JP2011505809A5 - - Google Patents
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- Publication number
- JP2011505809A5 JP2011505809A5 JP2010537144A JP2010537144A JP2011505809A5 JP 2011505809 A5 JP2011505809 A5 JP 2011505809A5 JP 2010537144 A JP2010537144 A JP 2010537144A JP 2010537144 A JP2010537144 A JP 2010537144A JP 2011505809 A5 JP2011505809 A5 JP 2011505809A5
- Authority
- JP
- Japan
- Prior art keywords
- meganuclease
- sequence
- eukaryotic cell
- chromosome
- cleavage site
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000003527 eukaryotic cell Anatomy 0.000 claims 16
- 238000003776 cleavage reaction Methods 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 230000007017 scission Effects 0.000 claims 10
- 210000000349 chromosome Anatomy 0.000 claims 9
- 150000007523 nucleic acids Chemical group 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 210000001671 embryonic stem cell Anatomy 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 108010050663 endodeoxyribonuclease CreI Proteins 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 230000006780 non-homologous end joining Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000037088 Chromosome Breakage Diseases 0.000 claims 1
- 102000007260 Deoxyribonuclease I Human genes 0.000 claims 1
- 108010008532 Deoxyribonuclease I Proteins 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000002459 blastocyst Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000003869 genetically modified organism Nutrition 0.000 claims 1
- 230000006801 homologous recombination Effects 0.000 claims 1
- 238000002744 homologous recombination Methods 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 210000001938 protoplast Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US568607P | 2007-12-07 | 2007-12-07 | |
| PCT/US2008/085878 WO2009076292A2 (en) | 2007-12-07 | 2008-12-08 | Rationally-designed meganucleases with recognition sequences found in dnase hypersensitive regions of the human genome |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011505809A JP2011505809A (ja) | 2011-03-03 |
| JP2011505809A5 true JP2011505809A5 (enExample) | 2012-02-02 |
Family
ID=40756084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010537144A Pending JP2011505809A (ja) | 2007-12-07 | 2008-12-08 | ヒトゲノムのＤＮａｓｅ高感受性領域に見出される認識配列を有する合理的に設計されたメガヌクレアーゼ |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20110033935A1 (enExample) |
| EP (1) | EP2215252A4 (enExample) |
| JP (1) | JP2011505809A (enExample) |
| AU (1) | AU2008335324A1 (enExample) |
| CA (1) | CA2703079A1 (enExample) |
| WO (1) | WO2009076292A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011036640A2 (en) * | 2009-09-24 | 2011-03-31 | Cellectis | Meganuclease reagents of uses thereof for treating genetic diseases caused by frame shift/non sense mutations |
| EP2504429B1 (en) | 2009-11-27 | 2016-04-20 | BASF Plant Science Company GmbH | Chimeric endonucleases and uses thereof |
| DE112010004582T5 (de) | 2009-11-27 | 2012-11-29 | Basf Plant Science Company Gmbh | Optimierte Endonukleasen und Anwendungen davon |
| JP2013511979A (ja) | 2009-11-27 | 2013-04-11 | ビーエーエスエフ プラント サイエンス カンパニー ゲーエムベーハー | キメラエンドヌクレアーゼおよびその使用 |
| WO2011095475A1 (en) * | 2010-02-02 | 2011-08-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and therapy of retinitis pigmentosa |
| ES2713529T3 (es) | 2011-06-01 | 2019-05-22 | Prec Biosciences Inc | Procedimientos y productos para la producción de líneas celulares de mamífero modificadas con transgenes amplificados |
| US9758796B2 (en) | 2011-06-10 | 2017-09-12 | Basf Plant Science Company Gmbh | Nuclease fusion protein and uses thereof |
| EP2790708B1 (en) | 2011-12-16 | 2024-10-23 | Targetgene Biotechnologies Ltd. | Compositions and methods for modifying a predetermined target nucleic acid sequence |
| EP2612918A1 (en) | 2012-01-06 | 2013-07-10 | BASF Plant Science Company GmbH | In planta recombination |
| WO2016037164A1 (en) | 2014-09-07 | 2016-03-10 | Selecta Biosciences, Inc. | Methods and compositions for attenuating gene expression modulating anti-viral transfer vector immune responses |
| MX2020003838A (es) | 2017-10-13 | 2020-08-06 | Selecta Biosciences Inc | Metodos y composiciones para atenuar las respuestas de inmunoglobulina m del vector de transferencia antiviral. |
| KR20200139679A (ko) | 2018-02-26 | 2020-12-14 | 안톨알엑스, 인크. | 면역관용성 리포솜 및 그의 사용 방법 |
| BR112021023594A2 (pt) | 2019-05-28 | 2022-02-08 | Selecta Biosciences Inc | Métodos e composições para resposta imune de vetor de transferência antiviral atenuada |
| US20230141563A1 (en) | 2021-10-12 | 2023-05-11 | Selecta Biosciences, Inc. | Methods and compositions for attenuating anti-viral transfer vector igm responses |
| US20230357437A1 (en) | 2022-03-09 | 2023-11-09 | Selecta Biosciences, Inc. | Immunosuppressants in combination with anti-igm agents and related dosing |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993004169A1 (en) * | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| US5792640A (en) * | 1992-04-03 | 1998-08-11 | The Johns Hopkins University | General method to clone hybrid restriction endonucleases using lig gene |
| US5436150A (en) * | 1992-04-03 | 1995-07-25 | The Johns Hopkins University | Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease |
| US5792632A (en) * | 1992-05-05 | 1998-08-11 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
| US5474896A (en) * | 1992-05-05 | 1995-12-12 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
| US6395959B1 (en) * | 1992-05-05 | 2002-05-28 | Institut Pasteur | Nucleotide sequence encoding the enzyme I SceI and the use thereof |
| US5830729A (en) * | 1996-04-18 | 1998-11-03 | Institut Pasteur | I Sce I-induced gene replacement and gene conversion in embryonic stem cells |
| US6265196B1 (en) * | 1996-05-07 | 2001-07-24 | Johns Hopkins University | Methods for inactivating target DNA and for detecting conformational change in a nucleic acid |
| JP2002535995A (ja) * | 1999-02-03 | 2002-10-29 | ザ チルドレンズ メディカル センター コーポレイション | 染色体標的部位での二本鎖ｄｎａ切断の誘導を含む遺伝子修復 |
| WO2000046385A1 (en) * | 1999-02-03 | 2000-08-10 | The Children's Medical Center Corporation | Gene repair involving in vivo excision of targeting dna |
| US6794136B1 (en) * | 2000-11-20 | 2004-09-21 | Sangamo Biosciences, Inc. | Iterative optimization in the design of binding proteins |
| DE10131786A1 (de) * | 2001-07-04 | 2003-01-16 | Sungene Gmbh & Co Kgaa | Rekombinationssysteme und Verfahren zum Entfernen von Nukleinsäuresequenzen aus dem Genom eukaryotischer Organismen |
| US7314712B2 (en) * | 2001-07-27 | 2008-01-01 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Systems for in vivo site-directed mutagenesis using oligonucleotides |
| AU2003251286B2 (en) * | 2002-01-23 | 2007-08-16 | The University Of Utah Research Foundation | Targeted chromosomal mutagenesis using zinc finger nucleases |
| AU2003215869B2 (en) * | 2002-03-15 | 2008-04-24 | Cellectis | Hybrid and single chain meganucleases and use thereof |
| JP2006502748A (ja) * | 2002-09-05 | 2006-01-26 | カリフォルニア インスティテュート オブ テクノロジー | 遺伝子ターゲッティングを誘発するキメラヌクレアーゼの使用方法 |
| US7285699B2 (en) * | 2002-10-07 | 2007-10-23 | Stowers Institute For Medical Research | Ends-out gene targeting method |
| US20030175968A1 (en) * | 2002-10-30 | 2003-09-18 | Golic Kent G. | Gene targeting method |
| AU2004208031B2 (en) * | 2003-01-28 | 2009-10-08 | Cellectis | Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof. |
| US7888121B2 (en) * | 2003-08-08 | 2011-02-15 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| ATE514782T1 (de) * | 2003-11-18 | 2011-07-15 | Bayer Bioscience Nv | Verbesserte gezielte dna insertion in pflanzen |
| WO2006097875A1 (en) * | 2005-03-14 | 2006-09-21 | Koninklijke Philips Electronics N.V. | Method of producing a component with a surface structure, ceramic component and application of such a method |
| EP2650366B1 (en) * | 2005-10-18 | 2017-03-22 | Precision Biosciences | Rationally designed meganucleases with altered sequence specificity and DNA-binding affinity |
| WO2007060495A1 (en) * | 2005-10-25 | 2007-05-31 | Cellectis | I-crei homing endonuclease variants having novel cleavage specificity and use thereof |
-
2008
- 2008-12-08 EP EP08860433A patent/EP2215252A4/en not_active Ceased
- 2008-12-08 JP JP2010537144A patent/JP2011505809A/ja active Pending
- 2008-12-08 AU AU2008335324A patent/AU2008335324A1/en not_active Abandoned
- 2008-12-08 WO PCT/US2008/085878 patent/WO2009076292A2/en not_active Ceased
- 2008-12-08 CA CA2703079A patent/CA2703079A1/en not_active Abandoned
-
2010
- 2010-06-07 US US12/795,477 patent/US20110033935A1/en not_active Abandoned
-
2013
- 2013-05-01 US US13/874,669 patent/US20130224863A1/en not_active Abandoned
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