JP2011080088A - Method of producing adhesive composition for adhesive plaster - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a method of producing an adhesive composition for an adhesive plaster, which is carried out by formulating a liquid component to an adhesive of an acrylic polymer, where the composition has good compatibility of the acrylic polymer with the liquid component, together with good adhesion to the skin, generating no stimulation to the skin. <P>SOLUTION: An acrylic oligomer formed by polymerizing at least one alkyl acrylate or alkyl methacrylate having 4-10C alkyl and having a prescribed number average molecular weight, is used as the liquid component. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  In the present invention, the entire surface (solid surface) or an appropriate pattern (polka dot pattern, checkered pattern, lattice pattern, vertical stripe or horizontal stripe pattern, etc.) is adhered to one side of a base sheet (plastic film, nonwoven fabric, woven fabric, paper, etc.) The present invention relates to an improvement of an adhesive composition constituting an adhesive layer in an adhesive bandage provided with a layer.

  As is well known, since this type of adhesive bandage is applied to the skin, its adhesive layer adheres to the skin firmly, and the skin stratum corneum is subject to skin irritation and rash caused by peeling damage. What has the peelability which does not make it develop is calculated | required.

  However, since skin adhesion and peelability required for such an adhesive layer are substantially contradictory properties, in the past, it has been considered that some sacrifice on one side is inevitable, Examination in terms of the contact area (wetting area) of the adhesive layer to the skin with minute irregularities, which is a characteristic value that affects the skin adhesion strength of the adhesive layer, and the adhesive force per unit contact area of the adhesive polymer as an adhesive Therefore, it is attempted to add various liquid components to the pressure-sensitive adhesive polymer, and several pressure-sensitive adhesive compositions have been proposed from this aspect.

  However, the proposed one has poor compatibility between the liquid component and the pressure-sensitive adhesive polymer, and even when the amount of the liquid component is small, the liquid component oozes out to the surface of the pressure-sensitive adhesive layer, significantly reducing the skin adhesion, The liquid component itself has problems such as causing skin irritation and has not yet reached the practical stage.

This invention is a pressure-sensitive adhesive composition for a pressure-sensitive adhesive bandage in which a liquid component is blended with the pressure-sensitive adhesive polymer as the pressure-sensitive adhesive as described above, and the compatibility between the pressure-sensitive adhesive polymer and the liquid component and the skin adhesiveness are good, and skin irritation does not occur. In particular, as a liquid component used for forming the adhesive composition for adhesive adhesive plaster, the compatibility with the adhesive polymer is good and the skin is not irritating. Finding what reduces the adhesive force per unit contact area and at the same time increases the skin contact area, and by adjusting the addition amount of the liquid component, in a form to suppress the adhesive force per unit contact area of the adhesive polymer, It has an object to provide a method for producing a pressure-sensitive adhesive plaster pressure-sensitive adhesive composition that allows adjust the skin adhesion strength of the adhesive layer.

In order to solve the above problems, the present inventor has conducted various experimental studies on adhesive bandages using an adhesive polymer (particularly an acrylic polymer) as an adhesive, and as a result, an acrylic having a number average molecular weight of 2,000 to 40,000. -Based oligomers (more preferably acrylic oligomers having a number average molecular weight of 2,000 to 4,400 ) have good compatibility with pressure-sensitive adhesive polymers (particularly acrylic polymers), and in the pressure-sensitive adhesive composition forming the pressure-sensitive adhesive layer When blended, increases the wetted area of the adhesive layer to the skin, but does not penetrate into the skin, and therefore has no effect on the lipid structure inside the skin and is non-irritating to the skin, completing the present invention. did.

That is, the method for producing a pressure-sensitive adhesive composition for adhesive bandages according to the present invention comprises an acrylic polymer solution in which a predetermined amount of an acrylic oligomer solution is dissolved and then a predetermined amount of a reactive crosslinking agent is added. A method for producing an adhesive composition for adhesive bandages,
(1) A step of producing a solution of an acrylic oligomer formed by solution polymerization of one or more of alkyl alkyl ester having 4 to 10 carbon atoms of alkyl group or alkyl methacrylate.
(2) Acrylic acid alkyl ester or methacrylic acid alkyl ester having 4 to 10 carbon atoms in the alkyl group, and selected from acrylic acid monomer, methacrylic acid monomer, 2-hydroxylethyl acrylate, or 2-hydroxyethyl methacrylate A process for producing an acrylic polymer solution comprising an acrylic polymer formed by solution polymerization of a monomer mixture containing the monomer
(3) With respect to the solution obtained by mixing the acrylic oligomer solution and the acrylic polymer solution, the reactive crosslinking agent is set to a value within the range of 0.01 to 5% by weight of the acrylic polymer. The basic feature is to include an adding step .

  In the pressure-sensitive adhesive composition of the present invention, the number average molecular weight of the acrylic oligomer is in the range of 2,000 to 40,000 because when the number average molecular weight exceeds 40,000, it becomes hard and is in a necessary liquid state. It is based on the knowledge that when it becomes impossible to hold and below 2,000, it easily penetrates into the skin, and as a result, the lipid structure inside the skin is affected and various skin irritation is likely to occur.

  In general, it is desirable to use an acrylic acid alkyl ester or a methacrylic acid alkyl ester having an alkyl group having 4 to 10 carbon atoms, for example, an alkyl group. Is selected from at least one of methyl, ethyl, propyl, isopropyl, 2-methoxyethyl, butyl, isobutyl, tertiary butyl, hexyl, octyl, isooctyl, 2-ethylhexyl, nonyl, isononyl, etc. Can do.

  In general, the acrylic oligomer can be produced by an ordinary method in which an acrylic monomer is polymerized (homopolymerized or copolymerized) using an appropriate chain transfer agent (such as lauryl mercaptan or mercaptoethanol).

As the pressure-sensitive adhesive polymer used in the pressure-sensitive adhesive composition of the present invention, an acrylic acid alkyl ester or methacrylic acid alkyl ester having an alkyl group having 4 to 10 carbon atoms , an acrylic acid monomer, a methacrylic acid monomer, 2- An acrylic polymer formed by solution polymerization from a monomer mixture containing hydroxylethyl acrylate or a monomer selected from 2-hydroxyethyl methacrylate is preferred.

  This acrylic polymer has good compatibility with acrylic oligomers, and it has been confirmed that the wet area of the adhesive layer on the skin can be most effectively increased.

As the acrylic acid alkyl ester or methacrylic acid alkyl ester having 4 to 10 carbon atoms of the alkyl group forming the acrylic polymer, as described above for the acrylic oligomer, generally, the alkyl group is methyl, ethyl, propyl. , Isopropyl, 2-methoxyethyl, butyl, isobutyl, tertiary butyl, hexyl, octyl, isooctyl, 2-ethylhexyl, nonyl, isononyl, and the like can be used. The methacrylic acid alkyl ester can be used in one form of polymerization or in the form of a copolymerization of two or more kinds, particularly from the viewpoint of adjusting the adhesive strength inherent to the pressure-sensitive adhesive.

Acrylic polymer as an adhesive is a copolymer of acrylic acid monomer, methacrylic acid monomer, 2-hydroxylethyl acrylate or 2-hydroxyethyl methacrylate of 1 to 15% by weight of the acrylic polymer in order to increase adhesion to the skin. characterized in that is also in order to adjust the cohesive force, 0.01 to 5% by weight of the reactive cross-linking agent of an acrylic polymer, for example, polyepoxy compound (ethylene glycol - diglycidyl ether, triglycidyl isocyanurate ), Polyisocyanate compounds (such as Coronate L and HL manufactured by Nippon Polyurethane Co., Ltd.), benzoyl peroxide (Nyper BO manufactured by Nippon Oil & Fats Co., Ltd.) and other peroxides that generate radicals (such as benzoyl peroxide) Can be added.

  However, in this pressure-sensitive adhesive composition for adhesive bandages, in order to ensure proper adhesion to the skin (adhesion without over-adhesion that damages the skin or inadequate adhesion that peels off immediately) In general, a peel adhesive strength (180 ° peel adhesive strength: in an atmosphere of 23 ° C., a 12 mm wide polyethylene terephthalate (PET) film attached by reciprocating a 2 kg roll on the pressure-sensitive adhesive application surface is a speed of 300 mm / min. It is desirable to set the resistance when peeling off at 40 to 400 g.

  This pressure-sensitive adhesive composition for adhesive bandages is usually prepared by adding a required amount of an acrylic oligomer to an acrylic polymer solution in which an acrylic polymer as a pressure-sensitive adhesive is easily removed by evaporation (toluene, ethyl acetate, hexane, etc.). Dispersed and dissolved, and can be manufactured in a dope state by adding a reactive cross-linking agent or adhesive force adjusting component as necessary. Apply this dope evenly on cloth, paper, plastic film, etc. Can form an adhesive bandage.

  In the above, it is desirable that the adhesive strength adjusting component added as necessary is limited to 30% by weight or less of the acrylic polymer as the pressure-sensitive adhesive so as not to weaken the effect of the acrylic oligomer.

  Examples of the present invention will be described in detail below.

[Example 1]
(1) Production of acrylic oligomer 300 g (1.63 mol) of 2-ethylhexyl acrylate and 27.6 g (0.136 mol) of lauryl mercaptan as a chain transfer agent were dissolved in 82 g of ethyl acetate as a solvent, A monomer mixed solution was formed. This monomer mixed solution was charged into a polymerization reactor equipped with a stirrer equipped with a vapor condensation reflux tower, and 0.6 g of azobisisobutyronitrile as a polymerization initiator was added and dissolved, and then immersed in a hot water bath as it was. The polymerization initiator was decomposed by slowly raising the temperature to 0 ° C. to initiate the polymerization reaction.

  As soon as heat generation started by the start of the polymerization reaction, the reaction was terminated by appropriately immersing in a cooling bath and cooling to control the temperature of the polymerization reaction solution at 70 ± 3 ° C. for about 7 hours to complete the polymerization reaction. (Here, the non-volatile residue of the polymerization reaction solution, that is, the concentration of the acrylic oligomer as the polymerization reaction product was measured and confirmed to be 80.4% by weight, and the termination was determined. The ratio of non-volatile residue after approximately 1 g of the sample solution was dried by heating at 150 ° C. for 1 hour). The viscous ethyl acetate solution of the acrylic oligomer thus obtained has a viscosity (measured with a B-type viscometer, the same shall apply hereinafter) of 14 poise, and the number average molecular weight of the acrylic oligomer (measured by a GPC method, hereinafter the same shall apply). ) Was 2,200.

(2) Production of Acrylic Polymer 25 g (5 parts by weight) of acrylic acid monomer and 500 g (100 parts by weight) of 2-ethylhexyl acrylate were dissolved in 1,575 g of ethyl acetate and polymerized with a stirrer equipped with a vapor condensation reflux tower. After charging the reactor and adding 0.5 g of benzoyl peroxide as a polymerization initiator, the polymerization initiator was decomposed by slowly immersing it in a hot water bath and slowly raising the temperature to 58 ° C. to initiate the polymerization reaction. .

  As a result, as soon as heat generation started, it was cooled by immersing in a cooling bath as appropriate, and the reaction was carried out for about 10 hours while controlling the temperature at 63 ± 3 ° C. After the exotherm was almost subsided, 0.1 g of benzoyl peroxide was further added, the temperature was raised to 70 ± 2 ° C., and heat polymerization was carried out for about 5 hours to complete the polymerization reaction. The ethyl acetate solution of the acrylic polymer thus obtained had a viscosity of 360 poise, a non-volatile residue, that is, an acrylic polymer concentration of 25.8% by weight, and a number average molecular weight of 840,000.

(3) Adhesive composition for adhesive bandages and manufacture of adhesive bandages coated with the composition
The acrylic oligomer ethyl acetate solution 64.2 g (non-volatile residue 51.6 g) produced in the above (1) and (2) and the acrylic polymer ethyl acetate solution 200 g (non-volatile residue 51.6 g) were mixed. After adding 0.21 g of a polyisocyanate compound (Coronate HL manufactured by Nippon Polyurethane Co., Ltd.) as a reactive crosslinking agent to the solution, the pressure-sensitive adhesive composition for adhesive adhesive plaster having a non-volatile residue of 25% by weight by adjustment with an ethyl acetate solvent Of ethyl acetate was prepared. The content of the acrylic oligomer as a liquid component in this pressure-sensitive adhesive composition is 50% by weight.

  The ethyl acetate solution of this pressure-sensitive adhesive composition was uniformly applied to a polyester nonwoven fabric (200 μm thickness) and then dried by heating at 110 ° C. to produce a pressure-sensitive adhesive composition, that is, a pressure-sensitive adhesive bandage having a pressure-sensitive adhesive layer thickness of 60 μm. . The adhesive strength of the adhesive bandage was 321 g.

(4) Production of pressure-sensitive adhesive composition for pressure-sensitive adhesive bandages that does not contain an acrylic oligomer and a pressure-sensitive adhesive bandage for comparison with the composition applied
For comparison, 0.21 g of a polyvalent isocyanate compound (Coronate HL manufactured by Nippon Polyurethane Co., Ltd.) as a reactive crosslinking agent was added to 200 g of the acrylic polymer ethyl acetate solution produced in (2) (nonvolatile residue 51.6 g). Then, an ethyl acetate solution of a pressure-sensitive adhesive composition for adhesive bandages with a non-volatile residue of 25% by weight was prepared by mixing and dissolving with an ethyl acetate solvent.

  An ethyl acetate solution of this pressure-sensitive adhesive composition was applied and dried in the same manner as in (3) to produce a comparative adhesive bandage with a pressure-sensitive adhesive layer thickness of 60 μm on the polyester nonwoven fabric. The adhesive strength of the adhesive bandage was 350 g.

(5) Measurement of peeling damage prevention effect of skin stratum corneum by acrylic oligomer
For each of the strip-like (width 12 mm, length 40 mm) test pieces (adhesive layer effective area: 480 mm ² ) of the adhesive adhesive plaster produced in the above (3) and (4), 24 hours on the inner skin of the human forearm After pasting, peeling off, staining the surface of the adhesive layer with ninhydrin solution, coloring the corneocytes attached to the surface of the adhesive layer due to peeling failure, and developing the color area ratio of the corneocytes (coloring in dark purple) by analyzing the photomicrograph Total area / adhesive layer area × 100) was 92% in the case of the adhesive bandage of (4), whereas it was 8% in the case of the adhesive bandage of (3). It was found that the exfoliation damage of the skin keratin was greatly improved by the presence of the system oligomer.

[Example 2]
(1) Production of acrylic oligomer 75 g (0.749 mol) of methyl methacrylate, 225 g (1.221 mol) of 2-ethylhexyl acrylate and 2.6 g (0.013 mol) of lauryl mercaptan were added to 76 g of ethyl acetate solution. To form a monomer mixed solution. This monomer mixed solution was subjected to a polymerization reaction under the same conditions and method as in (1) of Example 1 to produce an ethyl acetate solution of an acrylic oligomer. This solution had a non-volatile residue (concentration of acrylic oligomer) of 80.0% by weight, a viscosity of 28 poise, and the number average molecular weight of the acrylic oligomer was 24,000.

(2) Production of acrylic polymer
A monomer mixed solution in which 25 g (5 parts by weight) of an acrylic acid monomer, 125 g (25 parts by weight) of methyl methacrylate and 375 g (75 parts by weight) of 2-ethylhexyl acrylate were dissolved in 1,575 g of ethyl acetate was used. A polymerization reaction was carried out under the same conditions and method as in (2) to produce an ethyl acetate solution of an acrylic polymer. This solution had a viscosity of 344 poise, a non-volatile residue (acrylic polymer concentration) of 25.9% by weight, and a number average molecular weight of 980,000.

(3) Adhesive composition for adhesive bandages and manufacture of adhesive bandages coated with the composition
Mix 11.5 g (nonvolatile residue 9.2 g) of the acrylic oligomer ethyl acetate solution prepared in (1) and (2) above and 200 g of acrylic polymer ethyl acetate solution (nonvolatile residue 51.8 g). By adjusting with an ethyl acetate solvent, an ethyl acetate solution of a pressure-sensitive adhesive composition for adhesive bandages with a non-volatile residue of 25% by weight was produced. The acrylic oligomer content in the composition is 15% by weight.

  The ethyl acetate solution of the pressure-sensitive adhesive composition was uniformly applied to a polyester nonwoven fabric (thickness: 200 μm), and then heated and dried at 110 ° C. to produce a pressure-sensitive adhesive bandage having a pressure-sensitive adhesive layer thickness of 60 μm. The adhesive strength of the adhesive bandage was 328 g.

(4) Production of pressure-sensitive adhesive composition for pressure-sensitive adhesive bandages that does not contain an acrylic oligomer and a pressure-sensitive adhesive bandage for comparison with the composition applied
The acrylic polymer ethyl acetate solution prepared in (2) above was applied and dried in the same manner as in (3), and the comparative adhesive without the acrylic oligomer having an adhesive layer thickness of 60 μm on the polyester nonwoven fabric. A bandage was produced. The adhesive strength of the adhesive bandage was 341 g.

(5) Measurement of peeling damage prevention effect of acrylic oligomer on skin stratum corneum
For each of the adhesive bandages produced in the above (3) and (4), the ratio of the color development area by the keratinocytes of the attached skin was measured under the same conditions and method as in Example 1, and the adhesive of (4) The adhesive bandage was 94%, while the adhesive bandage of (3) was 21%. It was confirmed that the exfoliation damage of the skin keratin was greatly improved by the presence of the acrylic oligomer.

[Example 3]
(1) Production of acrylic oligomer
A monomer mixture was prepared by dissolving 120 g (0.922 mol) of 2-methoxyethyl acrylate, 180 g (0.977 mol) of 2-ethylhexyl acrylate and 17.4 g (0.086 mol) of lauryl mercaptan in 80 g of ethyl acetate. A solution was formed. This monomer mixed solution was subjected to a polymerization reaction under the same conditions and method as in (1) of Example 1 to produce an ethyl acetate solution of an acrylic oligomer. This solution had a non-volatile residue (concentration of acrylic oligomer) of 80.2% by weight, and the acrylic oligomer had a number average molecular weight of 3,100.

(2) Adhesive composition for adhesive bandages and manufacture of adhesive bandages coated with the composition
78.7 g (nonvolatile residue 63.1 g) of the ethyl acetate solution of the acrylic oligomer produced in the above (1) and 200 g (nonvolatile residue 51) of the ethyl acetate solution of the acrylic polymer produced in (2) of Example 1 .6 g) was added as a reactive crosslinking agent 0.21 g of a polyisocyanate compound (Coronate HL, manufactured by Nippon Polyurethane Co., Ltd.), and then adjusted with an ethyl acetate solvent to give a non-volatile residue of 25 wt% An ethyl acetate solution of the adhesive composition for adhesive bandages was produced. The content of the acrylic oligomer in this pressure-sensitive adhesive composition is 55% by weight.

  An ethyl acetate solution of this pressure-sensitive adhesive composition was uniformly applied to a polyester nonwoven fabric (200 μm thickness), and then dried and heated at 110 ° C. to produce a pressure-sensitive adhesive bandage with a pressure-sensitive adhesive layer thickness of 60 μm. The adhesive strength of the adhesive bandage was 324 g.

(3) Measurement of peeling damage prevention effect of acrylic oligomer on skin stratum corneum
For each of the adhesive bandages produced in the above (2) and Example 1 (4), the ratio of the color development area by the keratinocytes of the attached skin was measured under the same conditions and method as in Example 1. In the case of the adhesive adhesive bandage of 92%, it was 7% in the case of the former adhesive bandage of the above (2), and the acrylic oligomer significantly improves the peeling damage effect of the skin keratin. It has been found.

[Example 4]
(1) Production of acrylic oligomer
Except for using 300 g (1.63 mol) of 2-ethylhexyl acrylate and 13.8 g (0.068 mol) of laurel mercaptan, an ethyl acetate solution of an acrylic oligomer was used under the same conditions and method as in (1) of Example 1. Manufactured. This solution had a non-volatile residue of 82.3% by weight and an acrylic oligomer having a number average molecular weight of 4,400.

(2) Production of acrylic polymer
An acrylic polymer was polymerized by the same conditions and method as in (2) of Example 1 except that 50 g (10 parts by weight) of 2-hydroxyethyl acrylate and 500 g (100 parts by weight) of 2-ethylhexyl acrylate were used. A viscous ethyl acetate solution was prepared. This solution had a viscosity of 274 poise, a non-volatile residue (acrylic polymer concentration) of 22.5% by weight, and a number average molecular weight of 710,000.

(3) Adhesive composition for adhesive bandages and manufacture of adhesive bandages coated with the composition
Acrylic oligomer ethyl acetate solution 36.5 g (non-volatile residue 30.0 g) produced in (1) above and 200 g acrylic polymer ethyl acetate solution (non-volatile residue 45.0 g) produced in (2) After adding 0.3 g of a polyisocyanate compound (Coronate L manufactured by Nippon Polyurethane Co., Ltd.) as a reactive crosslinking agent to the mixed solution, the pressure-sensitive adhesive for adhesive adhesive plaster having a non-volatile residue of 25% by weight by adjustment with an ethyl acetate solvent An ethyl acetate solution of the composition was prepared. The content of the acrylic oligomer in this pressure-sensitive adhesive composition is 40% by weight.

  The ethyl acetate solution of this pressure-sensitive adhesive composition was uniformly applied to a polyester non-woven fabric (thickness: 200 μm) and then dried by heating at 110 ° C. to produce a pressure-sensitive adhesive bandage having a pressure-sensitive adhesive layer thickness of 60 μm. The adhesive strength of the adhesive bandage was 336 g.

(4) Production of pressure-sensitive adhesive composition for pressure-sensitive adhesive bandages that does not contain an acrylic oligomer and a pressure-sensitive adhesive bandage for comparison with the composition applied
The acrylic polymer ethyl acetate solution produced in the above (2) was applied and dried in the same manner as in the above (3) to produce a comparative adhesive bandage with an adhesive layer thickness of 60 μm on the polyester nonwoven fabric. The adhesive strength of the adhesive bandage was 340 g.

(5) Measurement of peeling damage prevention effect of acrylic oligomer on skin stratum corneum
For each of the adhesive bandages produced in the above (3) and (4), the ratio of the color development area by the corneocytes of the attached skin was measured under the same conditions and method as in Example 1, and (4) In the case of the adhesive adhesive bandage, it was 86%, whereas in the case of the adhesive adhesive bandage of (3), it was found that the acrylic oligomer significantly improved the exfoliation damage of the skin keratin.

As described above, according to the method for producing a pressure-sensitive adhesive composition for a pressure-sensitive adhesive bandage according to the present invention, it is possible to provide a pressure-sensitive adhesive bandage having excellent skin peelability and peelability (skin peeling damage prevention). .

Claims (7)

A method for producing a pressure-sensitive adhesive composition for an adhesive bandage comprising dissolving a predetermined amount of an acrylic oligomer solution in an acrylic polymer solution and then adding a predetermined amount of a reactive crosslinking agent,
(1) A step of producing a solution of an acrylic oligomer formed by solution polymerization of one or more of alkyl alkyl ester or alkyl methacrylate having 4 to 10 carbon atoms of alkyl group (2) carbon number of alkyl group Is a monomer mixed solution containing an alkyl ester of acrylic acid or methacrylic acid alkyl ester of 4 to 10 and a monomer selected from acrylic acid monomer, methacrylic acid monomer, 2-hydroxylethyl acrylate, or 2-hydroxyethyl methacrylate Step (3) for producing an acrylic polymer solution comprising an acrylic polymer formed by solution polymerization of the above-mentioned reactive crosslinking agent with respect to a solution obtained by mixing the acrylic oligomer solution and the acrylic polymer solution 0.01 ~ of the acrylic polymer A step of adding to a value within a range of% by weight,
The manufacturing method of the adhesive composition for adhesive adhesive plaster characterized by including.   The method for producing a pressure-sensitive adhesive composition for adhesive bandages according to claim 1, wherein the acrylic oligomer solution comprises an acrylic oligomer having a number average molecular weight of 2,000 to 4,400.   The said reactive crosslinking agent is a polyhydric epoxy compound or a polyvalent isocyanate compound, The manufacturing method of the adhesive composition for adhesive bandages of Claim 1 or 2 characterized by the above-mentioned. A predetermined amount of an acrylic oligomer solution is dissolved in an acrylic polymer solution, and then a predetermined amount of a reactive crosslinking agent is added to form an adhesive composition for an adhesive bandage. A method for producing an adhesive bandage comprising an adhesive layer comprising an adhesive composition for an adhesive bandage,
(1) A step of producing a solution of an acrylic oligomer formed by solution polymerization of one or more of alkyl alkyl ester or alkyl methacrylate having 4 to 10 carbon atoms of alkyl group (2) carbon number of alkyl group Is a monomer mixed solution containing an alkyl ester of acrylic acid or methacrylic acid alkyl ester of 4 to 10 and a monomer selected from acrylic acid monomer, methacrylic acid monomer, 2-hydroxylethyl acrylate, or 2-hydroxyethyl methacrylate Step (3) for producing an acrylic polymer solution comprising an acrylic polymer formed by solution polymerization of the above-mentioned reactive crosslinking agent with respect to a solution obtained by mixing the acrylic oligomer solution and the acrylic polymer solution 0.01 ~ of the acrylic polymer A step of adding to a value within a range of% by weight,
(4) providing a pressure-sensitive adhesive layer made of the pressure-sensitive adhesive composition for the pressure-sensitive adhesive bandage on one side of the base sheet to form a pressure-sensitive adhesive bandage;
The manufacturing method of the adhesive adhesive bandage characterized by including.   The method for producing an adhesive bandage according to claim 4, wherein the acrylic oligomer solution comprises an acrylic oligomer having a number average molecular weight of 2,000 to 4,400.   The method for producing an adhesive bandage according to claim 4 or 5, wherein the reactive crosslinking agent is a polyvalent epoxy compound or a polyvalent isocyanate compound.   The method for producing a pressure-sensitive adhesive bandage according to any one of claims 4 to 6, wherein the adhesive strength of the adhesive bandage is within a range of 40 to 400 gf.