JP2011058930A5 - - Google Patents
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- JP2011058930A5 JP2011058930A5 JP2009208273A JP2009208273A JP2011058930A5 JP 2011058930 A5 JP2011058930 A5 JP 2011058930A5 JP 2009208273 A JP2009208273 A JP 2009208273A JP 2009208273 A JP2009208273 A JP 2009208273A JP 2011058930 A5 JP2011058930 A5 JP 2011058930A5
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Description
従来のデータ処理では、上記のようにピークのＳＮ比を計算するときの信号値（Ｓ）としては検出されたピークのピークトップの強度値が用いられ、ノイズ値（Ｎ）は測定対象化合物の出現予測時間範囲の中でピーク区間（ピーク開始点からピーク終了点までの間）を除いた全ての測定点の値を使用して計算される。ところが、そのノイズ値を計算するノイズ区間に、ピーク検出されなかった夾雑成分が存在すると、その夾雑成分の影響がノイズ値に現れる。そのため、ノイズ値が真値よりも大きい値になってしまい、結果的にピークのＳＮ比が見かけ上悪くなって、測定対象化合物が含まれているにも拘わらず含まれていないと誤った判定を下す場合がある。 In the conventional data processing, the intensity value of the peak top of the detected peak is used as the signal value (S) when calculating the SN ratio of the peak as described above, and the noise value (N) is the value of the measurement target compound. It is calculated using the values of all measurement points excluding the peak interval (between the peak start point and the peak end point) in the appearance prediction time range. However, if there is a noise component for which no peak is detected in the noise interval for calculating the noise value, the influence of the noise component appears in the noise value. Therefore, the noise value becomes a value larger than the true value, and as a result, the SN ratio of the peak is apparently deteriorated, and it is erroneously determined that it is not included even though the measurement target compound is included. May be dropped.
まず、オペレータは入力部１８より、化合物含有判定パラメータとして少なくとも測定対象化合物毎に探索時間範囲とノイズ時間幅とを入力する（ステップＳ１）。入力された上記パラメータは、データ処理部１０の化合物含有判定パラメータ記憶部１４に保存される。図４に一例を示すように、探索時間範囲は探索開始時間と探索終了時間を一組としたものである。なお、同一種の測定対象化合物を対象とするスクリーニングでは、１回、上記のようなパラメータを設定すれば、そのパラメータを利用して多数の試料のスクリーニングを実施することができる。また、オペレータが入力することなく、予めデータベースに登録された値などを用いるようにしてもよい。 First, the operator inputs a search time range and a noise time width at least for each measurement target compound as compound content determination parameters from the input unit 18 (step S1). The input parameters are stored in the compound content determination parameter storage unit 14 of the data processing unit 10. As shown in FIG. 4 as an example, the search time range is a set of search start time and search end time. In the screening for the same type of measurement target compound, once the parameters as described above are set, a large number of samples can be screened using the parameters. Further, a value or the like registered in advance in the database may be used without input by the operator.
Claims (1)
前記探索時間範囲と前記ノイズ時間幅との少なくとも一方をオペレータが入力設定するためのパラメータ設定手段、をさらに備えることを特徴とするクロマトグラフ用データ処理装置。 The chromatographic data processing apparatus according to claim 1,
A chromatograph data processing apparatus, further comprising parameter setting means for an operator to input and set at least one of the search time range and the noise time width.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009208273A JP5333089B2 (en) | 2009-09-09 | 2009-09-09 | Chromatographic data processor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009208273A JP5333089B2 (en) | 2009-09-09 | 2009-09-09 | Chromatographic data processor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011058930A JP2011058930A (en) | 2011-03-24 |
| JP2011058930A5 true JP2011058930A5 (en) | 2012-01-19 |
| JP5333089B2 JP5333089B2 (en) | 2013-11-06 |
Family
ID=43946740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009208273A Active JP5333089B2 (en) | 2009-09-09 | 2009-09-09 | Chromatographic data processor |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP5333089B2 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10386346B2 (en) * | 2011-09-05 | 2019-08-20 | Shimadzu Corporation | System and method for processing chromatogram data |
| CA2862249A1 (en) | 2011-12-30 | 2013-07-04 | Dh Technologies Development Pte. Ltd. | Intelligent background data acquisition and subtraction |
| US10539540B2 (en) | 2016-06-10 | 2020-01-21 | Hitachi High-Tech Science Corporation | Liquid chromatograph and method for correcting detector output value fluctuation of liquid chromatograph |
| JP7012989B2 (en) * | 2016-06-10 | 2022-01-31 | 株式会社日立ハイテクサイエンス | Liquid chromatograph and detector output value fluctuation correction means for liquid chromatograph |
| JP7088306B2 (en) * | 2018-11-12 | 2022-06-21 | 株式会社島津製作所 | Chromatograph device |
| JP7424595B2 (en) * | 2020-06-23 | 2024-01-30 | 株式会社島津製作所 | Discriminator generation method and device |
| CN114609319B (en) * | 2022-02-14 | 2023-08-22 | 天津国科医疗科技发展有限公司 | Spectral peak identification method and system based on noise estimation |
| CN116046968A (en) * | 2023-03-02 | 2023-05-02 | 北京澳诺科技有限公司 | Liquid chromatography workstation data processing method, system and storable medium |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0954072A (en) * | 1995-08-17 | 1997-02-25 | Shimadzu Corp | Chromatograph data processing device |
| JPH1021373A (en) * | 1996-07-05 | 1998-01-23 | Fuji Photo Film Co Ltd | Picture analyzing device |
| JP3574010B2 (en) * | 1999-07-23 | 2004-10-06 | 昭和電工株式会社 | Differential refractive index detector and liquid chromatograph apparatus having the same |
| JP4470505B2 (en) * | 2004-02-04 | 2010-06-02 | 株式会社島津製作所 | Data processing equipment for chromatographic mass spectrometry |
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2009
- 2009-09-09 JP JP2009208273A patent/JP5333089B2/en active Active
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