JP2011521652A5 - - Google Patents

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Publication number
JP2011521652A5
JP2011521652A5 JP2011511949A JP2011511949A JP2011521652A5 JP 2011521652 A5 JP2011521652 A5 JP 2011521652A5 JP 2011511949 A JP2011511949 A JP 2011511949A JP 2011511949 A JP2011511949 A JP 2011511949A JP 2011521652 A5 JP2011521652 A5 JP 2011521652A5
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JP
Japan
Prior art keywords
ana
rna
chemically modified
modified sirna
sense
Prior art date
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Application number
JP2011511949A
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English (en)
Japanese (ja)
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JP2011521652A (ja
JP5684116B2 (ja
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Priority claimed from CA002635187A external-priority patent/CA2635187A1/en
Priority claimed from PCT/CA2008/002259 external-priority patent/WO2009076775A1/en
Application filed filed Critical
Publication of JP2011521652A publication Critical patent/JP2011521652A/ja
Publication of JP2011521652A5 publication Critical patent/JP2011521652A5/ja
Application granted granted Critical
Publication of JP5684116B2 publication Critical patent/JP5684116B2/ja
Active legal-status Critical Current
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JP2011511949A 2008-06-05 2009-06-05 Ｄｎａ様ヌクレオチドおよびｒｎａ様ヌクレオチドを含むオリゴヌクレオチド二重鎖およびその使用 Active JP5684116B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US5918608P 2008-06-05 2008-06-05
US61/059,186 2008-06-05
CA2,635,187 2008-06-17
CA002635187A CA2635187A1 (en) 2008-06-05 2008-06-17 Oligonucleotide duplexes and uses thereof
CAPCT/CA2008/002259 2008-06-17
PCT/CA2008/002259 WO2009076775A1 (en) 2007-12-19 2008-12-19 Immune response modulation and uses thereof
PCT/CA2009/000789 WO2009146556A1 (en) 2008-06-05 2009-06-05 Oligonucleotide duplexes comprising dna-like and rna-like nucleotides and uses thereof

Publications (3)

Publication Number Publication Date
JP2011521652A JP2011521652A (ja) 2011-07-28
JP2011521652A5 true JP2011521652A5 (https=) 2014-08-28
JP5684116B2 JP5684116B2 (ja) 2015-03-11

Family

ID=41397419

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011511949A Active JP5684116B2 (ja) 2008-06-05 2009-06-05 Ｄｎａ様ヌクレオチドおよびｒｎａ様ヌクレオチドを含むオリゴヌクレオチド二重鎖およびその使用

Country Status (6)

Country Link
US (2) US9090649B2 (https=)
EP (1) EP2294195B1 (https=)
JP (1) JP5684116B2 (https=)
CA (2) CA2635187A1 (https=)
ES (1) ES2643576T3 (https=)
WO (1) WO2009146556A1 (https=)

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WO2009141146A1 (en) 2008-05-21 2009-11-26 Gunther Hartmann 5' triphosphate oligonucleotide with blunt end and uses thereof
CA2635187A1 (en) 2008-06-05 2009-12-05 The Royal Institution For The Advancement Of Learning/Mcgill University Oligonucleotide duplexes and uses thereof
US9920317B2 (en) 2010-11-12 2018-03-20 The General Hospital Corporation Polycomb-associated non-coding RNAs
CA2817256A1 (en) 2010-11-12 2012-05-18 The General Hospital Corporation Polycomb-associated non-coding rnas
EP2508530A1 (en) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
AU2012308320C1 (en) 2011-09-14 2018-08-23 Translate Bio Ma, Inc. Multimeric oligonucleotide compounds
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
BR112014028631A2 (pt) 2012-05-16 2017-10-17 Rana Therapeutics Inc composições e métodos para modulação da expressão da família de genes da hemoglobina
EA201492122A1 (ru) 2012-05-16 2015-10-30 Рана Терапьютикс, Инк. Композиции и способы для модулирования экспрессии utrn
AU2013262699A1 (en) 2012-05-16 2015-01-22 Rana Therapeutics, Inc. Compositions and methods for modulating ATP2A2 expression
SG11201407483YA (en) 2012-05-16 2014-12-30 Rana Therapeutics Inc Compositions and methods for modulating smn gene family expression
EA201492116A1 (ru) 2012-05-16 2015-05-29 Рана Терапьютикс, Инк. Композиции и способы для модулирования экспрессии mecp2
US20150247141A1 (en) 2012-09-14 2015-09-03 Rana Therapeutics, Inc. Multimeric oligonucleotide compounds
EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
WO2015051283A1 (en) 2013-10-04 2015-04-09 Rana Therapeutics, Inc. Compositions and methods for treating amyotrophic lateral sclerosis
WO2016070060A1 (en) 2014-10-30 2016-05-06 The General Hospital Corporation Methods for modulating atrx-dependent gene repression
US10758558B2 (en) 2015-02-13 2020-09-01 Translate Bio Ma, Inc. Hybrid oligonucleotides and uses thereof
WO2016149455A2 (en) 2015-03-17 2016-09-22 The General Hospital Corporation The rna interactome of polycomb repressive complex 1 (prc1)
WO2021030763A1 (en) * 2019-08-15 2021-02-18 Ionis Pharmaceuticals, Inc. Modified oligomeric compounds and uses thereof

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