JP2011045494A - Hydrocolloid type adhesive composition and wound dressing material having base material with hydrocolloid type adhesive composition applied - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an adhesive composition which shows desired adhesion, keeps integrity without causing dissolution or disintegration of the shape by excessive water absorption on absorbing water, shows a desired amount and speed of water absorption, never loses the characteristics described above when being applied to a base material or the like, and achieves a stable adhesive product. <P>SOLUTION: The hydrocolloid type adhesive composition for adhering to a skin includes (A) an elastomer including a styrene-based block copolymer and a liquid rubber, (B) a tackifier resin, (C) at least one plasticizer, and (D) a water absorbent. The component (C) includes at least one polyester compound. A wound dressing material is configured by applying the adhesive composition to the base material. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a hydrocolloid pressure-sensitive adhesive composition, and more particularly to a pressure-sensitive adhesive composition suitable as a wound treatment agent and a wound material in which this is applied to a base material.

  Hydrocolloid adhesives are becoming more and more important in recent years as having good wound healing effects by adhering to themselves, absorbing wound secretions that exude during healing, and maintaining a moist condition. ing.

  In general, hydrocolloid pressure-sensitive adhesives have a structure in which absorbent colloid particles (water-absorbing agent) are dispersed in a continuous phase (base material) made of a plastic rubber, and many of them are self-weighted over a certain period of time. It is prepared to absorb about 3 to 5 times as much water or exudate from a wound site. Various proposals have been made on rubber components so that the base material does not lose its integrity even when water or the like is absorbed, and the desired adhesiveness can be exhibited (for example, Patent Document 1).

  In the hydrocolloid pressure-sensitive adhesive, one method for adjusting the water absorption amount and the water absorption speed is to use a plasticizer. Conventionally, general-purpose low molecular weight plasticizers such as phthalate ester (DOP: bis (2-ethylhexyl) phthalate) and adipic acid ester (DOA: bis (2-ethylhexyl) adipate) have been used.

Japanese translation of PCT publication No. 2002-512295

Plasticizers such as DOP and DOA that have been used so far have recently been suspected of environmental hormone action and carcinogenicity, and in the field of medical adhesives that are directly applied to the skin, etc., are particularly harmful to health. There is a need for alternative plasticizers as they are likely.
However, sufficient water absorption and water absorption speed can be adjusted while maintaining practical adhesion performance and integrity at the time of water absorption, and when the pressure-sensitive adhesive layer is formed, for example, it does not volatilize during hot melt coating, DOP and No plasticizer to replace DOA has been obtained so far.

  The present invention has the above-mentioned problems, i.e., has little possibility of adversely affecting health, possesses practical adhesiveness and integrity during water absorption, has a desired water absorption amount and water absorption speed, and has an adhesive property. It is an object of the present invention to provide a hydrocolloid pressure-sensitive adhesive composition that maintains such characteristics even after heating at the time of preparation of a pharmaceutical product.

As a result of intensive studies on the above problems, the present inventors have used polyester compounds as plasticizers, in particular, adipic acid polyesters as plasticizers, so that they have a desired adhesive property and collapse in shape upon water absorption. In addition, the present inventors have found that a pressure-sensitive adhesive composition having a desired water absorption amount and water absorption rate can be obtained.
Moreover, by adopting adipic acid polyester as a plasticizer, volatilization of the plasticizer due to heat during the production of the pressure-sensitive adhesive layer (at the time of hot melt coating) can be reduced. For this reason, this pressure-sensitive adhesive composition can be used as a base material. Even when applied, the above-mentioned adhesiveness, stability and water absorption can be maintained, and it is possible to provide an adhesive product (for example, a wound material) having excellent product stability, thus completing the present invention.

（上記式中、
Ｒ₁は互いに独立して炭素原子数２乃至１０のアルキレン基を表し、
Ｒ₂は炭素原子数２乃至１０のアルキレン基又は酸素原子により中断された炭素原子数２
乃至１０のアルキレン基を表し、
Ｒ₃は互いに独立して水素原子又は炭素原子数４乃至１４のアルキル基を表し、そして
ｎは１乃至１０の数を表す。）
で表されるポリエステル化合物を含む、皮膚貼付用ハイドロコロイド型粘着剤組成物に関する。 That is, the present invention is a composition containing (A) an elastomer containing a styrene block copolymer and liquid rubber, (B) a tackifier resin, (C) at least one plasticizer, and (D) a water absorbing agent. The component (C) is represented by the following formula (1)

(In the above formula,
R ₁ independently represents an alkylene group having 2 to 10 carbon atoms,
R ₂ is an alkylene group having 2 to 10 carbon atoms or 2 carbon atoms interrupted by an oxygen atom.
Represents 10 to 10 alkylene groups,
R ₃ independently represents a hydrogen atom or an alkyl group having 4 to 14 carbon atoms, and n represents a number of 1 to 10. )
The hydrocolloid-type adhesive composition for skin sticking containing the polyester compound represented by these.

In the present invention, the component (C) is preferably an adipic acid polyester in which two R _{1 s} in the formula (1) both represent an n-butylene group, and the component (C) in the adipic acid polyester component (C) The content is preferably 10% by mass or more.
The adipic acid polyester preferably contains a reaction product of adipic acid and a glycol having 2 to 8 carbon atoms, and more preferably the adipic acid polyester is end-capped with an alcohol having 8 to 10 carbon atoms. That is, in the formula (1), it is preferable that two R _{3 s} each represent an alkyl group having 8 to 10 carbon atoms.

  Furthermore, in the present invention, when immersed in a physiological saline at 37 ° C., the weight increase after one hour from immersion is 50% or more of the own weight, and the weight increase after 24 hours after immersion is 300% or more of the own weight. In addition, the present invention relates to a hydrocolloid pressure-sensitive adhesive composition, which maintains integrity even after being immersed in physiological saline at 37 ° C. for 24 hours without causing dissolution due to excessive water absorption or shape collapse.

  Moreover, this invention relates also to the wound material formed by apply | coating the said adhesive composition to a base material.

INDUSTRIAL APPLICABILITY The present invention can provide a pressure-sensitive adhesive composition having a practical sticking property (adhesive strength), integrity at the time of water absorption, and a sufficient water absorption amount and water absorption rate within a predetermined time.
Moreover, the plasticizer used in the pressure-sensitive adhesive composition of the present invention produces a product coated with the above-mentioned pressure-sensitive adhesive, since there is little volatilization during the production of the pressure-sensitive adhesive layer, that is, hot melt coating at a high temperature of 150 ° C. or higher. Even after the plasticizer, the plasticizer can exhibit its performance, and the above-mentioned characteristics such as adhesiveness and water absorption can be stably maintained.
Therefore, the wound material coated with the pressure-sensitive adhesive composition of the present invention can achieve sticking property, integrity at the time of water absorption, and a desired water absorption amount / water absorption rate, so that it exudes during the healing process when used on a wound site. It can be expected to absorb wound secretions and maintain a moist condition to show a good wound healing effect.
And the wound material which apply | coated this adhesive composition can anticipate expansion | deployment to the medical / hygiene field | areas, such as an emergency adhesive bandage and a dressing material.

The hydrocolloid pressure-sensitive adhesive composition for skin application of the present invention comprises (A) an elastomer containing a styrene-based block copolymer and a liquid rubber, (B) a tackifier resin, (C) at least one plasticizer, and (D) It contains a water-absorbing agent and may contain other components as desired.
Hereafter, each said component is explained in full detail.

<Elastomer containing (A) styrene block copolymer and liquid rubber>
The elastomer used in the present invention includes a styrenic block copolymer and a liquid rubber.
Examples of the styrenic block copolymer include styrene / butadiene block copolymer (SBS) and its hydrogenated rubber (SEBS), styrene / isoprene block copolymer (SIS) and its hydrogenated rubber (SEPS), styrene · An isobutylene block copolymer (SIBS) etc. are mentioned, These can be used 1 type or in combination.
Examples of the liquid rubber include liquid elastomer components such as liquid polyisoprene (LIR), liquid polybutadiene (LPB), polyisobutylene (PIB), and polybutene (PB).

  The styrene block copolymer and the liquid rubber are preferably used in a weight ratio of styrene block copolymer: liquid rubber = 20 to 80:80 to 20, particularly preferably 50 to 80:50 to 20. Is desirable. By changing these use ratios, the water absorption rate (especially the water absorption rate after long-time immersion) can be controlled.

<(B) Tackifying resin>
The tackifying resin used in the present invention is generally a hydrophobic resin that is compatible with a hydrophobic rubber base component and develops tackiness. Specifically, rosin resin, rosin ester resin, terpene resin, terpene phenol resins, C ₅ petroleum resins, C ₅ / C ₉ petroleum resins,
DCPD petroleum-based resin, coumarone-indene resin and the like can be mentioned.
In the present invention, if the tackifier resin of component (B) is, for example, Alcon P-125 (Arakawa Chemical Industries), which is an alicyclic saturated hydrocarbon resin, sufficient adhesive strength as a wound material and skin at the time of peeling. In consideration of irritation to the skin, it is present in an amount of 80 to 180 parts by mass, preferably 120 to 160 parts by mass with respect to 100 parts by mass of all elastomer components of the pressure-sensitive adhesive composition. preferable.

上記式中、Ｒ₁は互いに独立して炭素原子数２乃至１０のアルキレン基を表し、Ｒ₂は炭素原子数２乃至１０のアルキレン基又は酸素原子により中断された炭素原子数２乃至１０のアルキレン基を表し、Ｒ₃は互いに独立して水素原子又は炭素原子数４乃至１４のアル
キル基を表す。
そしてｎは１乃至１０の数を表し、好ましくは２乃至８の数を表す。 <(C) Plasticizer>
In the present invention, the polyester compound represented by the following formula (1) is included as at least one plasticizer.

In the above formula, R ₁ independently represents an alkylene group having 2 to 10 carbon atoms, and R ₂ represents an alkylene group having 2 to 10 carbon atoms or an alkylene group having 2 to 10 carbon atoms interrupted by an oxygen atom. R ₃ represents a hydrogen atom or an alkyl group having 4 to 14 carbon atoms, independently of each other.
N represents a number from 1 to 10, preferably a number from 2 to 8.

Examples of the polyester compound represented by the above formula (1) include aliphatic dicarboxylic acids having 4 to 12 carbon atoms such as succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, and sebacic acid. , Ethylene glycol, propylene glycol, butylene glycol, neopentyl glycol, diethylene glycol, etc. having 2 to 10 carbon atoms
And polyester compounds obtained by condensation polymerization with glycol.

In the present invention, as the component (C), two or more polyester compounds represented by the above formula (1) may be contained.
Furthermore, within the range not impairing the effects of the present invention, as the component (C), a polyester compound other than the polyester compound represented by the above formula (1), for example, an aromatic dicarboxylic acid such as phthalic acid, isophthalic acid, terephthalic acid, and glycol And a plasticizer made of other compounds may be included.

  Preferably, the polyester compound represented by the above formula (1) is a compound having a molecular weight of about 500 to 3,500, and particularly preferably an adipic acid polyester having a molecular weight of about 600 to 2,500.

The adipic acid polyester includes a reaction product of adipic acid and a glycol having 2 to 8 carbon atoms.
Examples of the glycol having 2 to 8 carbon atoms include ethylene glycol, propylene glycol, 1,3-propanediol, 1,2-butanediol, 1,3-butanediol, 2,3-butanediol, 1,4- Examples include butanediol, pentanediol, hexanediol, diethylene glycol, and triethylene glycol.
Further, the adipic acid polyester is preferably end-capped with an alcohol having 8 to 10 carbon atoms, that is, in the formula (1), both R ₃ are preferably an alkyl group having 8 to 10 carbon atoms. . Examples of the alcohol having 8 to 10 carbon atoms include n-octanol, isooctanol, 2-ethylhexanol, n-nonyl alcohol, isononyl alcohol, n-decanol and the like.

  In the component (C), the content of the adipic acid polyester may be any range as long as the effect of the present invention is achieved, but is preferably 10% by mass or more of the component (C), more preferably. Is 20% by mass or more, more preferably 50% by mass or more.

In this invention, it is preferable that the plasticizer of a component (C) exists in the quantity of 0.5 mass% thru | or 10 mass% with respect to the mass of all the components of an adhesive composition.
When the amount of the plasticizer used is less than 0.5% by mass, the effect as a plasticizer cannot be obtained. When the amount used exceeds 10% by mass, water is absorbed when immersed in physiological saline (37 ° C.). If the cohesive force is insufficient with respect to the swelling, the pressure-sensitive adhesive may be dissolved or the shape may be collapsed, and the integrity may not be maintained.

<(D) Water absorbing agent>
The water-absorbing agent used in the present invention is guar gum, locust bean gum, xanthan gum, karaya gum, pectin, alginic acid, gelatin, carboxymethylcellulose sodium, and other cellulose derivatives, chitin, chitosan, polyvinyl alcohol, polyacrylic acid salt, starch acrylic acid Examples thereof include graft polymers. Among these water-absorbing agents, it is preferable to use carboxymethyl cellulose / sodium having particularly good heat resistance, and the particle size of carboxymethyl cellulose is 5 to 500 μm, preferably 50 to 250 μm.

  In order to obtain an appropriate water absorption rate and amount of water absorption, for example, carboxymethylcellulose sodium is used in an amount of 10 to 50% by mass, preferably 20 to 20% by mass with respect to the mass of all components of the pressure-sensitive adhesive composition. It is desirable to use at a ratio of 40% by mass.

<Other components that can be contained>
In the pressure-sensitive adhesive composition of the present invention, a paraffinic or naphthenic petroleum process oil, a castor oil, a vegetable oil such as soybean oil, or a softener such as a fatty acid ester derived from a vegetable oil may be used.
Furthermore, anti-aging agents such as bisphenol-based, hindered amine-based, and benzimidazole-based used in general rubber-based pressure-sensitive adhesives, ultraviolet absorbers, light stabilizers, and the like may be appropriately added in one or more combinations.
In addition, various additives generally used in adhesive tapes and sheets for skin application, such as fillers, may be appropriately blended.
Alternatively, a medicinal component for the purpose of skin treatment or prevention of damage, beauty, etc. may be added to skin that has already been damaged or skin that is expected to be damaged. For example, by adding a substance having a moisturizing effect such as ceramide, it is possible to promote the regeneration of skin damaged by exfoliation into healthy skin, and γ-orizanol, which has a high blood flow promoting effect, etc. By adding, it can relieve the occlusion of blood vessels caused by body pressure at the site where pressure ulcers are concerned, and it can be expected to prevent pressure ulcers.

  When the hydrocolloid pressure-sensitive adhesive composition for skin application of the present invention is immersed in physiological saline at 37 ° C., the weight increase after 1 hour from immersion is 50% or more of its own weight, and the weight after 24 hours from immersion. The increase amount is 300% or more of its own weight, and even after being immersed in physiological saline at 37 ° C. for 24 hours, it does not cause dissolution or shape collapse due to excessive water absorption, and maintains integrity. It is preferable to blend each component. Here, dissolution means a state in which most of the hydrophilic components in the composition are separated from the hydrophobic portion and dissolved in water due to absorption of moisture by the pressure-sensitive adhesive composition, and the shape collapses. The hydrophilic component in the composition absorbs moisture and swells greatly, so that the swelling power of the hydrophilic component exceeds the cohesive force of the pressure-sensitive adhesive composition, and most of the hydrophilic component is in water. It means that a part of the hydrophobic part is dispersed in water, or the original shape collapses with very little force, in such a case. It becomes difficult to take out. In the case of such a composition, when it is applied to the skin, it may cause cohesive failure at the time of peeling, or a part of the pressure-sensitive adhesive composition may be detached during application.

<Wound material>
The wound material of the present invention can be obtained by applying an appropriate amount of the hydrocolloid pressure-sensitive adhesive composition for skin application of the present invention thus prepared to a substrate. The pressure-sensitive adhesive composition is applied (or pasted) on the hydrophobic pressure-sensitive adhesive layer or directly on the support so as to be positioned at the center of the support coated with the hydrophobic pressure-sensitive adhesive. The composition can also be used as a pad for emergency bandages.

The wound material of the present invention can be suitably produced by a calendar method, a hot melt method, or the like, which is a coating method that does not require an organic solvent.
The hot-melt method uses the characteristics of a block copolymer that softens and melts rapidly at high temperatures without using any dilution medium such as organic solvents, and does not require a drying process. There are advantages such as no danger of.
An example of manufacturing a wound material by the hot melt method will be described below. Heat-controllable high-speed rotating mixer. Elastomer component, tackifier resin, plasticizer and water-absorbing agent are heated and stirred at a temperature of usually 150-200 ° C for 30-120 minutes under nitrogen atmosphere. A uniform pressure-sensitive adhesive composition is obtained.
The pressure-sensitive adhesive composition obtained by the above method was extruded from a die head part temperature-controlled at 150 to 180 ° C. with a hot melt coating machine and spread on a release sheet to a thickness of 100 to 1,000 μm. Then, a wound material is produced by laminating a base material on this.
The above-mentioned pressure-sensitive adhesive composition of the present invention has a composition in which an additive such as a plasticizer does not disappear due to volatilization even in high-temperature heating and high-speed stirring at 170 to 180 ° C., and is suitable for a hot melt method. It has become a structure.

  The base material used here is not particularly limited as long as it has appropriate stretchability, flexibility, strength, appropriate air permeability and fungus barrier property, and examples thereof include polyolefins, polyurethanes, polyesters and polyacrylic acids. Examples thereof include films, foams, non-woven fabrics, woven fabrics, and knitted fabrics. Among these, a polyurethane film is preferable from the above viewpoint.

Moreover, the release sheet used can use a thing conventionally used in the field | area of a patch. For example, a paper base material such as high-quality paper or glassine paper subjected to silicone release treatment, a polyester film, or the like can be used. Also, the basis weight of the release body, but are not limited to, usually, preferably about 50 to 150 g / m ^2, about 60 to 100 / m ² is more preferable. Although one release sheet may be used, even if one release sheet is peeled off by providing one or two or more linear release sheet dividing portions that divide the outer shape at the substantially central portion of the release sheet, The other peeled body remains, and a sticking operation can be performed without touching the adhesive surface, thereby improving workability. In the case where the patch is in a roll shape, it is particularly effective for making the release sheet easy to peel off and improving the handleability. Moreover, even if it arrange | positions so that two or more release sheets may be easily peeled from an adhesive and it covers or peels on one side, it is effective in improving a handleability.
In the present invention, the length of the release sheet is 0.2 mm or more, particularly from the adhesive coating area, from the viewpoint of prevention of adhesive flow-out, productivity, handling, economy, and ease of production. It is preferable to increase it by 1 to 5 mm.

  The thickness of the pressure-sensitive adhesive layer of the wound material of the present invention is not particularly limited, but when securing a fixed thickness from the point of balance with the thickness of the support and ensuring the fixation to the skin, the thickness is 100 to 1200 μm or less. preferable. In addition, for example, the amount of adhesive applied to the border of the wound material is less than the amount of adhesive applied to the center of the wound agent, and the thickness is reduced to prevent rubbing between the border and clothing, etc. The effect that it becomes difficult to peel off when applied to is obtained. In this case, the coating amount of the pressure-sensitive adhesive is preferably 300 to 1,200 μm, more preferably 600 to 800 μm at the center, and the coating amount of the pressure-sensitive adhesive at the border is preferably 50 to 300 μm, more preferably. 100 to 300 μm.

  EXAMPLES Hereinafter, although this invention is demonstrated in detail using an Example, this invention is not limited to these Examples.

<Preparation of hydrocolloid adhesive composition for skin application>
A uniform pressure-sensitive adhesive composition was prepared by heating and stirring at 170 ° C. for 30 to 50 minutes using the hot melt method at the composition shown in Table 1.
The prepared pressure-sensitive adhesive composition was spread on a silicone-treated glassine paper (thickness 120 μm) to a thickness of 600 μm to form a pressure-sensitive adhesive layer. A 30 μm polyether-based polyurethane film was laminated on the pressure-sensitive adhesive layer as a base material to prepare wound materials of Examples and Comparative Examples.
Table 2 shows a list of materials used in the examples and comparative examples.

<Evaluation of water absorption rate>
The water absorption of the wound materials of Examples 1 to 4 and Comparative Examples 1 to 5 prepared in this way was evaluated.
A sample obtained by cutting each wound material into 20 mm × 20 mm was used and immersed in physiological saline at 37 ° C.
The weight increase (g) of the sample after 1 hour, 6 hours and 24 hours after immersion was measured, and the weight increase rate (%) with respect to the sample weight before immersion was determined as the water absorption rate according to the following formula. did.
Water absorption rate after time t (%) = [(sample weight after immersion in physiological saline for t time−sample weight before immersion) / sample weight before immersion] × 100
In addition, the case where the water absorption rate after 1 hour was 150% or more was evaluated as ◎, 50% or more and less than 150% as 〇, and less than 50% as Δ.
The obtained results are shown in Table 1.

<Evaluation of volatility of plasticizer>
About 1 g each of the plasticizer used for the adhesive of the wound material of Examples 1 to 4 and Comparative Examples 1 to 5 was weighed into an aluminum cup, heated in an oven at 180 ° C., and at regular intervals. The weight was measured and the volatility of the plasticizer was evaluated.
Specifically, the remaining amount after heating is calculated with respect to the initial weight before heating, and heating is performed until the remaining amount after heating becomes 0.1% or less of the initial weight or until the heating time reaches 30 minutes. And measurements were taken.
Evaluation was made with ○ indicating that the remaining volatility after heating at 180 ° C. for 30 minutes was 95% or more, Δ being 60% or more and less than 95%, and × being less than 60%.
The obtained results are also shown in Table 1.

As is apparent from the results shown in Table 1, the wound materials of Examples 1 to 4 show a high water absorption rate after 1 hour has passed since physiological saline immersion, and the volatilization amount of the plasticizer at 180 ° C. It was very low.
On the other hand, some of the wound materials of Comparative Examples 1 to 5 using a plasticizer other than adipic acid polyester show a water absorption rate equivalent to that of the wound material of the example after 24 hours from immersion in physiological saline. However, the water absorption after 1 hour was low as compared with the wound materials of the examples. Further, the volatilization amount of the plasticizer at 180 ° C. was very large, and particularly in Comparative Examples 3 to 5, the result was that most of the volatilization would occur after 30 minutes. In addition, no dissolution or shape collapse of the pressure-sensitive adhesive compositions of Examples and Comparative Examples was observed after 24 hours from immersion in physiological saline.

<Evaluation of skin irritation>
The wound materials of Examples 1 to 4 prepared above were applied to the inner side of the human forearm, the test piece was peeled off 24 hours after the sticking, and the skin irritation of the sticking site of the test piece 1 hour and 24 hours after the peeling was performed. Evaluation was performed according to Japanese standards (n = 30).
Here, the Japanese standard is the standard of the Japanese patch test research group. Specifically, depending on the degree of skin reaction,-: 0, ±: 0.5, +: 1, ++: 2, +++: 3, and +++: 4: are weighted, and the evaluation results of each subject according to the following formula Was multiplied by 100 to obtain the skin irritation index.
[Criteria]
-: No response ±: Mild erythema +: Erythema ++: Erythema + edema +++: Erythema + edema + papules +++: Erythema + edema + papules, serous papules, vesicles [Skin irritation index formula]
Skin irritation index = (total score / number of subjects) × 100

The obtained skin irritation index was evaluated according to the following criteria.
Safety product: 0 or more to less than 15 Improvement required product: 15 or more to less than 30 Dangerous product: 30 or more All the skin irritation of the wound materials of Examples 1 to 4 were classified as safety products.

From the above results, it was confirmed that the pressure-sensitive adhesive composition of the present invention is a pressure-sensitive adhesive having high water absorption, and the plasticizer used therein has little volatilization even at the temperature during coating. It was confirmed that an adhesive having excellent product stability can be provided without losing performance or the like. Furthermore, it was confirmed that the wound material using the pressure-sensitive adhesive composition of the present invention has weak skin irritation.
Therefore, the wound material to which the present adhesive composition is applied can be expected to be developed in the medical / hygiene field of emergency adhesive bandages and dressing materials.

Claims (7)

(A) an elastomer containing a styrenic block copolymer and liquid rubber,
(B) a tackifying resin,
(C) a composition containing at least one plasticizer, and (D) a water absorbing agent,
The component (C) is represented by the following formula (1)

(In the above formula,
R ₁ independently represents an alkylene group having 2 to 10 carbon atoms,
R ₂ is an alkylene group having 2 to 10 carbon atoms or 2 carbon atoms interrupted by an oxygen atom.
Represents 10 to 10 alkylene groups,
R ₃ independently represents a hydrogen atom or an alkyl group having 4 to 14 carbon atoms, and n represents a number of 1 to 10. )
A hydrocolloid pressure-sensitive adhesive composition for skin application, comprising a polyester compound represented by the formula: The component (C), the formula (1) two of R ₁ contains an adipic acid polyester representing together n- butylene group, claim 1 for application to the skin hydrocolloid pressure-sensitive adhesive composition according in. The hydrocolloid pressure-sensitive adhesive composition for skin application according to claim 2, wherein the content of the adipic acid polyester in the component (C) is 10% by mass or more. The hydrocolloid pressure-sensitive adhesive composition for skin application according to claim 2, wherein the adipic acid polyester contains a reaction product of adipic acid and a glycol having 2 to 8 carbon atoms. In the formula (1), two R _{3 s} each represent an alkyl group having 8 to 10 carbon atoms.
The hydrocolloid pressure-sensitive adhesive composition for skin application as described. When immersed in physiological saline at 37 ° C., the weight increase after 1 hour from immersion is 50% or more of its own weight, the weight increase after 24 hours after immersion is 300% or more of its own weight, and 37 ° C. 2. The hydrocolloid pressure-sensitive adhesive composition according to claim 1, wherein the hydrocolloid-type pressure-sensitive adhesive composition maintains integrity without being dissolved or deformed by excessive water absorption even after being immersed in a physiological saline solution for 24 hours. The wound material formed by apply | coating the adhesive composition as described in any one of Claims 1 thru | or 6 to a base material.