 0.000 claims description 5
- 239000000018 receptor agonist Substances 0.000 claims description 5
- 229940044601 receptor agonist Drugs 0.000 claims description 5
- NPFVRBCDMFKOPY-UHFFFAOYSA-N 3-(4-imidazol-1-ylthiophen-2-yl)-4-methyl-4,5-dihydro-1h-pyridazin-6-one Chemical compound CC1CC(=O)NN=C1C1=CC(N2C=NC=C2)=CS1 NPFVRBCDMFKOPY-UHFFFAOYSA-N 0.000 claims description 4
- 206010010774 Constipation Diseases 0.000 claims description 4
- 206010051606 Necrotising colitis Diseases 0.000 claims description 4
- SECKRCOLJRRGGV-UHFFFAOYSA-N Vardenafil Chemical compound CCCC1=NC(C)=C(C(N=2)=O)N1NC=2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(CC)CC1 SECKRCOLJRRGGV-UHFFFAOYSA-N 0.000 claims description 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 229950000484 exisulind Drugs 0.000 claims description 4
- 230000002496 gastric effect Effects 0.000 claims description 4
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims description 4
- 208000002551 irritable bowel syndrome Diseases 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 229950002910 motapizone Drugs 0.000 claims description 4
- 208000004995 necrotizing enterocolitis Diseases 0.000 claims description 4
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 4
- 201000006195 perinatal necrotizing enterocolitis Diseases 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- MVGSNCBCUWPVDA-MFOYZWKCSA-N sulindac sulfone Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)(=O)=O)C=C1 MVGSNCBCUWPVDA-MFOYZWKCSA-N 0.000 claims description 4
- 229960002381 vardenafil Drugs 0.000 claims description 4
- REZGGXNDEMKIQB-UHFFFAOYSA-N zaprinast Chemical compound CCCOC1=CC=CC=C1C1=NC(=O)C2=NNNC2=N1 REZGGXNDEMKIQB-UHFFFAOYSA-N 0.000 claims description 4
- 229950005371 zaprinast Drugs 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 3
- 206010005003 Bladder cancer Diseases 0.000 claims description 2
- 206010007559 Cardiac failure congestive Diseases 0.000 claims description 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 2
- 206010009944 Colon cancer Diseases 0.000 claims description 2
- 206010019280 Heart failures Diseases 0.000 claims description 2
- 206010020772 Hypertension Diseases 0.000 claims description 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 206010033799 Paralysis Diseases 0.000 claims description 2
- 206010068620 Post procedural constipation Diseases 0.000 claims description 2
- 208000004337 Salivary Gland Neoplasms Diseases 0.000 claims description 2
- 206010061934 Salivary gland cancer Diseases 0.000 claims description 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
- 230000036592 analgesia Effects 0.000 claims description 2
- 229940124599 anti-inflammatory drug Drugs 0.000 claims description 2
- 208000006673 asthma Diseases 0.000 claims description 2
- 206010006451 bronchitis Diseases 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 208000014797 chronic intestinal pseudoobstruction Diseases 0.000 claims description 2
- 210000001072 colon Anatomy 0.000 claims description 2
- 208000029742 colonic neoplasm Diseases 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000002183 duodenal effect Effects 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 230000005176 gastrointestinal motility Effects 0.000 claims description 2
- 208000024798 heartburn Diseases 0.000 claims description 2
- 201000007270 liver cancer Diseases 0.000 claims description 2
- 208000014018 liver neoplasm Diseases 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 201000001119 neuropathy Diseases 0.000 claims description 2
- 230000007823 neuropathy Effects 0.000 claims description 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims description 2
- 229940127240 opiate Drugs 0.000 claims description 2
- 210000000056 organ Anatomy 0.000 claims description 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims description 2
- 239000008024 pharmaceutical diluent Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 238000010992 reflux Methods 0.000 claims description 2
- 230000000241 respiratory effect Effects 0.000 claims description 2
- 201000000849 skin cancer Diseases 0.000 claims description 2
- 230000003637 steroidlike Effects 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 claims 3
- 102000035195 Peptidases Human genes 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 108091000080 Phosphotransferase Proteins 0.000 claims 2
- 235000018936 Vitellaria paradoxa Nutrition 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 102000020233 phosphotransferase Human genes 0.000 claims 2
- 235000019833 protease Nutrition 0.000 claims 2
- 210000002307 prostate Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 description 9
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 description 4
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 description 3
- 102000004861 Phosphoric Diester Hydrolases Human genes 0.000 description 2
- 108090001050 Phosphoric Diester Hydrolases Proteins 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 229960003310 sildenafil Drugs 0.000 description 2
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 201000004240 prostatic hypertrophy Diseases 0.000 description 1
- 239000002294 steroidal antiinflammatory agent Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5888808P | 2008-06-04 | 2008-06-04 | |
| US61/058,888 | 2008-06-04 | ||
| PCT/US2009/046287 WO2009149278A1 (en) | 2008-06-04 | 2009-06-04 | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011523662A JP2011523662A (ja) | 2011-08-18 |
| JP2011523662A5 true JP2011523662A5 (enExample) | 2013-05-02 |
Family
ID=41026379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011512657A Pending JP2011523662A (ja) | 2008-06-04 | 2009-06-04 | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US8207295B2 (enExample) |
| EP (1) | EP2296685B1 (enExample) |
| JP (1) | JP2011523662A (enExample) |
| AU (1) | AU2009256156B2 (enExample) |
| CA (1) | CA2726913C (enExample) |
| ES (1) | ES2559840T3 (enExample) |
| WO (1) | WO2009149278A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2905585C (en) | 2001-03-29 | 2020-02-18 | Synergy Pharmaceuticals, Inc. | Guanylate cyclase receptor agonists for the treatment and/or prevention of cancer or polyps |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders |
| JP5546451B2 (ja) | 2007-06-04 | 2014-07-09 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト |
| WO2009149278A1 (en) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US20100221329A1 (en) | 2008-12-03 | 2010-09-02 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase c agonists and methods of use |
| US8575087B2 (en) | 2009-05-30 | 2013-11-05 | The University Of Toledo | Treatment of cancers with A-8R peptide |
| US9301991B2 (en) | 2009-05-30 | 2016-04-05 | The University Of Toledo | sGCalphal inhibiting compositions |
| WO2011050242A1 (en) | 2009-10-23 | 2011-04-28 | Millennium Pharmaceuticals, Inc. | Anti-gcc antibody molecules and related compositions and methods |
| AT509267A1 (de) * | 2010-01-14 | 2011-07-15 | Apeptico Forschung & Entwicklung Gmbh | Organische verbindungen zur regulierung von vektoriellen ionenkanälen |
| RS54336B1 (sr) * | 2010-02-05 | 2016-02-29 | Adverio Pharma Gmbh | Sgc stimulatori ili sgc aktivatori, sami za sebe i kombinovani sa pde5 inhibitorima za tretman cistične fibroze |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| EP2621509A4 (en) | 2010-09-15 | 2016-08-03 | Synergy Pharmaceuticals Inc | FORMULATIONS OF GUANYLATE CYCLASE C AGONISTS AND METHOD OF USE |
| CN108676076A (zh) | 2011-03-01 | 2018-10-19 | 辛纳吉制药公司 | 制备鸟苷酸环化酶c激动剂的方法 |
| EP2841575B1 (en) | 2012-04-27 | 2019-06-26 | Millennium Pharmaceuticals, Inc. | Anti-gcc antibody molecules and use of same to test for susceptibility to gcc-targeted therapy |
| EP3718557A3 (en) | 2013-02-25 | 2020-10-21 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonist sp-333 for use in colonic cleansing |
| HK1220696A1 (zh) | 2013-03-15 | 2017-05-12 | Bausch Health Ireland Limited | 鸟苷酸环化酶激动剂及其用途 |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| EP4424697A3 (en) | 2013-06-05 | 2024-12-25 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
| EP3024455A1 (en) | 2013-07-25 | 2016-06-01 | Bayer Pharma Aktiengesellschaft | Sgc stimulators or sgc activators and pde5 inhibitors in combination with additional treatment for the therapy of cystic fibrosis |
| JP6694385B2 (ja) * | 2013-08-09 | 2020-05-13 | アーデリクス，インコーポレーテッド | リン酸塩輸送阻害のための化合物及び方法 |
| EA201690732A1 (ru) * | 2013-10-10 | 2016-12-30 | Синерджи Фармасьютикалз, Инк. | Агонисты гуанилатциклазы, используемые для лечения индуцированных опиоидами дисфункций |
| WO2015066285A2 (en) * | 2013-11-01 | 2015-05-07 | The University Of Toledo | sGCα1 INHIBITING COMPOSITIONS, AND METHODS OF TREATMENT OF CANCERS THEREWITH |
| CA3009814A1 (en) | 2016-01-11 | 2017-07-20 | Synergy Pharmaceuticals, Inc. | Formulations and methods for treating ulcerative colitis |
| US20210393621A1 (en) | 2018-10-26 | 2021-12-23 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| EP3972599B1 (en) | 2019-05-21 | 2025-10-22 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
| EP3983437A1 (en) | 2019-06-12 | 2022-04-20 | Novartis AG | Natriuretic peptide receptor 1 antibodies and methods of use |
| US12029718B2 (en) | 2021-11-09 | 2024-07-09 | Cct Sciences, Llc | Process for production of essentially pure delta-9-tetrahydrocannabinol |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5969097A (en) * | 1992-06-23 | 1999-10-19 | G. D. Searle & Co. | Human guanylin |
| CA2157793C (en) * | 1993-03-09 | 1999-07-13 | James E. Woiszwillo | Macromolecular microparticles and methods of production |
| US5601990A (en) * | 1994-09-13 | 1997-02-11 | Thomas Jefferson University | Methods of diagnosing colorectal tumors and metastasis thereof |
| US5879656A (en) * | 1993-10-26 | 1999-03-09 | Thomas Jefferson University | Methods of treating metastatic colorectal cancer with ST receptor binding compounds |
| JP4194113B2 (ja) * | 1993-10-26 | 2008-12-10 | トーマス・ジェファーソン・ユニバーシティ | 結腸直腸癌細胞に特異的に結合する組成物およびその使用方法 |
| US5518888A (en) * | 1993-10-26 | 1996-05-21 | Thomas Jefferson University | ST receptor binding compounds and methods of using the same |
| US5489670A (en) * | 1993-10-29 | 1996-02-06 | G. D. Searle & Co. | Human uroguanylin |
| US6180604B1 (en) * | 1996-08-21 | 2001-01-30 | Micrologix Biotech Inc. | Compositions and methods for treating infections using analogues of indolicidin |
| US6203513B1 (en) | 1997-11-20 | 2001-03-20 | Optonol Ltd. | Flow regulating implant, method of manufacture, and delivery device |
| US6235782B1 (en) * | 1998-11-12 | 2001-05-22 | Rifat Pamukcu | Method for treating a patient with neoplasia by treatment with a platinum coordination complex |
| DE19903087A1 (de) * | 1999-01-27 | 2000-08-10 | Forssmann Wolf Georg | Behandlung von erektilen Dysfunktionen mit C-Typ Natriuretischem Polypeptid (CNP) als Monotherapie oder in Kombination mit Phosphodiesterasehemmern |
| JP2003516316A (ja) | 1999-10-06 | 2003-05-13 | ファルマシア コーポレイション | 腸癌阻止剤としてのウログアニリン |
| JP4088412B2 (ja) * | 2000-12-26 | 2008-05-21 | トヨタ自動車株式会社 | 内燃機関の空燃比制御装置 |
| JP2004521123A (ja) | 2001-02-02 | 2004-07-15 | ファルマシア・コーポレーション | 腸癌阻害のためのウログアニリンおよびシクロオキシゲナーゼ−２阻害薬の組合わせ |
| JP2004525695A (ja) | 2001-03-16 | 2004-08-26 | グローコス コーポレーション | 緑内障治療用の小柱シャントを配置するためのアプリケータおよび方法 |
| CA2905585C (en) * | 2001-03-29 | 2020-02-18 | Synergy Pharmaceuticals, Inc. | Guanylate cyclase receptor agonists for the treatment and/or prevention of cancer or polyps |
| US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
| EP1392729A2 (de) * | 2001-06-05 | 2004-03-03 | Yalcin Cetin | Verwendung eines peptids, welches guanylat cyclase c aktiviert, für die behandlung von atemwegserkrankungen über die luftwege, arzneimittel, inhalationsvorrichtung und diagnoseverfahren |
| US6991726B2 (en) * | 2002-07-01 | 2006-01-31 | Usfilter Corporation | Filter having a media retaining plate |
| ATE419026T1 (de) | 2002-07-19 | 2009-01-15 | Univ Yale | Uveosklerale drainagevorrichtung |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| ATE477268T1 (de) | 2003-01-28 | 2010-08-15 | Ironwood Pharmaceuticals Inc | Zusammensetzungen zur behandlung von magen-darm- störungen |
| US7073363B2 (en) * | 2003-05-20 | 2006-07-11 | Schumag Ag | Method for processing drawn material and drawn material production installation |
| US7494979B2 (en) | 2003-06-13 | 2009-02-24 | Ironwood Pharmaceuticals, Inc. | Method for treating congestive heart failure and other disorders |
| DK1644021T3 (da) | 2003-06-13 | 2012-10-29 | Ironwood Pharmaceuticals Inc | Fremgangsmåder og sammensætninger til behandlingen af gastrointestinale sygdomme |
| NZ546226A (en) * | 2003-09-30 | 2009-03-31 | Shire Llc | Oxycodone conjugates for prevention of overdose or abuse |
| US7291125B2 (en) | 2003-11-14 | 2007-11-06 | Transcend Medical, Inc. | Ocular pressure regulation |
| TWI649790B (zh) * | 2004-11-18 | 2019-02-01 | 日商尼康股份有限公司 | 位置測量方法、位置控制方法、測量方法、裝載方法、曝光方法及曝光裝置、及元件製造方法 |
| DE102004062773A1 (de) | 2004-12-21 | 2006-06-22 | Röhm GmbH & Co. KG | Beschichtungsmittel zur Herstellung von umformbaren Kratzfestbeschichtungen mit schmutzabweisender Wirkung, kratzfeste umformbare schmutzabweisende Formkörper sowie Verfahren zu deren Herstellung |
| US20090253634A1 (en) | 2005-08-19 | 2009-10-08 | Microbia, Inc. | Methods and Compositions for the Treatment of Gastrointestinal Disorders |
| US20070101158A1 (en) * | 2005-10-28 | 2007-05-03 | Elliott Robert C | Security region in a non-volatile memory |
| WO2007101158A2 (en) | 2006-02-24 | 2007-09-07 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US7692307B2 (en) * | 2006-12-08 | 2010-04-06 | Intel Corporation | Compliant structure for an electronic device, method of manufacturing same, and system containing same |
| EP2129683A4 (en) | 2007-02-26 | 2011-01-05 | Ironwood Pharmaceuticals Inc | METHODS AND COMPOSITIONS FOR TREATMENT OF HEART FAILURE AND OTHER DISORDERS |
| WO2008137318A1 (en) * | 2007-05-04 | 2008-11-13 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating disorders associated with salt or fluid retention |
| US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders |
| JP5546451B2 (ja) * | 2007-06-04 | 2014-07-09 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト |
| WO2009149278A1 (en) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US20100221329A1 (en) | 2008-12-03 | 2010-09-02 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase c agonists and methods of use |
-
2009
- 2009-06-04 WO PCT/US2009/046287 patent/WO2009149278A1/en not_active Ceased
- 2009-06-04 AU AU2009256156A patent/AU2009256156B2/en active Active
- 2009-06-04 EP EP09759437.8A patent/EP2296685B1/en active Active
- 2009-06-04 US US12/478,505 patent/US8207295B2/en active Active
- 2009-06-04 JP JP2011512657A patent/JP2011523662A/ja active Pending
- 2009-06-04 CA CA2726913A patent/CA2726913C/en active Active
- 2009-06-04 ES ES09759437.8T patent/ES2559840T3/es active Active
-
2012
- 2012-05-09 US US13/467,703 patent/US8357775B2/en active Active
- 2012-12-17 US US13/716,874 patent/US8497348B2/en active Active
-
2013
- 2013-06-27 US US13/928,830 patent/US20130274204A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011523662A5 (enExample) | ||
| JP2011522828A5 (enExample) | ||
| JP2010530849A5 (enExample) | ||
| ES2391974T3 (es) | Procedimientos y composiciones para el tratamiento de trastornos gastrointestinales | |
| TWI801373B (zh) | 胜肽化合物 | |
| TWI359147B (en) | Inhibitors of serine proteases, particularly hcv n | |
| ES2856231T3 (es) | Compuestos para el tratamiento de pacientes con células cancerosas con ROS1 mutante | |
| ES2627848T3 (es) | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos | |
| Fisher et al. | Peptide-based therapeutics for oncology | |
| CA2726913A1 (en) | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders | |
| TW201514203A (zh) | 胜肽化合物 | |
| JP2017530090A5 (enExample) | ||
| AU2021217959A1 (en) | IL-7Rα binding compounds | |
| BRPI0718566A2 (pt) | Peptídeo, análogo do mesmo, composição farmacêutica, usos de um análogo de peptídeo, e de uma molécula de ácido nucléico, de um vetor de expressão, ou de uma célula hospedeira, molécula de ácido nucléico, vetor de expressão, célula hospedeira, métodos para produzir o análogo de peptídeo-2 tipo-glucagon (glp-2), e, kit terapêutico. | |
| KR20080015827A (ko) | 글루카곤-유사-펩티드-2(ｇｌｐ-2) 유사체 | |
| TW200528109A (en) | Method of treatment of atherosclerosis | |
| AU2016370846A1 (en) | Combinations for the treatment of cancer | |
| CN111225662B (zh) | 药物组合物和剂型 | |
| WO2011156453A4 (en) | Therapeutic peptides | |
| JP2014500862A5 (enExample) | ||
| TW200412995A (en) | Peptide YY analogs | |
| CN110291082A (zh) | Nhe介导的反向转运的抑制剂 | |
| JP2009536187A (ja) | 癌の処置のための４−（２，６−ジクロロ−ベンゾイルアミノ）−１ｈ−ピラゾール−３−カルボン酸（１−メタンスルホニル−ピペリジン−４−イル）−アミド | |
| JP2020203954A (ja) | 結腸洗浄及び胃腸障害の治療のための組成物 | |
| JP6251236B2 (ja) | 癌を治療するための官能性チエノ−インドール誘導体 |