JP2011501946A5 - - Google Patents
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- Publication number
- JP2011501946A5 JP2011501946A5 JP2010530235A JP2010530235A JP2011501946A5 JP 2011501946 A5 JP2011501946 A5 JP 2011501946A5 JP 2010530235 A JP2010530235 A JP 2010530235A JP 2010530235 A JP2010530235 A JP 2010530235A JP 2011501946 A5 JP2011501946 A5 JP 2011501946A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- acid sequence
- binding protein
- variant
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 38
- 102000023732 binding proteins Human genes 0.000 claims description 38
- 108091008324 binding proteins Proteins 0.000 claims description 38
- 206010028980 Neoplasm Diseases 0.000 claims description 32
- 201000011510 cancer Diseases 0.000 claims description 32
- 150000007523 nucleic acids Chemical group 0.000 claims description 24
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 22
- 239000000427 antigen Substances 0.000 claims description 20
- 210000004027 cell Anatomy 0.000 claims description 18
- 229920001184 polypeptide Polymers 0.000 claims description 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 16
- 102000036639 antigens Human genes 0.000 claims description 14
- 108091007433 antigens Proteins 0.000 claims description 14
- 230000027455 binding Effects 0.000 claims description 10
- 101710112752 Cytotoxin Proteins 0.000 claims description 9
- 231100000599 cytotoxic agent Toxicity 0.000 claims description 9
- 239000002619 cytotoxin Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 238000003259 recombinant expression Methods 0.000 claims description 8
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 7
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 7
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 7
- 239000013604 expression vector Substances 0.000 claims description 7
- 101100355842 Mus musculus Rbmx gene Proteins 0.000 claims description 6
- -1 carrier Substances 0.000 claims description 6
- 238000006467 substitution reaction Methods 0.000 claims description 5
- 108700033844 Pseudomonas aeruginosa toxA Proteins 0.000 claims description 4
- 108010039491 Ricin Proteins 0.000 claims description 4
- 239000012830 cancer therapeutic Substances 0.000 claims description 4
- 239000000032 diagnostic agent Substances 0.000 claims description 4
- 229940039227 diagnostic agent Drugs 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000012544 monitoring process Methods 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 239000003381 stabilizer Substances 0.000 claims description 4
- 229940127121 immunoconjugate Drugs 0.000 claims description 3
- 101000669426 Aspergillus restrictus Ribonuclease mitogillin Proteins 0.000 claims description 2
- 108090000790 Enzymes Proteins 0.000 claims description 2
- 102000004190 Enzymes Human genes 0.000 claims description 2
- 108700004714 Gelonium multiflorum GEL Proteins 0.000 claims description 2
- 101710120463 Prostate stem cell antigen Proteins 0.000 claims description 2
- 102100036735 Prostate stem cell antigen Human genes 0.000 claims description 2
- 108090000829 Ribosome Inactivating Proteins Proteins 0.000 claims description 2
- 108010084592 Saporins Proteins 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 108010049223 bryodin Proteins 0.000 claims description 2
- 239000003560 cancer drug Substances 0.000 claims description 2
- 238000012875 competitive assay Methods 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 239000002872 contrast media Substances 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000000539 dimer Substances 0.000 claims description 2
- 206010013023 diphtheria Diseases 0.000 claims description 2
- 239000007850 fluorescent dye Substances 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- 229940051026 immunotoxin Drugs 0.000 claims description 2
- 239000002596 immunotoxin Substances 0.000 claims description 2
- 230000002637 immunotoxin Effects 0.000 claims description 2
- 231100000608 immunotoxin Toxicity 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 229910021645 metal ion Inorganic materials 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 238000002955 isolation Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98257507P | 2007-10-25 | 2007-10-25 | |
| PCT/CA2008/001878 WO2009052628A1 (en) | 2007-10-25 | 2008-10-23 | Antibodies against a cancer-associated epitope of variant hnrnpg and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011501946A JP2011501946A (ja) | 2011-01-20 |
| JP2011501946A5 true JP2011501946A5 (OSRAM) | 2011-12-08 |
Family
ID=40579009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010530235A Pending JP2011501946A (ja) | 2007-10-25 | 2008-10-23 | 変異体ＨｎＲＮＰＧの癌関連エピトープに対する抗体およびその使用法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8273550B2 (OSRAM) |
| EP (1) | EP2215122A4 (OSRAM) |
| JP (1) | JP2011501946A (OSRAM) |
| CN (1) | CN101970498A (OSRAM) |
| AU (1) | AU2008316224A1 (OSRAM) |
| CA (1) | CA2703140A1 (OSRAM) |
| WO (1) | WO2009052628A1 (OSRAM) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
| EP2398504B1 (en) | 2009-02-17 | 2018-11-28 | Cornell Research Foundation, Inc. | Methods and kits for diagnosis of cancer and prediction of therapeutic value |
| WO2011069019A2 (en) | 2009-12-02 | 2011-06-09 | David Ho | J591 minibodies and cys-diabodies for targeting human prostate specific membrane antigen (psma) and methods for their use |
| CN111978409B (zh) | 2013-03-15 | 2024-01-26 | 因斯瑞拜奥有限公司 | 自组装合成蛋白 |
| NZ739721A (en) | 2015-08-07 | 2019-09-27 | Imaginab Inc | Antigen binding constructs to target molecules |
| EP3202783A1 (en) * | 2016-02-02 | 2017-08-09 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Engineered antigen presenting cells and uses thereof |
| US11266745B2 (en) | 2017-02-08 | 2022-03-08 | Imaginab, Inc. | Extension sequences for diabodies |
| US11124579B2 (en) * | 2017-03-29 | 2021-09-21 | Agency For Science, Technology And Research | Anti oligosaccharide antibody |
| JP7328261B2 (ja) | 2018-03-06 | 2023-08-16 | インケア バイオテック， エルエルシー | セリンプロテアーゼ阻害剤カザル（ｓｐｉｋ）組成物および方法 |
| CN114174341A (zh) | 2019-07-08 | 2022-03-11 | 英凯尔生物科技有限责任公司 | 抗丝氨酸蛋白酶抑制剂kazal(spik)抗体、免疫缀合物和使用方法 |
| US20240043512A1 (en) * | 2019-09-11 | 2024-02-08 | Imcare Biotech, Llc | Epitopes of anti-serine protease inhibitor kazal (spik) antibodies |
| CN113862359B (zh) * | 2021-09-30 | 2024-07-23 | 哈尔滨医科大学 | Fam13a基因转录本在评估胶质母细胞瘤患者临床预后中的应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6184205B1 (en) | 1994-07-22 | 2001-02-06 | University Of North Carolina At Chapel Hill | GRB2 SH3 binding peptides and methods of isolating and using same |
| US5856136A (en) | 1996-07-03 | 1999-01-05 | Incyte Pharmaceuticals, Inc. | Human stem cell antigens |
| US6258939B1 (en) | 1997-03-10 | 2001-07-10 | The Regents Of The University Of California | PSCA antibodies and hybridomas producing them |
| DE19722569A1 (de) | 1997-05-28 | 1998-12-03 | Basf Ag | Statistische Propylencopolymerisate |
| US6221999B1 (en) | 1999-09-10 | 2001-04-24 | Uniroyal Chemical Company, Inc. | High resilience, high clarity polyurethane elastomer |
| JP2006516089A (ja) * | 2002-10-02 | 2006-06-22 | ジェネンテック・インコーポレーテッド | 腫瘍の診断と治療のための組成物と方法 |
| AU2004263823B2 (en) * | 2003-05-30 | 2008-09-18 | Agensys, Inc. | Prostate stem cell antigen (PSCA) variants and subsequences thereof |
| EP1647596A4 (en) * | 2003-07-18 | 2008-02-13 | Mochida Pharm Co Ltd | MONOCLONAL ANTIBODY AGAINST GLYCOPROTEIN VI THE BLOOD PLATE MEMBRANE |
| RU2381234C2 (ru) * | 2004-05-28 | 2010-02-10 | Эдженсис, Инк. | Антитела и родственные молекулы, связывающиеся с белками psca |
| US8088908B2 (en) * | 2005-05-10 | 2012-01-03 | City Of Hope | Humanized anti-prostate stem cell antigen monoclonal antibody |
-
2008
- 2008-10-23 JP JP2010530235A patent/JP2011501946A/ja active Pending
- 2008-10-23 CA CA2703140A patent/CA2703140A1/en not_active Abandoned
- 2008-10-23 WO PCT/CA2008/001878 patent/WO2009052628A1/en not_active Ceased
- 2008-10-23 EP EP08841782A patent/EP2215122A4/en not_active Withdrawn
- 2008-10-23 US US12/738,883 patent/US8273550B2/en not_active Expired - Fee Related
- 2008-10-23 CN CN2008801229913A patent/CN101970498A/zh active Pending
- 2008-10-23 AU AU2008316224A patent/AU2008316224A1/en not_active Abandoned
-
2012
- 2012-08-22 US US13/591,715 patent/US20130039931A1/en not_active Abandoned
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