JP2011521957A - 自己防腐エマルジョン - Google Patents

自己防腐エマルジョン Download PDF

Info

Publication number
JP2011521957A
JP2011521957A JP2011511775A JP2011511775A JP2011521957A JP 2011521957 A JP2011521957 A JP 2011521957A JP 2011511775 A JP2011511775 A JP 2011511775A JP 2011511775 A JP2011511775 A JP 2011511775A JP 2011521957 A JP2011521957 A JP 2011521957A
Authority
JP
Japan
Prior art keywords
emulsion
alkyl
group
nhc
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011511775A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011521957A5 (enExample
Inventor
マスード エー. チョウハン,
マレー ゴーシュ,
Original Assignee
アルコン リサーチ, リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アルコン リサーチ, リミテッド filed Critical アルコン リサーチ, リミテッド
Publication of JP2011521957A publication Critical patent/JP2011521957A/ja
Publication of JP2011521957A5 publication Critical patent/JP2011521957A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0043Nose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0046Ear
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011511775A 2008-05-28 2009-05-27 自己防腐エマルジョン Pending JP2011521957A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5667508P 2008-05-28 2008-05-28
US61/056,675 2008-05-28
PCT/US2009/045282 WO2009154978A2 (en) 2008-05-28 2009-05-27 Self-preserved emulsions

Publications (2)

Publication Number Publication Date
JP2011521957A true JP2011521957A (ja) 2011-07-28
JP2011521957A5 JP2011521957A5 (enExample) 2012-06-28

Family

ID=41203940

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011511775A Pending JP2011521957A (ja) 2008-05-28 2009-05-27 自己防腐エマルジョン

Country Status (9)

Country Link
US (1) US20090298956A1 (enExample)
EP (1) EP2278953B1 (enExample)
JP (1) JP2011521957A (enExample)
KR (2) KR20160123400A (enExample)
AU (1) AU2009260572B2 (enExample)
BR (1) BRPI0912302A2 (enExample)
CA (1) CA2725523C (enExample)
ES (1) ES2586283T3 (enExample)
WO (1) WO2009154978A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012201617A (ja) * 2011-03-24 2012-10-22 Nof Corp ホスホリルコリン類似構造を有する化合物および化粧料

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2314354T3 (es) * 2004-11-09 2009-03-16 Novagali Pharma S.A. Emulsion de tipo aceite en agua con baja concentracion de agente cationico y potencial zeta positivo.
EP2228058A1 (en) 2009-03-04 2010-09-15 Novagali Pharma S.A. Anionic oil-in-water emulsion containing prostaglandins and uses thereof
EP2389939A1 (en) 2010-05-28 2011-11-30 Novagali Pharma S.A. Use of prostaglandins F2alpha and analogues for the healing of corneal and conjunctival lesions
JP5782846B2 (ja) * 2011-06-13 2015-09-24 日油株式会社 ホスホリルコリン類似構造を有する化合物および化粧料
JP5782847B2 (ja) * 2011-06-13 2015-09-24 日油株式会社 ホスホリルコリン類似構造を有する化合物および化粧料
US8980839B2 (en) * 2012-08-24 2015-03-17 Ocular Technologies Sarl Topical aqueous nanomicellar, ophthalmic solutions and uses thereof
WO2017083167A1 (en) 2015-11-10 2017-05-18 Ocular Technologies Sarl Topical formulations and uses thereof
NZ785158A (en) 2016-02-29 2025-03-28 Sun Pharmaceutical Ind Ltd Topical cyclosporine-containing formulations and uses thereof
ITUA20162425A1 (it) * 2016-04-08 2017-10-08 Medivis S R L Composizione oftalmica che comprende PVP-I
CN108201526A (zh) * 2018-03-13 2018-06-26 云南云龙制药股份有限公司 一种治疗鼻炎的凝胶及其制备方法和应用
CA3148362C (en) * 2019-08-18 2024-02-13 Bo Liang In-situ gel forming ophthalmic formulations containing difluprednate
AR124568A1 (es) * 2021-01-16 2023-04-12 Godrej Industries Ltd Agentes antifúngicos, mezcla de los mismos y composiciones de limpieza para el cuidado personal que los contienen
CN115463088A (zh) * 2021-06-11 2022-12-13 温士顿医药股份有限公司 含前列腺素衍生物的眼用纳米乳剂组合物

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4503002A (en) * 1978-11-30 1985-03-05 Mona Industries, Inc. Phosphate quaternary compounds
JPH07500607A (ja) * 1991-10-28 1995-01-19 フォスト,デニス・エル リン脂質抗菌性組成物
JPH0899867A (ja) * 1994-08-08 1996-04-16 Lab Cusi Sa 眼科用ビヒクルとして有用な水中油型ナノエマルジョンおよびその調製法
JPH08512145A (ja) * 1993-07-01 1996-12-17 アラーガン、インコーポレイテッド 第四アンモニウム置換ホスフェートエステルを含有するコンタクトレンズ洗浄溶液
JPH11513045A (ja) * 1996-08-09 1999-11-09 アルコン ラボラトリーズ,インコーポレイテッド シクロデキストリンを含有する薬学的組成物用防腐剤系

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3608073A (en) * 1968-07-16 1971-09-21 Barnes Hind Pharm Inc Emulsion of pilocarpine for ophthalmic use
US4215064A (en) * 1978-11-30 1980-07-29 Johnson & Johnson Phosphobetaines
US4209449A (en) * 1978-11-30 1980-06-24 Mona Industries Phosphate quaternary compounds
US4407791A (en) * 1981-09-28 1983-10-04 Alcon Laboratories, Inc. Ophthalmic solutions
US5648348A (en) * 1991-10-28 1997-07-15 Mona Industries, Inc. Phospholipid antimicrobial compositions
US5286719A (en) * 1991-10-28 1994-02-15 Mona Industries, Inc. Phospholipid virucidal compositions
US5505953A (en) * 1992-05-06 1996-04-09 Alcon Laboratories, Inc. Use of borate-polyol complexes in ophthalmic compositions
JP2742333B2 (ja) * 1994-05-06 1998-04-22 アルコン ラボラトリーズ,インコーポレイテッド 眼科用組成物におけるビタミンeトコフェリル誘導体の使用
US5827835A (en) * 1994-08-30 1998-10-27 Alcon Laboratories, Inc. Thermally-gelling emulsions
US5874469A (en) * 1996-01-05 1999-02-23 Alcon Laboratories, Inc. Fluoroalkyl hydrocarbons for administering water insoluble or unstable drugs
WO1999016471A1 (en) * 1997-10-01 1999-04-08 Wakamoto Pharmaceutical Co., Ltd. O/w emulsion compositions
US6120758A (en) * 1998-07-16 2000-09-19 Shaklee Corporation Preservative system for topically applied products
BR9914799A (pt) * 1998-10-27 2001-07-10 Alcon Lab Inc Sistema conservante para composições farmacêuticas administráveis topicamente contendo um sabão de ácido graxo/aminoácido
US6750250B1 (en) * 2001-07-12 2004-06-15 Alcon, Inc. 11,12-oxidoarachidonic acid derivatives and methods of their use in treating dry eye disorders
US6451775B1 (en) * 2001-08-29 2002-09-17 Colonial Chemical Inc. Castor amidopropyl dimethyl phospholipids as emulsifiers
US6585961B1 (en) * 2001-11-30 2003-07-01 Richard F. Stockel Antimicrobial compositions
WO2003086332A1 (en) * 2002-04-11 2003-10-23 Dvm Pharmaceuticals, Inc. Antimicrobial wash and carrier solutions, and uses thereof
US20060141059A1 (en) * 2004-12-27 2006-06-29 Alcon, Inc. Self-preserved ophthalmic pharmaceutical compositions containing tobramycin
US20070297990A1 (en) * 2006-06-27 2007-12-27 Shah Mandar V Self-preserving composition
US20080026013A1 (en) * 2006-07-28 2008-01-31 Laura Rabinovich-Guilatt Compositions containing quaternary ammonium compounds
WO2008035246A2 (en) * 2006-07-28 2008-03-27 Novagali Pharma Sa Compositions containing quaternary ammonium compounds
TW200904485A (en) * 2007-05-18 2009-02-01 Alcon Res Ltd Phospholipid compositions for contact lens care and preservation of pharmaceutical compositions

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4503002A (en) * 1978-11-30 1985-03-05 Mona Industries, Inc. Phosphate quaternary compounds
JPH07500607A (ja) * 1991-10-28 1995-01-19 フォスト,デニス・エル リン脂質抗菌性組成物
JPH08512145A (ja) * 1993-07-01 1996-12-17 アラーガン、インコーポレイテッド 第四アンモニウム置換ホスフェートエステルを含有するコンタクトレンズ洗浄溶液
JPH0899867A (ja) * 1994-08-08 1996-04-16 Lab Cusi Sa 眼科用ビヒクルとして有用な水中油型ナノエマルジョンおよびその調製法
JPH11513045A (ja) * 1996-08-09 1999-11-09 アルコン ラボラトリーズ,インコーポレイテッド シクロデキストリンを含有する薬学的組成物用防腐剤系

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012201617A (ja) * 2011-03-24 2012-10-22 Nof Corp ホスホリルコリン類似構造を有する化合物および化粧料

Also Published As

Publication number Publication date
ES2586283T3 (es) 2016-10-13
WO2009154978A2 (en) 2009-12-23
CA2725523C (en) 2017-01-10
BRPI0912302A2 (pt) 2015-10-20
KR20160123400A (ko) 2016-10-25
CA2725523A1 (en) 2009-12-23
US20090298956A1 (en) 2009-12-03
AU2009260572B2 (en) 2015-07-23
AU2009260572A1 (en) 2009-12-23
EP2278953B1 (en) 2016-05-04
EP2278953A2 (en) 2011-02-02
WO2009154978A3 (en) 2010-04-22
KR20110010788A (ko) 2011-02-07

Similar Documents

Publication Publication Date Title
JP2011521957A (ja) 自己防腐エマルジョン
EP2136782B1 (en) Ophthalmic oil-in-water emulsions containing prostaglandins
AU2010256684B2 (en) Omega-3 oil containing ophthalmic emulsions
CN107847432A (zh) D2o稳定化的药物制剂
AU2010256679B2 (en) Therapeutic ophthalmic emulsions
WO2010059894A1 (en) Ocular formulations of norketotifen
WO2017066052A1 (en) Formulations and methods for treating high intraocular pressure
JP2022548221A (ja) シクロスポリンおよびメントール含有ナノエマルジョン点眼組成物およびその製造方法
WO2021210646A1 (ja) エピナスチン又はその塩を含有する水性組成物
AU2014250656B2 (en) Omega-3 oil containing ophthalmic emulsions
HK1133598B (en) Ophthalmic oil-in-water emulsions containing prostaglandins

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120509

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120509

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20131008

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20131011

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20131224

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140107

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140207

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140217

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140307

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140314

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140407

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20140602