JP2011510085A5 - - Google Patents
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- Publication number
- JP2011510085A5 JP2011510085A5 JP2010544374A JP2010544374A JP2011510085A5 JP 2011510085 A5 JP2011510085 A5 JP 2011510085A5 JP 2010544374 A JP2010544374 A JP 2010544374A JP 2010544374 A JP2010544374 A JP 2010544374A JP 2011510085 A5 JP2011510085 A5 JP 2011510085A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- hydroxy
- compound
- following structure
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- -1 (3-methylphenoxy) methyl Chemical group 0.000 claims 38
- 150000001875 compounds Chemical class 0.000 claims 14
- 229940002612 prodrug Drugs 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 201000004384 Alopecia Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010030043 Ocular hypertension Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 231100000360 alopecia Toxicity 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- ZDTRMJAWAIZCSV-UHFFFAOYSA-N CC(OCCN1CCOCC1)=O Chemical compound CC(OCCN1CCOCC1)=O ZDTRMJAWAIZCSV-UHFFFAOYSA-N 0.000 description 1
- ZQIRVCXZLFAPDR-UHFFFAOYSA-N CCCCCC(c(cc1)ccc1N(C(C)=O)NCCCc1ccc(C(OCCO)=O)[s]1)O Chemical compound CCCCCC(c(cc1)ccc1N(C(C)=O)NCCCc1ccc(C(OCCO)=O)[s]1)O ZQIRVCXZLFAPDR-UHFFFAOYSA-N 0.000 description 1
- YWWJHHSTXKYWTD-UHFFFAOYSA-N CCCCCC(c(cc1)ccc1N(NCCCc1ccc(C(OCCN2CCOCC2)=O)[s]1)S(C)(=O)=O)O Chemical compound CCCCCC(c(cc1)ccc1N(NCCCc1ccc(C(OCCN2CCOCC2)=O)[s]1)S(C)(=O)=O)O YWWJHHSTXKYWTD-UHFFFAOYSA-N 0.000 description 1
- UCJAZMZVEXYBRO-UHFFFAOYSA-N CCCCCC(c(cc1)ccc1NN(CCCc1ccc(C(OCCO)=O)[s]1)C(C)=O)O Chemical compound CCCCCC(c(cc1)ccc1NN(CCCc1ccc(C(OCCO)=O)[s]1)C(C)=O)O UCJAZMZVEXYBRO-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2336508P | 2008-01-24 | 2008-01-24 | |
| US12/353,290 US7956051B2 (en) | 2008-01-24 | 2009-01-14 | Therapeutic amides and related compounds |
| PCT/US2009/031081 WO2009094286A1 (en) | 2008-01-24 | 2009-01-15 | Hydrazines in glaucoma therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011510085A JP2011510085A (ja) | 2011-03-31 |
| JP2011510085A5 true JP2011510085A5 (enExample) | 2012-03-08 |
Family
ID=40899866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010544374A Abandoned JP2011510085A (ja) | 2008-01-24 | 2009-01-15 | 緑内障治療におけるヒドラジン類 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7956051B2 (enExample) |
| EP (1) | EP2247583A1 (enExample) |
| JP (1) | JP2011510085A (enExample) |
| AU (1) | AU2009206587A1 (enExample) |
| BR (1) | BRPI0906661A2 (enExample) |
| CA (1) | CA2712741A1 (enExample) |
| WO (1) | WO2009094286A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014032735A1 (en) * | 2012-09-03 | 2014-03-06 | Grindeks | Use of 3-(2,2,2-trimethylhydrazinium)-ethylpropionate or a pharmaceutically acceptable salt for treating high tension glaucoma |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| PT674516E (pt) | 1992-12-16 | 2000-05-31 | Agouron Pharma | Compostos de 5-tiapirimidinona e 5-selenopirimidinona substituidos antiproliferativos |
| US5462968A (en) | 1994-01-19 | 1995-10-31 | Allergan, Inc. | EP2 -receptor agonists as agents for lowering intraocular pressure |
| US5698598A (en) | 1995-08-04 | 1997-12-16 | Allergan | EP2 -receptor agonists as agents for lowering intraocular pressure |
| US6090847A (en) | 1997-11-21 | 2000-07-18 | Allergan Sales, Inc. | EP2 -receptor agonists as neuroprotective agents for the eye |
| US6437146B1 (en) | 1998-09-25 | 2002-08-20 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compounds as prostaglandin e2 agonists or antagonists |
| BR0213911A (pt) | 2001-11-05 | 2004-09-28 | Allergan Inc | Análogos de Èmega-cicloalquil 17-heteroaril prostaglandina e2 como agonistas do receptor ep2 |
| US8148426B2 (en) | 2004-11-19 | 2012-04-03 | Synta Pharmaceuticals Corp. | Bis(thio-hydrazide amides) for increasing Hsp70 expression |
| US7091231B2 (en) | 2004-12-10 | 2006-08-15 | Allergan, Inc. | 12-Aryl prostaglandin analogs |
| WO2006121822A1 (en) * | 2005-05-06 | 2006-11-16 | Allergan, Inc. | USE OF β-LACTAMS FOR THE TREATMENTOF IBD AND GLAUCOMA |
| FR2887879B1 (fr) | 2005-07-01 | 2008-09-26 | Trophos Sa | Nouveaux composes chimiques et leurs utilisations comme medicament,particulierement dans le traitement des maladies neurodegeneratives |
| WO2007008942A2 (en) | 2005-07-11 | 2007-01-18 | Aerie Pharmaceuticals, Inc. | Phenylamino-acetic acid [1-(pyridin-4-yl)-methylidene]-hydrazide derivatives and related compounds as modulators of g protein-coupled receptor kinases for the treatment of eye diseases |
| DE102006005179A1 (de) | 2006-02-06 | 2007-08-09 | Merck Patent Gmbh | Aminoindazolderivate |
| JP2010500976A (ja) | 2006-08-09 | 2010-01-14 | アラーガン インコーポレイテッド | 治療用アミド類および関連化合物 |
-
2009
- 2009-01-14 US US12/353,290 patent/US7956051B2/en not_active Expired - Fee Related
- 2009-01-15 CA CA2712741A patent/CA2712741A1/en not_active Abandoned
- 2009-01-15 BR BRPI0906661-6A patent/BRPI0906661A2/pt not_active IP Right Cessation
- 2009-01-15 JP JP2010544374A patent/JP2011510085A/ja not_active Abandoned
- 2009-01-15 EP EP09703976A patent/EP2247583A1/en not_active Withdrawn
- 2009-01-15 AU AU2009206587A patent/AU2009206587A1/en not_active Abandoned
- 2009-01-15 WO PCT/US2009/031081 patent/WO2009094286A1/en not_active Ceased
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