JP2011516426A - キナゾリン誘導体および治療方法 - Google Patents
キナゾリン誘導体および治療方法 Download PDFInfo
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- JP2011516426A JP2011516426A JP2011502126A JP2011502126A JP2011516426A JP 2011516426 A JP2011516426 A JP 2011516426A JP 2011502126 A JP2011502126 A JP 2011502126A JP 2011502126 A JP2011502126 A JP 2011502126A JP 2011516426 A JP2011516426 A JP 2011516426A
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- KKEYFWRCBNTPAC-UHFFFAOYSA-L terephthalate(2-) Chemical compound [O-]C(=O)C1=CC=C(C([O-])=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-L 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229940071104 xylenesulfonate Drugs 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4064708P | 2008-03-28 | 2008-03-28 | |
| US61/040,647 | 2008-03-28 | ||
| US15754909P | 2009-03-04 | 2009-03-04 | |
| US61/157,549 | 2009-03-04 | ||
| PCT/US2009/038701 WO2009121042A1 (en) | 2008-03-28 | 2009-03-27 | Quinazoline derivatives and methods of treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011516426A true JP2011516426A (ja) | 2011-05-26 |
| JP2011516426A5 JP2011516426A5 (https=) | 2012-05-24 |
Family
ID=40638034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011502126A Pending JP2011516426A (ja) | 2008-03-28 | 2009-03-27 | キナゾリン誘導体および治療方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20090269354A1 (https=) |
| JP (1) | JP2011516426A (https=) |
| KR (1) | KR20110005828A (https=) |
| CN (1) | CN102083801A (https=) |
| WO (1) | WO2009121042A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016518371A (ja) * | 2013-04-17 | 2016-06-23 | メイン ファーマ インターナショナル プロプライエタリー リミテッドMayne Pharma International Pty.Ltd. | Hedgehog経路阻害剤を用いた増殖障害の処置および予後モニタリングの方法 |
| JP2022515256A (ja) * | 2018-12-25 | 2022-02-17 | ソル - ゲル テクノロジーズ リミテッド | Egfr阻害剤を含む組成物による皮膚障害の治療 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110053968A1 (en) | 2009-06-09 | 2011-03-03 | Auspex Pharmaceuticals, Inc. | Aminopyrimidine inhibitors of tyrosine kinase |
| US20110195066A1 (en) * | 2010-02-05 | 2011-08-11 | Auspex Pharmaceuticals, Inc. | Quinoline inhibitors of tyrosine kinase |
| WO2011133826A2 (en) * | 2010-04-23 | 2011-10-27 | Niiki Pharma Inc. | Method for treating pancreatic cancer |
| US9145390B2 (en) | 2011-03-03 | 2015-09-29 | Concert Pharmaceuticals, Inc. | Derivatives of pyrazole-substituted amino-heteroaryl compounds |
| WO2014028914A1 (en) * | 2012-08-17 | 2014-02-20 | Beta Pharma, Inc. | Deuterated icotinib derivatives |
| CN103536925B (zh) * | 2013-10-28 | 2015-07-01 | 中国医学科学院基础医学研究所 | 强心苷化合物在非小细胞肺癌治疗中的应用 |
| CN106188072A (zh) * | 2015-05-07 | 2016-12-07 | 刘文沛 | 氘代4-[(3-乙炔苯基)氨基]-6,7-苯-12冠-4-喹唑啉衍生物以及包含该衍生物的药物组合物 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10506633A (ja) * | 1995-03-30 | 1998-06-30 | ファイザー・インコーポレーテッド | キナゾリン誘導体 |
| JP2004518691A (ja) * | 2001-01-31 | 2004-06-24 | ファイザー・プロダクツ・インク | Pde4アイソザイムの阻害剤として有効なチアゾリル−、オキサゾリル−、ピロリル−、イミダゾリル−酸アミド誘導体 |
| WO2007041630A1 (en) * | 2005-10-06 | 2007-04-12 | Auspex Pharmaceuticals, Inc. | Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties |
| WO2008024439A2 (en) * | 2006-08-22 | 2008-02-28 | Concert Pharmaceuticals Inc. | 4-aminoquinazoline derivatives and methods of use thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL259609A (https=) * | 1959-12-31 | |||
| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| US5747498A (en) * | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| US6440710B1 (en) * | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| RS49836B (sr) * | 1999-03-31 | 2008-08-07 | Pfizer Products Inc., | Postupci i intermedijeri za dobijanje anti-kancernih jedinjenja |
| UA74803C2 (uk) * | 1999-11-11 | 2006-02-15 | Осі Фармасьютікалз, Інк. | Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування |
| PT1104760E (pt) * | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios |
| TW200413273A (en) * | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| WO2005117877A1 (en) * | 2004-06-03 | 2005-12-15 | F.Hoffmann-La Roche Ag | Treatment with irinotecan (cpt-11) and an egfr-inhibitor |
| US7750168B2 (en) * | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| WO2008030382A1 (en) * | 2006-09-05 | 2008-03-13 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
| WO2008076949A2 (en) * | 2006-12-15 | 2008-06-26 | Concert Pharmaceuticals Inc. | Quinazoline derivatives and methods of treatment |
| US20090076042A1 (en) * | 2007-09-15 | 2009-03-19 | Protia, Llc | Deuterium-enriched erlotinib |
-
2009
- 2009-03-27 CN CN2009801188299A patent/CN102083801A/zh active Pending
- 2009-03-27 KR KR1020107024204A patent/KR20110005828A/ko not_active Withdrawn
- 2009-03-27 JP JP2011502126A patent/JP2011516426A/ja active Pending
- 2009-03-27 US US12/413,510 patent/US20090269354A1/en not_active Abandoned
- 2009-03-27 WO PCT/US2009/038701 patent/WO2009121042A1/en not_active Ceased
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10506633A (ja) * | 1995-03-30 | 1998-06-30 | ファイザー・インコーポレーテッド | キナゾリン誘導体 |
| JP2004518691A (ja) * | 2001-01-31 | 2004-06-24 | ファイザー・プロダクツ・インク | Pde4アイソザイムの阻害剤として有効なチアゾリル−、オキサゾリル−、ピロリル−、イミダゾリル−酸アミド誘導体 |
| WO2007041630A1 (en) * | 2005-10-06 | 2007-04-12 | Auspex Pharmaceuticals, Inc. | Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties |
| WO2008024439A2 (en) * | 2006-08-22 | 2008-02-28 | Concert Pharmaceuticals Inc. | 4-aminoquinazoline derivatives and methods of use thereof |
Non-Patent Citations (1)
| Title |
|---|
| JPN7013003373; Journal of Medicinal Chemistry 21(6), 1978, 525-529 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016518371A (ja) * | 2013-04-17 | 2016-06-23 | メイン ファーマ インターナショナル プロプライエタリー リミテッドMayne Pharma International Pty.Ltd. | Hedgehog経路阻害剤を用いた増殖障害の処置および予後モニタリングの方法 |
| US9962381B2 (en) | 2013-04-17 | 2018-05-08 | Hedgepath Pharmaceuticals, Inc. | Treatment and prognostic monitoring of cancerous proliferation disorders using Hedgehog pathway inhibitors |
| US9968600B2 (en) | 2013-04-17 | 2018-05-15 | Hedgepath Pharmaceuticals, Inc. | Treatment and prognostic monitoring of non-cancerous proliferation disorders using hedgehog pathway inhibitors |
| US10328072B2 (en) | 2013-04-17 | 2019-06-25 | Hedgepath Pharmaceuticals, Inc. | Treatment of lung cancer using hedgehog pathway inhibitors |
| US10363252B2 (en) | 2013-04-17 | 2019-07-30 | Hedgepath Pharmaceuticals, Inc. | Treatment of prostate cancer using hedgehog pathway inhibitors |
| JP2019151652A (ja) * | 2013-04-17 | 2019-09-12 | メイン ファーマ インターナショナル プロプライエタリー リミテッドMayne Pharma International Pty.Ltd. | Hedgehog経路阻害剤を用いた増殖障害の処置および予後モニタリングの方法 |
| JP2022515256A (ja) * | 2018-12-25 | 2022-02-17 | ソル - ゲル テクノロジーズ リミテッド | Egfr阻害剤を含む組成物による皮膚障害の治療 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102083801A (zh) | 2011-06-01 |
| WO2009121042A8 (en) | 2010-11-25 |
| US20090269354A1 (en) | 2009-10-29 |
| KR20110005828A (ko) | 2011-01-19 |
| WO2009121042A1 (en) | 2009-10-01 |
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