JP2011508595A5 - - Google Patents
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- JP2011508595A5 JP2011508595A5 JP2010540954A JP2010540954A JP2011508595A5 JP 2011508595 A5 JP2011508595 A5 JP 2011508595A5 JP 2010540954 A JP2010540954 A JP 2010540954A JP 2010540954 A JP2010540954 A JP 2010540954A JP 2011508595 A5 JP2011508595 A5 JP 2011508595A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid segment
- composition
- derived
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001413 amino acids Chemical class 0.000 claims description 37
- 241000894007 species Species 0.000 claims description 23
- 241001673669 Porcine circovirus 2 Species 0.000 claims description 21
- 239000013604 expression vector Substances 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 12
- 239000000427 antigen Substances 0.000 claims description 10
- 102000036639 antigens Human genes 0.000 claims description 10
- 108091007433 antigens Proteins 0.000 claims description 10
- 241000223936 Cryptosporidium parvum Species 0.000 claims description 8
- 230000028993 immune response Effects 0.000 claims description 8
- 208000015181 infectious disease Diseases 0.000 claims description 6
- 201000010740 swine influenza Diseases 0.000 claims description 6
- 241001465754 Metazoa Species 0.000 claims description 5
- 101100382437 Porcine circovirus 2 Cap gene Proteins 0.000 claims description 5
- 230000001575 pathological effect Effects 0.000 claims description 5
- 239000013598 vector Substances 0.000 claims description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
- 230000002163 immunogen Effects 0.000 claims description 3
- 241000588724 Escherichia coli Species 0.000 claims description 2
- 206010069767 H1N1 influenza Diseases 0.000 claims description 2
- 108700026244 Open Reading Frames Proteins 0.000 claims description 2
- 208000009620 Orthomyxoviridae Infections Diseases 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 2
- 244000052769 pathogen Species 0.000 claims description 2
- 230000001717 pathogenic effect Effects 0.000 claims description 2
- 101710159752 Poly(3-hydroxyalkanoate) polymerase subunit PhaE Proteins 0.000 description 2
- 101710130262 Probable Vpr-like protein Proteins 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 241000701447 unidentified baculovirus Species 0.000 description 2
- 208000008953 Cryptosporidiosis Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1786307P | 2007-12-31 | 2007-12-31 | |
| PCT/US2008/088678 WO2009088950A2 (en) | 2007-12-31 | 2008-12-31 | Pcv2 orf2 virus like particle with foreign amino acid insertion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011508595A JP2011508595A (ja) | 2011-03-17 |
| JP2011508595A5 true JP2011508595A5 (enExample) | 2012-03-22 |
Family
ID=40853690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010540954A Pending JP2011508595A (ja) | 2007-12-31 | 2008-12-31 | 外来性アミノ酸の挿入を含むｐｃｖ２ｏｒｆ２ウイルス様粒子 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20110020394A1 (enExample) |
| EP (1) | EP2231182A4 (enExample) |
| JP (1) | JP2011508595A (enExample) |
| KR (1) | KR20100103535A (enExample) |
| CN (1) | CN101932336B (enExample) |
| AU (1) | AU2008347235A1 (enExample) |
| BR (1) | BRPI0821456A2 (enExample) |
| CA (1) | CA2710558A1 (enExample) |
| WO (1) | WO2009088950A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0821456A2 (pt) * | 2007-12-31 | 2015-06-16 | Boehring Ingelheim Vetmedica Inc | Partícula similar à pcv2 orf2 com inserção de aminoácido estranho |
| CN101773667A (zh) * | 2010-01-28 | 2010-07-14 | 洛阳普莱柯生物工程有限公司 | 一种猪圆环病毒ii型疫苗制备 |
| KR102153365B1 (ko) * | 2018-03-19 | 2020-09-08 | 주식회사 옵티팜 | 신규한 바이러스 유사입자, 이를 포함하는 돼지 써코바이러스 3에 의한 질환에 대한 백신 조성물, 및 이의 제조 방법 |
| CN114341191A (zh) * | 2019-08-20 | 2022-04-12 | Km生物医药股份公司 | 猪圆环病毒2型vlp疫苗 |
| BR102019017792A2 (pt) * | 2019-08-27 | 2021-11-16 | Fundação Oswaldo Cruz | Receptáculo proteico, método para produção do receptáculo, método de identificação de patógenos ou de diagnóstico de doenças, e, uso do receptáculo |
| EP4225361A1 (en) * | 2020-10-05 | 2023-08-16 | Boehringer Ingelheim Animal Health USA Inc. | Fusion protein comprising circoviridae capsid protein, and chimeric virus-like particles composed thereof |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5202430A (en) * | 1990-01-16 | 1993-04-13 | University Of Tennessee | Transmissible gastroenteritis virus genes |
| US5565205A (en) * | 1990-08-16 | 1996-10-15 | Solvay Animal Health, Inc. | Inactivated Mycoplasma hypopneumoniae bacterin and method of use thereof |
| GB9023111D0 (en) * | 1990-10-24 | 1990-12-05 | Wellcome Found | Expression system |
| DK0555366T3 (da) * | 1990-11-01 | 2000-08-28 | Univ Iowa State Res Found Inc | Fremgangsmåde til bakteriel svækkelse og vaccine |
| US5580557A (en) * | 1991-10-09 | 1996-12-03 | Iowa State University Research Foundation, Inc. | Live, avirulent salmonella choleraesuis vaccine used for inducing an immune response in animals |
| US5338543A (en) * | 1992-02-27 | 1994-08-16 | Ambico, Inc. | Thimerosal inactivated mycoplasma hyopneumoniae vaccine |
| US5885823A (en) * | 1995-06-05 | 1999-03-23 | Nobl Laboratories, Inc. | Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents |
| DK0835930T3 (da) * | 1996-10-09 | 2001-06-18 | Akzo Nobel Nv | Europæiske vaccinestammer af porcint reproduktions- og respirationssyndrom-virus. (PRRSV) |
| US5735555A (en) * | 1996-12-18 | 1998-04-07 | Siemens Automotive Corporation | Fuel rail to fuel tube end compact connector |
| UA78180C2 (uk) * | 1997-10-03 | 2007-03-15 | Меріаль | Кільцевий вірус свині типу ii, вакцини та діагностичні реагенти |
| US6391314B1 (en) * | 1997-10-03 | 2002-05-21 | Merial | Porcine circoviruses vaccines diagnostic reagents |
| US20060029617A1 (en) * | 1997-10-03 | 2006-02-09 | Charreyre Catherine E | Porcine circovirus and Helicobacter combination vaccines and methods of use |
| US6517843B1 (en) * | 1999-08-31 | 2003-02-11 | Merial | Reduction of porcine circovirus-2 viral load with inactivated PCV-2 |
| US7192594B2 (en) * | 1997-10-03 | 2007-03-20 | Merial Limited | Postweaning multisystemic wasting syndrome and porcine circovirus from pigs |
| FR2781159B1 (fr) * | 1998-07-06 | 2000-10-06 | Merial Sas | Vaccin circovirus et parvovirus porcin |
| US7211379B2 (en) * | 1997-10-03 | 2007-05-01 | Merial Sas | Prevention of myocarditis, abortion and intrauterine infection associated with porcine circovirus-2 |
| FR2772047B1 (fr) * | 1997-12-05 | 2004-04-09 | Ct Nat D Etudes Veterinaires E | Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection |
| US20040062775A1 (en) * | 1997-12-05 | 2004-04-01 | Agence Francaise De Securite Sanitaire Des Aliments | Circovirus sequences associated with piglet weight loss disease (PWD) |
| NZ505008A (en) * | 1997-12-11 | 2003-07-25 | Univ Saskatchewan | Porcine circovirus (PCV) isolates from pigs displaying postweaning multisystemic wasting syndrome virus |
| AU770002B2 (en) * | 1998-03-13 | 2004-02-12 | University Of Georgia Research Foundation, Inc., The | Vaccines against circovirus infections |
| US6294176B1 (en) * | 1998-07-10 | 2001-09-25 | Schering-Plough Veterinary Corp. | Recombinant raccoonpox virus and uses thereof as a vaccine in mammalian and avian species |
| FR2789695B1 (fr) * | 1999-02-11 | 2003-03-07 | Merial Sas | Vecteurs et vaccins viraux a base d'adenovirus porcins recombines et replicatifs |
| US6943152B1 (en) * | 1999-06-10 | 2005-09-13 | Merial | DNA vaccine-PCV |
| US6497883B1 (en) * | 1999-06-10 | 2002-12-24 | Merial | Porcine circovirus recombinant poxvirus vaccine |
| US6808900B2 (en) * | 2000-06-15 | 2004-10-26 | Manitoba, University Of | Cryptosporidium parvum antigens, antibodies thereto and diagnostic and therapeutic compositions thereof |
| US7018638B2 (en) * | 2000-12-19 | 2006-03-28 | Wyeth | Mycoplasma hyopneumoniae bacterin vaccine |
| KR100876629B1 (ko) * | 2001-03-27 | 2009-01-07 | 유니버시티 오브 사스카췌완 | 써코바이러스의 배양 방법 |
| US20030096377A1 (en) * | 2001-06-28 | 2003-05-22 | Virginia Tech Intellectual Properties, Inc. | Differential PCR-RFLP assay for detecting and distinguishing between nonpathogenic PCV-1 and pathogenic PCV-2 |
| TNSN03155A1 (fr) * | 2001-07-02 | 2005-12-23 | Pfizer Prod Inc | Vaccination unidose avec mycoplasma hyopneumoniae |
| US7361352B2 (en) * | 2001-08-15 | 2008-04-22 | Acambis, Inc. | Influenza immunogen and vaccine |
| US7279166B2 (en) * | 2001-12-12 | 2007-10-09 | Virginia Tech Intellectual Properties, Inc. | Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof |
| US7276353B2 (en) * | 2001-12-12 | 2007-10-02 | Virginia Tech Intellectual Properties, Inc. | Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof |
| US6841364B2 (en) * | 2002-01-22 | 2005-01-11 | Protatek International, Inc. | Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof |
| US20030215455A1 (en) * | 2002-05-14 | 2003-11-20 | Bailey Reynolds | Vaccine stabilizer and method of use |
| US7223207B1 (en) * | 2002-09-13 | 2007-05-29 | Simon Basyuk | Exercise and massage device |
| CN1458167A (zh) * | 2003-06-02 | 2003-11-26 | 中国农业科学院哈尔滨兽医研究所 | 截短表达的猪圆环病毒ⅱ型衣壳蛋白抗原及其应用 |
| US7335361B2 (en) * | 2003-06-09 | 2008-02-26 | Animal Technology Institute Taiwan | Fusion antigen used as vaccine |
| HRP20080235T3 (hr) * | 2003-07-24 | 2008-07-31 | Merial Limited | Formulacija vakcine koja sadrži emulziju ulje-u-vodi |
| UA87665C2 (ru) * | 2003-07-25 | 2009-08-10 | Берингер Ингельхайм Ветмедика, Инк. | Авирулентный изолят lawsonia intracellularis европейского происхождения, вакцина для иммунизации животных, применение заявленного авирулентного изолята как вакцины, способ получения вакцины, способ культивирования lawsonia intracellularis, способ диагностики пролиферативной энтеропатии свиней и способ получения антисыворотки к lawsonia intracellularis |
| FR2861731B1 (fr) * | 2003-10-30 | 2006-02-24 | Centre Nat Rech Scient | Nouvelle proteine de fixation du phosphate, compositions pharmaceutiques la contenant et ses utilisations |
| CN1579553A (zh) * | 2004-05-18 | 2005-02-16 | 浙江大学 | Ii型猪圆环病毒核酸疫苗的制备方法及其应用 |
| KR20070052273A (ko) * | 2004-06-30 | 2007-05-21 | 아이디 바이오메디컬 코포레이션 오브 퀘벡 | 코로나바이러스 감염의 치료를 위한 백신 조성물 |
| US7833707B2 (en) * | 2004-12-30 | 2010-11-16 | Boehringer Ingelheim Vetmedica, Inc. | Methods of overexpression and recovery of porcine circovirus type 2 ORF2 |
| US7700285B1 (en) * | 2005-12-29 | 2010-04-20 | Boehringer Ingelheim Vetmedica, Inc. | PCV2 immunogenic compositions and methods of producing such compositions |
| ES2343201T3 (es) * | 2005-01-13 | 2010-07-26 | Boehringer Ingelheim Vetmedica Gmbh | Vacunas contra el srrp. |
| US7300785B2 (en) * | 2005-02-03 | 2007-11-27 | Universiteit Ghent | Culturing circular ssDNA viruses for the production of vaccines |
| US8834891B2 (en) * | 2005-03-14 | 2014-09-16 | Boehringer Ingelheim Vetmedica, Inc. | Immunogenic compositions comprising Lawsonia intracellularis |
| BRPI0607540B1 (pt) * | 2005-04-13 | 2017-05-09 | Merial Ltd | ensaio para a produção de circovírus porcino |
| US7691368B2 (en) * | 2005-04-15 | 2010-04-06 | Merial Limited | Vaccine formulations |
| US20080226669A1 (en) * | 2005-12-29 | 2008-09-18 | Boehringer Ingelheim Vetmedica, Inc. | Multivalent pcv2 immunogenic compositions and methods of producing such compositions |
| PL2371383T3 (pl) * | 2005-12-29 | 2016-01-29 | Boehringer Ingelheim Vetmedica Inc | Zastosowanie kompozycji immunogennej do zmniejszania objawów klinicznych u świń |
| WO2008064299A2 (en) * | 2006-11-22 | 2008-05-29 | Boehringer Ingelheim Vetmedica, Inc. | Methods of reducing porcine circovirus-associated disease outbreaks |
| US20090017064A1 (en) * | 2007-07-10 | 2009-01-15 | Wyeth | Methods and Compositions for Immunizing Pigs Against Porcine Circovirus |
| US7829274B2 (en) * | 2007-09-04 | 2010-11-09 | Boehringer Ingelheim Vetmedica, Inc. | Reduction of concomitant infections in pigs by the use of PCV2 antigen |
| BRPI0821456A2 (pt) * | 2007-12-31 | 2015-06-16 | Boehring Ingelheim Vetmedica Inc | Partícula similar à pcv2 orf2 com inserção de aminoácido estranho |
-
2008
- 2008-12-31 BR BRPI0821456-5A patent/BRPI0821456A2/pt not_active IP Right Cessation
- 2008-12-31 CA CA 2710558 patent/CA2710558A1/en not_active Abandoned
- 2008-12-31 WO PCT/US2008/088678 patent/WO2009088950A2/en not_active Ceased
- 2008-12-31 EP EP20080869827 patent/EP2231182A4/en not_active Withdrawn
- 2008-12-31 KR KR1020107014080A patent/KR20100103535A/ko not_active Ceased
- 2008-12-31 AU AU2008347235A patent/AU2008347235A1/en not_active Abandoned
- 2008-12-31 JP JP2010540954A patent/JP2011508595A/ja active Pending
- 2008-12-31 CN CN200880126037.1A patent/CN101932336B/zh not_active Expired - Fee Related
- 2008-12-31 US US12/812,590 patent/US20110020394A1/en not_active Abandoned
-
2015
- 2015-01-08 US US14/592,562 patent/US20150202282A1/en not_active Abandoned
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