JP2011182753A - Sugar-coating liquid - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a stable sugar-coating liquid hardly causing precipitation, crystal growth, or the like, and to provide a sugar-coated product having good appearance without unevenness and rough feeling on the surface by using the sugar-coating liquid. <P>SOLUTION: The sugar-coating liquid is produced by adding 5-67 wt.% of a reduced palatinose based on the sugar-coating liquid to hydrated ethanol containing 500-30 pts.wt. of water based on 100 pts.wt. of the reduced palatinose to disperse the reduced palatinose as solid particles. The sugar-coated product having the excellent appearance can be produced because the sugar-coating liquid forms good-quality coating. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

The present invention relates to a sugar-coating liquid used for coating pharmaceuticals, foods, etc. and a sugar-coated product whose surface is coated with the sugar-coating liquid.

In general, sugar-coated products are edible core materials such as pharmaceuticals and foods coated with a sugar-coating layer mainly composed of sucrose, and the sucrose solution is applied to the entire surface of the core material put into a rotating sugar-coated bread. This is a method in which the core material is covered with a sucrose crystal layer by repeating the operation of drying by blowing and then precipitating sucrose crystals.

By the way, sucrose that has been used for sugar coatings has recently become a problem of caries and high calories. Alcohol has been used.

However, sugar alcohols generally have the property of crystallizing rapidly with subtle changes in temperature, so the sugar alcohol crystallization rate cannot be controlled arbitrarily during the sugar coating process, and the size of the crystals varies. Large irregularities are generated on the surface of the material, and the appearance is significantly deteriorated. In addition, when left at room temperature, sugar alcohol crystals grow large and crystals may precipitate, so that a uniform sugar coating solution may not be obtained.

Therefore, various methods have been proposed to prevent crystallization of sugar alcohol. For example, a sugar coating liquid containing erythritol and a predetermined amount of sugar or maltitol (Patent Document 1), and a method of allowing a predetermined amount of polyvinyl alcohol to coexist in an erythritol aqueous solution (Patent Document 2). However, neither method can completely prevent crystallization of sugar alcohol.

In addition, after applying the sugar-coating solution of sugar alcohol, the process of air-drying by sprinkling the powdered sugar alcohol in which the 60-mesh-on powder is 60% by weight or more is repeated, and the layer in which the powdered sugar alcohol is bound to the sugar-coating solution There has been proposed a method for controlling the crystallization of a sugar alcohol by forming glycans (Patent Document 3). However, this method has a problem that the sugar coating process becomes extremely complicated.

Furthermore, a sugar coating liquid in which powdered sugar alcohol is dispersed in an aqueous solution of sugar alcohol is also used. However, in order for sugar alcohol to exist as solid particles in the aqueous solution, it is necessary to saturate the sugar alcohol. Therefore, precipitation of solid particles, crystal growth of sugar alcohol with the solid particles as a nucleus, and the like become more prominent than simple aqueous solutions. In addition, the sugar coating liquid has a high viscosity and is difficult to spray.

JP-A-9-278671 JP 2004-107282 A Japanese Patent Laid-Open No. 11-127785

An object of the present invention is to provide a stable sugar-coating liquid that does not cause precipitation, crystal growth or the like in the sugar-coating process, and a sugar-coating product having a good appearance with no irregularities or roughness on the surface using the sugar-coating liquid.

As a result of diligent research to solve the above-mentioned problems, the present inventors dispersed a reduced palatinose as solid particles in water-containing ethanol containing a specific proportion of water with respect to the reduced palatinose. The present inventors have found that sugar-coated products having a good appearance can be obtained, and have completed the present invention.

The reduced palatinose according to the present invention is a disaccharide sugar alcohol obtained by hydrogenation of palatinose, and is an equimolar mixture of α-glucopyranosyl-1,6-D-sorbitol and α-glucopyranosyl-1,6-D-mannitol. is there. Reduced palatinose is low in calories, excellent in moisture absorption resistance, heat resistance and acid resistance, and has a refreshing sweetness, so it is extremely useful as a pharmaceutical or food material. On the other hand, since it is the least soluble in sugar alcohol and its solubility changes rapidly with temperature, the conventional sugar coating method has a drawback that it is difficult to control crystallization.

The blending amount of reduced palatinose in the sugar coating liquid of the present invention is preferably 5 to 67% by weight, particularly preferably 7 to 60% by weight. Since it is necessary to disperse the reduced palatinose of the solid particles in the sugar coating liquid, it is desirable that the particle diameter is small. Specifically, it is preferably 150 μm or less, particularly preferably 100 μm or less.

Hydrous ethanol is used for the sugar coating liquid according to the present invention. The water content in the hydrous ethanol is 500 to 30 parts by weight, more preferably 350 to 60 parts by weight with respect to 100 parts by weight of reduced palatinose. In addition, the compounding quantity of hydrous ethanol is suitably adjusted with the compounding quantity of reduced palatinose and other components.

The sugar-coating liquid according to the present invention may contain other components as necessary. For example, film forming agents such as hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxyethylcellulose, hydroxyethylmethylcellulose, hydroxypropylmethylcellulose acetate succinate, hydroxypropylmethylcellulose phthalate, shellac, and zein, erythritol, maltitol, sorbitol, mannitol, xylitol, Lactitol, sugar alcohols such as reduced starch saccharified products, pigments such as calcium carbonate, silicic anhydride, calcium phosphate, titanium dioxide, and talc, various tar-based pigments, pigments such as cochineal pigments, caramel pigments and cacao pigments, acesulfame potassium Sweeteners such as sucralose, stevia and thaumatin, mint oil, cinnamon oil, orange oil, and Perfumes such as lemon oil, surfactants such as sucrose fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, and lecithin, vitamins such as ascorbic acid, riboflavin, pyridoxine, niacin, and tocopherol, valine, leucine Amino acids such as isoleucine, lysine, glycine, and glutamine.

The sugar coating liquid according to the present invention can be produced by dispersing reduced palatinose as solid particles in hydrous ethanol containing 500 to 30 parts by weight of water with respect to 100 parts by weight of reduced palatinose.
A method in which reduced palatinose is pulverized with a hammer mill, pin mill, etc. into fine powder and added to water-containing ethanol, and dispersed by stirring. Existing dispersion methods such as a dispersion method can be employed.
Although reduced palatinose can be dispersed at room temperature, it is more preferred that the hydrated ethanol is dispersed in the range of 40 to 70 ° C.

The sugar-coating liquid of the present invention can be used for sugar-coating such as tablets, capsules, candy, gum, and chocolate in pharmaceuticals and foods, but is particularly suitable for tablets. For the sugar coating, a conventional sugar coating method can be employed in which sugar coating liquid is added or sprayed and blown and dried by using an existing machine such as a sugar coating bread or a coating machine. The amount of sugar coating is appropriately adjusted according to the purpose such as masking the taste / odor of the edible core material or hiding the color tone.

In the sugar-coating liquid of the present invention, the solid particles of reduced palatinose are uniformly dispersed, and precipitation and crystal growth do not occur even when allowed to stand at room temperature, and sugar-coated products using the sugar-coating liquid have reduced palatinose on the surface. Fine crystals are tightly bound and have a good appearance.
The reason why the solid particles of reduced palatinose are uniformly dispersed in hydrous ethanol is not clear, but it is estimated that the solid particles of reduced palatinose form a loose three-dimensional structure in hydrous ethanol and suppress their sedimentation. Is done.

Hereinafter, the present invention will be described in detail with reference to examples, but the present invention is not limited thereto.

Example 1
20 g of reduced palatinose was added to hydrous ethanol at 50 ° C. containing 135 g of ethanol and 45 g of water, and the mixture was stirred with a homomixer at a rotational speed of 5000 rpm for 5 minutes to prepare a sugar coating liquid of Example 1. In addition, the water in the water-containing ethanol with respect to 100 weight part of reduced palatinose is 225 weight part.

The reduced paratinol of Example 1 was replaced with erythritol or maltitol, and the sugar-coating liquids of Comparative Examples 1 and 2 were prepared using 30 ° C. hydrous ethanol having the same composition. Moreover, the reduced paratinol of Example 1 was replaced with sorbitol or xylitol, and the sugar-coating liquid of Comparative Examples 3 and 4 was prepared using hydrous ethanol at 40 ° C. containing 162 g of ethanol and 18 g of purified water.

Each sugar coating solution was sieved with 100 mesh (aperture 150 μm) and allowed to stand at room temperature for 24 hours, and then its state was evaluated. Table 1 shows the composition and results of each sugar coating solution.

In the sugar coating solutions of Comparative Examples 1 to 4, sugar alcohols such as erythritol and maltitol were precipitated immediately after preparation. In addition, except for Comparative Example 2, sugar alcohol crystals grew upon standing. On the other hand, in the sugar coating liquid of Example 1, fine solid particles of reduced palatinose were uniformly dispersed, and no precipitation or crystal growth was observed even when allowed to stand.

In addition, in the sugar coating liquid having the same composition as Example 1 and Comparative Examples 1 to 4, reduced palatinose was prepared at 80 ° C., erythritol and maltitol were prepared at 50 ° C., and sorbitol and xylitol were prepared at 60 ° C. When dissolved and allowed to stand at room temperature for 24 hours, in all cases crystals were precipitated and precipitation occurred.

(Examples 2 to 10)
In a range of 500 to 30 parts by weight of water in hydrous ethanol and 5 to 67% by weight of reduced palatinose with respect to 100 parts by weight of reduced palatinose, add reduced palatinose to 50 ° C hydrous ethanol and rotate with a homomixer. The sugar coating liquid of Examples 2-10 was prepared by stirring at 5000 rpm for 5 minutes.

In the same way, 1250 parts by weight of water in hydrous ethanol and 2% by weight of reduced palatinose with respect to 100 parts by weight of reduced palatinose and 20 parts by weight of water in hydrous ethanol with respect to 100 parts by weight of reduced palatinose. 15% by weight, and a sugar-coating solution containing 27 parts by weight of water in hydrous ethanol and 75% by weight of reduced palatinose based on 100 parts by weight of reduced palatinose was prepared as Comparative Examples 5, 6, and 7.

Table 2 shows the composition of each sugar coating solution, the state at the time of dispersion, the fluidity, and the finish of the coating film. The coating film was evaluated by subjecting each sugar-coating liquid to a thin film using a doctor blade having a thickness of 200 μm and naturally drying at room temperature for 24 hours.

In the sugar coating liquid of Comparative Example 5, the reduced palatinose was completely dissolved when dispersed, and when it was allowed to stand at room temperature, crystals precipitated and precipitation occurred. In the sugar coating liquids of Comparative Examples 6 and 7, roughness was observed on the coating film surface. Moreover, the sugar-coating liquid of the comparative example 7 had bad fluidity, and was unsuitable as a sugar-coating liquid.

On the other hand, the sugar-coating liquid of Examples 2 to 10 in which the water in the hydrous ethanol with respect to 100 parts by weight of the reduced palatinose is 500 to 30 parts by weight and the content of the reduced palatinose is 5 to 67% by weight is the dispersion of the reduced palatinose, Both the fluidity and the finished film were good. In particular, the sugar-coating liquid of Examples 3 to 8 in which water in water-containing ethanol is 350 to 60 parts by weight and the content of reduced palatinose is 7 to 60% by weight with respect to 100 parts by weight of reduced palatinose is excellent in fluidity, The coating was very smooth.

(Examples 11 to 15)
30 g of reduced palatinose was added to 20 to 70 ° C. hydrous ethanol containing 130 g of ethanol and 40 g of water, and the mixture was stirred with a homomixer at a rotational speed of 5000 rpm for 5 minutes to prepare sugar coating solutions of Examples 11 to 15. In addition, the water in hydrous ethanol with respect to 100 weight part of reduced palatinose is 133 weight part.
In the same composition and method, it was prepared using water-containing ethanol at 80 ° C. to obtain a sugar coating liquid of Comparative Example 8.

About each sugar-coating liquid, the state at the time of dispersion | distribution, fluidity | liquidity, and the finishing state of the coating film were evaluated in the same method and evaluation criteria as Example 2-10 mentioned above. Table 3 shows the composition and results of each sugar coating solution.

In Comparative Example 8 in which the temperature at the time of dispersion was 80 ° C., the reduced palatinose was completely dissolved at the time of dispersion, and when left at room temperature, crystals precipitated and precipitation occurred. In contrast, in Examples 11 to 15 in which the reduced palatinose was dispersed at 20 to 70 ° C., the dispersion of the reduced palatinose and the finish of the coating film were good. In particular, the coating liquids of the sugar coating liquids of Examples 13, 14, and 15 having a temperature of 40 to 70 ° C. were extremely smooth.

(Examples 16 and 17)
30 g of reduced palatinose was added to hydrous ethanol at 50 ° C. containing 136 g of ethanol and 34 g of water, stirred with a homomixer at a rotational speed of 5000 rpm for 5 minutes, and sieved with 140 mesh (aperture 106 μm) to prepare a sugar coating solution of Example 16. . The solid particles of reduced palatinose were uniformly dispersed, and no precipitation was observed. In addition, the water in the water-containing ethanol is 113 parts by weight with respect to 100 parts by weight of the reduced palatinose.

30 g of reduced palatinose was added to 50 ° C. water-containing ethanol containing 10 g of ethanol and 160 g of water, and a sugar coating solution of Comparative Example 9 was prepared in the same manner. Reduced palatinose was completely dissolved to give a transparent sugar coating solution. In addition, the water in the water-containing ethanol with respect to 100 weight part of reduced palatinose is 533 weight part.

Using the sugar-coating liquids of Example 16 and Comparative Example 9, the tablets were coated to prepare sugar-coated tablets of Example 17 and Comparative Example 10. The tablet formulation and coating conditions are shown below, and the coating amount and appearance of the sugar-coated tablets are shown in Table 4.

Tablet [Prescription] Compounding amount (% by weight)
(1) Reishi extract 20.0
(2) Reduced palatinose 50.0
(3) Cornstarch 29.0
(4) Magnesium stearate 1.0
[Manufacturing method] Components 1 to 3 are mixed and granulated. After component 4 is added and mixed, the mixture is molded by a tableting machine to obtain tablets of 300 mg / tablet, diameter 9 mm, and tablet thickness 4.5 mm.

Coating conditions (1) Sugar-coated bread: 15cm in diameter
(2) Amount of tablets: 50g
(3) Coating method: Spray (4) Pan rotation speed: 50 rpm
(5) Blower temperature: 60 ° C

The sugar-coated tablet of Comparative Example 10 had a very bad appearance, with large crystals of reduced palatinose adhering to the surface and having irregularities and roughness. On the other hand, the sugar-coated tablet of Example 17 was coated with fine crystals of reduced palatinose uniformly, and the surface was smooth and had a good appearance.

As described above, in the sugar coating liquid of the example according to the present invention, the solid particles of reduced palatinose are uniformly dispersed, and no precipitation or crystal growth occurs as in the comparative example. In addition, since a high-quality coating film is formed, a sugar coating with an excellent appearance can be produced.

The sugar-coating liquid of the present invention is a stable sugar-coating liquid in which precipitation or crystal growth does not occur despite the use of reduced palatinose whose control of crystallization is difficult. In addition, it is possible to produce a high-quality sugar-coated product having no irregularities or roughness on the surface. Therefore, it is very useful for the production of sugar-coated products with low calories and low hygroscopicity in pharmaceuticals and foods.

Claims (6)

In the sugar coating liquid in which the solid particles of reduced palatinose are dispersed in hydrous ethanol, the reduced palatinose is contained in an amount of 5 to 67% by weight, and the water in the hydrous ethanol is 500 to 30 parts by weight with respect to 100 parts by weight of the reduced palatinose. A sugar-coating liquid characterized by The sugar-coating liquid according to claim 1, wherein the content of the reduced palatinose is 7 to 60% by weight, and the water in the water-containing ethanol is 350 to 60 parts by weight with respect to 100 parts by weight of the reduced palatinose. The sugar-coating liquid according to claim 1 or 2, wherein the particle size of the solid particles of reduced palatinose is 150 µm or less. A sugar-coated article coated with the sugar-coating liquid according to any one of claims 1 to 3. In a sugar coating solution containing reduced palatinose, 5 to 67% by weight of reduced palatinose is added to hydrous ethanol containing 500 to 30 parts by weight of water with respect to 100 parts by weight of reduced palatinose, and the reduced palatinose is solid particles. A method for producing a sugar-coating liquid characterized by being dispersed as follows. The method for producing a sugar coating liquid according to claim 5, wherein the reduced palatinose is dispersed at 40 to 70 ° C.