JP2011515481A5 - - Google Patents
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- Publication number
- JP2011515481A5 JP2011515481A5 JP2011501983A JP2011501983A JP2011515481A5 JP 2011515481 A5 JP2011515481 A5 JP 2011515481A5 JP 2011501983 A JP2011501983 A JP 2011501983A JP 2011501983 A JP2011501983 A JP 2011501983A JP 2011515481 A5 JP2011515481 A5 JP 2011515481A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- cancer
- kit
- sodium meta
- cisplatin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 201000011510 cancer Diseases 0.000 claims 8
- PTLRDCMBXHILCL-UHFFFAOYSA-M Sodium arsenite Chemical compound [Na+].[O-][As]=O PTLRDCMBXHILCL-UHFFFAOYSA-M 0.000 claims 6
- 229960004316 cisplatin Drugs 0.000 claims 5
- LXZZYRPGZAFOLE-UHFFFAOYSA-L transplatin Chemical compound [H][N]([H])([H])[Pt](Cl)(Cl)[N]([H])([H])[H] LXZZYRPGZAFOLE-UHFFFAOYSA-L 0.000 claims 5
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- GCPXMJHSNVMWNM-UHFFFAOYSA-N Trihydroxyarsenite(Iii) Chemical compound O[As](O)O GCPXMJHSNVMWNM-UHFFFAOYSA-N 0.000 claims 3
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 claims 3
- 229910052785 arsenic Inorganic materials 0.000 claims 3
- 229960002594 arsenic trioxide Drugs 0.000 claims 3
- GOLCXWYRSKYTSP-UHFFFAOYSA-N arsenic trioxide Inorganic materials O1[As]2O[As]1O2 GOLCXWYRSKYTSP-UHFFFAOYSA-N 0.000 claims 3
- AOJJSUZBOXZQNB-TZSSRYMLSA-N ADRIAMYCIN Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 229940009456 Adriamycin Drugs 0.000 claims 2
- 210000000349 Chromosomes Anatomy 0.000 claims 2
- 229960004679 Doxorubicin Drugs 0.000 claims 2
- RCINICONZNJXQF-MZXODVADSA-N Intaxel Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 229960001592 Paclitaxel Drugs 0.000 claims 2
- 210000003411 Telomere Anatomy 0.000 claims 2
- 210000004027 cells Anatomy 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 229920000511 telomere Polymers 0.000 claims 2
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N Docetaxel Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 230000001472 cytotoxic Effects 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- 229930003347 taxol Natural products 0.000 claims 1
- 230000001225 therapeutic Effects 0.000 claims 1
Claims (12)
- 治療上有効な量の、メタ亜ヒ酸ナトリウム、もしくはメタ亜ヒ酸ナトリウムと三酸化ヒ素との組み合わせを含む第１の組成物、ならびにシスプラチン、アドリアマイシンおよびタキソールからなる群より選択される、治療上有効な量の細胞傷害性抗癌剤を含む第２の組成物を含む、癌の処置のためのキット。
- 前記第１の組成物は、メタ亜ヒ酸ナトリウムを含み、前記第２の組成物は、シスプラチンを含む、請求項１に記載のキット。
- 前記第１の組成物は、経口投与のために処方されている、請求項２に記載のキット。
- 前記第１の組成物は、メタ亜ヒ酸ナトリウムと三酸化ヒ素との組み合わせを含み、前記第２の組成物は、シスプラチンを含む、請求項１に記載のキット。
- 前記癌は、肺癌である、請求項１に記載のキット。
- 前記癌は、長いテロメアを有する染色体を含む癌細胞と関連する癌である、請求項１に記載のキット。
- 患者における癌の処置のための組成物であって、該組成物は非ヒ素抗癌剤を含み、ここで該患者は、メタ亜ヒ酸ナトリウム、メタ亜ヒ酸ナトリウムと三酸化ヒ素との組み合わせもしくはこれらの組み合わせの該患者への投与を含む処置レジメンに供されている、組成物。
- 前記患者は、肺癌を有する、請求項７に記載の組成物。
- 前記癌は、長いテロメアを有する染色体を含む癌細胞と関連する、請求項７に記載の組成物。
- 前記非ヒ素抗癌剤は、シスプラチン、アドリアマイシン、タキサンおよびこれらの組み合わせから選択される、請求項７に記載の組成物。
- 前記タキサンは、パクリタキセルもしくはドセタキセルである、請求項１０に記載の組成物。
- 前記非ヒ素抗癌剤は、シスプラチンである、請求項７に記載の組成物。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3998708P | 2008-03-27 | 2008-03-27 | |
| US61/039,987 | 2008-03-27 | ||
| US12/408,864 US20090246291A1 (en) | 2008-03-27 | 2009-03-23 | Method and compositions for treatment of cancer |
| US12/408,864 | 2009-03-23 | ||
| PCT/US2009/038104 WO2009120697A2 (en) | 2008-03-27 | 2009-03-24 | Method and compositions for treatment of cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014046212A Division JP2014101387A (ja) | 2008-03-27 | 2014-03-10 | 癌の処置のための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011515481A JP2011515481A (ja) | 2011-05-19 |
| JP2011515481A5 true JP2011515481A5 (ja) | 2012-04-05 |
| JP5543956B2 JP5543956B2 (ja) | 2014-07-09 |
Family
ID=41114644
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501983A Active JP5543956B2 (ja) | 2008-03-27 | 2009-03-24 | 癌の処置のための方法および組成物 |
| JP2014046212A Withdrawn JP2014101387A (ja) | 2008-03-27 | 2014-03-10 | 癌の処置のための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014046212A Withdrawn JP2014101387A (ja) | 2008-03-27 | 2014-03-10 | 癌の処置のための方法および組成物 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20090246291A1 (ja) |
| EP (1) | EP2268292B1 (ja) |
| JP (2) | JP5543956B2 (ja) |
| KR (1) | KR101634138B1 (ja) |
| CN (2) | CN102046187A (ja) |
| AU (1) | AU2009228378B2 (ja) |
| BR (1) | BRPI0909164A2 (ja) |
| CA (1) | CA2719766C (ja) |
| CY (1) | CY1120536T1 (ja) |
| DK (1) | DK2268292T3 (ja) |
| ES (1) | ES2656762T3 (ja) |
| HU (1) | HUE036609T2 (ja) |
| LT (1) | LT2268292T (ja) |
| MX (1) | MX2010010621A (ja) |
| PL (1) | PL2268292T3 (ja) |
| PT (1) | PT2268292T (ja) |
| RU (1) | RU2508116C2 (ja) |
| SI (1) | SI2268292T1 (ja) |
| WO (1) | WO2009120697A2 (ja) |
| ZA (1) | ZA201006988B (ja) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1721615A1 (en) | 2005-05-09 | 2006-11-15 | Komipharm International Co., Ltd. | Pharmaceutical compositions comprising sodium or potassium arsenite for the treatment of urogenital cancer and its metastasis |
| US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
| KR20120061908A (ko) * | 2009-09-10 | 2012-06-13 | 코미녹스 인코포레이티드 | 암 줄기세포-표적 및 약물 내성 암 치료 |
| US8795738B2 (en) * | 2009-11-12 | 2014-08-05 | Board Of Regents Of The University Of Texas System | Use of arsenic for cancer therapy protection |
| US11084811B2 (en) | 2010-03-01 | 2021-08-10 | Oncternal Therapeutics, Inc. | Compounds for treatment of cancer |
| AU2011279836A1 (en) * | 2010-07-18 | 2013-02-07 | Niiki Pharma Acquisition Corp. 2 | Combination therapy using a ruthenium complex |
| CA3030689C (en) * | 2010-08-24 | 2021-03-02 | Gtx, Inc. | Compounds for treatment of cancer |
| US20120251628A1 (en) * | 2011-03-30 | 2012-10-04 | Young Joo Min | Compositions and methods for treatment of cancer |
| EP2707008A4 (en) * | 2011-05-12 | 2014-11-26 | Univ Texas | USE OF ARSENIC IN THE PROTECTION AGAINST CANCER THERAPY |
| US8834938B2 (en) | 2011-05-18 | 2014-09-16 | Board Of Regents Of The University Of Texas System | Use of arsenic for cancer therapy protection |
| KR101309844B1 (ko) | 2013-03-15 | 2013-09-23 | 박상채 | 항암 활성 증진용 한약재 및 이의 제조방법 |
| WO2014152330A1 (en) * | 2013-03-15 | 2014-09-25 | Stc.Unm | Arsenic-based treatment of cancers and inflammatory disorders |
| AU2014290012B2 (en) * | 2013-07-19 | 2020-01-16 | Onyx Therapeutics, Inc. | Peptide epoxyketone proteasome inhibitors in combination with PIM kinase inhibitors for treatment of cancers |
| US11241453B2 (en) * | 2016-12-01 | 2022-02-08 | Eupharma Pty Ltd | Arsenic compositions |
| JP7419333B2 (ja) * | 2018-03-22 | 2024-01-22 | コミファーム インターナショナル オーストラリア ピーティーワイ リミテッド | メタ亜ヒ酸塩を含む医薬組成物および製造方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1621077E (pt) * | 1997-10-15 | 2008-11-04 | Polarx Biopharmaceuticals Inc | Composições farmacêuticas compreendendo trióxido de arsénico para o tratamento de um tumor do sistema nervoso central |
| DK2255800T3 (da) * | 1997-11-10 | 2013-02-04 | Sloan Kettering Inst Cancer | Arsentrioxid til anvendelse ved behandling af leukæmi |
| KR20020083678A (ko) * | 2001-04-28 | 2002-11-04 | 주식회사 한국미생물연구소 | 아르세닉산나트륨 염, 소디움 메타아르세나이트 또는 이의혼합물을 함유한 항암제 조성물 |
| ES2425418T3 (es) * | 2002-04-10 | 2013-10-15 | Komipharm International Co., Ltd. | Composición farmacéutica que comprende arsenito para el tratamiento de neoplasias |
| EP1721615A1 (en) * | 2005-05-09 | 2006-11-15 | Komipharm International Co., Ltd. | Pharmaceutical compositions comprising sodium or potassium arsenite for the treatment of urogenital cancer and its metastasis |
| US8097237B2 (en) * | 2005-08-23 | 2012-01-17 | Stc.Unm | Non-invasive diagnostic agents of cancer and methods of diagnosing cancer, especially leukemia and lymphoma |
| WO2009049258A1 (en) * | 2007-10-12 | 2009-04-16 | The Johns Hopkins University | Compounds for hedgehog pathway blockade in proliferative disorders, including hematopoietic malignancies |
-
2009
- 2009-03-23 US US12/408,864 patent/US20090246291A1/en not_active Abandoned
- 2009-03-24 CA CA2719766A patent/CA2719766C/en active Active
- 2009-03-24 PL PL09723788T patent/PL2268292T3/pl unknown
- 2009-03-24 ES ES09723788.7T patent/ES2656762T3/es active Active
- 2009-03-24 RU RU2010143893/15A patent/RU2508116C2/ru active
- 2009-03-24 PT PT97237887T patent/PT2268292T/pt unknown
- 2009-03-24 MX MX2010010621A patent/MX2010010621A/es active IP Right Grant
- 2009-03-24 WO PCT/US2009/038104 patent/WO2009120697A2/en active Application Filing
- 2009-03-24 KR KR1020107024132A patent/KR101634138B1/ko active IP Right Grant
- 2009-03-24 CN CN2009801187686A patent/CN102046187A/zh active Pending
- 2009-03-24 CN CN201510355863.5A patent/CN104997808A/zh active Pending
- 2009-03-24 DK DK09723788.7T patent/DK2268292T3/en active
- 2009-03-24 BR BRPI0909164A patent/BRPI0909164A2/pt not_active Application Discontinuation
- 2009-03-24 AU AU2009228378A patent/AU2009228378B2/en active Active
- 2009-03-24 HU HUE09723788A patent/HUE036609T2/hu unknown
- 2009-03-24 EP EP09723788.7A patent/EP2268292B1/en active Active
- 2009-03-24 SI SI200931809T patent/SI2268292T1/en unknown
- 2009-03-24 JP JP2011501983A patent/JP5543956B2/ja active Active
- 2009-03-24 LT LTEP09723788.7T patent/LT2268292T/lt unknown
-
2010
- 2010-09-30 ZA ZA2010/06988A patent/ZA201006988B/en unknown
-
2014
- 2014-03-10 JP JP2014046212A patent/JP2014101387A/ja not_active Withdrawn
-
2017
- 2017-06-02 US US15/613,020 patent/US20180055812A1/en not_active Abandoned
-
2018
- 2018-03-09 CY CY20181100285T patent/CY1120536T1/el unknown
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