JP2011502631A5 - - Google Patents
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- Publication number
- JP2011502631A5 JP2011502631A5 JP2010533109A JP2010533109A JP2011502631A5 JP 2011502631 A5 JP2011502631 A5 JP 2011502631A5 JP 2010533109 A JP2010533109 A JP 2010533109A JP 2010533109 A JP2010533109 A JP 2010533109A JP 2011502631 A5 JP2011502631 A5 JP 2011502631A5
- Authority
- JP
- Japan
- Prior art keywords
- medical device
- heparin cofactor
- biocompatible composition
- binding activity
- pmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000004032 Heparin Cofactor II Human genes 0.000 claims 24
- 108090000481 Heparin Cofactor II Proteins 0.000 claims 24
- 239000000463 material Substances 0.000 claims 23
- 239000000203 mixture Substances 0.000 claims 20
- 230000027455 binding Effects 0.000 claims 15
- 239000000126 substance Substances 0.000 claims 15
- 230000000975 bioactive effect Effects 0.000 claims 14
- 239000000758 substrate Substances 0.000 claims 12
- 239000011248 coating agent Substances 0.000 claims 11
- 238000000576 coating method Methods 0.000 claims 11
- 229920000642 polymer Polymers 0.000 claims 11
- 239000013543 active substance Substances 0.000 claims 9
- 150000004676 glycans Chemical class 0.000 claims 9
- 229920001282 polysaccharide Polymers 0.000 claims 9
- 239000005017 polysaccharide Substances 0.000 claims 9
- OEANUJAFZLQYOD-CXAZCLJRSA-N (2r,3s,4r,5r,6r)-6-[(2r,3r,4r,5r,6r)-5-acetamido-3-hydroxy-2-(hydroxymethyl)-6-methoxyoxan-4-yl]oxy-4,5-dihydroxy-3-methoxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](OC)O[C@H](CO)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](OC)[C@H](C(O)=O)O1 OEANUJAFZLQYOD-CXAZCLJRSA-N 0.000 claims 7
- 229920000045 Dermatan sulfate Polymers 0.000 claims 7
- VFNGKCDDZUSWLR-UHFFFAOYSA-L disulfate(2-) Chemical compound [O-]S(=O)(=O)OS([O-])(=O)=O VFNGKCDDZUSWLR-UHFFFAOYSA-L 0.000 claims 7
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 5
- 230000001028 anti-proliverative effect Effects 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 150000002484 inorganic compounds Chemical class 0.000 claims 4
- 229910010272 inorganic material Inorganic materials 0.000 claims 4
- 150000002894 organic compounds Chemical class 0.000 claims 4
- 102000004411 Antithrombin III Human genes 0.000 claims 3
- 108090000935 Antithrombin III Proteins 0.000 claims 3
- 229960005348 antithrombin iii Drugs 0.000 claims 3
- 230000006835 compression Effects 0.000 claims 3
- 238000007906 compression Methods 0.000 claims 3
- 230000001954 sterilising effect Effects 0.000 claims 3
- 238000004659 sterilization and disinfection Methods 0.000 claims 3
- 229920002307 Dextran Polymers 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 2
- 229960003957 dexamethasone Drugs 0.000 claims 2
- 229960002086 dextran Drugs 0.000 claims 2
- 229960000633 dextran sulfate Drugs 0.000 claims 2
- 230000007935 neutral effect Effects 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 239000008055 phosphate buffer solution Substances 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/938,162 US8021677B2 (en) | 2006-05-12 | 2007-11-09 | Immobilized biologically active entities having a high degree of biological activity |
| PCT/US2008/012595 WO2009064372A2 (en) | 2007-11-09 | 2008-11-06 | Immobilized biologically active entities having a high degree of biological activity |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013267640A Division JP6339362B2 (ja) | 2007-11-09 | 2013-12-25 | 高度の生物活性を持つ固定化された生物活性物質 |
| JP2014247267A Division JP6151680B2 (ja) | 2007-11-09 | 2014-12-05 | 高度の生物活性を持つ固定化された生物活性物質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011502631A JP2011502631A (ja) | 2011-01-27 |
| JP2011502631A5 true JP2011502631A5 (enExample) | 2011-12-22 |
Family
ID=40289419
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010533109A Withdrawn JP2011502631A (ja) | 2007-11-09 | 2008-11-06 | 高度の生物活性を持つ固定化された生物活性物質 |
| JP2013267640A Active JP6339362B2 (ja) | 2007-11-09 | 2013-12-25 | 高度の生物活性を持つ固定化された生物活性物質 |
| JP2014247267A Active JP6151680B2 (ja) | 2007-11-09 | 2014-12-05 | 高度の生物活性を持つ固定化された生物活性物質 |
| JP2016015910A Active JP6239015B2 (ja) | 2007-11-09 | 2016-01-29 | 高度の生物活性を持つ固定化された生物活性物質 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013267640A Active JP6339362B2 (ja) | 2007-11-09 | 2013-12-25 | 高度の生物活性を持つ固定化された生物活性物質 |
| JP2014247267A Active JP6151680B2 (ja) | 2007-11-09 | 2014-12-05 | 高度の生物活性を持つ固定化された生物活性物質 |
| JP2016015910A Active JP6239015B2 (ja) | 2007-11-09 | 2016-01-29 | 高度の生物活性を持つ固定化された生物活性物質 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US8021677B2 (enExample) |
| EP (2) | EP2700421B1 (enExample) |
| JP (4) | JP2011502631A (enExample) |
| AU (1) | AU2008321488B2 (enExample) |
| CA (1) | CA2703939C (enExample) |
| ES (2) | ES2644976T3 (enExample) |
| WO (1) | WO2009064372A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8021677B2 (en) * | 2006-05-12 | 2011-09-20 | Gore Enterprise Holdings, Inc. | Immobilized biologically active entities having a high degree of biological activity |
| US9114194B2 (en) * | 2006-05-12 | 2015-08-25 | W. L. Gore & Associates, Inc. | Immobilized biologically active entities having high biological activity following mechanical manipulation |
| GB0816783D0 (en) * | 2008-09-15 | 2008-10-22 | Carmeda Ab | Immobilised biological entities |
| GB201004101D0 (en) * | 2010-03-12 | 2010-04-28 | Carmeda Ab | Immobilised biological entities |
| US11839698B2 (en) | 2014-03-13 | 2023-12-12 | W. L. Gore & Associates, Inc. | Drug composition and coating |
| US10561766B2 (en) | 2015-09-15 | 2020-02-18 | W. L. Gore & Associates, Inc. | Drug composition and coating |
| US20190275213A1 (en) | 2018-03-09 | 2019-09-12 | Carmeda Ab | Immobilising biological entities |
| AU2019232163B2 (en) | 2018-03-09 | 2025-11-20 | Carmeda Ab | Improvements to processes for immobilising biological entities |
| AU2019354085B2 (en) | 2018-10-03 | 2025-06-05 | Carmeda Ab | Immobilised biological entities |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US432532A (en) | 1890-07-22 | Singletree for vehicles | ||
| CA962021A (en) | 1970-05-21 | 1975-02-04 | Robert W. Gore | Porous products and process therefor |
| US4329383A (en) | 1979-07-24 | 1982-05-11 | Nippon Zeon Co., Ltd. | Non-thrombogenic material comprising substrate which has been reacted with heparin |
| US4415490A (en) | 1979-07-24 | 1983-11-15 | Nippon Zeon Co., Ltd. | Non-thrombogenic material |
| US4326532A (en) | 1980-10-06 | 1982-04-27 | Minnesota Mining And Manufacturing Company | Antithrombogenic articles |
| US4526714A (en) | 1982-12-13 | 1985-07-02 | Cordis Europa N.V. | Conjugates of anticoagulant and protein |
| US4678671A (en) | 1981-12-15 | 1987-07-07 | Cordis Europa N.V. | Conjugates of anticoagulant and protein |
| SE8200751L (sv) * | 1982-02-09 | 1983-08-10 | Olle Larm | Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter |
| SE456347B (sv) | 1982-02-09 | 1988-09-26 | Ird Biomaterial Ab | Ytmodifierat fast substrat samt forfarande for framstellning derav |
| US4600652A (en) | 1985-04-01 | 1986-07-15 | Warner-Lambert Company | Permanently bonded antithrombogenic polyurethane surface |
| IT1213023B (it) | 1986-01-16 | 1989-12-07 | Rolando Barbucci | Materiale capace di adsorbire stabilmente elevate quantita' di eparina, e suo procedimento di preparazione. |
| SE452551B (sv) | 1986-05-27 | 1987-12-07 | Camurus Ab | Artikel belagd med heparinbaserat material samt forfarande for dess framstellning |
| US4745180A (en) | 1986-06-27 | 1988-05-17 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using heparin fragments |
| US5527524A (en) | 1986-08-18 | 1996-06-18 | The Dow Chemical Company | Dense star polymer conjugates |
| US5308617A (en) | 1988-08-10 | 1994-05-03 | Halzyme Ltd. | Protein heparin conjugates |
| US5130143A (en) | 1988-11-04 | 1992-07-14 | The Research Foundation Of State University Of New York | Use of a low affinity-heparin fraction in conjunction with t-pa for thrombolytic therapy |
| US5510418A (en) | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
| US5032666A (en) | 1989-06-19 | 1991-07-16 | Becton, Dickinson And Company | Amine rich fluorinated polyurethaneureas and their use in a method to immobilize an antithrombogenic agent on a device surface |
| US5213898A (en) | 1989-10-12 | 1993-05-25 | Norsk Hydro A.S. | Process for the preparation of surface modified solid substrates |
| US5049403A (en) | 1989-10-12 | 1991-09-17 | Horsk Hydro A.S. | Process for the preparation of surface modified solid substrates |
| WO1993005825A1 (en) | 1991-09-20 | 1993-04-01 | Baxter International Inc. | Processes for reducing the thrombogenicity of biomaterials |
| SE470006B (sv) | 1991-09-26 | 1993-10-25 | Corline Systems Ab | Nytt konjugat, dess framställning och användning samt substrat preparerat med konjugatet |
| IT1256236B (it) | 1992-12-23 | 1995-11-29 | Mediolanum Farmaceutici Srl | Oligosaccaridi aventi attivita' biologica e procedimento per la loro preparazione di glicosaminoglicani |
| US5532311A (en) | 1995-02-01 | 1996-07-02 | Minnesota Mining And Manufacturing Company | Process for modifying surfaces |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| US6120536A (en) | 1995-04-19 | 2000-09-19 | Schneider (Usa) Inc. | Medical devices with long term non-thrombogenic coatings |
| US5583213A (en) | 1995-05-12 | 1996-12-10 | Minnesota Mining And Manufacturing Company | Process to activate sulfated polysaccharides |
| US5679659A (en) | 1995-08-22 | 1997-10-21 | Medtronic, Inc. | Method for making heparinized biomaterials |
| US5767108A (en) | 1995-08-22 | 1998-06-16 | Medtronic, Inc. | Method for making improved heparinized biomaterials |
| US7045585B2 (en) | 1995-11-30 | 2006-05-16 | Hamilton Civic Hospital Research Development Inc. | Methods of coating a device using anti-thrombin heparin |
| NZ325248A (en) | 1995-12-23 | 1999-09-29 | Pfizer Res & Dev | Quinoline and quinazoline compounds useful in therapy |
| US5922690A (en) * | 1996-04-25 | 1999-07-13 | Van Gorp; Cornelius L. | Dermatan disulfate, an inhibitor of thrombin generation and activation |
| GB9608882D0 (en) | 1996-04-30 | 1996-07-03 | Luthra Ajay K | Non-thrombogenic and anti-thrombogenic polymers |
| US5876433A (en) | 1996-05-29 | 1999-03-02 | Ethicon, Inc. | Stent and method of varying amounts of heparin coated thereon to control treatment |
| US5914182A (en) | 1996-06-03 | 1999-06-22 | Gore Hybrid Technologies, Inc. | Materials and methods for the immobilization of bioactive species onto polymeric substrates |
| US5916585A (en) | 1996-06-03 | 1999-06-29 | Gore Enterprise Holdings, Inc. | Materials and method for the immobilization of bioactive species onto biodegradable polymers |
| US5728751A (en) | 1996-11-25 | 1998-03-17 | Meadox Medicals, Inc. | Bonding bio-active materials to substrate surfaces |
| JPH114883A (ja) | 1997-06-18 | 1999-01-12 | Toray Ind Inc | 抗血栓性医療材料 |
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| FI974321A0 (fi) | 1997-11-25 | 1997-11-25 | Jenny Ja Antti Wihurin Rahasto | Multipel heparinglykosaminoglykan och en proteoglykan innehaollande dessa |
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| US6936066B2 (en) | 1999-11-19 | 2005-08-30 | Advanced Bio Prosthetic Surfaces, Ltd. | Complaint implantable medical devices and methods of making same |
| SE515295C2 (sv) | 1999-11-23 | 2001-07-09 | Medicarb Ab | Förfarande för framställning av konjugat av en biologiskt aktiv polysackarid och ett fast substrat, samt sådana konjugat |
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| AU2001255741B2 (en) | 2000-04-28 | 2005-08-04 | Baylor College Of Medicine | Decellularized vascular prostheses |
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| TWI255224B (en) | 2002-01-09 | 2006-05-21 | Novartis Ag | Polymeric articles having a lubricious coating and method for making the same |
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| JP4624678B2 (ja) * | 2002-02-21 | 2011-02-02 | パイオニア・サージカル・オーソバイオロジックス，インコーポレイテッド | 架橋生物活性ヒドロゲルマトリックス |
| US6926919B1 (en) * | 2003-02-26 | 2005-08-09 | Advanced Cardiovascular Systems, Inc. | Method for fabricating a coating for a medical device |
| EP1668359A2 (en) | 2003-08-12 | 2006-06-14 | University of Utah Research Foundation | Heparin binding proteins: sensors for heparin detection |
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| GB0422877D0 (en) | 2004-10-14 | 2004-11-17 | Univ Glasgow | Bioactive polymers |
| CN101141948B (zh) * | 2005-03-14 | 2011-08-24 | 佰威控股有限公司 | 药物递送组合物及相关方法 |
| JP5475283B2 (ja) * | 2005-07-28 | 2014-04-16 | カーネギー メロン ユニバーシティ | 生体適合性ポリマーおよび使用方法 |
| US7767420B2 (en) | 2005-11-03 | 2010-08-03 | Momenta Pharmaceuticals, Inc. | Heparan sulfate glycosaminoglycan lyase and uses thereof |
| US20070212387A1 (en) | 2006-03-08 | 2007-09-13 | Sahajanand Medical Technologies Pvt. Ltd. | Coatings for implantable medical devices |
| US8021677B2 (en) * | 2006-05-12 | 2011-09-20 | Gore Enterprise Holdings, Inc. | Immobilized biologically active entities having a high degree of biological activity |
| AU2007249779B2 (en) * | 2006-05-12 | 2011-11-03 | W. L. Gore & Associates, Inc. | Immobilized biologically active entities having a high degree of biological activity following mechanical manipulation or sterilization |
| US20080279909A1 (en) | 2006-05-12 | 2008-11-13 | Cleek Robert L | Immobilized Biologically Active Entities Having A High Degree of Biological Activity Following Sterilization |
| US8986713B2 (en) | 2006-05-12 | 2015-03-24 | W. L. Gore & Associates, Inc. | Medical device capable of being compacted and expanded having anti-thrombin III binding activity |
| US9114194B2 (en) | 2006-05-12 | 2015-08-25 | W. L. Gore & Associates, Inc. | Immobilized biologically active entities having high biological activity following mechanical manipulation |
| US20100028402A1 (en) | 2006-10-25 | 2010-02-04 | Marina Dobrovolskaia | Nanoparticle-based anticoagulant |
| DE102008021894A1 (de) | 2008-05-02 | 2009-11-05 | Biotronik Vi Patent Ag | Implantat umfassend eine Oberfläche mit verringerter Thrombogenität |
| GB0816783D0 (en) | 2008-09-15 | 2008-10-22 | Carmeda Ab | Immobilised biological entities |
-
2007
- 2007-11-09 US US11/938,162 patent/US8021677B2/en active Active
-
2008
- 2008-11-06 WO PCT/US2008/012595 patent/WO2009064372A2/en not_active Ceased
- 2008-11-06 CA CA2703939A patent/CA2703939C/en active Active
- 2008-11-06 ES ES08850202.6T patent/ES2644976T3/es active Active
- 2008-11-06 ES ES13189447.9T patent/ES2690274T3/es active Active
- 2008-11-06 EP EP13189447.9A patent/EP2700421B1/en active Active
- 2008-11-06 AU AU2008321488A patent/AU2008321488B2/en active Active
- 2008-11-06 JP JP2010533109A patent/JP2011502631A/ja not_active Withdrawn
- 2008-11-06 EP EP08850202.6A patent/EP2205294B1/en active Active
-
2011
- 2011-08-11 US US13/208,220 patent/US8409604B2/en active Active
- 2011-08-11 US US13/208,196 patent/US8691260B2/en active Active
-
2013
- 2013-02-05 US US13/759,842 patent/US8945599B2/en active Active
- 2013-12-25 JP JP2013267640A patent/JP6339362B2/ja active Active
-
2014
- 2014-12-05 JP JP2014247267A patent/JP6151680B2/ja active Active
-
2016
- 2016-01-29 JP JP2016015910A patent/JP6239015B2/ja active Active
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