JP2011251058A - Method and apparatus of measuring auditory steady-state response - Google Patents

Abstract

PROBLEM TO BE SOLVED: To solve the problem that errors have been caused by an artifact due to electromagnetical field leaking from an acoustic transducer for presenting a stimulus sound, which is disposed in the proximity of bioelectrodes in an ASSR (auditory steady-state response) measurement.SOLUTION: In the measurement, an inaudible stimulus sound using a sine wave of an inaudible frequency as a carrier wave and the audible stimulus sound using a sine wave of an audible frequency as a carrier wave are alternatively presented to a subject, and the artifact is eliminated by subtracting a brain wave signal, which is monitored during the presentation of the inaudible stimulus sound, of the subject from brain wave signal, which is monitored during the presentation of the audible stimulus sound.

Description

  The present invention relates to a method and apparatus for measuring an auditory steady-state response of a living body.

  In recent years, objective hearing measurement based on auditory steady-state response (ASSR) has been generally performed mainly for infants who cannot perform hearing measurement by normal subjective evaluation (see Non-Patent Document 1).

  In this ASSR, as shown in FIG. 9A, a sine wave amplitude-modulated sound having a pure tone having a frequency for measuring hearing, that is, a sine wave as a carrier wave and a low frequency sine wave such as 40 Hz or 80 Hz as a modulation signal. A modulated sound such as (sinusoidally amplitude-modulated tone SAM sound) is used as a stimulus sound.

  The presence / absence of hearing is determined based on the presence / absence of an electroencephalogram component that appears when this stimulation sound is applied to a living body, and has the same frequency as the modulation signal of the stimulation sound as shown in FIG. can do.

  In general, since the ASSR is a weak component included in an electroencephalogram signal, it is easily affected by an artifact, and a technique for removing this artifact has been proposed.

  For example, Patent Document 1 discloses an artifact removal method using a Kalman filter.

International Publication No. 2008/038650

Yu Aoyagi, “Steady Steady Response (ASSR)”, Audiology Japan (Journal of Japan Audiological Society), 2006, Vol. 49, No. 2, p. 135-145

  Conventionally, when hearing evaluation by ASSR is implemented in a small device, as shown in FIG. 12A, an acoustic transducer such as an earphone that gives a stimulating sound and an electroencephalogram measurement electrode are arranged very close to each other. Inevitably, an electromagnetic field leaking from an acoustic transducer such as an earphone interferes with an electroencephalogram measurement electrode, resulting in an artifact in the electroencephalogram waveform.

  In particular, the artifact waveform due to the electromagnetic field leaking from the acoustic transducer such as the earphone described above becomes a sinusoidal waveform having the same frequency as the ASSR waveform to be measured as shown in FIG. Therefore, it is not removed even by the cumulative addition process or the filter process, causing an error factor at the time of ASSR measurement.

  The present invention has been made to solve the above-described problems, and provides an auditory steady-state reaction measurement method and measurement apparatus that eliminates and reduces the influence of artifacts caused by electromagnetic fields leaking from the above-described acoustic transducer such as an earphone. For the purpose.

  In order to solve the above-described problems, an auditory steady-state reaction measuring apparatus according to one aspect of the present invention is configured to use a first stimulus sound using an audio frequency carrier wave and a second non-audible frequency carrier wave for a subject. A stimulation sound output unit that alternately outputs the first stimulation sound, a first brain wave signal of the subject during the output time of the first stimulation sound, and a second brain wave signal of the subject during the output time of the second stimulation sound. An electroencephalogram acquisition unit to be acquired, and a reaction measurement unit that compares the first electroencephalogram signal and the second electroencephalogram signal to measure the auditory steady-state reaction of the subject.

  With this configuration, since the stimulating sound is inaudible during the output time of the second stimulating sound having a sine wave having a non-audible frequency as a carrier wave, the ASSR is not induced. An electroencephalogram signal not included can be obtained, and an artifact component can be removed from an electroencephalogram signal including an ASSR component obtained during a presentation period of a stimulus sound having a sine wave of an audible frequency as a carrier wave.

  The auditory steady-state reaction measuring apparatus according to the present invention may further include a stimulus sound generation unit that generates the first stimulus sound and the second stimulus sound modulated by the same modulation signal.

  With this configuration, the artifact component can be more appropriately removed from the electroencephalogram signal.

  The auditory steady reaction measuring apparatus of the present invention may be configured such that the stimulation sound output unit outputs the second stimulation sound for a time shorter than the output time of the first stimulation sound.

  With this configuration, the measurement time can be shortened, and the measurement with reduced burden on the subject can be performed while removing the artifact component.

  The auditory steady-state reaction measurement apparatus of the present invention further includes a storage unit that records the second electroencephalogram signal, and the reaction measurement unit subtracts the second electroencephalogram signal recorded in the storage unit from the first electroencephalogram signal. The structure which measures a test subject's auditory steady-state reaction may be sufficient.

  With this configuration, the artifact component can be removed in parallel with the acquisition of the first electroencephalogram signal.

  The auditory steady-state reaction measuring device of the present invention further includes a stimulation sound storage unit that stores a stimulation sound string in which the first stimulation sound and the second stimulation sound are alternately arranged, and the stimulation sound output unit includes the stimulation sound storage unit. The configuration may be such that the stimulation sound sequence stored in is output.

  With this configuration, it is possible to easily generate stimulus sounds and easily measure them without switching.

  According to the present invention, an artifact component can be efficiently removed from an electroencephalogram signal including an ASSR component.

FIG. 2 is a block diagram showing the configuration of the auditory steady-state reaction measuring apparatus according to the first embodiment. Waveform diagram showing an example of stimulation sound Signal flow diagram showing a flow of processing of the auditory steady-state reaction measuring apparatus according to Embodiment 1 The flowchart which shows an example of the process of the auditory steady-state reaction measuring apparatus of Embodiment 1. Waveform diagram showing another example of stimulation sound FIG. 3 is a block diagram showing a configuration of an auditory steady-state reaction measuring apparatus according to Embodiment 2. Block diagram showing an example of the configuration of the variable frequency sine wave generator Block diagram showing another example of the configuration of the variable frequency sine wave generator The flowchart which shows an example of a process of the auditory steady-state reaction measuring apparatus of Embodiment 2. FIG. 3 is a block diagram showing a configuration of an auditory steady-state reaction measuring apparatus according to Embodiment 3. (A) Waveform diagram showing a conventional SAM stimulation sound (b) Waveform diagram showing an example of an ASSR waveform (A) Photograph showing an example of the arrangement of the earphone and the measurement electrode (b) Waveform diagram showing an example of an interference signal from the earphone

  Hereinafter, embodiments of the present invention will be described with reference to the drawings. In addition, the same code | symbol is attached | subjected to the same element and description may be abbreviate | omitted.

(Embodiment 1)
FIG. 1 is a diagram showing an auditory steady reaction measuring apparatus 100 in the present embodiment. The auditory steady-state reaction measuring device 100 has headphones, speakers, and the like, and outputs a stimulation sound output unit 10 that outputs stimulation sound, an electroencephalogram measurement unit 20 that includes a biological electrode that acquires a biological signal that is a brain wave of a subject, and a measurement. A response measuring unit 30 that measures an auditory response from the electroencephalogram signal.

  FIG. 2 is a waveform diagram illustrating an example of the stimulation sound output from the stimulation sound output unit 10. The stimulus sound output unit 10 outputs a stimulus sound having a sine wave of an audible frequency between 100 Hz and 16 kHz as a carrier wave for a period of about 200 ms to less than 1 s (hereinafter referred to as an audible sound presentation period), and is generally inaudible higher than 16 kHz. Similarly, a stimulus sound having a frequency sine wave as a carrier wave is output for a period of about 100 ms to less than 1 s (hereinafter referred to as a non-audible sound presentation period). The stimulation sound is amplitude-modulated with a sine wave having a frequency in the vicinity of 40 Hz or 80 Hz that induces an ASSR reaction regardless of the frequency of the carrier wave. The audible sound presentation period influences the induction of ASSR in a very short time of less than 200 ms, and there is a possibility that an error may occur in the measurement, and if it is 1 s or more, the entire measurement time becomes long. It is desirable to be within the range.

  When such a stimulation sound is output to the subject, the electroencephalogram measurement unit 20 acquires an electroencephalogram signal including both the ASSR component and the artifact component during the audible sound presentation period as shown in FIG. Since a biological reaction that induces ASSR does not occur during the period, an electroencephalogram signal including an artifact component but not an ASSR component is acquired. The reaction measurement unit 30 compares the electroencephalogram signal acquired during the audible sound presentation period with the electroencephalogram signal acquired during the non-audible sound presentation period, and measures the auditory response.

  Next, the operation of the auditory steady reaction measuring apparatus 100 will be described with reference to FIG. FIG. 4 is a flowchart showing the processing steps of the auditory steady reaction measuring method in the auditory steady reaction measuring apparatus 100.

  When the measurement is started, the stimulus sound output unit 10 starts outputting a non-audible stimulus sound, which is a stimulus sound using a carrier wave having a non-audible frequency (step S101). Next, the electroencephalogram measurement unit 20 acquires an electroencephalogram signal for the non-audible stimulus sound and stores it in a memory included in the apparatus, an external memory connected thereto, or the like (step S102). When the non-audible sound presentation period ends (step S103), the stimulation sound output unit 10 starts outputting an audible stimulation sound that is a stimulation sound using a carrier wave with an audible frequency (step S105). The electroencephalogram measurement unit 20 acquires an electroencephalogram signal for the audible stimulus sound (step S105), and the reaction measurement unit 30 compares the electroencephalogram signal for the audible stimulus sound with the electroencephalogram signal for the inaudible stimulus sound (step S106). In step S106, both are compared while sequentially subtracting calculation processing based on the period of the modulation signal obtained by modulating the audible stimulus sound and the non-audible stimulus sound, and the calculation processing result is output (step S107). After the presentation period ends, the output of the calculation process is ended.

  In addition, although the example which sequentially subtracts the electroencephalogram signal with respect to a non-audible stimulus sound was shown here, acquiring the electroencephalogram signal with respect to the audible stimulus sound, the electroencephalogram signal with respect to the audible stimulus sound is obtained. Subsequent subtraction may be performed. In this case, the steps of S101 and S104 in FIG. 4 are interchanged. Moreover, although the example which performs a sequential calculation was demonstrated, both signals are once preserve | saved at the memory which an apparatus has, the connected external memory, etc., and it is the structure which performs an arithmetic processing after completing acquisition of a signal. There may be. In this case, the steps S106 and S107 in FIG. 4 are interchanged.

  Moreover, the auditory steady state reaction can be measured more accurately by repeating the processing of S101 to S107 approximately 10 to 1000 times.

  As described above, the auditory steady-state reaction measuring device according to the present invention includes an artifact component observed during non-audible stimulus sound presentation from an electroencephalogram signal including an artifact component and an ASSR component observed during audible stimulus sound presentation. The artifacts can be removed by subtracting the electroencephalogram signal that does not contain the ASSR component based on the modulation signal period.

  Although the stimulation sound modulation method has been described as amplitude modulation, the modulation method is not limited to this, and frequency modulation, phase modulation, mixed modulation of amplitude modulation and frequency modulation, or the like may be used.

  Furthermore, as shown in FIG. 5, the presentation period of the audible stimulus sound and the presentation period of the non-audible stimulus sound need not be the same, and the presentation period of the non-audible stimulus sound may be shortened to about 100 ms, for example. With such a signal configuration, the measurement time can be shortened without affecting the measurement result.

(Embodiment 2)
FIG. 6 is a block diagram illustrating a configuration of the auditory steady-state reaction measuring apparatus 200 according to the second embodiment. As shown in FIG. 6, the auditory steady-state reaction measuring apparatus 200 according to the second embodiment includes a stimulation sound output unit 10, an electroencephalogram measurement unit 20, a reaction measurement unit 30, a control unit 40, a storage unit 50, and a stimulation. A sound generation unit 60. The stimulation sound generation unit 60 includes a variable frequency sine wave generation unit 61, a modulation signal generation unit 62, and a modulation unit 63. The stimulation sound output unit 10 includes an output amplification unit 11 and an acoustic transducer 12. The electroencephalogram measurement unit 20 includes a biological electrode 21, an input amplification unit 22, and a switching unit 23. The reaction measurement unit 30 includes a calculation unit 31.

  The variable frequency sine wave generation unit 61 outputs an audible frequency sine wave or a non-audible frequency sine wave to the modulation unit 63 according to the control of the control unit 40. The modulation unit 63 modulates an input audible frequency or non-audible frequency sine wave with a modulation signal that is output from the modulation signal generation unit 62 and is a sine wave having a frequency in the vicinity of 40 Hz or 80 Hz that induces an ASSR reaction. And output to the output amplifier 11. In this way, the stimulation sound generation unit 60 outputs the stimulation sound using the audible frequency or non-audible frequency carrier wave modulated by the predetermined modulation signal to the stimulation sound output unit 10. The output amplification unit 11 amplifies the input signal and drives the acoustic transducer 12. In this way, the stimulation sound output unit 10 outputs the generated stimulation sound.

  In addition, the biological electrode 21 acquires a biological signal that is a brain wave of the subject, and the input amplification unit 22 inputs and amplifies the signal obtained by the biological electrode 21 and outputs the amplified signal to the switching unit 23. The switching unit 23 switches and outputs the input signal according to the control of the control unit 40 to the storage unit 50 and the calculation unit 31. In this way, the electroencephalogram measurement unit 20 measures the subject's electroencephalogram signal. The storage unit 50 temporarily stores the input waveform signal and outputs it to the calculation unit 31 according to the control of the control unit 40. Under the control of the control unit 40, the calculation unit 31 sequentially subtracts the output of the switching unit 23 and the output of the storage unit 50 and outputs a signal from which artifacts have been removed.

  FIG. 7 is a block diagram illustrating a detailed configuration example of the variable frequency sine wave generation unit 61. The variable frequency sine wave generation unit 61 includes a non-audible sine wave generation unit 611 that generates a sine wave having a non-audible frequency, and an audible sine wave generation unit 612 that generates an audible frequency sine wave. Furthermore, in response to a control signal for frequency setting input from the control unit 40, a non-audible sine wave output from the non-audible sine wave generation unit 611 and an output from the audible sine wave generation unit 612. A signal selection unit 613 that selectively outputs a sine wave having an audible frequency. The frequency set values set here are the variable length frequencies between 100 Hz and 16 kHz, respectively, and the non-variable length frequencies are higher than 16 kHz, as described in the above embodiments.

  FIG. 8 is a detailed block diagram showing another configuration example of the variable frequency sine wave generator 61. The variable frequency sine wave generation unit 61 includes a first frequency setting value holding unit 614 that holds a frequency setting value of a non-audible frequency, and a second frequency setting value holding unit 615 that holds a frequency setting value of an audible frequency. Furthermore, a frequency setting value corresponding to the inaudible frequency output by the first frequency setting value holding unit 614 and a second frequency setting in accordance with a frequency setting control signal input from the control unit 40. A frequency setting value selection unit 616 that selects and outputs a frequency setting value corresponding to the audible frequency output by the value holding unit 615, or a sine wave of an inaudible frequency based on the frequency setting value output from the frequency setting value selection unit 616 A sine wave generation unit 617 that generates an sine wave of an audible frequency. The frequency set values set here are the variable length frequencies between 100 Hz and 16 kHz, respectively, and the non-variable length frequencies are higher than 16 kHz, as described in the above embodiments.

  The operation of the auditory steady-state reaction measuring apparatus 200 configured as described above will be described with reference to FIG.

  First, the variable frequency sine wave generation unit 61 is controlled by the control signal for frequency setting output from the control unit 40, and a sine wave signal having an inaudible frequency is output from the variable frequency sine wave generation unit 61.

  The inaudible frequency sine wave signal output from the variable frequency sine wave generator 61 is a sine wave having a frequency in the vicinity of 40 Hz or 80 Hz that induces the ASSR reaction output from the modulation signal generator 62 by the modulator 63. It is modulated using the modulation signal, further amplified by the output amplifier 11, and presented as an inaudible stimulus sound wave by the acoustic transducer 12 (step S201).

  In this state, the electroencephalogram signal induced in the living body is amplified by the input amplification unit 22 through the biological electrode 21, and is temporarily recorded in the storage unit 50 through the switching unit 23 (step S202).

  The control unit 40 waits for a predetermined non-audible stimulus sound presentation period based on the period information of the modulation signal output from the modulation signal generation unit 62 (step S203), and the brain wave to the storage unit 50 after the presentation period ends. Signal recording is stopped (step S204). The predetermined presentation period is a period of about 100 ms to 1 s as shown in the above embodiments.

  Next, the variable frequency sine wave generation unit 61 is controlled by the control signal for frequency setting output from the control unit 40, and the signal output from the variable frequency sine wave generation unit 61 becomes an sine wave signal having an audible frequency. Switch.

  The audible frequency sine wave signal output from the variable frequency sine wave generation unit 61 is modulated by the modulation unit 63 using the modulation signal output from the modulation signal generation unit 62 in the same manner as the inaudible frequency sine wave signal. Further, it is amplified by the output amplifier 11 and presented as an audible stimulus sound wave by the acoustic transducer 12 (step S205).

  In this state, the electroencephalogram signal induced in the living body is amplified by the input amplifying unit 22 through the living body electrode 21, and is input to the calculating unit 31 through the switching unit 23. Based on the periodic signal of the modulation signal output from the control unit 40, the calculation unit 31 reads the signal waveform during presentation of the inaudible stimulus sound recorded in the storage unit 50, and the audible stimulus output from the switching unit 23. While subtracting from the signal waveform during sound presentation, the calculation results are sequentially output (step 206).

  Here, an electroencephalogram signal observed during presentation of an audible stimulus sound includes an artifact component and an ASSR component, and an electroencephalogram signal observed during presentation of a non-audible stimulus sound includes an artifact component but does not include an ASSR component. The signal output from the calculation unit 31 is a signal from which artifact components have been removed.

  The control unit 40 waits for a predetermined audible stimulus sound presentation period based on the period information of the modulation signal output from the modulation signal generation unit 62 (step S207), and performs a subtraction process of the calculation unit 31 after the presentation period ends. Stop (step S208). The presentation period here is about 200 ms to 1 s as described in the above embodiments.

  The measurement is completed by repeating the above processing 10 to 1000 times (step 209).

  As described above, the auditory steady-state reaction measuring apparatus according to Embodiment 2 can realize the removal of the artifact component included in the observed electroencephalogram signal.

  In the above description, the brain wave signal presenting the non-audible stimulus sound is stored in the storage unit 50, but the same effect can be obtained by storing the brain wave signal presenting the audible stimulus sound. .

  Further, although the stimulation sound modulation method has been described as amplitude modulation, the modulation method is not limited to this, and frequency modulation, phase modulation, mixed modulation of amplitude modulation and frequency modulation, or the like may be used.

(Embodiment 3)
FIG. 10 is a block diagram illustrating a configuration of the auditory steady-state reaction measuring apparatus 300 according to the third embodiment. As shown in FIG. 10, the steady auditory response measurement apparatus 300 according to the third embodiment includes a stimulation sound output unit 10, an electroencephalogram measurement unit 20, a reaction measurement unit 30, a control unit 40, and a storage unit 50. The stimulation sound output unit 10 includes a stimulation sound storage unit 13, a reproduction unit 14, and a timing detection unit 15 in addition to the output amplification unit 11 and the acoustic converter 12.

  In FIG. 10, a series of stimulus sound sequences including inaudible stimulus sounds and audible stimulus sounds as shown in the waveform diagram of FIG. 2 are created in advance and stored in the stimulus sound storage unit 13. This stimulation sound sequence is reproduced by the reproduction unit 14 and output to the output amplification unit 11 and the timing detection unit 15. The timing detection unit 15 detects the cycle timing of the modulated wave and the switching timing between the inaudible stimulation sound and the audible stimulation sound from the reproduced stimulation sound, and outputs the detected timing to the control unit 40 as an operation reference for the control unit 40. The operation of the auditory steady-state reaction measuring apparatus 300 is substantially the same as the operation of the auditory steady-state reaction measuring apparatus 200 except that the operation standard of the control unit 40 is different.

  With the above configuration, it is not necessary to generate a non-audible stimulus sound or an audible stimulus sound in real time, so that the amount of processing required for measurement can be reduced.

  Note that it is preferable to use a semiconductor memory as the stimulation sound storage unit 13, and it is also possible to use a replaceable memory card such as an SD card. This makes it easy to change the type of stimulation sound.

(Other variations)
Although the present invention has been described based on the above embodiments, the present invention is not limited to the above embodiments, and the following cases are also included in the present invention.

  (1) When all or a part of each of the above devices is configured by a computer system including a microprocessor, a ROM, a RAM, a hard disk unit, and the like. The RAM or the hard disk unit stores a computer program that achieves the same operation as each of the above devices. Each device achieves its functions by the microprocessor operating according to the computer program.

  (2) A part or all of the components constituting each of the above devices may be configured by one system LSI (Large Scale Integration). The system LSI is an ultra-multifunctional LSI manufactured by integrating a plurality of components on a single chip, and specifically, a computer system including a microprocessor, ROM, RAM, and the like. . The RAM stores a computer program that achieves the same operation as each of the above devices. The system LSI achieves its functions by the microprocessor operating according to the computer program.

  (3) Part or all of the constituent elements constituting each of the above devices may be configured from an IC card that can be attached to and detached from each device or a single module. The IC card or the module is a computer system including a microprocessor, a ROM, a RAM, and the like. The IC card or the module may include the super multifunctional LSI described above. The IC card or the module achieves its function by the microprocessor operating according to the computer program. This IC card or this module may have tamper resistance.

  (4) The present invention may be a method realized by the computer processing described above. Further, the present invention may be a computer program that realizes these methods by a computer, or may be a digital signal composed of the computer program.

  Further, the present invention may be the computer program or the digital signal recorded on a computer-readable recording medium. Examples of the computer-readable recording medium include a flexible disk, a hard disk, a CD-ROM, an MO, a DVD, a DVD-ROM, a DVD-RAM, a BD (Blu-ray Disc), and a semiconductor memory. Further, the present invention may be the digital signal recorded on these recording media.

  Further, the present invention may transmit the computer program or the digital signal via an electric communication line, a wireless or wired communication line, a network represented by the Internet, a data broadcast, or the like.

  The present invention may also be a computer system including a microprocessor and a memory, wherein the memory stores the computer program, and the microprocessor operates according to the computer program.

  In addition, the program or the digital signal is recorded on the recording medium and transferred, or the program or the digital signal is transferred via the network or the like, and executed by another independent computer system. It is good.

  (5) The above embodiment and the above modifications may be combined.

  As described above, the auditory steady-state reaction measuring method and measuring apparatus according to the present invention have an effect of efficiently removing an artifact component from an electroencephalogram signal including an ASSR component, and are useful in objective hearing measurement. It is.

DESCRIPTION OF SYMBOLS 10 Stimulation sound output part 11 Output amplification part 12 Acoustic transducer 13 Stimulation sound storage part 14 Playback part 15 Timing detection part 20 Electroencephalogram measurement part 21 Bioelectrode 22 Input amplification part 23 Switching part 30 Reaction measurement part 31 Calculation part 40 Control part 50 Storage unit 60 Stimulus sound generation unit 61 Variable frequency sine wave generation unit 62 Modulation signal generation unit 63 Modulation unit 611 Inaudible sine wave generation unit 612 Audible sine wave generation unit 613 Signal selection unit 614 First frequency setting value holding unit 615 First 2 frequency setting value holding unit 616 Frequency setting selection unit 617 Sine wave generation unit

Claims (8)

A stimulation sound output unit that alternately outputs a first stimulation sound using an audible frequency carrier wave and a second stimulation sound using an inaudible frequency carrier wave to the subject;
An electroencephalogram acquisition unit for acquiring the first electroencephalogram signal of the subject at the output time of the first stimulus sound and the second electroencephalogram signal of the subject at the output time of the second stimulus sound;
A steady-state auditory response measuring apparatus comprising: a reaction measuring unit that measures the steady-state auditory response of the subject by comparing the first electroencephalogram signal and the second electroencephalogram signal. The auditory steady-state reaction measuring device further includes:
The auditory steady-state reaction measuring device according to claim 1, further comprising a stimulus sound generation unit that generates the first stimulus sound and the second stimulus sound modulated by the same modulation signal. The auditory steady-state reaction measurement apparatus according to claim 1, wherein the stimulation sound output unit outputs the second stimulation sound for a time shorter than an output time of the first stimulation sound. The auditory steady-state reaction measuring device comprises:
A storage unit for recording the second electroencephalogram signal;
The response measurement unit subtracts the second electroencephalogram signal recorded in the storage unit from the first electroencephalogram signal to measure an auditory steady-state response of the subject. The auditory steady-state reaction measuring device described. The auditory steady-state reaction measuring device comprises:
A stimulating sound storage unit for storing a stimulating sound string in which the first stimulating sound and the second stimulating sound are alternately connected;
The auditory steady-state reaction measuring device according to claim 1, wherein the stimulation sound output unit outputs the stimulation sound string stored in the stimulation sound storage unit. An output step of alternately outputting a first stimulation sound using an audible frequency carrier wave and a second stimulation sound using an inaudible frequency carrier wave to the subject;
An electroencephalogram acquisition step of acquiring the first electroencephalogram signal of the subject in the output time of the first stimulus sound and the second electroencephalogram signal of the subject in the output time of the second stimulus sound;
A method of measuring a steady auditory response, comprising: comparing the first electroencephalogram signal with the second electroencephalogram signal and measuring the steady auditory response of the subject. An output step of alternately outputting a first stimulation sound using an audible frequency carrier wave and a second stimulation sound using an inaudible frequency carrier wave to the subject;
An electroencephalogram acquisition step of acquiring the first electroencephalogram signal of the subject in the output time of the first stimulus sound and the second electroencephalogram signal of the subject in the output time of the second stimulus sound;
A program for causing a computer to execute an auditory steady-state reaction measuring method, comprising: a response measuring step of measuring the steady-state auditory response of the subject by comparing the first electroencephalogram signal and the second electroencephalogram signal. A stimulation sound output unit that alternately outputs a first stimulation sound using an audible frequency carrier wave and a second stimulation sound using an inaudible frequency carrier wave to the subject;
An electroencephalogram acquisition unit for acquiring the first electroencephalogram signal of the subject at the output time of the first stimulus sound and the second electroencephalogram signal of the subject at the output time of the second stimulus sound;
An integrated circuit comprising: a reaction measuring unit that compares the first electroencephalogram signal and the second electroencephalogram signal to measure the steady auditory response of the subject.