JP5226230B2 - Adhesive composition for patch and use thereof - Google Patents

Description

  The present invention relates to a pressure-sensitive adhesive composition for patches and its use.

  In recent years, various patches and patch preparations have been developed. These patches and patch preparations are very excellent from the viewpoint of wound protection and continuous transdermal administration of drugs. Such patches and patch preparations have a structure in which an adhesive layer is laminated on a support made of a fabric or a plastic film, and a release film (release liner) is further laminated on the adhesive layer. Yes.

  Since the adhesive layer of such a patch is applied to the skin of a living body, it is necessary to satisfy various characteristics different from ordinary industrial tapes, such as an appropriate hydrophilic / hydrophobic balance and low skin irritation. is there. In such a patch, an organic liquid component may be contained in the pressure-sensitive adhesive layer for the purpose of good skin adhesion and reduction of physical skin irritation at the time of peeling.

  For example, Patent Document 1 discloses a patch preparation comprising a pressure-sensitive adhesive layer containing polyisobutylene and polybutene having a viscosity average molecular weight of 400,000 to 1,800,000, and an organic liquid component such as a fatty acid ester is added to the pressure-sensitive adhesive layer. It is described that 0 to 15% can be blended. However, in such a patch preparation, when a large amount of an organic liquid component is added to the adhesive layer, the adhesive layer is plasticized and its cohesive force is reduced, and the adhesive is applied to the skin surface when the patch and the patch preparation are peeled off. There is a possibility that part of the layer remains (so-called glue residue). Moreover, when the cohesive force of the pressure-sensitive adhesive layer is reduced, for example, when the release film is removed from the patch, a part of the pressure-sensitive adhesive remains on the release surface of the release film (adhesive residue), and as a result, in the preparation There is a possibility that the therapeutic effect will be reduced by reducing the amount of drug.

  Furthermore, a patch containing such an organic liquid component is more likely to diffuse and move as the organic liquid component has a lower molecular weight. Therefore, the organic liquid component oozes to the surface of the pressure-sensitive adhesive layer and becomes a release film. May reach. When such a phenomenon occurs, the adhesive force between the pressure-sensitive adhesive layer and the release film decreases, and the adhesive remains on the release film or the release film pressure-sensitive adhesive during manufacture or use of the patch. There is a possibility of lifting from the layer.

As a method of solving the so-called adhesive residue problem in which the adhesive remains (transfers) to the adherend and the release film, generally, a crosslinking agent is added to the adhesive layer to There are methods for crosslinking the pressure-sensitive adhesive (polymer component) or adding a filler to increase the cohesive strength of the pressure-sensitive adhesive layer (Patent Document 2). However, in the method of cross-linking the polymer component, there are cases where cross-linking cannot be performed due to cross-linking inhibition by the added drug or percutaneous absorption accelerator, and on the other hand, the effect may not be sufficiently obtained by the method of adding a filler.
Japanese Patent Laid-Open No. 06-145052 Japanese Patent Laid-Open No. 06-65066

  The present invention has been made in view of such circumstances, and a problem to be solved is to provide a pressure-sensitive adhesive composition for a patch that can achieve high cohesion and skin adhesion at a high level. . Another object of the present invention is to provide a patch and a patch preparation comprising a pressure-sensitive adhesive layer containing such a pressure-sensitive adhesive composition for a patch.

  As a result of intensive studies to solve the above-mentioned problems, the present inventors have found that the above-mentioned problems can be solved by combining a tackifier having a specific molecular weight with a rubber-based elastomer that should constitute the adhesive composition for a patch. The present invention has been completed.

That is, the present invention is as follows.
(1) A pressure-sensitive adhesive composition for a patch comprising a rubber-based elastomer and a tackifier having a weight average molecular weight of 1200 to 2500.
(2) The adhesive composition for patches according to (1) above, wherein the tackifier is at least one selected from petroleum resins, terpene resins, rosin resins, coumarone indene resins, and styrene resins.
(3) The adhesive composition for patches according to (2) above, wherein the petroleum resin is an alicyclic saturated hydrocarbon resin having a repeating unit represented by the following general formula (1).

(4) The rubber-based elastomer includes a first rubber-based elastomer and a second rubber-based elastomer, and the first rubber-based elastomer and the second rubber-based elastomer are each independently polyisobutylene, polyisoprene, butyl rubber, and The pressure-sensitive adhesive composition for patches according to any one of the above (1) to (3), which is at least one selected from styrene-based thermoplastic elastomers.
(5) The weight average molecular weight of the first rubber-based elastomer is 1,600,000 to 5,400,000, and the weight average molecular weight of the second rubber-based elastomer is 36,000 to 75,000. The pressure-sensitive adhesive composition according to (4) above.
(6) A patch comprising a pressure-sensitive adhesive layer containing the pressure-sensitive adhesive composition for a patch according to any one of (1) to (5) above on at least one surface of a support.
(7) A patch preparation in which the adhesive layer of the patch according to (6) above contains a transdermally absorbable drug (excluding bisoprolol).

The adhesive composition for patches of the present invention contains a tackifier having a weight average molecular weight of 1200 to 2500 in the adhesive composition, thereby maintaining skin cohesion while maintaining the cohesive strength of the rubber-based elastomer. Can be suppressed. Therefore, when a relatively high molecular weight rubber-based elastomer is combined with the above-mentioned tackifier, a pressure-sensitive adhesive composition for a patch that achieves a higher degree of cohesive force and hardly deteriorates skin adhesiveness can be obtained. Therefore, according to this invention, the adhesive composition for patches which can make high cohesion force and skin adhesiveness compatible at a high level is provided.
Further, when a large amount of organic liquid component is contained in the pressure-sensitive adhesive composition, the cohesive force of the pressure-sensitive adhesive composition tends to decrease, but a tackifier having a weight average molecular weight of 1200 to 2500 according to the present invention. By including in the pressure-sensitive adhesive composition, even when a relatively high molecular weight rubber elastomer having high cohesive force is used in the pressure-sensitive adhesive composition, the skin adhesiveness of the pressure-sensitive adhesive composition is unlikely to decrease. . That is, according to the pressure-sensitive adhesive composition for a patch of the present invention, it is possible to contain a large amount of an organic liquid component, and even in such a case, good pressure-sensitive adhesive properties that achieve both high cohesive force and skin adhesiveness are possible. A pressure-sensitive adhesive composition is obtained. As a result, the pressure-sensitive adhesive composition of the present invention can contain a large amount of an organic liquid component in the pressure-sensitive adhesive composition, and as a result, the irritation at the time of peeling from the skin is small.
Thus, since the adhesive composition for patches of the present invention can have the above-mentioned favorable adhesive properties, when it is used in the adhesive layer of the adhesive patch, the adhesiveness to the skin is reduced. The adhesive residue on the skin surface is reduced at the time of peeling from the skin, and the adhesive residue on the release film from the pressure-sensitive adhesive layer during production or use and the lifting of the release film are suppressed. Can be reapplied.
Furthermore, according to the adhesive preparation of the present invention containing a transdermally absorbable drug in the adhesive layer, the drug has a high transdermal absorbability, and a large amount of drug can be dissolved and retained in the adhesive layer. The therapeutic effect is enhanced.

  Hereinafter, the present invention will be described in detail with reference to preferred embodiments thereof. In the description of the drawings, the same elements are denoted by the same reference numerals, and redundant description is omitted. For the convenience of illustration, the dimensional ratios in the drawings do not necessarily match those described.

(Adhesive composition for patch)
First, the adhesive composition for patches of the present invention will be described.
The adhesive composition for patches of the present invention (hereinafter sometimes simply referred to as “adhesive composition”) contains a rubber-based elastomer and a tackifier having a weight average molecular weight of 1200 to 2500. It is characterized by.

The rubber-based elastomer is not particularly limited as long as it is a rubber-based elastomer that can be used as a pressure-sensitive adhesive for a patch, but from the viewpoint of price and handleability, polyisobutylene, polyisoprene, butyl rubber, styrene-based thermoplastic elastomer ( For example, a styrene-diene-styrene block copolymer such as a styrene-isoprene-styrene block copolymer is preferable, and a polyisobutylene is more preferable. These can be used individually by 1 type or in mixture of 2 or more types.
The molecular weight of the rubber-based elastomer is not particularly limited as long as the adhesive and cohesive force that can be used as a pressure-sensitive adhesive are imparted to the pressure-sensitive adhesive, but in order to obtain a higher cohesive force, a relatively high molecular weight is required. It is preferable to use the first rubber-based elastomer, and it is preferable to use a second rubber-based elastomer having a relatively low molecular weight in order to obtain even better skin adhesion. In order to achieve both of these characteristics, it is preferable to use a rubber-based elastomer mixture containing at least these two types.

The molecular weight of the first rubber-based elastomer is preferably 1,600,000 to 5,400,000, more preferably 1,800,000 to 4,800,000, most preferably 3 in terms of weight average molecular weight (Mw). , 000,000-4,500,000. When Mw is less than 1,600,000, it tends to be difficult to obtain the internal cohesive force of the pressure-sensitive adhesive. On the other hand, when Mw exceeds 5,400,000, the skin adhesiveness and tack of the pressure-sensitive adhesive tend to decrease.
The molecular weight of the second rubber-based elastomer is preferably 36,000 to 75,000, more preferably 40,000 to 60,000, and most preferably 45,000 to 55,000 in terms of Mw. If the Mw is less than 36,000, a sticky feeling is generated in the pressure-sensitive adhesive, and the skin surface may be contaminated from the time of application to the time of application. On the other hand, if it exceeds 75,000, the skin adhesiveness and tack of the pressure-sensitive adhesive tend to be lowered. In addition, Mw here means Mw of polystyrene conversion measured by a gel permeation chromatography (GPC) method. The measurement conditions are as follows.

Eluent: Tetrahydrofuran (THF)
Sample concentration (THF solution): 0.1% (W / V),
Column: G4000H _XL + G2000H _XL + G1000H _XL (manufactured by Tosoh Corporation, each 7.8 mmφ × 300 cm),
Column temperature: 40 ° C
Detector: Differential refractometer (RI)

The amount of the rubber-based elastomer is preferably 15 to 60% by weight, more preferably 15 to 55% by weight, based on the total weight of the pressure-sensitive adhesive composition. If the total amount of the rubber-based elastomer is less than 15% by weight, it may be difficult to impart the necessary internal cohesive force to the pressure-sensitive adhesive composition. On the other hand, if the total amount exceeds 60% by weight, skin adhesion of the pressure-sensitive adhesive composition may occur. There is a risk that the property and tack will be reduced. In addition, also when an adhesive composition is comprised with 2 or more types of rubber-type elastomers from which molecular weight differs, the total compounding quantity of a rubber-type elastomer is the same as the above. In the present invention, high cohesion and skin adhesion can be achieved even when the rubber-based elastomer is blended in an amount less than that normally used in the art (for example, about 30% by weight or less, preferably 27% by weight or less). It is compatible at a high level.
The blending ratio of the first rubber-based elastomer and the second rubber-based elastomer is a weight ratio (the former: the latter), preferably 1: 0.1 to 1: 3, more preferably 1: 0.1 to 2. .5. If it is less than 1: 0.1, the skin adhesiveness may be insufficient, and if it exceeds 1: 3, the cohesive force may be insufficient.
As described above, the rubber-based elastomer can be a mixture of two or more kinds, but when two or more kinds of mixtures are used, each elastomer may be the same or different, but from the viewpoint of compatibility between the two, the same kind is used. It is desirable that

  As the tackifier used in the present invention, as long as the Mw is 1200 to 2500, those known in the art can be appropriately selected and used. For example, petroleum resins (for example, liquid paraffin, alicyclic group) Saturated hydrocarbon resin), terpene resin, rosin resin, coumarone indene resin, styrene resin (for example, styrene resin, α-methylstyrene) and the like are preferable. Among these, petroleum resins, particularly alicyclic saturated hydrocarbon resins are more preferable because good tack can be obtained. You may use a tackifier individually by 1 type or in combination of 2 or more types.

  Although it is not particularly limited as an alicyclic saturated hydrocarbon resin, thermoplasticity obtained by polymerizing unsaturated hydrocarbons obtained by pyrolyzing naphtha is obtained because it provides good adhesion to the skin and tackiness. A hydrogenated resin having an alicyclic structure by adding hydrogen to the resin is preferably used, and among them, an alicyclic saturated hydrocarbon resin having a repeating unit represented by the following general formula (1) (hereinafter referred to as “resin ( 1) ") is particularly suitable.

  From the viewpoint of obtaining a good tack, the Mw of the tackifier needs to be 1200 to 2500, preferably 1300 to 2500, more preferably 1500 to 2400, and most preferably 1700 to 2300. If the Mw of the tackifier is less than 1200, a sticky feeling is generated, and there is a possibility that the skin surface is contaminated from the pasting to the pasting. On the other hand, when 2500 is exceeded, the effect as a tackifier is hard to express and a tendency for tack to fall is shown. In addition, although Mw here is also Mw of polystyrene conversion measured by a gel permeation chromatography (GPC) method, the measurement conditions are the same as the above.

  In order to give a high cohesive force to the pressure-sensitive adhesive composition, when the above-mentioned first rubber-based elastomer is used, it does not have a skin tack per se, and it is necessary to add a tackifier. According to the knowledge of the present inventors, even when a tackifier having an Mw of about 1100 is added, skin tack does not appear. In such a case, it was predicted that a tackifier having a lower molecular weight than the above may be added as a tackifier having a stronger tack imparting power. However, contrary to such prediction, it has been surprisingly found that a desired skin tack can be manifested only by adding a higher molecular weight tackifier than the above. The mechanism of this phenomenon is not necessarily clear, but the relatively high molecular weight of the first rubber-based elastomer has a relatively high molecular weight because the intermolecular gap is relatively large due to the long polymer chain. The present inventors presume that the tackifier effectively fills the gap so that the skin tack of the adhesive composition is efficiently expressed.

  The blending amount of the tackifier is preferably 15 to 55% by weight, more preferably 20 to 50% by weight, and most preferably 25 to 50% by weight with respect to the total weight of the pressure-sensitive adhesive composition. If the blending amount of the tackifier is less than 15% by weight, the tack may be poor. On the other hand, if it exceeds 55% by weight, the cohesive force in the adhesive may be remarkably reduced, and a tendency to break may be exhibited.

  The pressure-sensitive adhesive composition of the present invention can contain an organic liquid component. As the organic liquid component, when the pressure-sensitive adhesive composition contains a drug, a liquid compound having a function of enhancing the solubility and diffusibility of the drug and capable of improving the transdermal absorption of the drug is suitably used. . Specific examples of such a percutaneous absorption enhancer include the following compounds. For example, as a compound mainly enhancing drug solubility, glycols such as ethylene glycol, diethylene glycol, propylene glycol, triethylene glycol, polyethylene glycol, polypropylene glycol and the like, and as a compound mainly enhancing drug diffusibility, olive oil, And oils such as castor oil, squalane and lanolin. Other hydrocarbons such as liquid paraffin; various surfactants; ethoxylated stearyl alcohol; glycerin monoesters such as oleic acid monoglyceride, caprylic acid monoglyceride, lauric acid monoglyceride; glycerin diester, glycerin triester or a mixture thereof; lauryl Higher fatty acid esters such as ethyl acetate, isopropyl myristate, isotridecyl myristate, octyl palmitate, isopropyl palmitate, ethyl oleate and diisopropyl adipate; higher fatty acids such as oleic acid and caprylic acid; N-methylpyrrolidone; 1,3 -Butanediol etc. can be mentioned.

  The blending amount of the organic liquid component is preferably 20 to 50% by weight, more preferably 30 to 40% by weight, based on the total weight of the pressure-sensitive adhesive composition. If it is less than 20% by weight, the skin irritation tends to be strong. On the other hand, if it exceeds 50% by weight, the cold flow may not be sufficiently suppressed, and the cohesive force tends to be greatly reduced and cohesive failure tends to occur.

  Further, the pressure-sensitive adhesive composition of the present invention includes general additives such as ultraviolet absorbers, light stabilizers, release modifiers, plasticizers, softeners, fillers, colorants (pigments, dyes, etc.), You may mix | blend anti-aging agent, surfactant, etc. In addition, the compounding quantity of such a component can be suitably set with the use purpose, the kind and composition of the pressure-sensitive adhesive composition, and the like.

(Patch)
FIG. 1 is a cross-sectional view showing a preferred embodiment of the patch of the present invention.
The patch 10 includes a support 1, a pressure-sensitive adhesive layer 2 laminated on one side of the support 1, and a release film 3 laminated on the pressure-sensitive adhesive layer 2. The pressure-sensitive adhesive layer 2 includes the above-mentioned pressure-sensitive adhesive composition for patches.

  The support is not particularly limited, and polyester, polyamide (for example, nylon (trademark)), polyvinylidene chloride (for example, Saran (trademark)), polyethylene, polypropylene, and polychlorinated from the viewpoints of handleability, flexibility, and anchoring properties. A single film such as vinyl, ethylene-ethyl acrylate copolymer, polytetrafluoroethylene, ionomer resin (for example, Surlyn (trademark)), metal foil, or a laminated film of these can be used. In order to make the anchoring property better, a support in which a porous film is laminated on a single layer film made of the above material is more preferable. In this case, it is desirable to laminate an adhesive layer on the porous film side. Although the thickness of a support body does not have limitation in particular, Preferably it is 10-200 micrometers, More preferably, it is 10-100 micrometers.

Moreover, in order to improve the anchoring property between a support body and an adhesive layer, you may laminate | stack a nonwoven fabric and a woven fabric on a support body. The material of the nonwoven fabric or woven fabric is not particularly limited, and can be appropriately selected from materials usually used in the field of patches. Examples of such a material include polyester, polypropylene, polyamide, and the like. The basis weight of the nonwoven fabric or woven fabric, usually 1 to 100 g / ^{m 2,} preferably for the reason that is a 6~50g / ^{m 2,} the adhesion feeling to the skin surface at the time of flexibility and sticking is good 6 ˜30 g / m ² is particularly preferred.

The patch of the present invention is preferably laminated with a release film in order to protect the adhesive surface of the adhesive layer until use. It does not restrict | limit especially as a release film, A well-known peeling film can be used. For example, films such as polyester, polyvinyl chloride, polyvinylidene chloride, polyethylene terephthalate, etc. that have been subjected to release treatment by applying silicone resin, fluororesin, etc. to the contact surface with the adhesive layer, fine paper, glassine paper A laminated film of polyolefin such as high-quality paper or glassine paper and polyolefin is used. The thickness of the release film is usually 10 to 200 μm, preferably 25 to 100 μm.
Moreover, it is preferable that the peeling force from the adhesive layer of a release film is 10-400 mN / cm. When the peeling force is less than 10 mN / cm, there is a problem that the patch is peeled off from the release film when the patch is taken out from the packaging bag, or the patch is rolled during manufacture. On the other hand, when it exceeds 400 mN / cm, when the adhesive composition contains a drug, it remains on the release film, so that the drug content decreases and the therapeutic effect becomes low. A more preferable range of the peeling force is 20 to 300 mN / cm.

The method for producing the patch of the present invention is not particularly limited. For example, the above-mentioned pressure-sensitive adhesive composition is dissolved in an appropriate solvent such as toluene or hexane, and the obtained solution is applied onto a support and dried. Can be manufactured. Moreover, it can manufacture also by apply | coating the said solution on a release film, drying, forming an adhesive layer on a release film, and making a support body adhere to an adhesive layer after that. The thickness of the pressure-sensitive adhesive layer is preferably 20 to 300 μm, more preferably 50 to 250 μm, from the viewpoint of maintaining cohesive force and preventing adhesive residue. Moreover, it does not specifically limit as a shape of a patch, For example, a tape form and a sheet form may be sufficient.
The patch obtained in this way has high adhesiveness to the skin, can be peeled off without irritation on the skin surface, and can be re-applied. It is useful as a ruled wound bandage, a large adhesive bandage with pad, and a dressing material.

(Patch preparation)
The patch preparation of the present invention has the same laminated structure as that of the patch 10 described above, but differs from the patch 10 in that the adhesive layer 2 contains a transdermally absorbable drug (except for bisoprolol). Thus, the adhesive preparation of the present invention can be used as a transdermally absorbable preparation because the adhesive layer contains a transdermally absorbable drug.
The transdermal drug is not particularly limited as long as it has a property that can be administered through the skin of mammals such as humans, that is, transdermal drug. Specifically, general anesthetics, hypnotics / sedatives, antiepileptics, antipyretic analgesics / anti-inflammatory drugs, antipruritics, psychiatric drugs, local anesthetics, skeletal muscle relaxants, autonomic drugs, antispasmodics, anti Parkinson's, antihistamine, cardiotonic, arrhythmic, diuretic, antihypertensive, vasoconstrictor, coronary vasodilator, peripheral vasodilator, arteriosclerosis, cardiovascular, respiratory accelerator, antitussive expectorant Drugs, hormone drugs, topical suppurative drugs, analgesic / antipruritic / astringent / anti-inflammatory drugs, parasitic skin disease drugs, hemostatic drugs, gout treatment drugs, antidiabetic drugs, anti-neoplastic drugs, antibiotics And chemotherapeutic drugs, narcotics, anti-schizophrenia drugs, antidepressants, and smoking cessation aids.

Further, when the transdermally absorbable drug is a solid drug, there is a possibility of crystal precipitation in the pressure-sensitive adhesive layer, but in the present invention, the solid drug is preferably used as the transdermally absorbable drug in that this can be advantageously suppressed. Is done. The solid drug as used herein means a drug that is solid at room temperature (25 ° C.), that is, a drug having a melting point of 25 ° C. or higher.
Further, when the transdermally absorbable drug is a liquid drug, there is a possibility of bleeding from the pressure-sensitive adhesive layer, but in the present invention, a liquid drug is also preferably used as the transdermally absorbable drug in that this can be advantageously suppressed. . The liquid drug here means a drug that is liquid at room temperature (25 ° C.), that is, a drug having a melting point of less than 25 ° C. In addition, melting | fusing point here means the value measured by DSC (model number DSC6220, Seiko Instruments (SII) make) based on JISK7121.

  The compounding amount of the transdermally absorbable drug is appropriately set depending on the kind of drug, the purpose of administration, etc. Usually, the drug is preferably 0.5 to 40% by weight, more preferably 1 to 30% by weight in the adhesive layer. In the range of. When the blending amount is less than 0.5% by weight, it is difficult to absorb a sufficient amount of the drug to exert a pharmacological effect. On the other hand, when the blending amount exceeds 40% by weight, the skin adhesiveness tends to decrease. is there.

The patch preparation of the present invention can be produced by the same method as the above-mentioned patch using a solution obtained by incorporating a transdermally absorbable drug into the above-mentioned adhesive composition and dissolving it in a solvent. It is.
The patch preparation of the present invention is used after being applied to the skin surface about once every 1-2 days, although it varies depending on the type of drug, patient age, weight, symptoms and the like.

  EXAMPLES Hereinafter, the present invention will be specifically described with reference to examples, but these examples do not limit the present invention. The materials used in the examples and the like are as follows.

Polyisobutylene A: Mw 4,000,000
Polyisobutylene B: Mw 51,000
Tackifier T1: Alicyclic saturated hydrocarbon resin [resin (1)], Mw2,140
Tackifier T2: alicyclic saturated hydrocarbon resin [resin (1)], Mw1,530
Tackifier T3: alicyclic saturated hydrocarbon resin [resin (1)], Mw1,130
Organic liquid component: isopropyl myristate (IPM)

(Examples 1-5 and Comparative Examples 1-2)
A viscous toluene solution of a pressure-sensitive adhesive composition for a patch prepared according to the ratio shown in Table 1 was prepared, and the obtained solution was placed on a release film made of polyethylene terephthalate (PET) subjected to silicone release treatment. It applied so that the thickness after drying might be set to 80 micrometers, and this was dried at 100 degreeC for 5 minute (s) in the hot air circulation type dryer, and the adhesive layer was obtained. This pressure-sensitive adhesive layer was bonded to the nonwoven fabric side of a laminated film of 2 μm thick PET film and 12 g / m ² PET nonwoven fabric to obtain a sheet-like patch. In addition, the compounding quantity of each component of Table 1 is a ratio (weight%) of the total weight reference | standard of an adhesive composition.

  The following tests were conducted on the patches prepared in Examples and Comparative Examples, and the results are shown in Table 2.

<Skin adhesiveness>
The patches prepared in Examples and Comparative Examples were affixed to the upper arm side of the volunteer, and the affixed state after 24 hours was visually determined. Judgment criteria are as follows.
○: No peeling at all.
Δ: Some people have terminal peeling.
X: Some people are missing.

<Skin glue residue>
The state of the adhesive layer and the skin surface when the patch was peeled and removed from the upper arm side after the skin adhesion test was visually observed to determine the adhesive residue on the skin of the adhesive layer. Judgment criteria are as follows.
○: No adhesive remains on the skin surface during peeling.
Δ: Slight pressure-sensitive adhesive remains on the skin surface during peeling.
X: The adhesive remains on the skin surface at the time of peeling.

<Re-stickability>
The patch peeled and removed from the upper arm side after the skin adhesion test was applied to the upper arm side again to determine whether or not it could be applied. Judgment criteria are as follows.
○: Re-paste is possible.
(Triangle | delta): Although it can reapply, skin adhesiveness is quite weak.
×: Cannot be reapplied.

<Remaining glue on release film>
For the patches prepared in Examples and Comparative Examples, the release film was peeled off from the patches, and the amount of the adhesive adhered to the release film was visually observed, and the adhesive layer adhesive on the release film The rest was judged. Judgment criteria are as follows.
○: The adhesive cannot be confirmed visually.
Δ: Slight deposits are present.
X: A deposit is clearly present.

<Floating release film>
The interlayer strength between the release film and the pressure-sensitive adhesive layer when the patches prepared in Examples and Comparative Examples were bent with the support side inward was visually determined. Judgment criteria are as follows.
○: No lifting between the release film and the pressure-sensitive adhesive layer is observed.
Δ: Slight lifting of release film and adhesive is observed.
X: Lifting of the release film and the pressure-sensitive adhesive layer is clearly observed.

(Examples 6 to 10 and Comparative Examples 3 to 4)
Except that 1 part by weight of indomethacin (anti-inflammatory analgesic, solid drug) was added to 100 parts by weight of the ingredients shown in Table 1, a transdermal absorbable adhesive composition was prepared in the same manner as in the above Examples. A patch preparation was obtained.

As is clear from Table 2, the adhesive patch of Example 2 tended to have a slight decrease in skin adhesiveness, but the adhesive patches of Examples 1 and 3-5 had good skin adhesiveness. That is, it was found that T1 and T2 have good skin adhesiveness, and in particular, T1 is good. Moreover, it was confirmed that the patch of an Example is excellent in the following points compared with the patch of a comparative example.
(I) high adhesion to the skin;
(Ii) There is no adhesive residue on the skin surface when peeling from the skin, and there is little irritation when peeling from the skin,
(Iii) There is no adhesive residue on the release film from the pressure-sensitive adhesive layer during production or use, and the lifting of the release film is suppressed,
(Iv) Re-sticking to the skin is possible.
In addition, it was confirmed that the patch preparations of Examples 6 to 10 also had the above characteristics (i) to (iv) and had anti-inflammatory analgesic effects. On the other hand, in the patch preparation of Comparative Examples 3-4, the same result as Comparative Examples 1-2 was obtained, and it was confirmed that it was inferior in performance to the patch preparation of Examples 6-10.
Therefore, it was confirmed that the patch and the patch preparation according to this example are compatible with high cohesiveness and skin adhesiveness at a high level.

It is sectional drawing which shows one Embodiment of the patch which concerns on this invention.

Explanation of symbols

  DESCRIPTION OF SYMBOLS 1 ... Support body, 2 ... Adhesive layer, 3 ... Release film, 10 ... Patch.

Claims (6)

A patch comprising a pressure-sensitive adhesive layer containing a pressure-sensitive adhesive composition for a patch containing a rubber-based elastomer and a tackifier having a weight average molecular weight of 1300 to 2500 on at least one side of the support ,
The tackifier is a petroleum resin;
The patch, wherein the petroleum resin is an alicyclic saturated hydrocarbon resin having a repeating unit represented by the following general formula (1) .

The rubber-based elastomer includes a first rubber-based elastomer and a second rubber-based elastomer,
At least one is, the adhesive patch of claim 1 Symbol placement of rubber elastomer and a second rubber elastomer of the first are each independently selected from polyisobutylene, polyisoprene, butyl rubber and styrene thermoplastic elastomer. The first rubber-based elastomer has a weight average molecular weight of 1,600,000 to 5,400,000;
The patch according to claim 2 , wherein the weight average molecular weight of the second rubber-based elastomer is 36,000 to 75,000. The patch according to any one of claims 1 to 3 , comprising 15 to 60% by weight of a rubber-based elastomer and 15 to 55% by weight of a tackifier with respect to the total amount of the pressure-sensitive adhesive composition. The patch according to any one of claims 1 to 4 , comprising 20 to 50% by weight of an organic liquid component with respect to the total amount of the pressure-sensitive adhesive composition. A patch preparation, wherein the adhesive layer of the patch according to any one of claims 1 to 5 contains a transdermally absorbable drug (excluding bisoprolol).

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