JP2011507194A5 - - Google Patents
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- JP2011507194A5 JP2011507194A5 JP2010538162A JP2010538162A JP2011507194A5 JP 2011507194 A5 JP2011507194 A5 JP 2011507194A5 JP 2010538162 A JP2010538162 A JP 2010538162A JP 2010538162 A JP2010538162 A JP 2010538162A JP 2011507194 A5 JP2011507194 A5 JP 2011507194A5
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- 238000000034 method Methods 0.000 claims description 91
- 238000005040 ion trap Methods 0.000 claims description 38
- 239000012491 analyte Substances 0.000 claims description 29
- 239000006200 vaporizer Substances 0.000 claims description 23
- 239000003623 enhancer Substances 0.000 claims description 19
- 230000008016 vaporization Effects 0.000 claims description 19
- 238000003795 desorption Methods 0.000 claims description 16
- 238000009834 vaporization Methods 0.000 claims description 16
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims description 10
- 208000035699 Distal ileal obstruction syndrome Diseases 0.000 claims description 6
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 6
- 238000000688 desorption electrospray ionisation Methods 0.000 claims description 6
- 238000000375 direct analysis in real time Methods 0.000 claims description 6
- 238000012063 dual-affinity re-targeting Methods 0.000 claims description 6
- 238000004949 mass spectrometry Methods 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 238000000672 surface-enhanced laser desorption--ionisation Methods 0.000 claims description 6
- 230000003321 amplification Effects 0.000 claims description 4
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 4
- 238000012544 monitoring process Methods 0.000 claims description 3
- 239000011261 inert gas Substances 0.000 claims 4
- 230000008021 deposition Effects 0.000 claims 2
- 239000007789 gas Substances 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 description 10
- 210000004027 cell Anatomy 0.000 description 8
- 229920000642 polymer Polymers 0.000 description 6
- 241000700605 Viruses Species 0.000 description 4
- 239000002105 nanoparticle Substances 0.000 description 4
- 210000003463 organelle Anatomy 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 108091005461 Nucleic proteins Proteins 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 210000003763 chloroplast Anatomy 0.000 description 2
- 210000000349 chromosome Anatomy 0.000 description 2
- 239000000412 dendrimer Substances 0.000 description 2
- 229920000736 dendritic polymer Polymers 0.000 description 2
- 238000010894 electron beam technology Methods 0.000 description 2
- 230000005686 electrostatic field Effects 0.000 description 2
- 239000010419 fine particle Substances 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 238000010884 ion-beam technique Methods 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 239000011859 microparticle Substances 0.000 description 2
- 210000003470 mitochondria Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 210000003568 synaptosome Anatomy 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1340807P | 2007-12-13 | 2007-12-13 | |
| US61/013,408 | 2007-12-13 | ||
| PCT/US2008/086441 WO2009076535A1 (en) | 2007-12-13 | 2008-12-11 | System and method for performing charge-monitoring mass spectrometry |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014012159A Division JP5793207B2 (ja) | 2007-12-13 | 2014-01-27 | 検体生体粒子の電荷監視質量分析を行うためのシステムおよび方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011507194A JP2011507194A (ja) | 2011-03-03 |
| JP2011507194A5 true JP2011507194A5 (https=) | 2013-01-17 |
| JP5477295B2 JP5477295B2 (ja) | 2014-04-23 |
Family
ID=40755885
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010538162A Expired - Fee Related JP5477295B2 (ja) | 2007-12-13 | 2008-12-11 | 電荷監視質量分析を行うためのシステムおよび方法 |
| JP2014012159A Expired - Fee Related JP5793207B2 (ja) | 2007-12-13 | 2014-01-27 | 検体生体粒子の電荷監視質量分析を行うためのシステムおよび方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014012159A Expired - Fee Related JP5793207B2 (ja) | 2007-12-13 | 2014-01-27 | 検体生体粒子の電荷監視質量分析を行うためのシステムおよび方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8963075B2 (https=) |
| EP (1) | EP2232213A4 (https=) |
| JP (2) | JP5477295B2 (https=) |
| WO (1) | WO2009076535A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7915579B2 (en) * | 2008-09-05 | 2011-03-29 | Ohio University | Method and apparatus of liquid sample-desorption electrospray ionization-mass specrometry (LS-DESI-MS) |
| US8309912B2 (en) * | 2008-11-21 | 2012-11-13 | Applied Nanotech Holdings, Inc. | Atmospheric pressure ion trap |
| US8153964B2 (en) * | 2009-05-29 | 2012-04-10 | Academia Sinica | Ultrasound ionization mass spectrometer |
| CN101937823B (zh) * | 2009-06-30 | 2012-05-23 | 同方威视技术股份有限公司 | 离子迁移谱仪的离子收集装置和离子迁移谱仪 |
| US9224586B2 (en) * | 2009-12-23 | 2015-12-29 | Academia Sinica | Apparatuses and methods for portable mass spectrometry |
| US9459247B2 (en) * | 2010-03-29 | 2016-10-04 | Academia Sinica | Quantitative measurement of nano/micro particle endocytosis with cell mass spectrometry |
| US10504713B2 (en) * | 2011-06-28 | 2019-12-10 | Academia Sinica | Frequency scan linear ion trap mass spectrometry |
| GB201111560D0 (en) * | 2011-07-06 | 2011-08-24 | Micromass Ltd | Photo-dissociation of proteins and peptides in a mass spectrometer |
| US8648297B2 (en) | 2011-07-21 | 2014-02-11 | Ohio University | Coupling of liquid chromatography with mass spectrometry by liquid sample desorption electrospray ionization (DESI) |
| US20130062517A1 (en) * | 2011-09-12 | 2013-03-14 | Battelle Memorial Institute | Accelerated high resolution differential ion mobility separations using hydrogen carrier gas |
| JP6278895B2 (ja) * | 2011-12-15 | 2018-02-14 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | 周期場微分型電気移動度分析装置 |
| EP2797105B1 (en) * | 2013-04-26 | 2018-08-15 | Amsterdam Scientific Instruments Holding B.V. | Detection of ions in an ion trap |
| WO2014183105A1 (en) * | 2013-05-10 | 2014-11-13 | Academia Sinica | Nanoparticle measurement virus mass spectrometry |
| WO2015183837A1 (en) | 2014-05-27 | 2015-12-03 | Brian Haynes | Compositions, methods, and uses related to ntrk2-tert fusions |
| WO2015183836A1 (en) | 2014-05-27 | 2015-12-03 | Brian Haynes | Compositions, methods, and uses related to ntrk2-tert fusions |
| TWI649118B (zh) * | 2016-05-10 | 2019-02-01 | 譜光儀器股份有限公司 | 偵測帶電粒子裝置及體現該裝置於質譜法的設備 |
| CN108289063B (zh) * | 2017-09-11 | 2021-07-27 | 上海金融期货信息技术有限公司 | 一种低延迟通讯系统 |
| EP3738137A1 (en) | 2018-01-12 | 2020-11-18 | The Trustees of Indiana University | Electrostatic linear ion trap design for charge detection mass spectrometry |
| GB201802917D0 (en) | 2018-02-22 | 2018-04-11 | Micromass Ltd | Charge detection mass spectrometry |
| EP4443473A3 (en) | 2018-12-03 | 2025-01-01 | The Trustees of Indiana University | Apparatus for simultaneously analyzing multiple ions with an electrostatic linear ion trap |
| WO2020198332A1 (en) * | 2019-03-25 | 2020-10-01 | The Regents Of The University Of California | Multiplex charge detection mass spectrometry |
| EP3959741A1 (en) | 2019-04-23 | 2022-03-02 | The Trustees of Indiana University | Identification of sample subspecies based on particle charge behavior under structural change-inducing sample conditions |
| WO2021061650A1 (en) | 2019-09-25 | 2021-04-01 | The Trustees Of Indiana University | Apparatus and method for pulsed mode charge detection mass spectrometry |
| CN114728237B (zh) | 2019-10-10 | 2026-02-24 | 印地安纳大学理事会 | 用于识别、选择和纯化粒子的系统和方法 |
| JP7690209B2 (ja) * | 2019-12-18 | 2025-06-10 | ザ・トラスティーズ・オブ・インディアナ・ユニバーシティー | 電荷測定装置を有する質量分析計 |
| WO2021126971A1 (en) * | 2019-12-18 | 2021-06-24 | The Trustees Of Indiana University | Charge filter arrangement and applications thereof |
| WO2021207494A1 (en) | 2020-04-09 | 2021-10-14 | Waters Technologies Corporation | Ion detector |
| US20240047191A1 (en) * | 2020-12-24 | 2024-02-08 | Micromass Uk Limited | Mass and/or ion mobility spectrometry |
| GB202020575D0 (en) * | 2020-12-24 | 2021-02-10 | Micromass Ltd | Characterising mixtures of high-mass particles using m/z seperation |
| CN113281397B (zh) * | 2021-05-19 | 2023-04-25 | 中国科学技术大学 | 追踪单溶酶体中亲溶酶体内容物的方法 |
| US11985756B2 (en) * | 2021-10-20 | 2024-05-14 | Applied Materials, Inc. | Linear accelerator coil including multiple fluid channels |
| CN118402037A (zh) | 2021-12-15 | 2024-07-26 | 水技术公司 | 具有集成放大器的感应式检测器 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8503125D0 (en) * | 1985-02-07 | 1985-03-13 | Sherritt Gordon Mines Ltd | Quadrupole mass spectrometers |
| US5383019A (en) * | 1990-03-23 | 1995-01-17 | Fisons Plc | Inductively coupled plasma spectrometers and radio-frequency power supply therefor |
| US5572022A (en) | 1995-03-03 | 1996-11-05 | Finnigan Corporation | Method and apparatus of increasing dynamic range and sensitivity of a mass spectrometer |
| US5591969A (en) * | 1995-04-12 | 1997-01-07 | The United States Of America As Represented By The Secretary Of The Navy | Inductive detector for time-of-flight mass spectrometers |
| US5843603A (en) * | 1995-08-25 | 1998-12-01 | Kabushiki Kaisha Toshiba | Method of evaluating shaped beam of charged beam writer and method of forming pattern |
| US5729014A (en) * | 1996-07-11 | 1998-03-17 | Varian Associates, Inc. | Method for injection of externally produced ions into a quadrupole ion trap |
| US6049086A (en) * | 1998-02-12 | 2000-04-11 | Quester Technology, Inc. | Large area silent discharge excitation radiator |
| US6262638B1 (en) | 1998-09-28 | 2001-07-17 | Axcelis Technologies, Inc. | Tunable and matchable resonator coil assembly for ion implanter linear accelerator |
| WO2001033605A2 (en) * | 1999-10-29 | 2001-05-10 | Rijksuniversiteit Groningen | Atmospheric pressure photoionization (appi): a new ionization method for liquid chromatography-mass spectrometry |
| US6700120B2 (en) * | 2000-11-30 | 2004-03-02 | Mds Inc. | Method for improving signal-to-noise ratios for atmospheric pressure ionization mass spectrometry |
| US6855906B2 (en) * | 2001-10-16 | 2005-02-15 | Adam Alexander Brailove | Induction plasma reactor |
| US6646256B2 (en) | 2001-12-18 | 2003-11-11 | Agilent Technologies, Inc. | Atmospheric pressure photoionization source in mass spectrometry |
| US6777673B2 (en) | 2001-12-28 | 2004-08-17 | Academia Sinica | Ion trap mass spectrometer |
| WO2003075790A2 (en) * | 2002-03-08 | 2003-09-18 | The University Of Texas Health Science Center At San Antonio | Gas-plasma treatment of implants |
| US7196324B2 (en) * | 2002-07-16 | 2007-03-27 | Leco Corporation | Tandem time of flight mass spectrometer and method of use |
| CA2800040C (en) | 2002-10-29 | 2015-12-29 | Target Discovery, Inc. | Method for increasing ionization efficiency in mass spectroscopy |
| US6710334B1 (en) * | 2003-01-20 | 2004-03-23 | Genspec Sa | Quadrupol ion trap mass spectrometer with cryogenic particle detector |
| US7019289B2 (en) | 2003-01-31 | 2006-03-28 | Yang Wang | Ion trap mass spectrometry |
| JP2006522340A (ja) * | 2003-04-02 | 2006-09-28 | メルク エンド カムパニー インコーポレーテッド | 質量分析データの分析法 |
| US7119331B2 (en) * | 2003-08-07 | 2006-10-10 | Academia Sinica | Nanoparticle ion detection |
| EP1564780A3 (en) | 2003-12-08 | 2006-05-31 | Rohm And Haas Company | Apparatus for determining molecular weight of polymers |
| US7161147B1 (en) | 2005-05-20 | 2007-01-09 | Academia Sinica | Biological whole cell mass spectrometer |
| US20070023677A1 (en) * | 2005-06-29 | 2007-02-01 | Perkins Patrick D | Multimode ionization source and method for screening molecules |
| US7645987B2 (en) | 2005-09-22 | 2010-01-12 | Academia Sinica | Acoustic desorption mass spectrometry |
| US20070272852A1 (en) | 2006-01-26 | 2007-11-29 | Sionex Corporation | Differential mobility spectrometer analyzer and pre-filter apparatus, methods, and systems |
| US20080304522A1 (en) * | 2006-04-04 | 2008-12-11 | Mills Randell L | Catalyst laser |
| US7619217B2 (en) * | 2006-05-26 | 2009-11-17 | Purdue Research Foundation | High power laser induced acoustic desorption probe |
| US7649170B2 (en) | 2006-10-03 | 2010-01-19 | Academia Sinica | Dual-polarity mass spectrometer |
| US7943899B2 (en) | 2006-12-21 | 2011-05-17 | Thermo Finnigan Llc | Method and apparatus for identifying the apex of a chromatographic peak |
-
2008
- 2008-12-11 WO PCT/US2008/086441 patent/WO2009076535A1/en not_active Ceased
- 2008-12-11 JP JP2010538162A patent/JP5477295B2/ja not_active Expired - Fee Related
- 2008-12-11 EP EP08860095.2A patent/EP2232213A4/en not_active Withdrawn
- 2008-12-11 US US12/314,520 patent/US8963075B2/en active Active
-
2014
- 2014-01-27 JP JP2014012159A patent/JP5793207B2/ja not_active Expired - Fee Related
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