JP2011502966A - ドーパミントランスポーターレベルを評価することによるレビー小体型認知症の診断およびレビー小体型認知症の処置のモニタリングのための方法 - Google Patents

ドーパミントランスポーターレベルを評価することによるレビー小体型認知症の診断およびレビー小体型認知症の処置のモニタリングのための方法 Download PDF

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JP2011502966A
JP2011502966A JP2010531330A JP2010531330A JP2011502966A JP 2011502966 A JP2011502966 A JP 2011502966A JP 2010531330 A JP2010531330 A JP 2010531330A JP 2010531330 A JP2010531330 A JP 2010531330A JP 2011502966 A JP2011502966 A JP 2011502966A
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dopamine transporter
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lewy body
dementia
ligand
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マーク ハート,
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アルセレス ファーマシューティカルズ, インコーポレイテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K51/0448Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil tropane or nortropane groups, e.g. cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
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    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/133Amines having hydroxy groups, e.g. sphingosine
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/473Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03Computed tomography [CT]
    • A61B6/037Emission tomography

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nuclear Medicine (AREA)
JP2010531330A 2007-10-31 2008-10-29 ドーパミントランスポーターレベルを評価することによるレビー小体型認知症の診断およびレビー小体型認知症の処置のモニタリングのための方法 Pending JP2011502966A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98419407P 2007-10-31 2007-10-31
PCT/US2008/081569 WO2009058851A2 (en) 2007-10-31 2008-10-29 Methods for diagnosing and monitoring treatment of lewy body dementia by assessing dopamine transporter level

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JP2011502966A true JP2011502966A (ja) 2011-01-27
JP2011502966A5 JP2011502966A5 (enExample) 2012-11-15

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US (2) US20100312105A1 (enExample)
EP (1) EP2211911A4 (enExample)
JP (1) JP2011502966A (enExample)
CA (1) CA2703563A1 (enExample)
WO (1) WO2009058851A2 (enExample)

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WO2009040727A2 (en) * 2007-09-26 2009-04-02 Philips Intellectual Property & Standards Gmbh Method of differentially diagnosing different types of dementia
KR20160138339A (ko) * 2013-03-15 2016-12-05 아담 제이 사이먼 뇌 건강의 다중-모드 약리-진단 평가
WO2014143896A2 (en) 2013-03-15 2014-09-18 Simon Adam J System and signatures for the multi-modal physiological stimulation and assessment of brain health
GB201313291D0 (en) * 2013-07-25 2013-09-11 Ge Healthcare Ltd Imaging neurological disease
CN104720840A (zh) * 2015-02-11 2015-06-24 清华大学深圳研究生院 基于多巴胺转运体显像特异性摄取比的半自动量化方法
EP3579887A4 (en) * 2017-02-10 2020-09-16 Likeminds, Inc. PROCEDURE FOR IN VIVO MONITORING OF DOPAMINER DISORDERS AND EFFECTIVENESS OF TREATMENT PRODUCTS THEREFORE
WO2020018743A1 (en) * 2018-07-18 2020-01-23 Likeminds, Inc. Method for accelerated tissue penetration of compounds into brain
AU2019319837A1 (en) * 2018-08-07 2021-02-25 Likeminds, Inc. Method for diagnosis of dopaminergic and movement disorders
TWI686178B (zh) * 2019-10-09 2020-03-01 中原大學 自動化定位核子醫學腦部影像紋狀體與計算紋狀體專一性攝取率的方法與系統
WO2021092096A1 (en) * 2019-11-06 2021-05-14 Likeminds, Inc. Individualized dosing of radioactive tracers for imaging
WO2022240817A1 (en) * 2021-05-13 2022-11-17 Likeminds, Inc. Methods of visualizing dopamine transporters

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AU2001249091A1 (en) * 2000-03-03 2001-09-17 Eisai Co. Ltd. Novel methods using cholinesterase inhibitors
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WO2009058851A3 (en) 2010-01-14
CA2703563A1 (en) 2009-05-07
WO2009058851A2 (en) 2009-05-07
EP2211911A4 (en) 2012-11-14
EP2211911A2 (en) 2010-08-04
US20160121003A1 (en) 2016-05-05
US20100312105A1 (en) 2010-12-09

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