JP2011514337A - 糖ガラス化ウィルス様粒子(vlp) - Google Patents

糖ガラス化ウィルス様粒子(vlp) Download PDF

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Publication number
JP2011514337A
JP2011514337A JP2010547860A JP2010547860A JP2011514337A JP 2011514337 A JP2011514337 A JP 2011514337A JP 2010547860 A JP2010547860 A JP 2010547860A JP 2010547860 A JP2010547860 A JP 2010547860A JP 2011514337 A JP2011514337 A JP 2011514337A
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Japan
Prior art keywords
composition
vlp
powder
sugar glass
sugar
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Pending
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JP2010547860A
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English (en)
Japanese (ja)
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JP2011514337A5 (cg-RX-API-DMAC10.html
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シェノイ,ディネッシュ
ロビンソン,ジェームス
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ノババックス,インコーポレイテッド
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Publication of JP2011514337A publication Critical patent/JP2011514337A/ja
Publication of JP2011514337A5 publication Critical patent/JP2011514337A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16023—Virus like particles [VLP]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2010547860A 2008-02-25 2009-02-25 糖ガラス化ウィルス様粒子(vlp) Pending JP2011514337A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3124308P 2008-02-25 2008-02-25
PCT/US2009/035122 WO2009108689A1 (en) 2008-02-25 2009-02-25 Sugar glassified virus like particles (vlps)

Publications (2)

Publication Number Publication Date
JP2011514337A true JP2011514337A (ja) 2011-05-06
JP2011514337A5 JP2011514337A5 (cg-RX-API-DMAC10.html) 2012-04-05

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ID=41016454

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JP2010547860A Pending JP2011514337A (ja) 2008-02-25 2009-02-25 糖ガラス化ウィルス様粒子(vlp)

Country Status (8)

Country Link
EP (1) EP2254554A1 (cg-RX-API-DMAC10.html)
JP (1) JP2011514337A (cg-RX-API-DMAC10.html)
CN (1) CN102014873A (cg-RX-API-DMAC10.html)
BR (1) BRPI0908861A2 (cg-RX-API-DMAC10.html)
CA (1) CA2716546A1 (cg-RX-API-DMAC10.html)
MX (1) MX2010009351A (cg-RX-API-DMAC10.html)
RU (1) RU2010139478A (cg-RX-API-DMAC10.html)
WO (1) WO2009108689A1 (cg-RX-API-DMAC10.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017502962A (ja) * 2013-12-31 2017-01-26 インフェクシャス ディズィーズ リサーチ インスティチュート 単一バイアルのワクチン製剤
JP2017507165A (ja) * 2013-12-16 2017-03-16 マサチューセッツ インスティテュート オブ テクノロジー マイクロモールド成形された、または3次元印刷されたパルス放出ワクチン製剤
WO2025058011A1 (ja) * 2023-09-13 2025-03-20 国立大学法人大阪大学 経鼻投与用組成物

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US11446374B2 (en) 2008-12-09 2022-09-20 Novavax, Inc. Modified RSV F proteins and methods of their use
ES2987238T3 (es) 2008-12-09 2024-11-14 Novavax Inc Proteínas F del RSV modificadas y métodos de su uso
EP2519539A4 (en) * 2009-12-28 2013-11-13 Ligocyte Pharmaceuticals Inc METHODS FOR STABILIZING VIRUS-LIKE PARTICULATE SOLUTIONS BASED ON INFLUENZA-INFLUENZA-VIRUSED VIRUSES
GB201002419D0 (en) * 2010-02-12 2010-03-31 Isis Innovation Stable live vaccine formulations
MX373096B (es) 2010-12-02 2020-04-27 Oncolytics Biotech Inc Formulaciones virales líquidas.
CA2819236A1 (en) * 2010-12-02 2012-06-07 Oncolytics Biotech Inc. Lyophilized viral formulations
KR102049988B1 (ko) 2011-06-24 2019-11-28 머크 샤프 앤드 돔 코포레이션 알루미늄 아주반트를 포함하는 hpv 백신 제제 및 그의 제조 방법
SG10201602434UA (en) * 2011-09-30 2016-05-30 Novavax Inc Recombinant nanoparticle rsv f vaccine for respiratory syncytial virus
US20130089638A1 (en) * 2011-10-11 2013-04-11 Mead Johnson Nutrition Company Compositions Comprising Maltotriose And Methods Of Using Same To Inhibit Damage Caused By Dehydration Processes
JP6611720B2 (ja) 2013-09-03 2019-11-27 ジョージア テック リサーチ コーポレイション 熱安定性ワクチン製剤及びマイクロニードル
CN106061292B (zh) 2013-12-16 2020-01-21 麻省理工学院 强化的微量营养素盐调配物
WO2015171810A1 (en) * 2014-05-06 2015-11-12 The Regents Of The University Of Colorado, A Body Corporate Compositions, methods and uses for thermally stable human papillomavirus formulations
US11273127B2 (en) 2014-05-06 2022-03-15 The Regents Of The University Of Colorado, A Body Corporate Compositions, methods and uses for thermally stable multi-targeted antigens
CN114617959A (zh) 2015-09-03 2022-06-14 诺瓦瓦克斯股份有限公司 具有改进的稳定性和免疫原性的疫苗组合物
CN108472357A (zh) * 2015-09-04 2018-08-31 创赏有限公司 Vlp稳定的疫苗组合物
CN111148509A (zh) 2017-07-24 2020-05-12 诺瓦瓦克斯股份有限公司 治疗呼吸系统疾病的方法和组合物
CN120227451A (zh) 2018-03-19 2025-07-01 诺瓦瓦克斯股份有限公司 多价流感纳米颗粒疫苗
BR112021023726A2 (pt) 2019-05-25 2022-02-15 Infectious Disease Res Inst Composição e método para secagem por pulverização de uma emulsão de vacina adjuvante
IL298019A (en) 2020-05-13 2023-01-01 Massachusetts Inst Technology Compositions of polymeric microdevices and their use in cancer immunotherapy
CN115350281B (zh) * 2022-09-20 2026-01-02 华派生物技术(集团)股份有限公司 一种病毒样颗粒疫苗冻干保护剂及其制备方法

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JP2002504090A (ja) * 1997-03-18 2002-02-05 クアドラント ホールディングス ケンブリッジ リミテッド 液体調合物における安定な粒子
WO2006017246A2 (en) * 2004-07-12 2006-02-16 Sd Pharmaceuticals, Inc. Compositions for delivering highly water soluble drugs
WO2006085082A1 (en) * 2005-02-09 2006-08-17 Stabilitech Ltd. A desiccated product
JP2006518761A (ja) * 2003-02-24 2006-08-17 ファーマシューティカル プロダクションズ, インコーポレイテッド 経粘膜薬物送達システム
WO2006088336A1 (en) * 2005-02-21 2006-08-24 Lg Life Sciences, Ltd. Sustained release composition of protein drug
JP2007535514A (ja) * 2004-04-30 2007-12-06 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 乾燥方法

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Patent Citations (6)

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JP2002504090A (ja) * 1997-03-18 2002-02-05 クアドラント ホールディングス ケンブリッジ リミテッド 液体調合物における安定な粒子
JP2006518761A (ja) * 2003-02-24 2006-08-17 ファーマシューティカル プロダクションズ, インコーポレイテッド 経粘膜薬物送達システム
JP2007535514A (ja) * 2004-04-30 2007-12-06 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 乾燥方法
WO2006017246A2 (en) * 2004-07-12 2006-02-16 Sd Pharmaceuticals, Inc. Compositions for delivering highly water soluble drugs
WO2006085082A1 (en) * 2005-02-09 2006-08-17 Stabilitech Ltd. A desiccated product
WO2006088336A1 (en) * 2005-02-21 2006-08-24 Lg Life Sciences, Ltd. Sustained release composition of protein drug

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017507165A (ja) * 2013-12-16 2017-03-16 マサチューセッツ インスティテュート オブ テクノロジー マイクロモールド成形された、または3次元印刷されたパルス放出ワクチン製剤
US10300136B2 (en) 2013-12-16 2019-05-28 Massachusetts Institute Of Technology Micromolded or 3-D printed pulsatile release vaccine formulations
JP2020055818A (ja) * 2013-12-16 2020-04-09 マサチューセッツ インスティテュート オブ テクノロジー マイクロモールド成形された、または3次元印刷されたパルス放出ワクチン製剤
US10960073B2 (en) 2013-12-16 2021-03-30 Tokitae Llc Micromolded or 3-D printed pulsatile release vaccine formulations
JP2021120413A (ja) * 2013-12-16 2021-08-19 マサチューセッツ インスティテュート オブ テクノロジー マイクロモールド成形された、または3次元印刷されたパルス放出ワクチン製剤
JP2023075311A (ja) * 2013-12-16 2023-05-30 マサチューセッツ インスティテュート オブ テクノロジー マイクロモールド成形された、または3次元印刷されたパルス放出ワクチン製剤
US11975069B2 (en) 2013-12-16 2024-05-07 Massachusetts Institute Of Technology Micromolded or 3-D printed pulsatile release vaccine formulations
US12622963B2 (en) 2013-12-16 2026-05-12 Massachusetts Institute Of Technology Micromolded or 3-D printed pulsatile release vaccine formulations
JP2017502962A (ja) * 2013-12-31 2017-01-26 インフェクシャス ディズィーズ リサーチ インスティチュート 単一バイアルのワクチン製剤
WO2025058011A1 (ja) * 2023-09-13 2025-03-20 国立大学法人大阪大学 経鼻投与用組成物

Also Published As

Publication number Publication date
RU2010139478A (ru) 2012-05-20
MX2010009351A (es) 2011-03-04
BRPI0908861A2 (pt) 2018-02-06
EP2254554A1 (en) 2010-12-01
CA2716546A1 (en) 2009-09-03
CN102014873A (zh) 2011-04-13
WO2009108689A1 (en) 2009-09-03

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